scholarly journals A Proper Increasing in the Testosterone Level May Be Associated With Better Pregnancy Outcomes for in Vitro Fertilization (IVF)/intracytoplasmic Sperm Injection (ICSI) Patients With Tubal or Male Infertility

2021 ◽  
Author(s):  
Zhiyan Chen ◽  
Duoduo Zhang ◽  
Zhengyi Sun ◽  
Qi Yu
Keyword(s):  
Male Infertility ◽  
Pregnancy Outcomes ◽  
Vitro Fertilization ◽  
Time Points ◽  
Inflection Points ◽  
Group 3 ◽  
The Relationship ◽  
Androgen Levels ◽  
Group 1

Abstract Background To investigate the relationship between androgen levels and pregnancy outcomes in patients with tubal or male infertility at different times of the in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles. Methods Patients with tubal or male infertility but normal androgen levels receiving IVF/ICSI were continuously recruited. We made longitudinal analysis of the testosterone (T) levels at three time points (T0: basal T levels, T1: T levels on the trigger day, T2: T levels on the next day of the trigger day) in three groups with different pregnancy outcomes (Group 1: no pregnancy, Group 2: clinical pregnancy but no live birth, Group 3: live birth) as repeated measurement data using linear mixed effect models. We also plotted fitting curves depicting the relationship of the T levels and the numbers of oocytes retrieved at different time points, and the inflection points of the curves were identified. Results A total of 3012 patients were recruited in the study. Improvements in androgen levels were identified at the three-time points in Group 1 and 3. The slope in Group 3 after refitting was significantly higher than Group 1 (P = 0.000). The curves that reflected the association of androgen levels and numbers of retrieved oocytes presented an upward trend before a certain inflection point, after which the curves had no obvious changes or fell with the increase of androgen levels. The inflection points for T0, T1, T2 were calculated as 0.45, 0.94, 1.09, respectively. Conclusion The faster upward trend of the T levels might be associated with better pregnancy outcomes. Within the range of lower than a certain value of the T levels, more oocytes and embryos could be obtained with the increasing of the T levels.

scholarly journals A Proper Increasing in the Testosterone Level May Be Associated With Better Pregnancy Outcomes for Patients With Tubal or Male Infertility During in vitro Fertilization/Intracytoplasmic Sperm Injection

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhiyan Chen ◽  
Duoduo Zhang ◽  
Zhengyi Sun ◽  
Qi Yu
Keyword(s):  
Male Infertility ◽  
Pregnancy Outcomes ◽  
Inflection Point ◽  
Upward Trend ◽  
Time Points ◽  
Inflection Points ◽  
Group 3 ◽  
The Relationship ◽  
Group 1

We aimed to investigate the relationship between testosterone (T) levels and pregnancy outcomes in patients with tubal or male infertility at different times during in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles. Patients with tubal or male infertility and normal androgen levels undergoing IVF/ICSI were consecutively recruited. We performed a longitudinal analysis of T levels at three time points (i.e., T0: baseline, T1: trigger day, and T2: day after the trigger day) in three groups with different pregnancy outcomes (i.e., group 1: no pregnancy; group 2: clinical pregnancy but no live birth; and group 3: live birth) as repeated measurement data using linear mixed-effects models. We also plotted fitted curves depicting the relationship between T levels and a number of oocytes retrieved at different time points and identified the inflection points of the curves. In total, 3,012 patients were recruited. Groups 1 and 3 had improvements in T levels at the three time points. After refitting, the slope in group 3 was significantly higher than that in group 1 (P = 0.000). Curves that reflected the association between T levels and numbers of retrieved oocytes presented an upward trend before a certain inflection point, after which the curves had no obvious changes or fell with increasing T levels. The inflection points for T0, T1, and T2 were calculated as 0.45, 0.94, and 1.09, respectively. A faster upward trend in T levels might be associated with better pregnancy outcomes. Within a range lower than a T level inflection point, more oocytes and embryos could be obtained with increasing T levels.

scholarly journals Association Between Serum Oestradiol Level on the Human Chorionic Gonadotrophin Administration Day and Neonatal Birthweight After in Vitro Fertilization-embryo Transfer: A Retrospective Study of 3659 Singleton Live Births

2020 ◽  
Author(s):  
Yu Liu ◽  
Jing Li ◽  
Yihong Guo
Keyword(s):  
Retrospective Study ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Vitro Fertilization ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Ivf Et ◽  
Group 1

Abstract BackgroundOestradiol, an important hormone in follicular development and endometrial receptivity, is closely related to clinical outcomes of fresh in vitro fertilization-embryo transfer (IVF-ET) cycles. A supraphysiologic E2 level is inevitable during controlled ovarian hyper-stimulation (COH), and its effect on the outcome of IVF-ET is controversial. The aim of this retrospective study is to evaluate the association between elevated serum oestradiol (E2) levels on the day of human chorionic gonadotrophin (hCG) administration and neonatal birthweight after IVF-ET cycles.MethodsThe data of 3659 infertile patients with fresh IVF-ET cycles were analysed retrospectively between August 2009 and February 2017 in First Hospital of Zhengzhou University. Patients were categorized by serum E2 levels on the day of hCG administration into six groups: group 1 (serum E2 levels≤1000 pg/mL, n=230), group 2 (serum E2 levels between 1001 and 2000 pg/mL, n=524), group 3 (serum E2 levels between 2001 and 3000 pg/mL, n=783), group 4 (serum E2 levels between 3001 and 4000 pg/mL, n = 721), group 5 (serum E2 levels between 4001 and 5000 pg/mL, n=548 ), and group 6 (serum E2 levels > 5000 pg/mL, n=852). Univariate linear regression was used to evaluate the independent correlation between each factor and outcome index. Multiple logistic regression was used to adjust for confounding factors.ResultsThe LBW rates were as follows: 3.0% (group 1), 2.9% (group 2), 1.9% (group 3), 2.9% (group 4), and 2.0% (group 6) (P =0.629), respectively. There were no statistically significant differences in the incidences of neonatal LBW among the six groups. We did not detect an association between peak serum E2 level during ovarian stimulation and neonatal birthweight after IVF-ET.ConclusionThe results of this retrospective cohort study showed that serum E2 peak levels during ovarian stimulation were not associated with birth weight during IVF cycles. In addition, no association was found between higher E2 levels and increased LBW risk. Our observations suggest that the hyper-oestrogenic milieu during COS does not seem to have adverse effects on the birthweight of offspring after IVF.

scholarly journals 253 COMPARISON OF THREE DIFFERENT IVF PROTOCOLS FOR BOVINE OOCYTES

2005 ◽  
Vol 17 (2) ◽  
pp. 277
Author(s):  
S. Romo ◽  
J. Pryor ◽  
D.D. Varner ◽  
K. Hinrichs ◽  
C.R. Looney
Keyword(s):  
Embryo Culture ◽  
Culture Media ◽  
Sperm Concentration ◽  
Vitro Fertilization ◽  
Group 3 ◽  
Group 2 ◽  
The Given ◽  
Sperm Separation ◽  
Group 1

Recently, the development of commercially available defined media and sperm centrifugation gradients has offered new possibilities for increasing the efficiency of commercial in vitro fertilization (IVF) systems. The objective of this study was to compare three different IVF protocols using two different separation gradients, two fertilization media, and two embryo culture media, as follows: Group 1. sperm separation (SS): Percoll (Sigma, St. Louis, MO, USA), fertilization medium (FM): TALP-Fert (TFM), embryo culture media (ECM): G1/G2 (version 3, Vitrolife, Englewood, CO, USA). Group 2. SS: Percoll, FM: Bovine vitro Fert (Cook, Brisbane, Australia), ECM: Bovine vitro Blast/Bovine vitro Cleave (Cook); and Group 3. SS: EquiPure (Nidacon, Spectrum Technologies, Healdsburg, CA, USA), FM: TFM, ECM: G1/G2. Oocytes were obtained from slaughterhouse ovaries and matured in vitro (Looney et al. 1994 Theriogenology 41, 67). IVF was conducted using frozen/thawed semen from one bull. Semen was separated by centrifugation at 700g for 30 min in the given density gradients; Percoll was used in a 45% to 90% gradient. Sperm viability after separation was assessed by fast-green/eosin stain (Sigma). IVF was carried out in 0.5 mL of the given fertilization medium supplemented with PHE1 and heparin (10 μg/mL), in humidified 5% CO2 in air atmosphere at 38.7°C. Final sperm concentration in the IVF wells was 1 × 106/mL. In Experiment 1, a total of 368 oocytes (2 replicates) were fixed and stained (Hoechst 33342, Sigma) 24 h post-IVF to assess sperm penetration (Group 1, n = 128, Group 2, n = 108, Group 3, n = 132). In Experiment 2, a total of 400 embryos (2 replicates) were cultured in 0.5 mL of the given culture medium under mineral oil in a 5% O2, 5% CO2, 90% N2 atmosphere at 38.7°C with high humidity for 112 h before fixation and staining. Embryos in Groups 1 (n = 129) and 3 (n = 139) and Group 2 (n = 132) were changed to G2 and Cleave media, respectively, at 84 h. Sperm separation with Percoll yielded lower numbers of sperm (average sperm concentration after separation of 218 vs. 383 × 106 for EquiPure; P < 0.05), but resulted in higher total motility (60% vs. 41%, respectively; P < 0.05) and higher viability (93% vs. 70%, respectively; P < 0.05) of separated sperm. In Experiment 1, rates of normal fertilization were significantly lower for Group 3 (58%) than for Groups 1 and 2 (74% and 77%, respectively, P < 0.05). In Experiment 2, rates of development to <8, 9 to 16, and >16 cells at 112 h were not significantly different among groups (43, 48, and 46% for Group 1; 22, 18, and 31% for Group 2; and 35, 34, and 23% for Group 3, respectively; P > 0.1). These results indicate that the commercial separation medium, EquiPure, may be associated with lowered sperm motility, viability, and fertilization rates when compared to a standard medium (Percoll) for bovine sperm separation. Commercial fertilization and embryo culture media (Bovine vitro Fert, Cleave, and Blast) provided equivalent embryo development to that currently in use by our laboratory (TFM, G1/G2).

scholarly journals Maternal characteristics and pregnancy outcomes of Chinese women with infertility undergoing in vitro fertilization  with  embryonic cryopreservation :  a retrospective cohort study

2020 ◽  
Author(s):  
jingxue wang ◽  
qiwei liu ◽  
Boer Deng ◽  
fang chen ◽  
xiaowei liu ◽  
...  
Keyword(s):  
Male Infertility ◽  
Pregnancy Outcomes ◽  
Chinese Women ◽  
Placenta Previa ◽  
Vitro Fertilization ◽  
Maternal Characteristics ◽  
Tubal Disease ◽  
Nicu Admission ◽  
Singleton Pregnancies

Abstract Background: To examine differences in the maternal characteristics and pregnancy outcomes of Chinese women with various causes of infertility who underwent in vitro fertilization (IVF) with embryonic cryopreservation treatment.Methods: Cases were pregnancies after IVF-ET with embryonic cryopreservation; controls were spontaneously conceived pregnancies. Subgroup analysis was carried out according to etiology of infertility. The IVF treatment group was divided into 5 subgroups according to infertility etiology as follows: ovulation disorder, tubal disease, male infertility, endometriosis, and mixed infertility. Data on demographic characteristics, medical history, laboratory tests, and delivery were reviewed. Logistic regression analysis was performed for pregnancy and perinatal complications and neonatal outcomes. The multivariable model was adjusted for potential confounders.Results: Among singleton pregnancies, compared with spontaneous pregnancies, IVF pregnancies were associated with significant increases in the rates of the following: gestational diabetes mellitus (GDM) (aOR 1.76[95% CI 1.33-2.33]), preeclampsia (2.60[1.61-4.20]), preterm preeclampsia (4.52[2.03-10.06]), postpartum hemorrhage (1.57[1.04-2.36]), intrahepatic cholestasis of pregnancy (3.84[1.06-13.94]), preterm premature rupture of membranes (2.11[1.17-3.81]), preterm birth (1.95[CI 1.26-3.01]), low birthweight (1.90[1.13-3.20]), macrosomia (1.53[1.03-2.27]), and neonatal intensive care unit (NICU) admission (1.69[1.22-2.34]) in the ovulation disorder group; GDM (1.50[1.21-1.86]), placenta previa (2.70[1.59-4.59]), placenta accreta (1.78[1.10-2.89]), postpartum hemorrhage (1.61[1.19-2.18]), macrosomia (1.60[1.21-2.13]) and 5-minute Apgar score ≤7 (4.09[1.04-16.08]) in the tubal disease group; placenta previa (9.33[4.22-20.62]), small for gestational age (2.29[1.04-5.08]), macrosomia (2.00[1.02-3.95]) and NICU admission (2.35[1.35-4.09]) in the endometriosis group; placenta previa (4.14[2.23-7.68]) and placenta accreta (2.05[1.08-3.87]) in the male infertility group; and GDM (1.85[1.15-2.98]), placenta previa (4.73[1.83-12.21]), placental abruption (3.39[1.20-9.56]), chorioamnionitis (2.93[1.04-8.26]), preterm birth (2.69[1.41-5.15]), and 1-minute Apgar score ≤7 (4.68[1.62-13.51]) in the mixed infertility group. Among multiple pregnancies, most of the differences that were significant in singleton pregnancies were less extensive or had disappeared.Conclusions: Infertility etiology within the IVF population was found to affect maternal and neonatal outcomes among all births. During the perinatal period, infertility etiology appears to be an additional risk factor for abnormal pregnancy outcomes besides the use of IVF techniques compared with spontaneous pregnancies. Higher risk was found for ovulation disorders, and lower risk was found for male infertility.

scholarly journals Progesterone levels predict pregnancy outcome in individuals with fallopian tube associated infertility

2020 ◽  
Author(s):  
Wenjia BO ◽  
Ning Zhang
Keyword(s):  
Fallopian Tube ◽  
Clinical Data ◽  
Pregnancy Outcomes ◽  
Birth Rate ◽  
Fertilization Rate ◽  
Clinical Pregnancy ◽  
Vitro Fertilization ◽  
Group 3 ◽  
Group 2

Abstract Background: To investigate the predictive value of human chorionic gonadotropin(HCG) and progesterone(P) levels on pregnancy outcomes in patients receiving in vitro fertilization(IVF) due to simple fallopian tube factors. METHODS:We retrospectively analyzed the clinical data of 854 cycles from the simple fallopian tube factor IVF fresh embryo transfer.The clinical data of 854 cycles from January 2010 to December 2018 was divided into 7 groups according to the P level on HCG day.Live birth rates(LBR) and observe trends were calculated. The receiver operating characteristic(ROC) curve was established to determine the optimal cutoff value for P, which was used to further divide the data into 3 groups: Group 1 (P ≦ 1.0 ng/ml), Group 2 (1.0 ng/ml ≤ P ≤ 1.25 ng/ml), and Group 3 (P≥1.25ng/ml). We then compared the ovulation results and clinical outcomes between the 3 groups. RESULTS There were no significant differences in age, infertility years, Gonadotropin(Gn)dosage, Gn days, Luteinizing hormone(LH) level on HCG day, 2pronuclear(2PN) fertilization rate, clinical pregnancy rate(CPR), LBR, full-term birth rate, and preterm birth rate among the three groups, but body mass index （BMI）(P = 0.001), basal LH (P = 0.034), estrogen peak (P = 0.000), number of eggs obtained (P = 0.000) were significantly different. CONCLUSION The level of P level on HCG day does not affect the CPR and LBR after IVF. However, P levels between 1.0-1.25ng/ml may lead to good clinical pregnancy outcomes.

scholarly journals Maternal characteristics and pregnancy outcomes of Chinese women with infertility undergoing in vitro fertilization with embryonic cryopreservation: a retrospective cohort study

2020 ◽  
Author(s):  
jingxue wang ◽  
qiwei liu ◽  
Boer Deng ◽  
fang chen ◽  
xiaowei liu ◽  
...  
Keyword(s):  
Male Infertility ◽  
Pregnancy Outcomes ◽  
Chinese Women ◽  
Placenta Previa ◽  
Vitro Fertilization ◽  
Maternal Characteristics ◽  
Tubal Disease ◽  
Nicu Admission ◽  
Singleton Pregnancies

Abstract Background: To examine differences in the maternal characteristics and pregnancy outcomes of Chinese women with various causes of infertility who underwent in vitro fertilization(IVF) with embryonic cryopreservation treatment.Methods: This retrospective cohort study included women with various causes of infertility who used IVF. In order to reduce the research error, we deliberately removed the fresh ET cycles and ICSI cycles at the beginning, so in our data the IVF-ET method was frozen-embryo transfer.[MOU1] [MOU2] Data on demographic characteristics, medical history, laboratory tests, and delivery were reviewed. Logistic regression analysis was performed to calculate odds ratios and 95% confidence intervals for pregnancy and perinatal complications and neonatal outcomes. The multivariable model was adjusted for age, gravidity, parity, pre-pregnancy obesity, birth plurality, and history of previous caesarean section.[MOU3] Results: The IVF treatment group was divided into 5 subgroups according to infertility cause as follows: ovulation disorder, tubal disease, male infertility, endometriosis, and mixed infertility. Among singleton pregnancies, we verified that IVF with embryonic cryopreservation pregnancies are related to increased risks of adverse perinatal outcomes. Besides，compared with spontaneous pregnancies, IVF pregnancies were associated with significant increases in the rates of the following: gestational diabetes mellitus (GDM), preeclampsia, preterm preeclampsia, postpartum haemorrhage, intrahepatic cholestasis of pregnancy, preterm premature rupture of membranes, preterm birth, low birthweight, macrosomia, and neonatal intensive care unit (NICU) admission in the ovulation disorder group; GDM, placenta previa, placenta accreta, postpartum haemorrhage, macrosomia and 5-minute Apgar score ≤7 in the tubal disease group; placenta previa, small for gestational age, macrosomia and NICU admission in the endometriosis group; placenta previa and placenta accreta in the male infertility group; and GDM, placenta previa, placental abruption, chorioamnionitis, preterm birth, and 1-minute Apgar score≤7 in the mixed infertility group. Among multiple pregnancies, most of the differences that were significant in singleton pregnancies were less extensive or had disappeared.[MOU4] [MOU5] Conclusions: During the perinatal period, maternal characteristics, in particular type of infertility, appears an additional risk factor for abnormal pregnancy outcomes besides use of IVF techniques. Lower risk is found in male infertility and higher risk for ovulation disorders.[MOU6]

Choice, Gift, or Patriarchal Bargain? Women's Consent to In Vitro Fertilization in Male Infertility

Hypatia ◽  
1989 ◽  
Vol 4 (3) ◽  
pp. 23-36 ◽  
Author(s):  
Judith Lorber
Keyword(s):  
In Vitro Fertilization ◽  
Male Infertility ◽  
Medical Staff ◽  
Male Partner ◽  
Infertile Male ◽  
Vitro Fertilization ◽  
Biological Child ◽  
The Relationship

This paper explores the reasons why women who are themselves fertile might consent to undergo in vitro fertilization (1VF) with an infertile male partner. The reasons often given are desire to have that particular man's child, or altruism, giving a gift to the partner. Although ethically, the decision should be completely woman's prerogative, because IVF programs usually treat the couple as a unit, she may be offered few other options by the medical staff. In social terms, whether the woman is or is not infertile may be immaterial because in either situation, if she wants to try to have a biological child and maintain the relationship, she may have to make a patriarchal bargain and undergo in vitro fertilization.

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