scholarly journals Evaluation of Vector-Borne Disease Intervention Strategies Using Compartmental Models: A Case Study of 2016 Zika Epidemic In Miami-Dade County, Florida

2021 ◽  
Author(s):  
Nana Luo ◽  
Susan Cassels ◽  
Atsushi Nara ◽  
Zhanfeng Shen
Keyword(s):  
Scale Up ◽  
Transmission Probability ◽  
Intervention Strategies ◽  
Dade County ◽  
Transmission Cycle ◽  
Vector Borne Diseases ◽  
Vector Borne Disease ◽  
Vector Borne ◽  
Human Infections

Abstract Background: In August 2016, Miami-Dade County implemented Zika intervention strategies to combat a dramatic increase in incidence. Encouragingly, there was a significant decrease; howbeit, the effectiveness of these interventions remains unclear, and many countries in the world still suffer from various vector-borne diseases.Methods: To evaluate emerging vector-borne disease intervention strategies, we propose a Susceptible–Exposed–Infectious–Recovered Intervention Model (SEIR-IM) and apply the model to the 2016 Zika outbreak in Miami-Dade County, Florida as a case study. The proposed model allows for the impacts of the interventions on the transmission cycle of vector-borne diseases, and is parameterized by the Markov Chain Monte Carlo (MCMC).Results: Within the exiting literature, we find that vector-borne disease intervention strategies promote disease control in the context of human, vector, and human-vector contact. Overall, during the course of interventions, the transmission probability of humans decreases from 0.417 to 0.38 versus mosquitoes from 0.418 to 0.19. Through further analysis, the host-based controls are able to reduce the human infections to 27, while the vector-based controls are 50. On the basis of analysis of the human infections at high intervention coverage, in particular, continued scale-up of the interventions from baseline, we find that the interventions at higher coverage lead to an earlier but higher infection peak: 20 more infections and 100 days in advance.Conclusions: The three interventions result in a remarkable decline of the Zika infection in Miami-Dade County, and the host-based and contact- based controls are the most effective in reducing Zika incidence.

scholarly journals A comparative study on knowledge and perception of vector borne diseases among rural and urban population in Tamil Nadu

2019 ◽  
Vol 6 (6) ◽  
pp. 2672
Author(s):  
Roselin V. ◽  
Srisanthanakrishnan V.
Keyword(s):  
Urban Population ◽  
Tamil Nadu ◽  
Community Education ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Vector Borne Diseases ◽  
Vector Borne Disease ◽  
Rural And Urban ◽  
Vector Borne ◽  
Knowledge And Practice

Background: Vector-borne diseases (VBD) remain a major public health challenge, in India. Knowledge about VBD, social, demographic and environmental factors strongly influence the vector transmission and results in major outbreaks. Hence this study was conducted to assess knowledge and practice along with environmental conditions prevailing in both rural and urban areas.Methods: Cross sectional study was conducted in rural and urban field practice area of Sri Muthukumaran Medical College and Research Institute, Chennai, during June 2018 to December 2018. A total of 472 participants with 236 participants from each urban and rural area were included. Data was collected using proforma and analysis was done using SPSS 16.Results: Knowledge about VBD like dengue was 63.6% and 76.7% among rural and urban population, respectively. Similarly malaria was known by knows 59.3% and 68.2% of rural and urban participants. Japanese Encephalitis was the least known mosquito borne disease in both the groups. (p=0.0136). Common breeding sites addressed by the rural population were artificial collected water (36.9%) and urban population was dirty water (42.8%).Conclusions: Knowledge and practice of preventing vector borne disease is still lacking among both rural and urban participants. Spreading knowledge about VBD is a part in effective vector borne disease control which can be achieved by community education alone rather than insecticides and sprays.

scholarly journals Mapping the basic reproduction number (R0) for vector-borne diseases: A case study on bluetongue virus

Epidemics ◽  
2009 ◽  
Vol 1 (3) ◽  
pp. 153-161 ◽  
Author(s):  
N.A. Hartemink ◽  
B.V. Purse ◽  
R. Meiswinkel ◽  
H.E. Brown ◽  
A. de Koeijer ◽  
...  
Keyword(s):  
Basic Reproduction Number ◽  
Bluetongue Virus ◽  
Reproduction Number ◽  
Vector Borne Diseases ◽  
Vector Borne ◽  
The Basic Reproduction Number

Vector Control, Optimal Control, and Vector-Borne Disease Dynamics

2020 ◽  
pp. 267-288
Author(s):  
Michael B. Bonsall
Keyword(s):  
Optimal Control ◽  
Population Genetics ◽  
Population Dynamics ◽  
Vector Control ◽  
Cost Effective ◽  
Disease Suppression ◽  
Medical Interventions ◽  
Vector Borne Disease ◽  
Vector Borne

Understanding methods of vector control is essential to vector-borne disease (VBD) management. Vaccines or standard medical interventions for many VDBs do not exist or are poorly developed so disease control is focused on managing vector numbers and dynamics. This involves understanding not only the population dynamics but also the population genetics of vectors. Using mosquitoes as a case study, in this chapter, the modern genetics-based methods of vector control (self-limiting, self-sustaining) on mosquito population and disease suppression will be reviewed. These genetics-based methods highlight the importance of understanding the interplay between genetics and ecology to develop optimal, cost-effective solutions for control. The chapter focuses on how these genetics-based methods can be integrated with other interventions, and concludes with a summary of regulatory and policy perspectives about the use of these approaches in the management of VBDs.

scholarly journals Time to Micromanage the Pathogen-Host-Vector Interface: Considerations for Vaccine Development

Vaccines ◽  
2019 ◽  
Vol 7 (1) ◽  
pp. 10 ◽  
Author(s):  
Jessica E. Manning ◽  
Tineke Cantaert
Keyword(s):  
Vaccine Development ◽  
Blood Feeding ◽  
Adaptive Responses ◽  
Host Pathogen Interactions ◽  
Current Increase ◽  
Vector Borne Diseases ◽  
Vector Borne Disease ◽  
Host Pathogen ◽  
Added Benefit ◽  
Vector Borne

The current increase in vector-borne disease worldwide necessitates novel approaches to vaccine development targeted to pathogens delivered by blood-feeding arthropod vectors into the host skin. A concept that is gaining traction in recent years is the contribution of the vector or vector-derived components, like salivary proteins, to host-pathogen interactions. Indeed, the triad of vector-host-pathogen interactions in the skin microenvironment can influence host innate and adaptive responses alike, providing an advantage to the pathogen to establish infection. A better understanding of this “bite site” microenvironment, along with how host and vector local microbiomes immunomodulate responses to pathogens, is required for future vaccines for vector-borne diseases. Microneedle administration of such vaccines may more closely mimic vector deposition of pathogen and saliva into the skin with the added benefit of near painless vaccine delivery. Focusing on the ‘micro’–from microenvironments to microbiomes to microneedles–may yield an improved generation of vector-borne disease vaccines in today’s increasingly complex world.

scholarly journals Leishmaniasis and Climate Change—Case Study: Argentina

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Oscar Daniel Salomón ◽  
María Gabriela Quintana ◽  
Andrea Verónica Mastrángelo ◽  
María Soledad Fernández
Keyword(s):  
Public Health ◽  
Climate Change ◽  
Large Scale ◽  
Local Level ◽  
Point Of View ◽  
Mitigation Strategies ◽  
Vector Borne Diseases ◽  
Scale Models ◽  
Vector Borne

Vector-borne diseases closely associated with the environment, such as leishmaniases, have been a usual argument about the deleterious impact of climate change on public health. From the biological point of view interaction of different variables has different and even conflicting effects on the survival of vectors and the probability transmission of pathogens. The results on ecoepidemiology of leishmaniasis in Argentina related to climate variables at different scales of space and time are presented. These studies showed that the changes in transmission due to change or increase in frequency and intensity of climatic instability were expressed through changes in the probability of vector-human reservoir effective contacts. These changes of contact in turn are modulated by both direct effects on the biology and ecology of the organisms involved, as by perceptions and changes in the behavior of the human communities at risk. Therefore, from the perspective of public health and state policy, and taking into account the current nonlinear increased velocity of climate change, we concluded that discussing the uncertainties of large-scale models will have lower impact than to develop-validate mitigation strategies to be operative at local level, and compatibles with sustainable development, conservation biodiversity, and respect for cultural diversity.

Identifying environmental drivers of insect phenology across space and time: Culicoides in Scotland as a case study

2012 ◽  
Vol 103 (2) ◽  
pp. 155-170 ◽  
Author(s):  
K.R. Searle ◽  
A. Blackwell ◽  
D. Falconer ◽  
M. Sullivan ◽  
A. Butler ◽  
...  
Keyword(s):  
Seasonal Abundance ◽  
Environmental Drivers ◽  
Spatial And Temporal Patterns ◽  
Biting Midges ◽  
Vector Borne Diseases ◽  
Temperature And Precipitation ◽  
Vector Borne ◽  
Analytical Tools ◽  
Insect Phenology

AbstractInterpreting spatial patterns in the abundance of species over time is a fundamental cornerstone of ecological research. For many species, this type of analysis is hampered by datasets that contain a large proportion of zeros, and data that are overdispersed and spatially autocorrelated. This is particularly true for insects, for which abundance data can fluctuate from zero to many thousands in the space of weeks. Increasingly, an understanding of the ways in which environmental variation drives spatial and temporal patterns in the distribution, abundance and phenology of insects is required for management of pests and vector-borne diseases. In this study, we combine the use of smoothing techniques and generalised linear mixed models to relate environmental drivers to key phenological patterns of two species of biting midges, Culicoides pulicaris and C. impunctatus, of which C. pulicaris has been implicated in transmission of bluetongue in Europe. In so doing, we demonstrate analytical tools for linking the phenology of species with key environmental drivers, despite using a relatively small dataset containing overdispersed and zero-inflated data. We demonstrate the importance of landcover and climatic variables in determining the seasonal abundance of these two vector species, and highlight the need for more empirical data on the effects of temperature and precipitation on the life history traits of palearctic Culicoides spp. in Europe.

scholarly journals Assessment of national vector borne disease control programme in state of Karnataka

2019 ◽  
Vol 6 (2) ◽  
pp. 525
Author(s):  
Puneet Kumar Arali ◽  
Deepthi N. Shanbhag
Keyword(s):  
Disease Control ◽  
Lymphatic Filariasis ◽  
Health Workers ◽  
Medical Officer ◽  
Control Programme ◽  
Family Welfare ◽  
Vector Borne Diseases ◽  
Vector Borne Disease ◽  
Vector Borne ◽  
Disease Control Programme

ABSTRACTBackground:National vector borne disease control programme(NVBDCP) was launched to control the prevalence of vector borne diseases like malaria, filaria, Japanese encephalitis (JE), Dengue/DHF, chikungunya, lymphatic filariasis and Kala Azar. The present study was done to assess the activities of NVBDCP in state of Karnatakaand to analyze selective qualitative and quantitative indicators related to the activities.Methods:Quantitatively retrospective data was collected from Directorate office Department of Health and Family Welfare, NVBDCP section from April 2016 to March 2017. Qualitatively questionnaire based protocol was made and interviews were conducted with District programme officer, PHC medical officer and  grass root level health workers like ANM, ASHA with reference to one each of selected least performing districts and good performing districts in the state. The collected data was analysed by using Microsoft Excel 2010 version.Results:The highest prevalent districts in Karnataka areDakshina Kannada for malaria, Udupi for dengue, Tumakurufor chikungunya andBidar for lymphatic filariasis. Major factors related to poor outcome in some districts were rigid attitude of the community, poor support of local panchayats and less human resources.Conclusion:The result of this investigation revealed that Dakshina Kannada has got highest number of cases with greater proposition and high prevalence rate of vector borne diseases due to lack of sufficient human resources and geographical factors. Strengthening the surveillance activities along with integrated vector control programmes will improves the outcome of the programme.

scholarly journals The use of islands and cluster-randomized trials to investigate vector control interventions: a case study on the Bijagós archipelago, Guinea-Bissau

2020 ◽  
Vol 376 (1818) ◽  
pp. 20190807 ◽  
Author(s):  
Robert T. Jones ◽  
Elizabeth Pretorius ◽  
Thomas H. Ant ◽  
John Bradley ◽  
Anna Last ◽  
...  
Keyword(s):  
Vector Control ◽  
Statistical Power ◽  
Randomized Trials ◽  
Control Strategies ◽  
Cluster Randomized Trials ◽  
Vector Borne Diseases ◽  
Guinea Bissau ◽  
Vector Borne ◽  
Cluster Randomized

Vector-borne diseases threaten the health of populations around the world. While key interventions continue to provide protection from vectors, there remains a need to develop and test new vector control tools. Cluster-randomized trials, in which the intervention or control is randomly allocated to clusters, are commonly selected for such evaluations, but their design must carefully consider cluster size and cluster separation, as well as the movement of people and vectors, to ensure sufficient statistical power and avoid contamination of results. Island settings present an opportunity to conduct these studies. Here, we explore the benefits and challenges of conducting intervention studies on islands and introduce the Bijagós archipelago of Guinea-Bissau as a potential study site for interventions intended to control vector-borne diseases. This article is part of the theme issue ‘Novel control strategies for mosquito-borne diseases'.

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