scholarly journals The Association Between the Gut Microbiota and Systemic Lupus Erythematosus, a Meta-Analysis

2021 ◽  
Author(s):  
Shate XIANG ◽  
Yiqian Qu ◽  
Suhai Qian ◽  
Yao Wang ◽  
Yibo Jin ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Gut Microbiota ◽  
Lupus Erythematosus ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Case Control ◽  
Healthy People ◽  
Case Control Studies ◽  
Systemic Lupus ◽  
Significant Difference

Abstract Introduction: Evaluate the changes of gut Microbiota in patients with Systemic Lupus Erythematosus (SLE) and healthy people by meta-analysis. Methods We searched the case-control studies of SLE and healthy controls (HCs) for detecting the diversity of gut Microbiota and the abundance level of some microbiota in the two groups. StataMP16 software was applied for this meta-analysis. The Newcastle-Ottawa quality assessment scale (NOS) was used to assess the quality of the included studies. Results Eleven case-control studies were included. There were 373 SLE patients and 1288 healthy people, involving 5 countries and 9 different cities. Compared with the HCs, the Shannon-wiener diversity index (WMD=-0.22; 95% CI=-0.32 to -0.13; P = 0.000) and Chao1 richness estimator (SMD=-0.62; 95% CI=-1.04 to -0.21; P = 0.003) of gut Microbiota in SLE decreased, and the abundance level of Ruminococcaceae decreased (SMD=--0.48; 95% CI = 0.76 to-0.21; P = 0.001). Enterobacteriaceae (SMD = 0.39,95% CI = 0.11 to 0.66;P = 0.006) and Enterococcaceae (SMD = 0.55; 95% CI = 0.19 to 0.9; P = 0.03) showed higher abundance levels in comparison with HCs. The subgroup analysis showed the abundance level of Ruminococcaceae (SMD=-0.89; 95% CI =-1.34 to -0.45; P = 0.000) was lower and Enterococcaceae was higher (SMD = 0.77; 95% CI = 0.34 to 1.21༛P = 0.001) in Chinese with SLE compared with HCs. In non-Chinese patients with SLE, there were no significant difference between the abundance level of Ruminococcaceae (SMD=-0.22; 95% CI=--0.58 to 0.13; P = 0.216) and Enterococcaceae (SMD=-0.08; 95% CI=-0.49 to 0.32; P = 0.682 ) with HCs. The subgroup analysis also found the level of Enterobacteriaceae was affected by the sample size. Conclusion Compared with the diversity of healthy people, richness and evenness of gut microbiota in patients with SLE are impaired. There is a decrease in the abundance level of beneficial bacteria and an increase in the harmful bacteria. Thus, gut microbiota in patients with SLE appear disorder, which may lead to metabolic imbalance, destruction of the integrity of the small intestine, immune system disorders and pro-inflammatory. Regulating the abundance of gut microbiota can be used as one of the key strategies for treating SLE.

scholarly journals The Regulatory B Cell in Active Systemic Lupus Erythematosus Patients: A Systemic Review and Meta-analysis

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Xiaohuan Chen ◽  
Lei Liu ◽  
Lei Liao ◽  
Yahui Wang ◽  
Jiacheng Shi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Sensitivity Analysis ◽  
Lupus Erythematosus ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Systemic Review ◽  
Systemic Lupus ◽  
Regulatory B Cell ◽  
Sledai Score ◽  
Significant Difference

Background: The study of regulatory B cells (Bregs) in systemic lupus erythematosus (SLE) has been in full swing in recent years, but the number and function of Bregs in SLE patients have also present quite contradictory results. Therefore, we conducted a meta-analysis to verify the changes in Bregs in active SLE. Methods: We identified studies reporting the proportions of Bregs in SLE patients by searching Pubmed, Embase, Web of Science, Cochrane and CNKI. Due to the degree of heterogeneity is very high, we used a random effects model to assess the mean differences in percentages of Bregs between active SLE and controls. Then, sensitivity analysis and subgroup analysis were performed to verify potential sources of heterogeneity. Results: Seven eligible articles involving 301 active SLE patients and 218 controls were included in the meta-analysis. The pooled percentages of Bregs were found no significant difference between active SLE patients and healthy controls [0.259, (−1.150, 1.668), p = 0.719], with great heterogeneity ( I2 = 97.5%) . The result of sensitivity analysis showed that exclusion of any single study or single article did not materially resolve the heterogeneity, but after excluding the article conducted by Cai X and his colleagues, the percentages of Bregs were significantly higher in active SLE than those in controls [1.394, (0.114,2.675), p = 0.033]. The results of subgroup analysis revealed that when the disease activity was judged by SLEDAI score ≥ 5, the percentages of Bregs were significantly lower in the SLE groups than in the control groups[-1.99,(-3.241,-0.739), p = 0.002], but when the threshold of SLEDAI score ≥ 6 chosen for active SLE, the percentages of Bregs were significantly increased in the SLE groups[2.546,(1.333,3.759), p < 0.001]. Meanwhile, other subgroup analysis based on the different phenotypes of Bregs, diagnostic criteria, enrolled research countries, treatment status, and organ involvement did not differ in proportion of Bregs between SLE patients and controls. Conclusions: The study implies that Bregs may play a role in the pathogenesis of active SLE, and the thresholds of SLEDAI score to distinguish between active and inactive SLE patients are important factors affecting the percentages of Bregs.

scholarly journals The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: Two case-control studies and a meta-analysis

2005 ◽  
Vol 52 (12) ◽  
pp. 3966-3974 ◽  
Author(s):  
Young Ho Lee ◽  
Torsten Witte ◽  
Tanja Momot ◽  
Reinhold E. Schmidt ◽  
Kenneth M. Kaufman ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Case Control ◽  
Mannose Binding Lectin ◽  
Case Control Studies ◽  
Systemic Lupus ◽  
Mannose Binding ◽  
Binding Lectin

Association between circulating leptin levels and systemic lupus erythematosus: an updated meta-analysis

Lupus ◽  
2017 ◽  
Vol 27 (3) ◽  
pp. 428-435 ◽  
Author(s):  
Y H Lee ◽  
G G Song
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Sample Size ◽  
Lupus Erythematosus ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Data Type ◽  
Cochrane Library ◽  
Control Group ◽  
Systemic Lupus ◽  
Size Data

Objective We aimed to evaluate the relationship between circulating leptin levels and systemic lupus erythematosus (SLE). Methods MEDLINE, EMBASE, and Cochrane library databases were searched. Meta-analyses were performed comparing serum/plasma leptin levels in patients with SLE and healthy controls, and on patients with SLE in subgroups based on ethnicity, sample size, data type, and matched variables (age, sex, and/or body mass index (BMI)). Results Eighteen studies including 1333 patients with SLE and 1048 controls were ultimately selected, which showed that leptin levels were significantly higher in the SLE group than in the control group (SMD = 0.611, 95% CI = 0.275–0.947, p < 0.001). When we excluded two outlier studies because of high heterogeneity, leptin levels were also significantly higher in the SLE group than in the control group (SMD = 0.619, 95% CI = 0.431–0.807, p < 0.001). Stratification by ethnicity showed significantly elevated leptin levels in the SLE group in European, Asian, Arab, Latin American, and mixed populations. Subgroup analysis by sample size showed significantly higher leptin levels in the SLE group by small ( n ≤ 100) and large sample numbers ( n > 100) (SMD = 0.780, 95% CI = 0.445–1.115, p < 0.001; SMD = 0.495, 95% CI = 0.275–0.715, p < 0.001). Stratification by data type revealed significantly higher leptin levels in the original data and imputed data groups. Subgroup analysis adjustment revealed significantly higher leptin levels in the SLE group, regardless of adjustment for variables. Conclusions Our meta-analysis demonstrated that leptin levels were significantly higher in patients with SLE, regardless of ethnicity, sample size, data type, and matched variables.

Regulatory T-cell levels in systemic lupus erythematosus patients: a meta-analysis

Lupus ◽  
2019 ◽  
Vol 28 (4) ◽  
pp. 445-454 ◽  
Author(s):  
Y Zhu ◽  
Y Huang ◽  
B Ming ◽  
X Wu ◽  
Y Chen ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
Ethnic Groups ◽  
Lupus Erythematosus ◽  
Subgroup Analysis ◽  
Peripheral Blood ◽  
Meta Analysis ◽  
Systemic Lupus

Background The contribution of regulatory T-cells (Tregs) to systemic lupus erythematosus (SLE) pathogenesis remains a matter of debate. The objective of this study was to quantify the association between peripheral blood Tregs and disease status in SLE patients. Method EMBASE and PubMed databases were searched using ‘systemic lupus erythematosus’ and ‘regulatory T-cells’ as relevant key terms. A meta-analysis of studies that examined the proportion of Tregs among peripheral blood mononuclear cells (PBMCs) and CD4+T-cells was performed using Stata software. Subgroup analysis was performed based on ethnic groups and Treg definition markers. Results The Treg/PBMC and Treg/CD4+T-cell ratios were significantly lower in SLE patients than in healthy controls (HCs), whereas patients with active and inactive SLE showed no difference in these indicators. A subgroup analysis indicated that Asian SLE patients had a substantially lower proportion of Tregs/PBMCs than HCs, but this difference was not seen for white and Latin American SLE patients. Patients defined by CD4+CD25+Foxp3+, CD4+CD25+ and CD4+Foxp3+ had a much lower Treg/PBMC ratio compared with HCs. Ethnic groups and choice of Treg definition markers had no influence on the proportion of Tregs/CD4+T-cells. Conclusion The proportion of Tregs among both PBMCs and CD4+T-cells was significantly decreased in SLE patients. Ethnic group and Treg definition markers may influence the proportion of Tregs among PBMCs. Further study of the correlation between SLE disease activity and the proportion of Tregs in peripheral blood is needed to determine the physiological role of this association.

Systemic lupus erythematosus and risk of preterm birth: a systematic review and meta-analysis of observational studies

Lupus ◽  
2017 ◽  
Vol 26 (6) ◽  
pp. 563-571 ◽  
Author(s):  
S Wei ◽  
K Lai ◽  
Z Yang ◽  
K Zeng
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Preterm Birth ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Systemic Lupus ◽  
History Of ◽  
Control Disease

We performed a meta-analysis to identify the association between systemic lupus erythematosus (SLE) and preterm birth. In this study, we studied the effects of SLE, SLE disease activity, a history of nephritis and active nephritis on preterm birth. Searches were conducted before 20 May 2016 of PubMed, Embase, Medline and Cochrane Library of literature and article reference lists. Eleven observational case–control studies and thirteen cohort studies met the inclusion criteria. The pooled relative risk (RR) for the risk of preterm birth in SLE patients versus controls was 2.05 (95% confidence interval (CI): 1.72–3.32); for active SLE patients versus inactive was 2.98 (95% CI: 2.32–3.83); for SLE patients with a history of lupus nephritis versus those without nephritis it was 1.62 (95% CI: 1.35–1.95); and for SLE patients with active nephritis versus those with quiescent nephritis it was 1.78 (95% CI: 1.17–2.70). In summary, this study identified a significant association in the above results. This association was more significant in active SLE patients versus inactive. With respect to SLE itself, active inflammation (such as disease activity) may be more hazardous for the management of the pregnancy. This suggests that it is essential to control disease activity in order to achieve a better outcome of SLE pregnancy.

scholarly journals Association between Toll-Like Receptor 4 Polymorphisms and Systemic Lupus Erythematosus Susceptibility: A Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Weiping Hu ◽  
Senchao Wu ◽  
Yanlin Zhang ◽  
Keshav Raj Sigdel ◽  
Yong Lin ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Meta Analysis ◽  
Positive Association ◽  
Included Study ◽  
Case Control Studies ◽  
Human Immune System ◽  
Systemic Lupus ◽  
Family Aggregation

Family aggregation was observed among systemic lupus erythematosus (SLE) cases, suggesting the genetic factor may contribute to the susceptibility. Toll-like receptors (TLR) play key role in human immune system; in order to gain better insight on the association between TLR4 polymorphisms and SLE risk, a meta-analysis was conducted. In total 4 case-control studies have been included, involving 503 SLE cases and 636 healthy controls. The association between TLR4 polymorphisms and SLE risk was evaluated by calculating pooled odd ratio (OR) and its 95% confidential interval (CI). TheQ-test andI2statistic were used to estimate the degree of heterogeneity. Publication bias among enrolled studies was examined by using Egger’s test and Begg’s test. Overall, there was no evidence of positive association between SLE risk and D299G and T399I polymorphisms in TLR4. The meta-analysis reported a null association between TLR4 polymorphisms and SLE risk in included study populations, but the role of TLR4 polymorphisms in developing SLE among other populations remains undetermined. Moreover, some laboratory studies still discovered the involvement of TLR4 in SLE process. Therefore, the association between TLR4 polymorphisms and SLE risk requires further investigation both in laboratory and in epidemiological efforts.

scholarly journals Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese

2009 ◽  
Vol 69 (2) ◽  
pp. 368-373 ◽  
Author(s):  
K Nishimoto ◽  
Y Kochi ◽  
K Ikari ◽  
K Yamamoto ◽  
A Suzuki ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Association Study ◽  
Lupus Erythematosus ◽  
Case Control ◽  
Nucleotide Polymorphisms ◽  
Systemic Lupus ◽  
Control Series ◽  
Significant Difference ◽  
And Control

Objective:The primary aim of this study was to investigate the association of polymorphisms of TRAF1-C5, a newly identified rheumatoid arthritis (RA) risk locus in Caucasians, with susceptibility to RA and systemic lupus erythematosus (SLE) in Japanese populations. Gene expression levels of TRAF1 and C5 to assess the functional significance of genotypes were also analysed.Methods:A multicentre association study consisting of 4 RA case-control series (4397 cases and 2857 controls) and 3 SLE case-control series (591 cases and 2199 shared controls) was conducted. Genotyping was performed using TaqMan genotyping assay for two single nucleotide polymorphisms (SNPs) that showed the best evidence of association in the previous Caucasian studies. Quantifications of TRAF1 and C5 expression were performed with TaqMan expression assay.Results:Significant differences in allele frequency for both SNPs were observed between RA and control subjects (combined odds ratio  = 1.09), while no significant difference was detected between patients with SLE and controls. Interestingly, alleles rs3761847 A and rs10818488 G had increased the risk for RA in the present study, while they decreased the risk in the original studies. A significant difference was found between risk allele carriers and non-carriers of rs10818488 for the expression level of TRAF1 in phorbol myristate acetate-stimulated lymphoblastoid cell lines (p = 0.04).Conclusion:Association of TRAF1-C5 locus with RA susceptibility was detected in the Japanese populations with modest magnitude, while no significant association was observed for SLE. Significant positive effect of genotype on the expression of TRAF1 might support the genetic association between TRAF1 and RA.

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