scholarly journals The Associations Between Maternal Adverse Childhood Experiences, Substance Use During Pregnancy and Poor Infant Outcomes: A Protocol for Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Chad Lance Hemady ◽  
Siu Ching Wong ◽  
Christina Thurston ◽  
Deborah Fry ◽  
Aja Louise Murray ◽  
...  
Keyword(s):  
Systematic Review ◽  
Substance Use ◽  
Adverse Childhood Experiences ◽  
Meta Analysis ◽  
The Body ◽  
Future Research ◽  
Supporting Evidence ◽  
Childhood Experiences ◽  
Infant Outcomes ◽  
Adverse Childhood

Abstract Background: Research suggests that maternal exposure to childhood adversity is associated with substance use during pregnancy and poor infant outcomes (i.e., premature birth, low birth weight). However, to date, no systematic review has synthesised the effect of ACEs on these three outcomes. Method: The framework for this review will be adapted from the guidelines laid out in the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 statement. The electronic databases to be searched will include: PubMed, SCOPUS, PsycInfo, Web of Science, and CINAHL and will be carried out by one reviewer. Studies that fit the pre-specified eligibility criteria will be screened, assessed, and extracted independently by two reviewers with discrepancies to be resolved by a third reviewer. The Newcastle-Ottawa Scale (NOS) for cross-sectional and cohort studies will be used to critically evaluate the methodological quality of the selected studies. If a sufficient number of studies are found to be comparable, a meta-analysis will be conducted using a random effects model.Discussion: This review will provide supporting evidence on the body of literature exploring the long-term and intergenerational consequences of adverse childhood experiences. The results of the review can help inform policies and interventions related to maternal health as well as early childhood development. The gaps identified in the review can also help inform recommendations for future research.

scholarly journals The Associations between Maternal Adverse Childhood Experiences, Substance Use During Pregnancy and Poor Infant Outcomes: A Protocol for Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Chad Lance Hemady ◽  
Siu Ching Wong ◽  
Christina Thurston ◽  
Deborah Fry ◽  
Aja Louise Murray ◽  
...  
Keyword(s):  
Systematic Review ◽  
Substance Use ◽  
Adverse Childhood Experiences ◽  
Meta Analysis ◽  
The Body ◽  
Future Research ◽  
Supporting Evidence ◽  
Childhood Experiences ◽  
Infant Outcomes ◽  
Adverse Childhood

Abstract Background: Research suggests that maternal exposure to childhood adversity is associated with substance use during pregnancy and poor infant outcomes (i.e., premature birth, low birth weight). However, to date, no systematic review has synthesised the effect of ACEs on these three outcomes.Method: The framework for this review will be adapted from the guidelines laid out in the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 statement. The electronic databases to be searched will include: PubMed, SCOPUS, PsycInfo, Web of Science, and CINAHL and will be carried out by one reviewer. Studies that fit the pre-specified eligibility criteria will be screened, assessed, and extracted independently by two reviewers with discrepancies to be resolved by a third reviewer. The Newcastle-Ottawa Scale (NOS) for cross-sectional and cohort studies will be used to critically evaluate the methodological quality of the selected studies. If a sufficient number of studies are found to be comparable, a meta-analysis will be conducted using a random effects model.Discussion: This review will provide supporting evidence on the body of literature exploring the long-term and intergenerational consequences of adverse childhood experiences. The results of the review can help inform policies and interventions related to maternal health as well as early childhood development. The gaps identified in the review can also help inform recommendations for future research.

Adverse childhood experiences and risk of cancer during adulthood: A systematic review and meta-analysis

2021 ◽  
Vol 117 ◽  
pp. 105088
Author(s):  
Zhao Hu ◽  
Atipatsa Chiwanda Kaminga ◽  
Jun Yang ◽  
Jiefeng Liu ◽  
Huilan Xu
Keyword(s):  
Systematic Review ◽  
Adverse Childhood Experiences ◽  
Meta Analysis ◽  
Childhood Experiences ◽  
Adverse Childhood ◽  
Risk Of Cancer

Adverse childhood experiences and risk of type 2 diabetes: A systematic review and meta-analysis

Metabolism ◽  
2015 ◽  
Vol 64 (11) ◽  
pp. 1408-1418 ◽  
Author(s):  
Hao Huang ◽  
Peipei Yan ◽  
Zhilei Shan ◽  
Sijing Chen ◽  
Moying Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Adverse Childhood Experiences ◽  
Meta Analysis ◽  
Childhood Experiences ◽  
Adverse Childhood

scholarly journals Adverse childhood experiences and chronic lung diseases in adulthood: a systematic review and meta-analysis

2020 ◽  
Vol 11 (1) ◽  
pp. 1720336 ◽  
Author(s):  
Samuel Lopes ◽  
Jaime Eduardo Cecilio Hallak ◽  
João Paulo Machado de Sousa ◽  
Flávia de Lima Osório
Keyword(s):  
Systematic Review ◽  
Adverse Childhood Experiences ◽  
Lung Diseases ◽  
Meta Analysis ◽  
Childhood Experiences ◽  
Chronic Lung Diseases ◽  
Adverse Childhood

scholarly journals Adverse Childhood Experiences and Early Pubertal Timing Among Girls: A Meta-Analysis

2019 ◽  
Vol 16 (16) ◽  
pp. 2887 ◽  
Author(s):  
Lei Zhang ◽  
Dandan Zhang ◽  
Ying Sun
Keyword(s):  
Sexual Abuse ◽  
Adverse Childhood Experiences ◽  
Pubertal Timing ◽  
Meta Analysis ◽  
Father Absence ◽  
Family Dysfunction ◽  
Future Research ◽  
Childhood Experiences ◽  
Adverse Childhood ◽  
Early Pubertal Timing

The association between adverse childhood experiences (ACEs) and pubertal timing has been a topic of enduring controversy. A systematic search of PubMed and Web of Science databases was undertaken to quantify the magnitude of total and specific forms of ACEs effects on early pubertal timing among girls. Our search identified 3280 records, of which 43 studies with 46 independent data sets met inclusion criteria. We estimated pooled effect sizes (Cohen’s ds) for the association between ACEs with early pubertal timing. Total ACEs was not associated with early pubertal timing. When we examined the specific types of ACEs, associations were small to medium for father absence (d = −0.40, 95% confidence interval [CI]: −0.63, −0.16) and small for sexual abuse (d = −0.13, CI: −0.17, −0.10) and family dysfunction (d = −0.08, CI: −0.11, −0.02). We identified considerable heterogeneity between estimates for almost all of the outcomes. ACEs exposure may affect female reproductive reproduction, particularly father absence, sexual abuse, and family dysfunction. We propose that future research in this area test a theoretical model linking adversity with earlier reproductive strategy, which includes early pubertal timing as a core component linking early adversity and stress physiology with poor health outcomes later in life in females.

scholarly journals Identifying Targets for Substance Use Prevention in Young People Exposed to Childhood Adversity: Protocol for a Systematic Review (Preprint)

2020 ◽  
Author(s):  
Lucinda Rachel Grummitt ◽  
Erin Veronica Kelly ◽  
Emma Louise Barrett ◽  
Katherine M Keyes ◽  
Nicola Clare Newton
Keyword(s):  
Substance Use ◽  
Young People ◽  
Adverse Childhood Experiences ◽  
Meta Analysis ◽  
Childhood Adversity ◽  
Substance Use Prevention ◽  
Childhood Experiences ◽  
Adverse Childhood ◽  
Quantitative Synthesis ◽  
The Relationship

BACKGROUND Adverse childhood experiences are prevalent robust risk factors for the development of substance use problems. However, less is known about the causal mechanisms that explain these relationships. While directly preventing adverse childhood experiences is ideal, it is not always possible. In such cases, the mechanisms themselves may be amenable to intervention, allowing for the effective prevention of problematic substance use among children exposed to adversity. Identifying such mechanisms is therefore a critical step for efforts aiming to reduce the high individual and societal burdens associated with substance use globally. OBJECTIVE This study aims to systematically identify and synthesize evidence on the modifiable mediators and moderators of the relationship between adverse childhood experiences and substance use outcomes in young people (age 10-24 years). METHODS A systematic review will be conducted using PubMed, MEDLINE, PsycINFO, Web of Science, and CINAHL databases to determine the modifiable mediators and moderators of the relationship between adverse childhood experiences and substance use in young people. Data from the review will be qualitatively synthesized, unless we identify a sufficient number of studies (at least five) that examine the same type of adversity (eg, physical or sexual abuse) and the same mediator/moderator, in which case a quantitative synthesis (meta-analysis) will be conducted. If a quantitative synthesis is warranted, standardized effect estimates of the indirect (mediated) effect between adverse childhood experiences and substance use outcomes will be combined using a random-effects meta-analysis. Mediators/moderators will be grouped according to a socioecological perspective, using the four levels of individual, interpersonal, community, and public policy/culture. RESULTS Electronic searches were completed in August 2019. A total of 4004 studies were included for screening after removing duplicates. After evaluating titles and abstracts against eligibility criteria, a further 3590 studies were excluded, leaving 415 studies for full-text screening. The results of the review are expected to be available by December 2020. CONCLUSIONS The mechanisms linking adverse childhood experiences and substance use outcomes in young people are vital targets for substance use prevention efforts. This review will provide evidence to inform the development of prevention strategies in order to interrupt the negative life trajectory that can begin with childhood adversity. CLINICALTRIAL PROSPERO International Prospective Register of Systematic Reviews CRD42020148773; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020148773 INTERNATIONAL REGISTERED REPORT DERR1-10.2196/22368

scholarly journals Relationship between adverse childhood experiences and Alzheimer’s disease: a systematic review and meta-analysis protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e049768
Author(s):  
Kayla B Corney ◽  
Julie A Pasco ◽  
Amanda L Stuart ◽  
Emma C West ◽  
Shae E Quirk ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Adverse Childhood Experiences ◽  
Meta Analysis ◽  
Population Exposure ◽  
Published Data ◽  
Childhood Experiences ◽  
Substantial Impact ◽  
Adverse Childhood

IntroductionAlzheimer’s disease has a high prevalence and a substantial impact on society, as well as the individual. Findings from clinical studies to date, suggest that multiple factors are likely to contribute to the variability seen in the progression of Alzheimer’s disease. However, despite this accumulating evidence, current identified factors do not explain the full extent of disease onset. Thus, the role of additional factors needs to be explored further.One such factor is exposure to adverse childhood experiences. However, the degree of this association is unknown. This systematic review will examine the literature investigating the associations between adverse childhood experiences and the risk of Alzheimer’s disease.Methods and analysisArticles investigating associations between exposure to adverse childhood experiences and the risk of Alzheimer’s disease will be identified systematically by searching CINAHL, MEDLINE and PsycInfo using Ebscohost. No restrictions on date of publication will be applied. The search strategy will be built combining the main key elements of the Population, Exposure, Comparator, and Outcomes inclusion criteria. A meta-analysis is planned and statistical methods will be used to identify and control for heterogeneity, if possible. The development of this protocol was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols.Ethics and disseminationOnly published data will be used for this study, thus, ethical approval will not be required. Findings of the review will be published in a peer-reviewed scientific journal, and presented at national and international conferences.PROSPERO registration numberCRD42020191439.

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