scholarly journals Relationship Between Periosteal Reaction and Medial Compartment Knee Osteoarthritis in Observation of Chinese Patients: A Retrospective Single-Centre Comparative Study

2020 ◽  
Author(s):  
Xiangtian Deng ◽  
Hongzhi Hu ◽  
Xiaodong Cheng ◽  
Jian Zhu ◽  
Zhipeng Ye ◽  
...  
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
Comparative Study ◽  
Knee Osteoarthritis ◽  
Proximal Tibia ◽  
Periosteal Reaction ◽  
Medial Compartment ◽  
Tibia Diaphysis ◽  
Logistical Regression ◽  
Logistical Regression Analysis

Abstract Background: The purpose of this study to evaluate the potential relationship between the periosteal reaction and medial compartment knee osteoarthritis (KOA), and to assess the related risk factors for the development of periosteal reaction associated with medial compartment KOA.Methods: From January 2019 to December 2019, a total of 476 consecutive patients with medial compartment KOA were included and assessed in this retrospective comparative study. They were divided into two groups: periosteal reaction group and non-periosteal reaction group. Radiological parameters was measured for malalignment of the lower extremities in coronal plane. Intra-observer and inter-observer reliabilities of all radiological measurements were analyzed by intraclass correlation coefficients (ICCs). Univariate analyses was conducted for comparison of differences with continuous variables between patients with periosteal reaction and without periosteal reaction. Multivariate binary logistical regression analysis were performed to determine the independent risk factors of radiographic parameters for periosteal reaction.Results: A total of 363 patients (726 knees) were selected for the study, including 91 males and 272 females, with an average age of 57.9±12.8 years (range, 18-82 years). The overall incidence of periosteal reaction associated with medial compartment KOA was 56.7%. Furthermore, the incidence of periosteal reaction significantly increased with age and K-L grade progressed (P＜0.05). Multivariate logistical regression analysis found that HKA and JICA were significantly correlated with the development of periosteal reaction adjacent to the lateral of proximal tibia diaphysis in medial compartment KOA (P＜0.05).Conclusions: Our observation of the reaction of periosteum may be an anatomical adaptation for medial compartment KOA. Patients with lower HKA and higher JICA are more likely to developing periosteal reaction, which occurred most commonly adjacent to the lateral of proximal tibia diaphysis.

scholarly journals Anatomical basis of the support of fibula to tibial plateau and its clinical significance

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Wen-Bin Jiang ◽  
Shi-Zhu Sun ◽  
Chan Li ◽  
Philip Adds ◽  
Wei Tang ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Tibial Plateau ◽  
Proximal Tibia ◽  
Medial Compartment ◽  
Lateral Side ◽  
Lateral Tibial Plateau ◽  
Anatomical Basis ◽  
Tibiofibular Joint ◽  
Nonuniform Settlement ◽  
Tibia Plateau

Abstract Background The fibula is only indirectly involved in the composition of the human knee joint and has therefore been neglected in the research on knee osteoarthritis. Nonuniform settlement of the proximal tibia plateau is clinically defined as when the height of the medial tibial plateau is lower than that of the lateral side in medial compartment knee osteoarthritis (KOA). The non-uniform settlement of the proximal tibia plateau may be caused by fibular support on the lateral side. Orthopedic surgeons practice partial fibulectomy based on the clinical manifestation of nonuniform settlement, and this technique has been shown to reduce pain and improve function in patients with medial compartment KOA. However, this hypothesis of the mechanism of nonuniform settlement lacks an anatomical basis. Methods The P45 polyester plastination technique was used to prepare sections of the proximal tibiofibular joint to investigate the distribution of the bone trabeculae in the region of the lateral tibial plateau. Results There was uneven distribution of trabeculae in the lateral condyle of the tibia and the head and neck of the fibula. The fibula and the posterolateral cortex of the shaft of the tibia united to form an arch beam via the tibiofibular joint. Many thick, dense trabeculae were present in a longitudinal direction above the tibiofibular arch. Conclusions The fibula supports the lateral tibial plateau, and the trabeculae were concentrated above the tibiofibular arch.

scholarly journals Risk Factors for Radiographic Tibiofemoral Knee Osteoarthritis: The Wuchuan Osteoarthritis Study

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Jianhao Lin ◽  
Rujun Li ◽  
Xiaozheng Kang ◽  
Hu Li
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Knee Osteoarthritis ◽  
Weight Bearing ◽  
Lateral Compartment ◽  
Activity Level ◽  
Medial Compartment ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Knee Oa

Objective. To investigate the risk factors of radiographic tibiafemoral knee osteoarthritis (OA).Methods. A population-based cross-sectional survey was conducted in Wuchuan County. A questionnaire and bilateral weight-bearing posterior-anterior semi-flexed knee radiographs were completed and read for Kellgren and Lawrence (K/L) grade and joint space narrowing (JSN; 0–3 scale) in each compartment. An logistic regression analysis was performed for radiographic tibiafemoral, lateral compartment, and medial compartment knee OA, respectively. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated.Results. Age, sex, and knee injury were strongly associated with tibiafemoral, lateral and medial compartment knee OA. BMI also had a dose-response relationship with them. Physical activity level, and physical activity exposure at work, not significantly though, were associated with an elevated risk for this three kinds of knee OA.Conclusions. Physical activity exposure increased the risk of knee OA. It was likely to be the heavier physical activity in Wuchuan osteoarthritis study that counteracted the BMI gap compared with the Beijing and the Framingham OA study. We verified that Chinese had a more valgus alignment of the knee compared with Caucasian population, and this provide a possible explanation why Chinese have a higher prevalence of lateral compartment OA.

scholarly journals Associations Between Periosteal Reaction of Proximal Tibial and Medial Compartment Knee Osteoarthritis

2021 ◽  
Author(s):  
Xiang‐tian Deng ◽  
Hong‐zhi Hu ◽  
Jian Zhu ◽  
Wei Chen ◽  
Zhong‐zheng Wang ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Periosteal Reaction ◽  
Medial Compartment

scholarly journals Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Li Xue ◽  
Li Tao ◽  
Xueyi Li ◽  
Yan Wang ◽  
Biao Wang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Regression Analysis ◽  
Disease Activity ◽  
Roc Curve ◽  
Degradation Product ◽  
Plasma Fibrinogen ◽  
Fibrin Degradation Product ◽  
Activity Data ◽  
Logistical Regression ◽  
Logistical Regression Analysis

AbstractThis study aimed to assess the association of coagulation-related indicators such as plasma fibrinogen (FIB), d-dimer, and fibrin degradation product (FDP) in rheumatoid arthritis (RA) with the disease activity. Data from 105 RA patients and 102 age- and gender-matched healthy controls were collected in the retrospective study. Disease activity score in 28 joints based on C-reactive protein (DAS28-CRP) was used to divide RA patients into low activity group (DAS28-CRP ≤ 2.7) and active group (DAS28-CRP > 2.7). Receiver operating characteristic (ROC) curve was applied to determine area under the curve (AUC). The association between plasma FIB, d-dimer, and FDP and DAS28-CRP was evaluated by spearman correlation. Logistical regression analysis was used to identify the independent variables associated with RA disease activity. RA patients showed higher levels of plasma FIB, d-dimer, and FDP than the controls (P < 0.01). Plasma FIB, d-dimer, and FDP were also increased in active groups of RA patients than those in inactive groups (P < 0.001). ROC curve analyses revealed that the AUC of d-dimer was higher than erythrocyte sedimentation rate (ESR) and rheumatoid factor (RF), and that of FDP was higher than RF in RA patients. In addition, the optimal cut-off value of plasma FIB, d-dimer, and FDP for RA diagnosis was 286 mg/dL, 470 μg/L, and 1.45 mg/L, respectively. Spearman analysis showed that plasma FIB, d-dimer, and FDP were positively related with DAS28-CRP (P < 0.001) in RA patients. Logistical regression analysis showed that d-dimer (odds ratio 2.862, 95% confidence interval 1.851–5.426, P < 0.001) was an independent variable associated with RA disease activity. FIB, d-dimer, and FDP were increased in RA patients and positively correlated with the disease activity of RA. d-dimer may act as a novel inflammatory indice for indicating disease activity in RA patients.

scholarly journals Gender and propensity to risk in advanced countries

2018 ◽  
Vol 2 (1) ◽  
pp. 24-34 ◽  
Author(s):  
Maria Lago ◽  
Catarina Delgado ◽  
Manuel Castelo Branco
Keyword(s):  
Regression Analysis ◽  
Design Methodology ◽  
The Other ◽  
Risk Propensity ◽  
National Cultures ◽  
Men And Women ◽  
Content Type ◽  
Two Samples ◽  
Logistical Regression ◽  
Logistical Regression Analysis

Purpose The purpose of this paper is to compare the way in which gender and propensity to risk are associated in two samples, one of entrepreneurs and the other of non-entrepreneurs, while controlling for other factors, namely, national cultures. Design/methodology/approach On the basis of data from 19 advanced countries, and by using two different samples, one of entrepreneurs and the other of non-entrepreneurs, the authors have used logistical regression analysis to analyse the relation between gender and propensity to risk has been used. Findings Findings suggest that gender and culture are much stronger in influencing risk propensity among non-entrepreneurs than among entrepreneurs. Originality/value Instead of analysing the effects of propensity to risk in entrepreneurship, as is usually done, the authors study some of its determinants, highlighting the differences between men and women.

Incidence of depression and its influencing factors in 387 patients with asthma from Xinjiang, China

2020 ◽  
Vol 41 (2) ◽  
pp. e45-e53 ◽  
Author(s):  
Dilinuer Wufuer ◽  
Haidiya Aierken ◽  
Yan Fang ◽  
Mihereguli Simayi ◽  
Kelibiena Tuerxun ◽  
...  
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
Depression Scale ◽  
High Morbidity ◽  
Hamilton Depression Scale ◽  
Multiple Factors ◽  
Asthma Symptoms ◽  
Depression Status ◽  
Treatment Of Depression ◽  
Quality Life

Background: Our study aimed to investigate the incidence of depression in 387 patients with asthma. Methods: The Zung self-rating depression scale and the Hamilton depression scale were used to evaluate the depression status in patients with asthma. Results: Results of logistic regression analysis indicated that, severity of asthma symptoms, taking medicine, frequency of asthma onset, and lack of education were the major risk factors for depression in patients with asthma. Conclusion: Depression is a complication with high morbidity in patients with asthma. It largely affects disease control of asthma and the quality life in patients. Multiple factors are relevant for depression in the patient with asthma. This study provided a comprehensive horizon for clinical management and treatment of depression in patients with asthma.

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