Clinical and Imaging Characteristics of Two COVID-19 Cluster Infections in Beijing, China: A Retrospective Study

Abstract Background: As a new infectious disease, coronavirus disease 2019 (COVID-19) is not fully understood. During January - July 2020, there were two clusters infections in Beijing, China. This study was to analyze the features of the two COVID-19 infections in Beijing.Methods: In this retrospective single-center study, 89 cases with the positive novel coronavirus nucleic acid test were collected from January to July 2020 in Beijing. They were divided into January-March group and June-July group. Two groups of data were compared.Results: The eighty-nine cases, 47 males and 42 females, mean age (41±14 years), were used for our study. The most common symptoms were fever (46/89, 52%) and cough (34/89, 38%). The clinical classification were moderate type (56/89,63%), mild type (24/89, 27%), severe type (4/89, 4%), critical type (0), respectively. Ground glass opacity (GGO) (47%) was the majority CT pattern. The frequency of involvement of lower lobe was higher than that of upper lobe (P＜0.01). In January - March group, there were 5 patients (18%) exposure to Wuhan, 15 patients (54%) family clusters, 5 patients (18%) colleague clusters, 3 patients (11%) imported cases. In June-July group, 41 patients (68%) had an exposure to Xinfadi market of Beijing, 6 patients (10%) family clusters, and 14 patients (23%) colleague clusters. The number of patients with fever, cough, chest CT severity score and the number of lesion lung lobes in January-March group was higher than that in June-July group (P＜0.05).Conclusions: Two COVID-19 clusters were dominated moderate and mild type, but few severe types. Patients in June-July group had less symptoms, imaging and family clusters than that in January-March group. This suggested that closely monitoring, early quarantined, nucleic acid test of COVID-19 and chest CT were important measures to prevent epidemic.

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Clinical and Imaging features in COVID-19 Patients: Analysis of Data from Patients in Non-pandemic areas

10.21203/rs.3.rs-21373/v1 ◽

2020 ◽

Author(s):

Shengkun Peng ◽

Lingai Pan ◽

Shaojin Zhang ◽

Yalong Liu ◽

Hua Zhang ◽

...

Keyword(s):

Peripheral Zone ◽

Chest Ct ◽

Ct Scans ◽

Severe Illness ◽

Imaging Features ◽

Imaging Characteristics ◽

Number Of Patients ◽

Patient Will ◽

Acid Test

Abstract Purpose To describe the imaging characteristics in COVID-19 Patients from non-pandemic regions to improve understanding of the disease. Methods We reviewed chest CT scans of 30 COVID-19 patients from three hospitals in Sichuan province, China. Results Typical CT manifestations include the involvement of multiple lobes, mostly in the peripheral zone of the lungs, and subpleural distribution. GGO, crazy paving or mixed GGO and consolidation is the most common signs. Few patients can present small amount of pleural effusion. It is worth noting that none of the lung cavities, tree buds, and lymphadenopathy appeared. The follow-up imaging findings of some patients showed progress when the initial CT score reached 7. Conclusion The CT scan still play an important role in screening the COVID-19, most of the images present positive signs, mainly subpleural, multiple GGO. CT might can predict the severity or whether the patient will progress to severe illness. A small number of patients may be missed if they are based on CT findings alone, which should be closely combined with the patient's epidemiological history and nucleic acid test.

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Combination of chest CT and clinical features for diagnosis of 2019 novel coronavirus pneumonia

Open Medicine ◽

10.1515/med-2020-0107 ◽

2020 ◽

Vol 15 (1) ◽

pp. 723-727

Author(s):

Xin Wang ◽

Peng Wen ◽

Zhi-Gang Sun ◽

Chun-Yan Xing ◽

Yun Li

Keyword(s):

Nucleic Acid ◽

Clinical Features ◽

Comprehensive Evaluation ◽

High Sensitivity ◽

Chest Ct ◽

Nucleic Acid Test ◽

First Case ◽

History Of ◽

Novel Coronavirus ◽

Acid Test

AbstractIn December 2019, novel coronavirus pneumonia-19 (COVID-19) was discovered in the viral pneumonia cases that occurred in Wuhan, China, and then quickly spread around the world. This report described the clinical course of two COVID-19 patients and the purpose of the study was to discuss the combination of chest CT and clinical features for diagnosis of COVID-19. The first case was a typical COVID-19 case. A 66-year-old female presented to our hospital with a 3-day history of fever. She had contact with a COVID-19 patient. Chest CT showed a typical COVID-19 appearance. She was diagnosed with COVID-19 by a positive nucleic acid test. The second case was a 50-year-old male with a 2-day history of fever. He denied having been to Wuhan. Chest CT also showed typical features of COVID-19 pneumonia. COVID-19 nucleic acid tests were repeated up to seven times and the results remained controversial. Eventually, he was diagnosed with COVID-19. Our study shows that chest CT has high sensitivity for diagnosis of COVID-19 in clinical practice, particularly when the nucleic acid test is negative. The chest CT should be considered as a diagnostic tool for the COVID-19 screening, comprehensive evaluation, and follow-up and patients would benefit from effective treatments in time.

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Chest CT Could Be Used to Diagnose 2019 Novel Coronavirus Pneumonia Clinically in Hubei Province

10.21203/rs.3.rs-17422/v1 ◽

2020 ◽

Author(s):

Xin Wang ◽

Peng Wen ◽

Zhi-Gang Sun ◽

Chun-Yan Xing ◽

Yun Li

Keyword(s):

Nucleic Acid ◽

Comprehensive Evaluation ◽

Hubei Province ◽

Ct Imaging ◽

Chest Ct ◽

Nucleic Acid Test ◽

First Case ◽

History Of ◽

Novel Coronavirus ◽

Acid Test

Abstract Background: In December 2019, novel coronavirus pneumonia-19 (COVID-19) was discovered in the viral pneumonia cases that occurred in Wuhan, Hubei Province, China; and then quickly spread inside and outside of Wuhan and even other countries. This report describes the clinical course of two patients who had COVID-19.Case presentation: The first case was a typical COVID-19 case. A 66-year-old female presented to our hospital with a 3-day history of fever with coughing, white sputum, runny nose and dizziness. She had contacted with a COVID-19 patient, her daughter-in-law who was diagnosed with COVID-19 two days before. Chest CT showed typical COVID-19 CT imaging. She was diagnosed with COVID-19 by positive nucleic acid test. The second case was a 50-year-old male with a 2-day history of fever and dry coughing. He denied having been to Wuhan. Chest CT also showed typical COVID-19 CT imaging. He accepted COVID-19 nucleic acid test using reverse-transcription polymerase chain reaction of his throat swab sampling 7 times and the test results remained controversial. Eventually, he was diagnosed with COVID-19 after 5 days.Conclusions: Chest CT examination has high sensitivity for diagnosis of COVID-19 clinically, particularly when nucleic acid test is negative. Chest CT should be considered for the COVID-19 screening, comprehensive evaluation and following-up and patients could benefit from effective treatment in time.

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Metode Nucleic Acid Test untuk Uji Saring Virus Hepatitis B pada Darah Donor dengan Hepatitis B Occult

Jurnal Biotek Medisiana Indonesia ◽

10.22435/jbmi.v4i2.5123.51-58 ◽

2016 ◽

Vol 4 (2) ◽

Author(s):

Ulfah Suryani ◽

Vivi Setiawaty

Keyword(s):

Nucleic Acid ◽

Hepatitis B ◽

Virus Hepatitis ◽

Nucleic Acid Test ◽

Acid Test

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Clinical characteristics and outcomes of COVID-19 long-term nucleic acid positive patients

Technology and Health Care ◽

10.3233/thc-212921 ◽

2021 ◽

pp. 1-10

Author(s):

Xuan Zhu ◽

Xinxin Zhu ◽

Min Wang ◽

Fang Yang ◽

Zhibing Sun ◽

...

Keyword(s):

Nucleic Acid ◽

Clinical Characteristics ◽

Clinical Symptoms ◽

Control Group ◽

Viral Shedding ◽

Imaging Characteristics ◽

And Gender ◽

Acid Test ◽

Pulmonary Ct

OBJECTIVE: This study aimed to investigate the clinical characteristics and outcomes of coronavirus disease-19 (COVID-19) long-term nucleic acid positive patients (hereinafter referred to as CLTAPs). METHODS: Patients were recruited from the Xiaogan Central Hospital between 16 January 2020 and 28 March 2020. Among the 562 cases of patients with laboratory-identified COVID-19 infection by real-time polymerase chain reaction (qtPCR), 19 cases of COVID-19 patients with more than 41 days from the first to the last time of nucleic acid test were selected as the study group, and 76 cases of age- and gender-matched COVID-19 patients were selected as the control group (hereinafter referred to as C-CLTAPs). Demographic characteristics, clinical symptoms, laboratory examination and computed tomography (CT) imaging characteristics were retrospectively analyzed. RESULTS: On admission, among the 562 cases of patients with COVID-19, there were 398 cases of ordinary COVID-19 patients, 99 cases of severe COVID-19 patients and 99 cases of critical COVID-19 patients. CLTAPs had milder clinical symptoms and longer viral shedding time in comparison to C-CLTAPs. Compared to C-CLTAPs, CLTAPs had a lower infection index at admission. CLTAPs used less oxygen therapy and a higher proportion of hydroxychloroquine treatment in comparison to C-CLTAPs. In comparison to C-CLTAPs, CLTAPs showed slower pulmonary CT progression and faster pulmonary CT absorption. CONCLUSION: In this study, out of the 562 cases, we found 19 CLTAPs. The clinical differences between CLTAPs and C-CLTAPs were compared and analyzed. We hope that these finding can provide a theoretical basis for the treatment of CLTAPs.

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Cost-effectiveness of nucleic acid test screening of volunteer blood donations for hepatitis B, hepatitis C and human immunodeficiency virus in the United States

Vox Sanguinis ◽

10.1111/j.0042-9007.2004.00379.x ◽

2004 ◽

Vol 86 (1) ◽

pp. 28-40 ◽

Cited By ~ 99

Author(s):

D. A. Marshall ◽

S. H. Kleinman ◽

J. B. Wong ◽

J. P. AuBuchon ◽

D. T. Grima ◽

...

Keyword(s):

United States ◽

Human Immunodeficiency Virus ◽

Cost Effectiveness ◽

Hepatitis C ◽

Nucleic Acid ◽

Hepatitis B ◽

The United States ◽

Nucleic Acid Test ◽

Immunodeficiency Virus ◽

Acid Test

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What is the meaning of a nonresolved viral nucleic acid test-reactive minipool?

Transfusion ◽

10.1111/trf.12818 ◽

2014 ◽

Vol 55 (2) ◽

pp. 395-404 ◽

Cited By ~ 4

Author(s):

Lunan Wang ◽

Le Chang ◽

Yunzheng Xie ◽

Chengyin Huang ◽

Lei Xu ◽

...

Keyword(s):

Nucleic Acid ◽

Viral Nucleic Acid ◽

Nucleic Acid Test ◽

Acid Test

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Cases Report of Cured Novel Coronavirus-infected Pneumonia Patients with Viral Nucleic Acid Test Positive in Fecal Specimens

10.21203/rs.3.rs-20799/v1 ◽

2020 ◽

Author(s):

Mei Han ◽

Jingbo Zou ◽

Wenguang Tian ◽

Xiaoyu Wei ◽

Yang Zhou ◽

...

Keyword(s):

Nucleic Acid ◽

Molecular Diagnostic ◽

Clinical Practices ◽

Rt Pcr ◽

Viral Nucleic Acid ◽

Nucleic Acid Test ◽

Assessment Standard ◽

Novel Coronavirus ◽

Acid Test ◽

Respiratory Specimens

Abstract Background: The outbreak of the novel coronavirus in China (COVID-19) represents a significant and urgent threat to global health. We report here five cases of COVID-19 infection patients in our clinical practices who are medically stable and presumed to successfully “cleared” the virus after antiviral treatments. Case presentation: The clinical evaluation depends on the viral nucleic acid test in respiratory specimens by real-time PCR reverse transcription (RT-PCR) assays according to the authorized guidance. We found that the stool samples of these cured patients remain positive in RT-PCR assay while the virus is undetectable in respiratory specimens. RT-PCR molecular diagnostic assay was designed to specifically detect the presence of viral RNA. Thus, the positive result in the fecal specimens implies the existence of viable virions with the patients. Conclusions: This highlights the importance to look closely at the assessment standard of medical treatment, as well as the need for reevaluation of the criteria for the initial screening, prevention, and care of patients with this emerging infection.

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