scholarly journals Study on rapid screening technology of antisense oligonucleotides for SARS-CoV-2

2021 ◽  
Author(s):  
Huawei Shen
Keyword(s):  
Nucleic Acid ◽  
Antisense Oligonucleotides ◽  
Structural Characteristics ◽  
Inhibitory Effect ◽  
Rapid Screening ◽  
Short Term ◽  
Physical Isolation ◽  
The World ◽  
Actual Use ◽  
Screening Technology

Abstract According to the structural characteristics of SARS-CoV-2 nucleic acid,SARS-CoV-2 genomes were virtually segmented.After comparing with human genome,44707 SARS-CoV-2 genomes and 26 primates' genomes, 19 antisense oligonucleotides sequences were selected.Experimental results show that the combined inhibitory effect reaches 100% . Significance statement：Currently, effective methods of controlling the spread of SARS-CoV-2 are very limited, only physical isolation and vaccination.Although physical isolation can achieve some short-term results, but can not fundamentally solve the problem of epidemic spread.The time between the development of a vaccine and its actual use is very long.It often happens that the vaccine is developed successfully, but the epidemic situation is beyond control.If a mutant strain emerges, it will take longer.I hope that the rapid screening technology of SARS-CoV-2 antisense oligonucleotides will light up new hope for the future of mankind and contribute oriental wisdom to the world.

scholarly journals Study on rapid screening technology of antisense oligonucleotides for SARS-CoV-2

2021 ◽  
Author(s):  
Huawei Shen
Keyword(s):  
Nucleic Acid ◽  
Human Genome ◽  
Antisense Oligonucleotides ◽  
Structural Characteristics ◽  
Inhibitory Effect ◽  
Experimental Results ◽  
Rapid Screening ◽  
Screening Technology

Abstract According to the structural characteristics of SARS-CoV-2 nucleic acid,SARS-CoV-2 genomes were virtually segmented. After comparing with human genome, 44707 SARS-CoV-2 genomes and 26 primates' genomes, 18 antisense oligonucleotides sequences were selected. Experimental results show that the combined inhibitory effect reaches 100% .

scholarly journals The Internationalisation of the Academy: Convergence and Divergence across Disciplines

2015 ◽  
Vol 23 (S1) ◽  
pp. S38-S54 ◽  
Author(s):  
Michele Rostan ◽  
Flavio Antonio Ceravolo
Keyword(s):  
International Research ◽  
Research Collaboration ◽  
Structural Characteristics ◽  
Academic Profession ◽  
Academic Disciplines ◽  
International Mobility ◽  
Short Term ◽  
International Research Collaboration ◽  
The World ◽  
International Comparative

The internationalisation of the academy varies according to individual, institutional and structural characteristics. Among factors influencing it, discipline plays a major role. Relying on data collected by two international comparative studies – the Changing Academic Profession Study and the Academic Profession in Europe Study – this article focuses on two aspects of the internationalisation of the academy – namely, international research collaboration and international mobility – asking whether these two aspects are associated with academic disciplines and how. Results from multivariate data analyses – comparing Europe and the Rest of the World or other meaningful macro-regions – show that in some areas, such as international research collaboration and educational circulation, the international behaviours of academics belonging to different disciplines diverge, while in some others, such as research productivity related to international research collaboration and short-term professional circulation, they converge.

The Long-term Use of Short-term Debt around the World

2019 ◽  
Author(s):  
Lifang Chen ◽  
Yong Li ◽  
Yizhong Wang ◽  
Bohui Zhang
Keyword(s):  
Short Term ◽  
The World

In vitro evaluation of hexitol nucleic acid antisense oligonucleotides

1999 ◽  
Author(s):  
Arthur Van Aerschot ◽  
Mark Vandermeeren ◽  
Johan Geysen ◽  
Walter Luyten ◽  
Marc Miller ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Antisense Oligonucleotides ◽  
In Vitro Evaluation

Comprehensive Effects of Short-Term Rental Platforms Across Hotel Types in U.S. and International Destinations

2021 ◽  
pp. 193896552110335
Author(s):  
John W. O’Neill ◽  
Jihwan Yeon
Keyword(s):  
Service Providers ◽  
Comprehensive Analysis ◽  
Competitive Market ◽  
Substitution Effects ◽  
Short Term ◽  
Hotel Performance ◽  
The World ◽  
Different Types ◽  
Location Type ◽  
The Impact

In recent years, short-term rental platforms in the lodging sector, including Airbnb, VRBO, and HomeAway, have received extensive attention and emerged as potentially alternative suppliers of services traditionally provided by established commercial accommodation providers, that is, hotels. Short-term rentals have dramatically increased the available supply of rooms for visitors to multiple international destinations, potentially siphoning demand away from hotels to short-term rental businesses. In a competitive market, an increase in supply with constant demand would negatively influence incumbent service providers. In this article, we examine the substitution effects of short-term rental supply on hotel performance in different cities around the world. Specifically, we comprehensively investigate the substitution effects of short-term rental supply on hotel performance based on hotel class, location type, and region. Furthermore, we segment the short-term rental supply based on its types of accommodations, that is, shared rooms, private rooms, and entire homes, and both examine and quantify the differential effects of these types of short-term rentals on different types of hotels. This study offers a comprehensive analysis regarding the impact of multiple short-term rental platforms on hotel performance and offers both conceptual and practical insights regarding the nature and extent of the effects that were identified.

The Effect of High Concentrations of Ethylene on Seed Germination of Douglas Fir (Pseudotsugamenziesii (Mirb.) Franco)

1975 ◽  
Vol 5 (3) ◽  
pp. 419-423 ◽  
Author(s):  
Carey Borno ◽  
Iain E. P. Taylor
Keyword(s):  
Seed Germination ◽  
Germination Rate ◽  
Inhibitory Effect ◽  
Germination Percentage ◽  
Douglas Fir ◽  
Control Treatment ◽  
Continuous Exposure ◽  
Short Term ◽  
Short Term Exposure ◽  
High Concentrations

Stratified, imbibed Douglas fir (Pseudotsugamenziesii (Mirb.) Franco) seeds were exposed to 100% ethylene for times between 0 and 366 h. Germination rate and germination percentage were increased by treatments up to 48 h. The 12-h treatment gave largest stimulation; 30% enhancement of final germination percentage over control. Treatment for 96 h caused increased germination rate for the first 5 days but reduced the germination percentage. Germinants were subject to continuous exposure to atmospheres containing 0.1 – 200 000 ppm ethylene in air, but it did not stimulate growth, and the gas was inhibitory above 100 ppm. Although some effects of high concentrations of ethylene may have been due to the lowering of oxygen supplies, this alone was insufficient to account for the full inhibitory effect. The mechanism of stimulation by short-term exposure to ethylene is discussed.

Man and Nature in China

1967 ◽  
Vol 1 (4) ◽  
pp. 313-333 ◽  
Author(s):  
Rhoads Murphey
Keyword(s):  
Public Good ◽  
New Order ◽  
Short Term ◽  
Contemporary China ◽  
The Past ◽  
The World ◽  
Man And Nature ◽  
Individual Actions ◽  
Communist Past ◽  
Chinese View

After nearly two decades of revolutionary rule in China, the break with the past which Communist direction has seemed to represent is increasingly being seen in a wider perspective. Few scholars would attempt to argue that the Communists have not brought a genuine revolution or that their ascendancy is merely the equivalent of a new dynasty. But as the character of the new order has become clearer with time and as an analysis both more detailed and less concerned with short-term matters has become possible, many scholars have been as much impressed by continuities with the pre-Communist past as by discontinuities. To take perhaps the clearest example, the current Chinese view of their relation to the rest of the world appears to represent little change from the traditional Sinocentric image. Ideological absolutism is also not new to China with Mao Tse-tung, nor is the conception of individual subsevience to public good, the unquestioned rightness of close social limits on individual actions. And contemporary China retains, for all its professed egalitarianism, a strongly elitist and hierarchial pattern.

scholarly journals Planting Systems for Modern Olive Growing: Strengths and Weaknesses

Agriculture ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 494
Author(s):  
Riccardo Lo Bianco ◽  
Primo Proietti ◽  
Luca Regni ◽  
Tiziano Caruso
Keyword(s):  
Large Scale ◽  
New Technologies ◽  
Production Costs ◽  
Biotic And Abiotic Stress ◽  
Short Term ◽  
Mediterranean Countries ◽  
Social Concerns ◽  
The World ◽  
Fruit Growing ◽  
Cultivar Diversity

The objective of fully mechanizing olive harvesting has been pursued since the 1970s to cope with labor shortages and increasing production costs. Only in the last twenty years, after adopting super-intensive planting systems and developing appropriate straddle machines, a solution seems to have been found. The spread of super-intensive plantings, however, raises serious environmental and social concerns, mainly because of the small number of cultivars that are currently used (basically 2), compared to over 100 cultivars today cultivated on a large scale across the world. Olive growing, indeed, insists on over 11 million hectares. Despite its being located mostly in the Mediterranean countries, the numerous olive growing districts are characterized by deep differences in climate and soil and in the frequency and nature of environmental stress. To date, the olive has coped with biotic and abiotic stress thanks to the great cultivar diversity. Pending that new technologies supporting plant breeding will provide a wider number of cultivars suitable for super-intensive systems, in the short term, new growing models must be developed. New olive orchards will need to exploit cultivars currently present in various olive-growing areas and favor increasing productions that are environmentally, socially, and economically sustainable. As in fruit growing, we should focus on “pedestrian olive orchards”, based on trees with small canopies and whose top can be easily reached by people from the ground and by machines (from the side of the top) that can carry out, in a targeted way, pesticide treatments, pruning and harvesting.

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