scholarly journals Assessment of Musculoskeletal Pain, Fatigue and Grip Strength in Hospitalized Patients with COVID-19

2020 ◽  
Author(s):  
Sansin Tuzun ◽  
Aslinur Keles ◽  
dilara okutan ◽  
Tugbay Yildiran ◽  
Deniz Palamar
Keyword(s):  
Disease Activity ◽  
Grip Strength ◽  
Disease Severity ◽  
Musculoskeletal System ◽  
Mental Fatigue ◽  
Musculoskeletal Symptoms ◽  
Musculoskeletal Symptom ◽  
Physical Fatigue ◽  
Fatigue Severity ◽  
Lower Grip

Abstract IMPORTANCE Coronavirus disease 2019 (COVID-19) is an emerging disease that was declared as a pandemic by WHO. Although there are many retrospective studies to present clinical aspects of the COVID-19, still the involvement of the musculoskeletal system has not been deeply investigated.OBJECTIVE To classify the symptoms of musculoskeletal system in COVID-19 patients, to evaluate myalgia, arthralgia and physical/mental fatigue, to assess handgrip muscle strength, and to examine the relationship of these parameters with the severity and laboratory values of the disease. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study was performed at the IUC-Cerrahpaşa Pandemic Clinic. Hospitalized 150 adults with laboratory and radiological confirmation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) according to WHO interim guidance were included in the study. Data were recorded from May 15,2020, to June 30, 2020.MAIN OUTCOMES AND MEASURES Demographic data, comorbidities, musculoskeletal symptoms, laboratory findings and CT scans were recorded. To determine the disease severity 2007 idsa/ats guidelines for community acquired pneumonia was used. Myalgia severity was calculated by numerical rating scale (NRS). Visual analog scale and Chalder Fatigue Scale (CFS) were used for fatigue severity determination. Handgrip strength (HGS) was measured by Jamar hand dynamometer.RESULTS 103 patients (68.7%) were nonsevere and 47 patients (31.3%) were severe. The most common musculoskeletal symptom was fatigue (133 [85.3%]), followed by myalgia (102 [68.0%]), arthralgia (65 [43.3%]) and back pain (33 [22.0%]). Arthralgia, which was mostly notable at wrist (25 [16.7%]), ankle (24 [16.0%]) and knee (23 [15.3%]) joints, showed significant correlation with disease severity. There was severe myalgia according to NRS regardless of disease severity. The physical fatigue severity score was significantly higher in severe cases, whereas no relationship was found with mental fatigue score. Female patients with severe infection had lower grip strength with a mean value of 18.26 kg (P= .010) in dominant hand, whereas no relationship was found between disease severity and grip strength in male patients, but the mean values in both genders and in decades appears below the specified normative values. Lactate dehydrogenase (LDH) level and lymphocyte count were significantly correlated with lower grip strength. LDH, C-reactive protein (CRP) and D-dimer levels were above the normal range in patients with myalgia, arthralgia and fatigue. CONCLUSIONS AND RELEVANCE Musculoskeletal symptoms are quite common aside from other multi-systemic symptoms in patients with COVID-19. Arthralgia, which is related to the disease severity, should be considered apart from myalgia. COVID-19 patients have severe ischemic myalgia regardless of the disease activity. Although there is a muscle weakness in all patients, the loss of muscle function is related with the disease activity especially in women. Muscular involvement in coronavirus disease is a triangle of myalgia, physical fatigue, and functional impairment.

Interleukin 38 serum level is increased in patients with vitiligo, correlated with disease severity, and associated with signs of disease activity

2021 ◽  
Author(s):  
Radwa El‐ Sayed Mahmoud Marie ◽  
Al‐ Zahraa Mohamed Adel ◽  
Noha M. Abd El‐ Fadeal ◽  
Moustafa Mohamad Kamel Eyada
Keyword(s):  
Serum Level ◽  
Disease Activity ◽  
Disease Severity

Evaluating musculoskeletal symptoms

2011 ◽  
pp. 3-18
Author(s):  
Alan J. Hakim ◽  
Gavin P.R. Clunie ◽  
Inam Haq
Keyword(s):  
Young Children ◽  
Pain Threshold ◽  
Behavioural Response ◽  
Musculoskeletal Symptoms ◽  
Musculoskeletal Symptom ◽  
Emotional Change ◽  
Unpleasant Sensation ◽  
Religious Differences

Introduction 4 Localization of pain and pain patterns 6 Changes in pain on examination 8 The assessment of pain in young children 10 Stiffness, swelling, and constitutional symptoms 11 Gait, arms, legs, spine—the GALS screen 12 Pain is the most common musculoskeletal symptom. It is defined by its subjective description, which may vary depending on its physical (or biological) cause, the patient's understanding of it, its impact on function, and the emotional and behavioural response it invokes. Pain is also often ‘coloured’ by cultural, linguistic, and religious differences. Therefore, pain is not merely an unpleasant sensation; it is, in effect, an ‘emotional change’. The experience is different for every individual; patients who think of themselves as having a ‘high pain threshold’ may have the hardest time coping....

scholarly journals The longitudinal effect of biologic use on patient outcomes (disease activity, function, and disease severity) within a rheumatoid arthritis registry

2019 ◽  
Vol 38 (11) ◽  
pp. 3081-3092 ◽  
Author(s):  
Nancy A. Shadick ◽  
Nicole M. Gerlanc ◽  
Michelle L. Frits ◽  
Bradley S. Stolshek ◽  
Brenna L. Brady ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Disease Severity ◽  
Patient Outcomes

scholarly journals Soluble CD26 is inversely Associated with Disease Severity in Patients with Chronic Eosinophilic Pneumonia

2006 ◽  
Vol 1 ◽  
pp. 117727190600100 ◽  
Author(s):  
Osamu Matsuno ◽  
Eishi Miyazaki ◽  
Shinichi Nureki ◽  
Takuya Ueno ◽  
Masaru Ando ◽  
...  
Keyword(s):  
Cell Surface ◽  
Disease Activity ◽  
Disease Severity ◽  
Arterial Oxygen Tension ◽  
Eosinophilic Pneumonia ◽  
Soluble Form ◽  
Arterial Oxygen ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cell Surface Glycoprotein ◽  
Chronic Eosinophilic Pneumonia

Backgrounds CD26, a multifunctional T cell surface glycoprotein, is a type II transmembrane protein containing only six amino acid residues in its cytoplasmic region. In addition to its membrane form, CD26 exists in plasma in a soluble form (sCD26), which is thought to be the extracellular domain of the molecule cleaved from the cell surface. Recent studies indicated CD26 have an important role in the pathogenesis of asthma, known as Th2 like disease. The function of CD26 in the esosinophlic lung disease is not well understood. Methods Serum sCD26 was determined by enzyme-linked immunosorbent assay in patients with acute eosinophilic pneumonia, chronic eosinophilic pneumonia (CEP), and sarcoidosis, and in healthy volunteers, to establish its value for discriminating between disease entities and as marker of disease activity. Results Soluble CD26 was significantly reduced in CEP and was related to disease severity. In particular, sCD26 was inversely correlated with arterial oxygen tension in CEP. Conclusion Serum levels of sCD26 might appear to be useful as a new marker of CEP disease activity.

scholarly journals Hand Grip Strength as a Clinical Biomarker for ME/CFS and Disease Severity

2018 ◽  
Vol 9 ◽  
Author(s):  
Luis Carlos Nacul ◽  
Kathleen Mudie ◽  
Caroline C. Kingdon ◽  
Taane G. Clark ◽  
Eliana Mattos Lacerda
Keyword(s):  
Grip Strength ◽  
Disease Severity ◽  
Hand Grip Strength ◽  
Hand Grip ◽  
Clinical Biomarker

scholarly journals Grip strength among Indigenous and non-Indigenous Australian adults: a longitudinal study of the effects of birth size and current size

BMJ Open ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. e024749
Author(s):  
Timothy Howarth ◽  
Belinda Davison ◽  
Gurmeet Singh
Keyword(s):  
Young Adults ◽  
Grip Strength ◽  
Lean Mass ◽  
Low Birthweight ◽  
Indigenous Australians ◽  
Birth Size ◽  
Indigenous Australian ◽  
Cross Sectional ◽  
Increased Risk ◽  
Lower Grip

ObjectivesIndigenous Australians are born smaller than non-Indigenous Australians and are at an increased risk of early onset of frailty. This study aimed to identify the relationship between birth size, current size and grip strength, as an early marker of frailty, in Indigenous and non-Indigenous young adults.DesignCross sectional data from two longitudinal studies: Aboriginal birth cohort (Indigenous) and top end cohort (non-Indigenous).SettingParticipants reside in over 40 urban and remote communities across the Northern Territory, Australia.ParticipantsYoung adults with median age 25 years (IQR 24–26); 427 participants (55% women), 267 (63%) were remote Indigenous, 55 (13%) urban Indigenous and 105 (25%) urban non-Indigenous.Outcome measuresReliable birth data were available. Anthropometric data (height, weight, lean mass) and grip strength were directly collected using standardised methods. Current residence was classified as urban or remote.ResultsThe rate of low birthweight (LBW) in the non-Indigenous cohort (9%) was significantly lower than the Indigenous cohort (16%) (−7%, 95% CI −14 to 0, p=0.03). Indigenous participants had lower grip strength than non-Indigenous (women, −2.08, 95% CI −3.61 to –0.55, p=0.008 and men, −6.2, 95% CI −9.84 to –2.46, p=0.001). Birth weight (BW) was associated with grip strength after adjusting for demographic factors for both women (β=1.29, 95% CI 0.41 to 2.16, p=0.004) and men (β=3.95, 95% CI 2.38 to 5.51, p<0.001). When current size (lean mass and body mass index [BMI]) was introduced to the model BW was no longer a significant factor. Lean mass was a positive indicator for grip strength, and BMI a negative indicator.ConclusionsAs expected women had significantly lower grip strength than men. Current size, in particular lean mass, was the strongest predictor of adult grip strength in this cohort. BW may have an indirect effect on later grip strength via moderation of lean mass development, especially through adolescence and young adulthood.

scholarly journals Prevalence and correlates of fatigue in patients with meningioma before and after surgery

2019 ◽  
Vol 7 (1) ◽  
pp. 77-85 ◽  
Author(s):  
Sophie D van der Linden ◽  
Karin Gehring ◽  
Geert-Jan M Rutten ◽  
Willem J Kop ◽  
Margriet M Sitskoorn
Keyword(s):  
Tumor Volume ◽  
Mental Fatigue ◽  
Normative Values ◽  
Common Symptom ◽  
Physical Fatigue ◽  
Cognitive Complaints ◽  
Time Points ◽  
General Fatigue ◽  
Before And After ◽  
Reduced Activity

Abstract Background Fatigue is a common symptom in patients with brain tumors, but comprehensive studies on fatigue in patients with meningioma specifically are lacking. This study examined the prevalence and correlates of fatigue in meningioma patients. Methods Patients with grade I meningioma completed the Multidimensional Fatigue Inventory (MFI-20) before and 1 year after neurosurgery. The MFI consists of 5 subscales: General Fatigue, Physical Fatigue, Mental Fatigue, Reduced Motivation, and Reduced Activity. Patients’ scores were compared with normative data. Preoperative fatigue was compared with postoperative fatigue. Correlations with sex, age, education, tumor hemisphere, preoperative tumor volume, antiepileptic drugs (AEDs), symptoms of anxiety/depression, and self-reported cognitive complaints were explored. Results Questionnaires were completed by 65 patients preoperatively, and 53 patients postoperatively. Of 34 patients, data from both time points were available. Patients had significantly higher fatigue levels on all subscales compared to normative values at both time points. Mean scores on General Fatigue, Physical Fatigue, and Mental Fatigue remained stable over time and improvements were observed on Reduced Motivation and Reduced Activity. Preoperatively, the prevalence of high fatigue (Z-score ≥ 1.3) varied between 34% for Reduced Motivation and 43% for General Fatigue/Mental Fatigue. The postoperative prevalence ranged from 19% for Reduced Activity to 49% on Mental Fatigue. Fatigue was associated with cognitive complaints, anxiety and depression, but not with education, tumor lateralization, tumor volume, or AEDs. Conclusion Fatigue is a common and persistent symptom in patients with meningioma undergoing neurosurgery. Findings emphasize the need for more research and appropriate care targeting fatigue for meningioma patients.

scholarly journals Effects of physical fatigue on the induction of mental fatigue of construction workers: A pilot study based on a neurophysiological approach

2020 ◽  
Vol 120 ◽  
pp. 103381
Author(s):  
Xuejiao Xing ◽  
Botao Zhong ◽  
Hanbin Luo ◽  
Timothy Rose ◽  
Jue Li ◽  
...  
Keyword(s):  
Pilot Study ◽  
Mental Fatigue ◽  
Construction Workers ◽  
Physical Fatigue

Lower Fatigue in Fit and Positive Women with Fibromyalgia: The al-Ándalus Project

Pain Medicine ◽  
2019 ◽  
Vol 20 (12) ◽  
pp. 2506-2515 ◽  
Author(s):  
Fernando Estévez-López ◽  
María Rodriguez-Ayllon ◽  
Alberto Soriano-Maldonado ◽  
Pedro Acosta-Manzano ◽  
Víctor Segura-Jiménez ◽  
...  
Keyword(s):  
Negative Affect ◽  
Physical Fitness ◽  
Positive Affect ◽  
Mental Fatigue ◽  
Physical Fatigue ◽  
Cross Sectional ◽  
General Fatigue ◽  
Different Dimensions ◽  
Independent Association ◽  
Reduced Activity

Abstract Objective To analyze 1) the independent association of physical fitness, positive affect, and negative affect with the different dimensions of fatigue (general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue) and 2) whether the interactions of physical fitness, positive affect, and negative affect were associated with fatigue over and above the independent association. Design Cross-sectional study in 420 women with fibromyalgia. Setting Fibromyalgia associations from southern Spain. Methods Physical fitness was measured by performance-based tests, and questionnaires were used to measure positive affect, negative affect, and different dimensions of fatigue (general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue). Age, body mass index, and current pain level were included as potential confounders in all analyses. Results Physical fitness was independently associated with general fatigue, physical fatigue, and reduced activity (all P ≤ 0.02). Positive affect was independently associated with all fatigue dimensions (all P &lt; 0.001). Negative affect was independently associated with general fatigue, physical fatigue, reduced motivation, and mental fatigue (all P ≤ 0.04). The interaction of overall physical fitness and positive affect was related to general fatigue and physical fatigue (all P ≤ 0.02). Women with fibromyalgia with higher levels of overall physical fitness and positive affect showed the lowest general fatigue and physical fatigue. Conclusions In women with fibromyalgia, positive affect was independently and consistently associated with all dimensions of fatigue. The combination of higher levels of overall physical fitness and positive affect might serve as a buffer against general and physical fatigue in women with fibromyalgia.

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