scholarly journals Cardiovascular Risk Profile in Dupuytren’s Disease: A Systematic Review and Meta-Analysis.

2020 ◽  
Author(s):  
Sylvain Mathieu ◽  
Bruno Pereira ◽  
Frederic Dutheil ◽  
Martin Soubrier
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Meta Analysis ◽  
Risk Profile ◽  
Dupuytren’S Disease ◽  
Cardiovascular Risk Profile ◽  
Dupuytren's Disease ◽  
Risk Of Death ◽  
Inverse Variance ◽  
Mean Differences

Abstract Background. Patients with Dupuytren’s disease (DD) may have a higher cardiovascular (CV) risk because of association with diseases with a higher recognized CV risk, such as diabetes. However, DD is not always linked to these diseases; therefore, it seems relevant to assess the CV profile in DD.Methods. We performed a systematic literature review up to April 2020. Differences between DD patients and controls were expressed as standardized mean differences using the inverse-variance method or as odds ratios (ORs) using the Mantel-Haenszel method. Results. We obtained 51 references corresponding to 112,900 DD patients and 2,383,177 controls. We found a higher risk of death (OR=1.72 [95%CI:1.37-2.16]) and CV death (118/974 DD patients vs. 372/3948 controls; OR=1.33 [95%CI:1.07-1.66]) among DD patients compared to controls. DD patients were more often diabetic (OR=3.44 [95% CI:2.69-4.38]). In 17 studies of the general population, the incidence of diabetes was 17.5% among DD patients (11.7-24.2%). DD patients were older, and more often men or alcohol drinkers. The percentage of smokers and levels of blood pressure or total cholesterol were not different among DD patients and controls. No difference was found in triglycerides, but the risk of obesity was significantly lower in DD patients.Conclusions. We found a higher CV risk in DD but not a higher prevalence of CV risk factors, except diabetes. This may be due to the predominance of men or greater number of alcohol drinkers or diabetics. Management of CV risk is important in patients with DD, including research on alcohol consumption or diabetes.

scholarly journals Systematic Review and Meta-Analysis of the Dose-Response and Risk Factors for Obliteration of Arteriovenous Malformations Following Radiosurgery: An Update Based on the Last 20 Years of Published Clinical Evidence

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Shaoyu Zhu ◽  
N Patrik Brodin ◽  
Madhur K Garg ◽  
Patrick A LaSala ◽  
Wolfgang A Tomé
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Dose Response ◽  
Meta Analysis ◽  
Gamma Knife Radiosurgery ◽  
Lesion Size ◽  
Intracranial Arteriovenous Malformation ◽  
Factors Associated ◽  
Obliteration Rate ◽  
Inverse Variance

ABSTRACT BACKGROUND Intracranial arteriovenous malformation (AVM) is a congenital lesion that can potentially lead to devastating consequences if not treated. Many institutional cohort studies have reported on the outcomes after radiosurgery and factors associated with successful obliteration in the last few decades. OBJECTIVE To quantitatively assess the dose-response relationship and risk factors associated with AVM obliteration using a systematic review and meta-analysis approach. METHODS Data were extracted from reports published within the last 20 yr. The dose-response fit for obliteration as a function of marginal dose was performed using inverse-variance weighting. Risk factors for AVM obliteration were assessed by combining odds ratios from individual studies using inverse-variance weighting. RESULTS The logistic model fit showed a clear association between higher marginal dose and higher rates of obliteration. There appeared to be a difference in the steepness in dose-response when comparing studies with patients treated using Gamma Knife radiosurgery (Elekta), compared to linear accelerators (LINACs), and when stratifying studies based on the size of treated AVMs. In the risk-factor analysis, AVM obliteration rate decreases with larger AVM volume or AVM diameter, higher AVM score or Spetzler-Martin (SM) grade, and prior embolization, and increases with compact AVM nidus. No statistically significant associations were found between obliteration rate and age, sex, prior hemorrhage, prior aneurysm, and location eloquence. CONCLUSION A marginal dose above 18 Gy was generally associated with AVM obliteration rates greater than 60%, although lesion size, AVM score, SM grade, prior embolization, and nidus compactness all have significant impact on AVM obliteration rate.

scholarly journals Effect of multidisciplinary educational programs delivered to scholar children on cardiovascular risk profile of their relatives: Systematic review and meta-analysis

BBA Clinical ◽  
2015 ◽  
Vol 3 ◽  
pp. S1
Author(s):  
Cristina P. Baena ◽  
Bianca Linnemkamp ◽  
Luis C. Guarita-Souza ◽  
Andre Minamihara ◽  
Carlos E.A. Fujisawa ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiovascular Risk ◽  
Meta Analysis ◽  
Educational Programs ◽  
Risk Profile ◽  
Cardiovascular Risk Profile

scholarly journals Effect of Berry Polyphenols on Glucose Metabolism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Theresa F Rambaran ◽  
Jonathan Bergman ◽  
Peter Nordström ◽  
Anna Nordström
Keyword(s):  
Systematic Review ◽  
Glucose Metabolism ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Randomized Controlled ◽  
Inverse Variance ◽  
Central Register ◽  
Mean Differences

ABSTRACT The effect of berry polyphenols on glucose metabolism has been evaluated in several studies; however, the results are conflicting. A systematic review and meta-analysis was therefore conducted to evaluate the effect of berry polyphenol consumption on glucose metabolism in adults with impaired glucose tolerance or insulin resistance. PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, CINAHL (EBSCO), and Scopus were searched for randomized controlled trials published by June 2019. Of the 3240 articles found, 21 met inclusion criteria. Study-specific effects were calculated as mean differences, which were pooled using fixed-effect, inverse-variance weighting. Overall, berry polyphenol consumption did not have a clear effect on biomarkers of glucose metabolism compared with placebo or no treatment. Although some analyses showed statistically significant effects, these effects were too small to be of clinical relevance. The review protocol was registered in the PROSPERO International Prospective Register of Systematic Reviews as CRD42019130811.

scholarly journals Mortality risk factors of COVID-19 infection in kidney transplantation recipients: a systematic review and meta-analysis of cohorts and clinical registries

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Suwasin Udomkarnjananun ◽  
Stephen J. Kerr ◽  
Natavudh Townamchai ◽  
Paweena Susantitaphong ◽  
Wasee Tulvatana ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Kidney Transplantation ◽  
Mortality Risk ◽  
Case Reports ◽  
Meta Analysis ◽  
Factors Associated ◽  
Presenting Symptoms ◽  
Risk Of Death ◽  
Published Evidence

AbstractKidney transplantation recipients (KTR) with coronavirus disease 2019 (COVID-19) are at higher risk of death than general population. However, mortality risk factors in KTR are still not clearly identified. Our objective was to systematically analyze published evidence for risk factors associated with mortality in COVID-19 KTR. Electronic databases were searched for eligible studies on 1 August 2021. All prospective and retrospective studies of COVID-19 in KTR were considered eligible without language restriction. Since data in case reports and series could potentially be subsets of larger studies, only studies with ≥ 50 patients were included. Random-effects model meta-analysis was used to calculate weighted mean difference (WMD) and pooled odds ratio (OR) of factors associated with mortality. From a total 1,137 articles retrieved, 13 were included in the systematic review and meta-analysis comprising 4,440 KTR. Compared with survivors, non-survivors were significantly older (WMD 10.5 years, 95% CI 9.3–11.8). KTR of deceased donor were at higher risk of death (OR 1.73, 95% CI 1.10–2.74). Comorbidities including diabetes mellitus, cardiovascular disease, and active cancer significantly increased mortality risk. KTR with dyspnea (OR 5.68, 95% CI 2.11–15.33) and pneumonia (OR 10.64, 95% CI 3.37–33.55) at presentation were at higher mortality risk, while diarrhea decreased the risk (OR 0.61, 95% CI 0.47–0.78). Acute kidney injury was associated with mortality (OR 3.24, 95% CI 1.36–7.70). Inflammatory markers were significantly higher in the non-survivors, including C-reactive protein, procalcitonin, and interleukine-6. A number of COVID-19 mortality risk factors were identified from KTR patient characteristics, presenting symptoms, and laboratory investigations. KTR with these risk factors should receive more intensive monitoring and early therapeutic interventions to optimize health outcomes.

scholarly journals Omega-6 fatty acids and the Risk of Cardiovascular Disease: Insights from a Systematic Review and Meta-Analysis of Randomized Controlled Trials and a Mendelian Randomization Study.

2021 ◽  
Author(s):  
Mohsen Mazidi ◽  
Niloofar Shekoohi ◽  
Niki Katsiki ◽  
Maciej Banach ◽  
the Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Sequential Analysis ◽  
Mendelian Randomization ◽  
Meta Analysis ◽  
Trial Sequential Analysis ◽  
Large Artery ◽  
Inverse Variance ◽  
Omega 6 ◽  
Adrenic Acid

IntroductionThe effects of omega-6 PUFAs on the CV risk factors are still controversial. Thus, we performed a systematic review and meta-analysis of RCTs as well as a Mendelian Randomization analysis to evaluate the links and possible causality between omega-6 PUFA, CVD and cardiometabolic risk factors.Material and methodsSelected databases were searched until September 2019 to identify prospective studies investigating the effects of omega-6 PUFAs supplementation on CVD events/mortality. Random-effects model meta-analysis was performed for quantitative data synthesis. Trial sequential analysis (TSA) was used to evaluate the optimal sample size to detect a 20% reduction in outcomes after administration of omega-6 PUFAs. Inverse variance weighted method (IVW), weighted median-based method, MR-Egger and MR-PRESSO were applied for MR.ResultsThe pooled estimate risk ratio (RR) of omega-6 PUFAs supplementation was 0.94 for any CVD event (95%CI:0.77-1.15, I2=66.2%), 1.06 for CVD death (95%CI:0.73-1.55, I2=66.2%), 0.84 for coronary heart disease (CHD) events (95%CI:0.61-1.16, I2=79.4%), 0.87 for myocardial infarction (MI) (95%CI:0.74-1.01, I2=2.3%) and 1.36 for stroke (95%CI:0.45-4.07, I2=55.3%). In contrast, MR showed that individuals with higher serum adrenic acid (AA) levels had a greater risk for CHD events (IVW=Beta:0.526), MI (IVW=Beta:0.606) and large artery stroke (IVW=Beta:1.694), as well as increased levels of FBG (IVW=Beta:0.417), LDL-C (IVW=Beta:0.806,) HDL-C (IVW=Beta:0.820), and lower levels of triglycerides (TG) (IVW=Beta:-1.064) and total cholesterol (TC) (IVW=Beta:-1.064).ConclusionsOmega-6 PUFAs supplementation did not affect the risk for CVD morbidity and mortality. Additionally, in MR analysis we showed that higher AA levels might even significantly increase with the risk of CHD, MI and large artery stroke.

Efficacy and adverse effects of collagenase use in the treatment of Dupuytren’s disease

2018 ◽  
Vol 100-B (1) ◽  
pp. 73-80 ◽  
Author(s):  
R. Sanjuan-Cerveró ◽  
F. J. Carrera-Hueso ◽  
P. Vazquez-Ferreiro ◽  
M. A. Ramon-Barrios
Keyword(s):  
Adverse Effects ◽  
Clinical Efficacy ◽  
Meta Analysis ◽  
Movement Analysis ◽  
Dupuytren’S Disease ◽  
Joint Movement ◽  
Case Control Studies ◽  
Dupuytren's Disease ◽  
Inverse Variance ◽  
Before And After

Aims The aim of this meta-analysis was to assess the safety and efficacy of collagenase clostridium histolyticum compared with fasciectomy and percutaneous needle fasciotomy (PNF) for Dupuytren’s disease. Materials and Methods We systematically searched PubMed, EMBASE, LILACS, Web of Science, Cochrane, Teseo and the ClinicalTrials.gov registry for clinical trials and cohort or case-control studies which compared the clinical outcomes and adverse effects of collagenase with those of fasciectomy or PNF. Of 1345 articles retrieved, ten were selected. They described the outcomes of 425 patients treated with collagenase and 418 treated by fasciectomy or PNF. Complications were assessed using inverse-variance weighted odds ratios (ORs). Clinical efficacy was assessed by differences between the means for movement of the joint before and after treatment. Dose adjustment was applied in all cases. Results Random-effects modelling showed that patients treated with collagenase had 3.24 increased odds of adverse effects compared with those treated by fasciectomy (OR 4.39) or PNF (OR 1.72,). The effect was lost when only major complications were assessed. Joint movement analysis revealed a difference between means of less than 10%, indicating equivalent clinical efficacy in the short and medium term for collagenase and fasciectomy. We were unable to analyse this for PNF due to a shortage of data. Conclusion There were no significant differences in effect size between collagenase and fasciectomy. The use of collagenase was associated with a higher overall risk of adverse effects than both fasciectomy and PNF. Cite this article: Bone Joint J 2018;100-B:73–80.

scholarly journals Dupuytren's Disease and exposure to vibration: Systematic review and Meta-analysis

2020 ◽  
Vol 87 (3) ◽  
pp. 203-207
Author(s):  
Sylvain Mathieu ◽  
Geraldine Naughton ◽  
Alexis Descatha ◽  
Martin Soubrier ◽  
Frédéric Dutheil
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Dupuytren’S Disease ◽  
Dupuytren's Disease

scholarly journals The Association of HScore Parameters with Severe COVID-19: a Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Elham Roshandel ◽  
Mohammad Hossein Kazemi ◽  
Bentolhoda Kuhestani Dehaghi ◽  
Hossein Bonakchi ◽  
Sayeh Parkhideh ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Odds Ratio ◽  
Meta Analysis ◽  
P Value ◽  
Aspartate Transaminase ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Exclusion Criteria ◽  
Common Features ◽  
Mean Differences

Abstract Several reports associated the severe Coronavirus disease-2019 (sCOVID-19) with secondary-haemophagocytic lymphohistiocytosis (sHLH) and proposed the HScore table for sCOVID-19 patients. We conducted a meta-analysis to found the possible association of HScore parameters with severity in COVID-19 patients. Systematic search was performed in Medline (PubMed), EMBASE, and Cochrane databases using all HScore and COVID-19 keywords. The records were screened based on inclusion/exclusion criteria. Random/fixed-effect models were employed. The pooled mean differences were estimated for continuous parameters. The pooled odds-ratio was estimated for fever. Eighteen studies met the criteria and included in the meta-analysis (2459 patients). Significant higher levels of leukocyte, neutrophil, aspartate-transaminase (AST), ferritin, and fibrinogen, as well as lower level of lymphocyte, platelet, and hemoglobin were found in sCOVID-19 patients compared to non-severe ones. Fever was nearly associated with 2 times increased odds of sCOVID-19 (p-value = 0.051). Lymphopenia, thrombocytopenia, hypohemoglobinemia, hyperferritinemia, high levels of AST, and fever are common features of both sCOVID-19 and HLH. However, leukocytosis, neutrophilia, and hyperfibrinogenemia found in sCOVID-19 contrast with HScore. Conclusively, HScore parameters could be risk factors for the severity of COVID-19. However, some parameters’ roles are contradictory, suggesting further investigation and a new way of HScore interpretation for sCOVID-19 patients.

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