scholarly journals Tmem45b is essential for inflammation and tissue injury-induced persistent mechanical hyperalgesia

2021 ◽  
Author(s):  
Tadashi Tanioku ◽  
Masayoshi Nishibata ◽  
Yasuyuki Tokinaga ◽  
Kohtarou Konno ◽  
Masahiko Watanabe ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Molecular Mechanism ◽  
Sensory Neurons ◽  
Daily Activity ◽  
Essential Role ◽  
Tissue Injury ◽  
Mechanical Hyperalgesia ◽  
Peripheral Inflammation ◽  
Primary Sensory Neurons

Abstract Persistent mechanical hyperalgesia, associated with peripheral inflammation and tissue injury, impairs patient’s quality of life and daily activity. However, its molecular mechanism and treatment are yet to be deciphered. Herein, we report that Tmeme45b is expressed in a subset of unmyelinated primary sensory neurons and plays an essential role in inflammation and tissue injury-induced mechanical hyperalgesia. Our findings provide new insights into the mechanisms and the treatment of mechanical hyperalgesia.

Improving the Quality of Life for High-Risk Infants

2008 ◽  
Vol 27 (6) ◽  
pp. 369-369
Author(s):  
Sharyn Gibbins
Keyword(s):  
Quality Of Life ◽  
Medical Education ◽  
High Risk ◽  
Scientific Knowledge ◽  
Essential Role ◽  
Pediatric Patients ◽  
Health Advocacy ◽  
Medical Speciality ◽  
High Risk Infants

NEONATOLOGY IS A RELATIVELY NEW MEDICAL SPECIALITY that arose from the recognition that neonates were different from adults and other pediatric patients. The recognition of these differences between patients led, in part, to the development of perinatology and neonatology programs across the globe. As scientific knowledge and medical education evolved, so too did the recognition that nurses played an essential role in the care of high-risk infants. No longer restricted to Florence Nightingale’s initial advocacy for a nurturing environment only, the profession of nursing extends into areas of practice, education, mentorship, health advocacy, and research.

scholarly journals Influence Of High-intensity Training On Quality Of Life And Daily Activity Performance In Multiple Sclerosis

2020 ◽  
Vol 52 (7S) ◽  
pp. 138-139
Author(s):  
Sebastian Proschinger ◽  
Jens Bansi ◽  
Annette Rademacher ◽  
Niklas Joisten ◽  
Alexander Schenk ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
High Intensity ◽  
Daily Activity ◽  
High Intensity Training ◽  
Activity Performance ◽  
Intensity Training

scholarly journals Ghrelin Prevents Cisplatin-Induced Mechanical Hyperalgesia and Cachexia

Endocrinology ◽  
2007 ◽  
Vol 149 (2) ◽  
pp. 455-460 ◽  
Author(s):  
José M. Garcia ◽  
Juan P. Cata ◽  
Patrick M. Dougherty ◽  
Roy G. Smith
Keyword(s):  
Quality Of Life ◽  
Chemotherapeutic Agent ◽  
Thermal Sensitivity ◽  
Mechanical Hyperalgesia ◽  
Behavioral Tests ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Unique Model ◽  
Igf I

Complications induced by the chemotherapeutic agent cisplatin, such as neuropathy and cachexia, occur frequently, are often dose limiting, and have an impact on quality of life and survival in cancer patients. The recently discovered hormone ghrelin is a potent GH secretagogue with orexigenic and neuroprotective properties that may prevent or ameliorate these complications. The objective of this study was to determine the effects of ghrelin administration on mechanical hyperalgesia, anorexia, and cachexia induced by cisplatin. Adult male Sprague-Dawley rats were given cisplatin, ghrelin, ghrelin-cisplatin, or vehicle ip. Food intake and body weight were measured daily. Behavioral tests to assess the development of hyperalgesia were conducted by measuring mechanical and thermal sensitivity. Plasma ghrelin and IGF-I levels were also measured. Our results indicate that ghrelin coadministration inhibited the development of cisplatin-induced mechanical hyperalgesia, anorexia, and cachexia induced by cisplatin. Although ghrelin treatment had no effect on plasma IGF-I levels in control rats, it prevented the decrease in IGF-I levels induced by cisplatin. The attenuation of cisplatin-induced mechanical hyperalgesia induced by ghrelin was correlated with the prevention of cisplatin-induced lowering of IGF-I. In conclusion, ghrelin administration may be useful in the treatment or prevention of chemotherapy induced neuropathy and cachexia. Attenuation of mechanical hyperalgesia in the rat by the hormone ghrelin provides a unique model for elucidating the mechanisms involved, which are essential toward our understanding of these complications.

scholarly journals Prevention of spine deforimities in adoloscents due to inaduquate posture

2010 ◽  
Vol 63 (11-12) ◽  
pp. 855-858
Author(s):  
Elizabeta Popova-Ramova ◽  
Milica Lazovic
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Spinal Deformity ◽  
Daily Activity ◽  
Musical Instruments ◽  
Spine Deformity ◽  
Spine Deformities ◽  
Watching Tv ◽  
Out Of School

Introduction. The spine deformities tend to increase, and in 90% of children they change the quality of life. The aim of this study was to determine the percents of spinal deformity in our population of adolescents, and long bad posture in and out of school as a factor for its increase. Material and methods. The study included 124 adolescents attending High Musical School in Bitola and Skopje, who underwent four standard spine tests and an interview. Results. According to the test 3, 50% of the examined adolescents in Bitola and 69% in Skopje had the postural spine deformity, the average being 59.5%. The results obtained by the questionnaire showed that 50% of adolescents did not have any physical activity out of school, the longest daily activity, lasting four hours, in 48% of the examinees was practising their musical instruments; 40% of the examinees spent two hours watching TV or using the computer, whereas 18% did not use any of them at all. Conclusion. The bad spine posture tends to deteriorate in adolescents and the factor influencing this result should be established by studies aimed at determining the effects of physical activity on reducing such deformities, since the specific type of their education induces the risk of developing pain and early degenerative changes of the spine, which are predominant in the professionals.

scholarly journals Resolvin E1 Inhibits Substance P-Induced Potentiation of TRPV1 in Primary Sensory Neurons

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Youn Yi Jo ◽  
Ji Yeon Lee ◽  
Chul-Kyu Park
Keyword(s):  
Substance P ◽  
G Protein ◽  
Sensory Neurons ◽  
Inflammatory Pain ◽  
Dorsal Root Ganglion Neurons ◽  
Peripheral Inflammation ◽  
Transient Receptor Potential Vanilloid ◽  
Primary Sensory Neurons ◽  
Nociceptive Neurons ◽  
Ganglion Neurons

The neuropeptide substance P (SP) is expressed in primary sensory neurons and is commonly regarded as a “pain” neurotransmitter. Upon peripheral inflammation, SP activates the neurokinin-1 (NK-1) receptor and potentiates activity of transient receptor potential vanilloid subtype 1 (TRPV1), which is coexpressed by nociceptive neurons. Therefore, SP functions as an important neurotransmitter involved in the hypersensitization of inflammatory pain. Resolvin E1 (RvE1), derived from omega-3 polyunsaturated fatty acids, inhibits TRPV1 activity via activation of the chemerin 23 receptor (ChemR23)—an RvE1 receptor located in dorsal root ganglion neurons—and therefore exerts an inhibitory effect on inflammatory pain. We demonstrate here that RvE1 regulates the SP-induced potentiation of TRPV1 via G-protein coupled receptor (GPCR) on peripheral nociceptive neurons. SP-induced potentiation of TRPV1 inhibited by RvE1 was blocked by the Gαi-coupled GPCR inhibitor pertussis toxin and the G-protein inhibitor GDPβ-S. These results indicate that a low concentration of RvE1 strongly inhibits the potentiation of TRPV1, induced by the SP-mediated activation of NK-1, via a GPCR signaling pathway activated by ChemR23 in nociceptive neurons. RvE1 might represent a new therapeutic target for the treatment of inflammatory pain as a prospective endogenous inhibitor that strongly inhibits TRPV1 activity associated with peripheral inflammation.

Abstract 15636: Effect of COVID-19 Public Health Measures on Activity and Quality of Life in Patients With Pulmonary Arterial Hypertension

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Jennifer T Middleton ◽  
Shiran Konganige ◽  
Payman Dahaghin ◽  
Hamza Zafar ◽  
Ashwin Reddy ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Rate ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Daily Activity ◽  
Low Risk ◽  
Health Measures ◽  
Critical Measure ◽  
Pulmonary Arterial

Background: Limitation of physical activity has been widely enforced to reduce COVID-19 transmission, however it is a critical measure in the prevention of cardiovascular disease. In patients with pulmonary arterial hypertension (PAH), exercise capacity relates to clinical outcomes and exercise training improves cardiopulmonary function. Here, we describe the temporal effects of UK government restriction measures on daily activity and quality of life (QoL) in patients with PAH. Methods: Patients Enrolled in The United Kingdom National Cohort Study of Idiopathic and Heritable PAH Study were implanted with insertable cardiac monitors (LinQ, Medtronic) in the clinic setting. Data were transmitted and reviewed in accordance with established clinical protocols. Standard questionnaires were administered remotely to assess QoL (EmPHasis-10), anxiety (GAD-7) and depression (PHQ-9). Results: Median age of the 26 patients was 49 years, 23 (88%) were female and 5 (19%) had heritable PAH with mutations in BMPR2. At enrolment 10 (38.5%) patients were low risk (<5% 1-year mortality), 10 (38.5%) were intermediate risk (5-10%) and 6 (23%) were high risk (>10%). The mean duration from insertion to census date was 21.1 weeks (SD 5.7). No complications were reported. Completeness of remote monitoring data was 100%. Following lockdown, mean activity was reduced compared to pre-lockdown levels (3.16 vrs 2.68 hours/day, -0.48 hours, 95%CI -0.27- -0.69, 16%, p<0.0001). This reduction was present each week following lockdown. Although not statistically significant the greatest reduction in activity was observed in patients in the low-risk group. Following lockdown QoL was reduced (26 (18-38) vrs 32 (17-47), p<0.01) and anxiety (1 (0-9) vrs 10 (5-18), p<0.001) and depression scores increased (3 (1-16) vrs 11 (3-17), p<0.001) compared to pre-lockdown levels. No change in day or night heart rate, or heart rate variability was observed and no patients developed COVID-19. Conclusion: In this cohort of patients with PAH, protective health measures were effective in preventing COVID-19 in patients thought to be highly vulnerable. However, these measures resulted in reduced daily activity and QoL and were associated increased anxiety and depression indicators.

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