scholarly journals In vitro and in vivo evaluation of silver needle white tea extract against colon cancer

2020 ◽  
Author(s):  
Fatemeh Hajiaghaalipour ◽  
Elham Bagheri ◽  
Elham Rouhollahi ◽  
Nur'ain Salehen ◽  
Mahmood Ameen Abdulla
Keyword(s):  
Colon Cancer ◽  
In Vivo Evaluation ◽  
White Tea ◽  
Tea Extract

Abstract The authors have withdrawn this preprint due to author disagreement.

scholarly journals In vitro and in vivo evaluation of silver needle white tea extract against colon cancer

2020 ◽  
Author(s):  
Fatemeh Hajiaghaalipour ◽  
Elham Bagheri ◽  
Elham Rouhollahi ◽  
Nur'ain Salehen ◽  
Mahmood Ameen Abdulla
Keyword(s):  
Colon Cancer ◽  
Body Weight ◽  
Acute Toxicity ◽  
Aberrant Crypt Foci ◽  
Male Rats ◽  
White Tea ◽  
Group I ◽  
Tea Extract

Abstract Background Tea (Camellia sinensis) is one of the most consumed beverages in the world. White tea is an unfermented tea made from young tea leaves or unopened buds. Methods The in vitro antiproliferation assay and in vivo Chemopreventive effects of white tea extract (WTE) using azoxymethane (AOM) induced aberrant crypt foci (ACF) in rats was assessed. Twenty-four adult male rats were injected 15 mg/kg body weight AOM subcutaneously once a week for two weeks and then were divided randomly into four groups. Group I (Cancer control), Group II (treated whit 200 mg/kg white tea extract), Group III (treated whit 400 mg/kg white tea extract) and group IV (35 mg/kg body weight 5-fluorouracil as reference control). On the last day of the experiment, the animals were euthanized using an overdose of ketamine and xylazine and the colon tissue was collected. The colon tissues were evaluated grossly and histopathologically for aberrant crypt foci (ACF). Prior to the cancer studies, the acute toxicity test was performed to demonstrate the safety usage of the extract. Results The antiproliferative activity of the extract was observed in HT-29 and HCT 116 colon cancer cells. The ACF score was significantly reduced following the white tea extract treatment in a dose-dependent manner. Furthermore, the acute toxicity study indicated that there were no nephrotoxic and hepatotoxic effects or any serum biochemical changes in the rats that were orally administered with 2000 mg/kg body weight of the extract. Conclusions This study suggested the the potential of white tea as a chemopreventative agent through inhibition of Azoxymethane-induced Colonic Aberrant Crypt Foci Formation in the male Sprague-Dawley rats.

scholarly journals Modification of In Vitro and In Vivo Antioxidant Activity by Consumption of Cooked Chickpea in a Colon Cancer Model

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2572 ◽  
Author(s):  
María S. Cid-Gallegos ◽  
Xariss M. Sánchez-Chino ◽  
Isela Álvarez-González ◽  
Eduardo Madrigal-Bujaidar ◽  
Verónica R. Vásquez-Garzón ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Antioxidant Activity ◽  
Nutritional Composition ◽  
Standard Diet ◽  
In Vivo Evaluation ◽  
Phytochemical Compounds ◽  
Nutritional Compounds ◽  
In Vitro Antioxidant Activity

Chickpea has been classified as a nutraceutical food due to its phytochemical compounds, showing antioxidant, anti-inflammatory, and anticancer activity. To investigate this, we evaluated the effect of cooking on the nutritional and non-nutritional composition and the in vitro and in vivo antioxidant activity of chickpea seed. The latter was determined by the variation in the concentration of nitric oxide (NO), oxidized carbonyl groups (CO), malondialdehyde (MDA), and the expression of 4-hydroxy-2-nonenal (4-HNE) in the colon of male BALB/c mice fed with a standard diet with 10 and 20% cooked chickpea (CC). We induced colon cancer in mice by administering azoxymethane/dextran sulfate sodium (AOM/DSS); for the evaluation, these were sacrificed 1, 7, and 14 weeks after the induction. Results show that cooking does not significantly modify (p < 0.05) nutritional compounds; however, it decreases the concentration of non-nutritional ones and, consequently, in vitro antioxidant activity. The in vivo evaluation showed that animals administered with AOM/DSS presented higher concentrations of NO, CO, MDA, and 4-HNE than those in animals without AOM/DSS administration. However, in the three evaluated times, these markers were significantly reduced (p < 0.05) with CC consumption. The best effect on the oxidation markers was with the 20% CC diet, demonstrating the antioxidant potential of CC.

In vitro and in vivo evaluation of organometallic gold(i) derivatives as anticancer agents

2016 ◽  
Vol 45 (6) ◽  
pp. 2462-2475 ◽  
Author(s):  
Elena García-Moreno ◽  
Alejandro Tomás ◽  
Elena Atrián-Blasco ◽  
Sonia Gascón ◽  
Eduardo Romanos ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Line ◽  
Anticancer Agents ◽  
Cancer Cell Line ◽  
Colon Cancer Cell Line ◽  
Colon Cancer Cell ◽  
Water Soluble ◽  
In Vivo Evaluation

Alkyne gold(i) derivatives with the water soluble phosphanes PTA and DAPTA were described and their anticancer potential against the colon cancer cell line Caco-2 (PD7 and TC7 clones) was studied.

Nanoliposome-mediated FL/TRAIL double-gene therapy for colon cancer: In vitro and in vivo evaluation

2012 ◽  
Vol 315 (1) ◽  
pp. 69-77 ◽  
Author(s):  
Nian-feng Sun ◽  
Qing-yi Meng ◽  
Ai-ling Tian ◽  
San-yuan Hu ◽  
Rui-hua Wang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Colon Cancer ◽  
In Vivo Evaluation

In vitro and in vivo evaluation of the anti-inflammatory effects of Arzanol from Helichrysum italicum

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
J Bauer ◽  
F Dehm ◽  
A Koeberle ◽  
F Pollastro ◽  
G Appendino ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Anti Inflammatory
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