scholarly journals Risk Factors of Early-Onset Neonatal Sepsis A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Qiang Wang ◽  
Guoxuan Peng ◽  
Lebin Gan ◽  
Jianhui Sun ◽  
Dalin Wen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gestational Age ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Neonatal Resuscitation ◽  
Labor And Delivery ◽  
Premature Rupture Of Membranes ◽  
Male Fetus ◽  
Premature Rupture ◽  
Independent Risk Factors

Abstract Background: Early-onset neonatal sepsis is a great managerial challenge worldwide. Studying the risk factors of early-onset neonatal sepsis is one of the most significant ways of reducing the incidence of sepsis and the associated health burden.Methods: A literature search strategy was constructed, including PubMed, EMBASE, Web of Science, and the Cochrane Library. All publications until April 30, 2021 were retrieved; the key words were “neonatal sepsis” and “risk factors.” Moreover, the references of the retrieved articles were screened to identify related eligible studies. Data abstraction was performed in accordance with PRISMA guidelines. The Newcastle-Ottawa Scale and Agency for Healthcare Research and Quality scale scores were used to evaluate the quality of the included studies, and the fixed-effects model was used to combine the results. Risk factors related to the occurrence of early-onset neonatal sepsis, the pooled OR, and the 95% CI upper and lower limits were obtained to represent the correlation strength between risk factors and early-onset neonatal sepsis occurrence; the pooled I2 value was used to determine the heterogeneity of the combined results.Results: We included 21 articles with 44 non-repetitive risk factors, 91985 neonates, and 6627 cases of neonatal sepsis. We identified seven independent risk factors of early-onset neonatal sepsis, including at least three per vaginal examinations during labor and delivery, chorioamnionitis, premature rupture of membranes > 18 h, male fetus, gestational age < 37 weeks, neonatal resuscitation, and central venous catheterization, with the following ORs and 95% CIs: 7.18 (3.51-14.69), 6.56 (3.19-13.49), 2.74 (1.44-5.21), 3.03 (1.94-4.73), 4.08 (2.76-6.03), 2.6 (2.03-3.34), and 3.06 (1.64-5.73), respectively.Conclusions: Our results suggest that frequent per vaginal examination during labor and delivery, chorioamnionitis, premature rupture of membranes (> 18 h), male fetus, gestational age (< 37 weeks), neonatal resuscitation, and central vascular catheterization are independent risk factors of early-onset neonatal sepsis. These findings support the use of empirical antibiotic therapy in neonates with these risk factors.

scholarly journals Faktor Risiko Ibu Dalam Meningkatkan Kejadian Sepsis Neonatorum Di RSUD Dr. H. Moch. Ansari Saleh Banjarmasin

2019 ◽  
pp. 73-83
Author(s):  
Fitri Yuliana ◽  
Mahpolah Mahpolah ◽  
Eriza Nopariyanti
Keyword(s):  
Risk Factors ◽  
Gestational Age ◽  
Neonatal Sepsis ◽  
Case Control ◽  
Maternal Risk Factors ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Maternal Risk ◽  
Purposive Sampling ◽  
Prolonged Labor

Latar Belakang: Penyebab utama kematian bayi baru lahir atau neonatal di dunia antara lain bayi lahir premature 29%, sepsis dan pneumonia 25% dan 23% merupakan bayi baru lahir dengan asfiksia dan trauma. Sepsis neonatorum merupakan salah satu penyakit infeksi yang dapat menyebabkan kematian pada bayi baru lahir, angka kejadian sepsis di Indonesia masih tinggi yaitu 8,7% sampai 30,29% dengan angka kematian 11,56% sampai 49,9%.  Kejadian sepsis neonatorum di RSUD dr. H. Moch. Ansari Saleh pada tahun 2014 sebanyak 2,9%, tahun 2015 sebanyak 1,2%, dan tahun 2016 sebanyak 1,2%.Tujuan: Menganalisis faktor risiko ibu dalam meningkatkan kejadian sepsis neonatorum di RSUD Dr. H. Moch. Ansari Saleh Tahun 2017.Metode: Penelitian kuantitatif dengan rancangan case control. Populasi penelitian ini adalah semua bayi baru lahir yang tercatat di rekam medik RSUD dr. H. Moch Ansari Saleh tahun 2017 sebanyak 4516 orang. Sampel kasus diambil dengan total sampling sebanyak 55 orang sedangkan sampel kontrol diambil dengan teknik purposive sampling sebanyak 55 orang. Data dianalisis menggunakan uji chi-square.Hasil: Faktor risiko ibu yang terjadi selama kehamilan terbukti dapat meningkatkan kejadian sepsis neonatorum yaitu persalinan lama (ρ=0,032 a=0,05), ketuban pecah dini (ρ=0,015 a=0,05), dan usia kehamilan (ρ=0,022 a=0,05). Dari ketiga faktor tersebut ibu yang mengalami ketuban pecah dini merupakan faktor yang paling berisiko menyebabkan sepsis neonatorum dibandingkan dengan yang tidak mengalami ketuban pecah dini (OR = 2,571) sedangkan faktor risiko ibu yang tidak berhubungan adalah infeksi antepartum dan komplikasi kehamilan.Simpulan: Dari lima faktor risiko ibu terdapat tiga faktor yang dapat meningkatkan kejadian sepsis neonatorum yaitu faktor yang paling beresiko adalah ketuban pecah dini dan faktor lainnya adalah persalinan lama dan usia kehamilan. Kata Kunci: Ketuban pecah dini, Persalinan lama, Sepsis neonatorum, Usia kehamilan Mother Risk Factors In Increasing The Incidence Of Neonatal Sepsis At Dr. H. Moch. Ansari Saleh Hospital Of BanjarmasinABSTRACT  Background: The main causes of newborn or neonatal deaths in the world include premature babies 29%, sepsis and pneumonia 25% and 23% are newborns with asphyxia and trauma. Neonatal sepsis is one of the infectious diseases that can cause death in newborns, the incidence of sepsis in Indonesia is still high at 8.7% to 30.29% with a mortality rate of 11.56% to 49.9%. The incidence of Neonatal Sepsis at Dr. H. Moch. Ansari Saleh Hospital of Banjarmasin in 2014 as much as 2.9%, in 2015 as many as 1.2%, and in 2016 as many as 1.2%.Objective: To analyzing maternal risk factors in increasing the incidence of neonatal sepsis at Dr. H. Moch. Ansari Saleh Hospital of Banjarmasin in 2017.Methods: Quantitative research with case control design. The study population was all newborns recorded in the medical record at Dr. H. Moch. Ansari Saleh Hospital of Banjarmasin in 2017 as many as 4516 people. Case samples were taken with a total sampling of 55 people while the control samples were taken with a purposive sampling technique of 55 people. Data were analyzed using the chi-square test.Results: Maternal risk factors that occur during pregnancy have been shown to increase the incidence of neonatal sepsis, prolonged labor (ρ=0,032 a=0,05), premature rupture of membranes (ρ=0,015 a=0,05), and gestational age (ρ=0,022 a=0,05). Of the three factors, mothers who experienced premature rupture of membranes were the most at risk for causing neonatal sepsis compared with those who did not experience premature rupture of membranes (OR = 2,571) while unrelated maternal risk factors were antepartum infection and pregnancy complications.Conclusion: Of the five maternal risk factors there are three factors that can increase the incidence of neonatal sepsis, which is the most risky factor is premature rupture of the membranes and other factors are prolonged labor and gestational age.  Key Words: Gestational age, Neonatal sepsis, Premature rupture of membranes, Prolonged labor  

NEONATAL SEPSIS AND IDENTIFICATION OF RISK FACTORS: STUDY IN AVBRH HOSPITAL SAWANGI

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Pramod P. Singhavi
Keyword(s):  
Risk Factors ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Late Onset ◽  
Signs And Symptoms ◽  
Premature Rupture ◽  
Maternal Risk ◽  
Late Onset Sepsis ◽  
Early Onset Sepsis ◽  
Meconium Stained Amniotic Fluid

Introduction: India has the highest incidence of clinical sepsis i.e.17,000/ 1,00,000 live births. In Neonatal sepsis septicaemia, pneumonia, meningitis, osteomyelitis, arthritis and urinary tract infections can be included. Mortality in the neonatal period each year account for 41% (3.6 million) of all deaths in children under 5 years and most of these deaths occur in low income countries and about one million of these deaths are due to infectious causes including neonatal sepsis, meningitis, and pneumonia. In early onset neonatal sepsis (EOS) Clinical features are non-specific and are inefficient for identifying neonates with early-onset sepsis. Culture results take up to 48 hours and may give false-positive or low-yield results because of the antenatal antibiotic exposure. Reviews of risk factors has been used globally to guide the development of management guidelines for neonatal sepsis, and it is similarly recommended that such evidence be used to inform guideline development for management of neonatal sepsis. Material and Methods: This study was carried out using institution based cross section study . The total number neonates admitted in the hospital in given study period was 644, of which 234 were diagnosed for neonatal sepsis by the treating pediatrician based on the signs and symptoms during admission. The data was collected: Sociodemographic characteristics; maternal information; and neonatal information for neonatal sepsis like neonatal age on admission, sex, gestational age, birth weight, crying immediately at birth, and resuscitation at birth. Results: Out of 644 neonates admitted 234 (36.34%) were diagnosed for neonatal sepsis by the paediatrician based on the signs and symptoms during admission. Of the 234 neonates, 189 (80.77%) infants were in the age range of 0 to 7 days (Early onset sepsis) while 45 (19.23%) were aged between 8 and 28 days (Late onset sepsis). Male to female ratio in our study was 53.8% and 46% respectively. Out of total 126 male neonates 91(72.2%) were having early onset sepsis while 35 (27.8%) were late onset type. Out of total 108 female neonates 89(82.4%) were having early onset sepsis while 19 (17.6%) were late onset type. Maternal risk factors were identified in 103(57.2%) of early onset sepsis cases while in late onset sepsis cases were 11(20.4%). Foul smelling liquor in early onset sepsis and in late onset sepsis was 10(5.56%) and 2 (3.70%) respectively. In early onset sepsis cases maternal UTI, Meconium stained amniotic fluid, Multipara and Premature rupture of membrane was seen in 21(11.67%), 19 (10.56%), 20(11.11%) and 33 (18.33%) cases respectively. In late onset sepsis cases maternal UTI, Meconium stained amniotic fluid, Multipara and Premature rupture of membrane was seen in 2 (3.70%), 1(1.85%), 3 (5.56%) and 3 (5.56%) cases respectively. Conclusion: Maternal risk identification may help in the early identification and empirical antibiotic treatment in neonatal sepsis and thus mortality and morbidity can be reduced.

scholarly journals Low Vitamin D Levels Increase the Risk of Early Onset Neonatal Sepsis

2020 ◽  
pp. 87-91
Author(s):  
Lisnawati Yuyun ◽  
Ali Sungkar ◽  
Rinawati Rohsiswatno ◽  
Noroyono Wibowo ◽  
Denni Hermartin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Umbilical Cord ◽  
Neonatal Sepsis ◽  
Medical Records ◽  
Early Onset ◽  
Study Data ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Vitamin D Levels

Abstract Objective: To identify the association between maternal and umbilical cord vitamin D levels with suspects of early-onset of neonatal sepsis (EONS) in newborns from mothers with preterm premature rupture of membranes (PPROM).Methods: This is a retrospective cohort study conducted from January 2017 to Augusts 2018. Data was taken consecutively from medical records and previous study data at Dr. Cipto Mangunkusumo and Persahabatan Hospital, Jakarta.Results: From total of 72 infants from mothers with PPROM, 22 infants (31%) were EONS-suspected and 50 infants (69%) were not EONS-suspected. There was a significant association between maternal and umbilical cord vitamin D levels with EONS.Conclusion: There was a significant association between maternal and umbilical cord vitamin D levels with EONS.Keywords: early-onset neonatal sepsis, preterm premature rupture of membrane, vitamin D,   Abstrak Tujuan: Untuk mengetahui hubungan antara kadar vitamin D maternal dan tali pusat dengan risiko tejadinya Sepsis Neonatal Awitan Dini (SNAD) pada bayi dari ibu dengan Ketuban Pecah Dini (KPD).Metode: Desain penelitian kohort retrospektif secara consecutive sampling. Data diambil dari rekam medis dan data penelitian sebelumnya di Rumah Sakit Umum Pusat Nasional (RSUPN) Dr. Cipto Mangunkusumo dan Rumah Sakit Umum Pusat (RSUP) Persahabatan, Jakarta. Hasil:  Dari 72 bayi yang dilahirkan dari ibu dengan KPD, 22 bayi (31%) diantaranya diduga mengalami SNAD, sedangkan 50 bayi lainnya tidak mengalami SNAD. Terdapat hubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD. Kesimpulan:Terdapathubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD.Kata kunci: ketuban pecah dini,  sepsis neonatal awitan dini, vitamin D

scholarly journals Risk Factors for Neonatal Sepsis in Pregnant Women with Premature Rupture of the Membrane

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Dwiana Ocviyanti ◽  
William Timotius Wahono
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Gestational Age ◽  
Neonatal Sepsis ◽  
Sampling Method ◽  
Cross Sectional Study ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Mortality Risks ◽  
Autoimmune Condition

Background. Premature rupture of the membrane (PROM) is associated with high maternal as well as perinatal morbidity and mortality risks. It occurs in 5 to 10% of all pregnancy while incidence of amniotic membrane infection varies from 6 to 10%. This study aimed to determine the incidence of neonatal sepsis in Cipto Mangunkusumo Hospital and the risk factors. Methods. A cross-sectional study was done in Cipto Mangunkusumo Hospital, Jakarta, from December 2016 to June 2017. The study used total sampling method including all pregnant women with gestational age of 20 weeks or more experiencing PROM, who came to the hospital at that time. Samples with existing comorbidities such as diabetes mellitus or other serious systemic illnesses such as heart disease or autoimmune condition were excluded from the analysis. Results. A total of 405 pregnant women with PROM were included in this study. There were 21 cases (5.2%) of neonatal sepsis. The analysis showed that risk of neonatal sepsis was higher in pregnant women with prolonged rupture of membrane for ≥ 18 hours before hospital admission (OR 3.08), prolonged rupture of membrane for ≥ 15 hours during hospitalization (OR 7.32), and prolonged rupture of membrane for ≥ 48 hours until birth (OR 5.77). The risk of neonatal sepsis was higher in preterm pregnancy with gestational age of <37 weeks (OR 18.59). Conclusion. Risk of neonatal sepsis is higher in longer duration of prolonged rupture of membrane as well as preterm pregnancy.

scholarly journals Predictors of Early-onset Neonatal Sepsis in Premature Newborns: Case Control Study

2021 ◽  
Author(s):  
Ounoo Elom Takassi ◽  
Yawo Dzayisse Atakouma
Keyword(s):  
Risk Factors ◽  
Gestational Age ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Case Control Study ◽  
Statistical Tests ◽  
Case Control ◽  
Diagnostic Process ◽  
Premature Newborns ◽  
Control Study

Abstract Background: Early-onset neonatal sepsis (EOS) is difficult to diagnose clinically because the semiology of premature newborns is poor during the first days of life. This study aimed to identify predictive factors of EOS in neonates less than 37 weeks gestational age in neonatal care at Louis Mourier Hospital. Method: This was a case-control study of all newborns <37 weeks of gestational age diagnosed and managed for EOS from January 1 to December 31, 2019. The main parameters studied were demographic characteristics, risk factors, biological and bacteriological characteristics. At the benchmarking level, the statistical tests used were the Mac Nemar test for qualitative variables and the paired Student's test for quantitative variables. Results: A total of 50 mother-child pairs were included in this study (25 cases and 25 matched controls). The results showed a statistically significant relationship between the birth of a child suffering from an EOS and between a premature rupture of membranes (PRM)> 18 h (68% of cases versus 36% of controls ( p: 0.042)); a positive culture of the placenta (p: 0.0002); a CRP> 6 mg / l (88% of cases against 20% of controls (p: 0.001)); a PCT> 0.6 ng / ml (72% of cases vs. 16% of controls (p: 0.001)). Grams negative including E. coli (44.5%) and Haemophilus Influenzae (14.8%) were the most common bacteria found. Conclusion: The search for risk factors must be systematic. The dosage of PCT must be coupled with that of CRP and the clinic must remain at the center of the diagnostic process.

scholarly journals Sensitivity of histological chorioaminionitis and premature rupture of membranes for neonatal sepsis and its risk factors

2016 ◽  
Vol 18 (70) ◽  
pp. 10-15
Author(s):  
I. Rodríguez-Balderrama ◽  
M.E. de la O-Cavazos ◽  
A. Martínez-Rios ◽  
I.M. Cadena-López ◽  
K.A. Flores-Treviño
Keyword(s):  
Risk Factors ◽  
Neonatal Sepsis ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture

scholarly journals Neonatal outcome of maternal premature rupture of membranes more than 18 hours

2020 ◽  
Vol 9 (2) ◽  
pp. 81-86
Author(s):  
Amshu Shakya ◽  
Sweta Kumari Gupta
Keyword(s):  
Risk Factors ◽  
Respiratory Distress Syndrome ◽  
Neonatal Sepsis ◽  
Distress Syndrome ◽  
Maternal Risk Factors ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Maternal Risk ◽  
History Of ◽  
Study Population

Background: Premature Rupture of Membranes  has been known to complicate pregnancy since ages. Several risk factors may be associated with occurrence of premature rupture of membranes. It is associated with varied neonatal complications, neonatal sepsis and prematurity being the most hazardous ones. Objectives: This study was conducted to evaluate the incidence of neonatal sepsis following premature rupture of membranes, risk factors and neonatal complications associated with premature rupture of membrane of more than 18 hours in the neonates admitted in a tertiary care center. Methodology: Descriptive observational study was undertaken for 18 months from August 2013 to January 2015 in the College of Medical Sciences, Chitwan, Nepal. This study included 82 neonates admitted to the Neonatal Intensive Care Unit with maternal history of premature rupture of membranes of more than 18 hours with medical conditions excluded.  Results: The incidence of premature rupture of membranes in this hospital was 8.9%. Frequently associated maternal risk factors were history of prior abortion (16, 19.5%), urinary tract infection (7, 8.5%), and antecedent coitus (7, 8.5%). In the study population, 68 (83%) neonates had complications and 14 (17%) neonates had no complication. The incidence of neonatal sepsis following PROM in present study was 6.1%. Neonatal sepsis was significantly associated with chorioamnionitis (p<0.001). The most frequently occurring complication was probable neonatal sepsis (53, 64.6%), followed by prematurity (31, 37.8%) and perinatal asphyxia (15, 18.3%). There was a directly proportional relation of neonatal sepsis, chorioamnionitis, respiratory distress syndrome and mortality with duration of premature rupture of membranes. Conclusion: Commonly occurring maternal risk factors with PROM were prior abortion, UTI and antecedent coitus. In the study population, infectious morbidity was highest.  Chorioamnionitis was significantly associated with culture proven neonatal sepsis. Prolonged duration of premature rupture of membranes increased the risk of neonatal sepsis, meningitis, respiratory distress syndrome and perinatal death. Prevention of these risk factors, appropriate and timely management including improved obstetric and neonatal care can provide intact survival of the neonates.

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