scholarly journals A Pan-Cancer Analysis of Transcription Factor Forkhead Box O-3: FOXO3

2021 ◽  
Author(s):  
Guiyang cai ◽  
Jiacheng Li ◽  
Qing Yang ◽  
Wei Sun
Keyword(s):  
Transcription Factor ◽  
Cancer Associated Fibroblasts ◽  
Promoting Effect ◽  
Clinical Prognosis ◽  
Statistical Correlations ◽  
Forkhead Box ◽  
Tumor Mutational Burden ◽  
The Relationship ◽  
Pan Cancer

Abstract Background: Although available cell - or animal- based evidence supports the relationship between transcription factor FOXO3 and cancers, so far, there has been no pan-cancer analysis of FOXO3. Methods: We thus first carry on a pan-cancer analysis of FOXO3 across multiple tumors via several online websites based on the datasets of TCGA, including statistical correlations of FOXO3 expression with clinical prognosis, protein phosphorylation, cancer-associated fibroblasts infiltration, tumor mutational burden, and relevant cellular pathway. Results: FOXO3 was usually as an anti-tumor gene in KIRC, BLCA, CESC, UVM, LUAD and BRCA cancers, while a higher level of FOXO3 may have a certain cancer-promoting effect. As FOXO3 usually played a cancer-promoting role in ERα- BRCA but in ERα+ BRCA played an anti-tumor role, which may be due to transcription factor ERα translocating FOXO3 to the cytoplasm to weaken the transcription activity of FOXO3. FOXO3 activates autophagy related genes through transcription to maintain the occurrence of basal autophagy when basal autophagy is inhibited. However, FOXO3 can also induce apoptosis through transcription of pro-apoptotic genes if autophagy inhibition persists. The expression of phosphorylated FOXO3 protein at different sites may also affect its transcriptional activity by changing its shuttle between nucleus and cytoplasm. Therefore, When we analyze the functions of FOXO3 in a specific type of cancer, we should combine with the expression of FOXO3, the alteration status of FOXO3, the overall phosphorylation status of FOXO3, the basic autophagy status, the expression levels of ERα, SIRT1, CBP, FKBP5, RERE and SMAD4, and cancer-associated fibroblasts subtype, even consider the KRAS mutation, P53 mutation or non-genetic factors which can influence the functions of cancer-associated fibroblasts in the specific type of cancer. Conclusions: Our first pan-cancer study has provided a relatively comprehensive understanding of the role of FOXO3 in different tumors, and will give some help and enlightenment to later researchers who study the role of FOXO3 in various cancers.

Novel role of forkhead box O 4 transcription factor in cancer: Bringing out the good or the bad

2018 ◽  
Vol 50 ◽  
pp. 1-12 ◽  
Author(s):  
Shuai Jiang ◽  
Zhi Yang ◽  
Shouyin Di ◽  
Wei Hu ◽  
Zhiqiang Ma ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Forkhead Box

473 Role of the transcription factor forkhead box p3 in breast cancer and metastasis

2010 ◽  
Vol 8 (5) ◽  
pp. 121
Author(s):  
V. Uva ◽  
L. Sfondrini ◽  
T. Triulzi ◽  
P. Casalini ◽  
R. Orlandi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Forkhead Box P3 ◽  
Forkhead Box

scholarly journals Systematic pan-cancer landscape identifies CARM1 as a potential prognostic and immunological biomarker

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Yingqi Qiu ◽  
Hao Wang ◽  
Peiyun Liao ◽  
Binyan Xu ◽  
Rong Hu ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Integrated Analysis ◽  
Regulation Of Transcription ◽  
Immune Microenvironment ◽  
Arginine Methyltransferase ◽  
Clinical Prognosis ◽  
Tumor Immune Microenvironment ◽  
Arginine Residues ◽  
Pan Cancer

Abstract Background Belonging to the protein arginine methyltransferase (PRMT) family, the enzyme encoded by coactivator associated arginine methyltransferase 1 (CARM1) catalyzes the methylation of protein arginine residues, especially acts on histones and other chromatin related proteins, which is essential in regulating gene expression. Beyond its well-established involvement in the regulation of transcription, recent studies have revealed a novel role of CARM1 in tumorigenesis and development, but there is still a lack of systematic understanding of CARM1 in human cancers. An integrated analysis of CARM1 in pan-cancer may contribute to further explore its prognostic value and potential immunological function in tumor therapy. Results Based on systematic analysis of data in multiple databases, we firstly verified that CARM1 is highly expressed in most tumors compared with corresponding normal tissues, and is bound up with poor prognosis in some tumors. Subsequently, relevance between CARM1 expression level and tumor immune microenvironment is analyzed from the perspectives of tumor mutation burden, microsatellite instability, mismatch repair genes, methyltransferases genes, immune checkpoint genes and immune cells infiltration, indicating a potential relationship between CARM1 expression and tumor microenvironment. A gene enrichment analysis followed shortly, which implied that the role of CARM1 in tumor pathogenesis may be related to transcriptional imbalance and viral carcinogenesis. Conclusions Our first comprehensive bioinformatics analysis provides a broad molecular perspective on the role of CARM1 in various tumors, highlights its value in clinical prognosis and potential association with tumor immune microenvironment, which may furnish an immune based antitumor strategy to provide a reference for more accurate and personalized immunotherapy in the future.

scholarly journals Cancer-Associated Fibroblasts’ Functional Heterogeneity in Pancreatic Ductal Adenocarcinoma

Cancers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 290 ◽  
Author(s):  
Mohammad Awaji ◽  
Rakesh Singh
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Adverse Outcome ◽  
Ductal Adenocarcinoma ◽  
Cancer Associated Fibroblasts ◽  
Functional Heterogeneity ◽  
Paracrine Factors ◽  
Myofibroblast Phenotype ◽  
The Usa ◽  
The Relationship

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths in the USA. Desmoplasia and inflammation are two major hallmarks of PDAC. Desmoplasia, composed of extracellular matrix (ECM), cancer-associated fibroblasts (CAFs), and infiltrating immune and endothelial cells, acts as a biophysical barrier to hinder chemotherapy and actively contributes to tumor progression and metastasis. CAFs represent a multifunctional subset of PDAC microenvironment and contribute to tumor initiation and progression through ECM deposition and remodeling, as well as the secretion of paracrine factors. Attempts to resolve desmoplasia by targeting CAFs can render an adverse outcome, which is likely due to CAFs heterogeneity. Recent reports describe subsets of CAFs that assume more secretory functions, in addition to the typical myofibroblast phenotype. Here, we review the literature and describe the relationship between CAFs and inflammation and the role of the secretory-CAFs in PDAC.

scholarly journals The Role of Forkhead Box Protein M1 in Breast Cancer Progression and Resistance to Therapy

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Raya Saba ◽  
Alhareth Alsayed ◽  
James P. Zacny ◽  
Arkadiusz Z. Dudek
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Regulatory Pathways ◽  
Forkhead Box ◽  
Epidermal Growth

The Forkhead box M1 (FOXM1) is a transcription factor that has been implicated in normal cell growth and proliferation through control of cell cycle transition and mitotic spindle. It is implicated in carcinogenesis of various malignancies where it is activated by either amplification, increased stability, enhanced transcription, dysfunction of regulatory pathways, or activation of PI3K/AKT, epidermal growth factor receptor, Raf/MEK/MAPK, and Hedgehog pathways. This review describes the role of FOXM1 in breast cancer. This includes how FOXM1 impacts on different subtypes of breast cancer, that is, luminal/estrogen receptor positive (ER+), expressing human epidermal growth factor receptor 2 (HER2), basal-like breast cancer (BBC), and triple negative breast cancer (TNBC). The review also describes different tested preclinical therapeutic strategies targeting FOXM1. Developing clinically applicable therapies that specifically inhibit FOXM1 activity is a logical next step in biomarker-driven approaches against breast cancer but will not be without its challenges due to the unique properties of this transcription factor.

scholarly journals FOXL2: a central transcription factor of the ovary

2013 ◽  
Vol 52 (1) ◽  
pp. R17-R33 ◽  
Author(s):  
Adrien Georges ◽  
Aurelie Auguste ◽  
Laurianne Bessière ◽  
Anne Vanet ◽  
Anne-Laure Todeschini ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Forkhead Transcription Factor ◽  
Gene Encoding ◽  
Post Translational Modifications ◽  
Forkhead Box ◽  
Molecular Aspects ◽  
And Function ◽  
Craniofacial Defects ◽  
The Impact

Forkhead box L2 (FOXL2) is a gene encoding a forkhead transcription factor preferentially expressed in the ovary, the eyelids and the pituitary gland. Its germline mutations are responsible for the blepharophimosis ptosis epicanthus inversus syndrome, which includes eyelid and mild craniofacial defects associated with primary ovarian insufficiency. Recent studies have shown the involvement of FOXL2 in virtually all stages of ovarian development and function, as well as in granulosa cell (GC)-related pathologies. A central role of FOXL2 is the lifetime maintenance of GC identity through the repression of testis-specific genes. Recently, a highly recurrent somatic FOXL2 mutation leading to the p.C134W subtitution has been linked to the development of GC tumours in the adult, which account for up to 5% of ovarian malignancies. In this review, we summarise data on FOXL2 modulators, targets, partners and post-translational modifications. Despite the progresses made thus far, a better understanding of the impact of FOXL2 mutations and of the molecular aspects of its function is required to rationalise its implication in various pathophysiological processes.

scholarly journals An Essential Role of the Forkhead-Box Transcription Factor Foxo1 in Control of T Cell Homeostasis and Tolerance

Immunity ◽  
2009 ◽  
Vol 30 (3) ◽  
pp. 358-371 ◽  
Author(s):  
Weiming Ouyang ◽  
Omar Beckett ◽  
Richard A. Flavell ◽  
Ming O. Li
Keyword(s):  
Transcription Factor ◽  
T Cell ◽  
Essential Role ◽  
T Cell Homeostasis ◽  
Cell Homeostasis ◽  
Forkhead Box

scholarly journals CircANKRD52 Promotes the Tumorigenesis of Hepatocellular Carcinoma by Sponging miR-497-5p and Upregulating BIRC5 Expression

2021 ◽  
Vol 30 ◽  
pp. 096368972110088
Author(s):  
Mingzhi Zhang ◽  
Xinxin Yan ◽  
Peihao Wen ◽  
Wenkun Bai ◽  
Qingyu Zhang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Colony Formation ◽  
Tumor Model ◽  
Rna Seq ◽  
Promoting Effect ◽  
Clinical Prognosis ◽  
Xenograft Tumor Model ◽  
Elevated Expression ◽  
Hcc Cells

CircRNAs participate in the pathogenesis of a variety of cancers. Previous studies showed that baculoviral IAP repeat containing 5 (BIRC5) can promote tumor progression. But, the mechanisms by which circRNAs regulate BIRC5 expression in hepatocellular carcinoma (HCC) remain unknown. The clinical prognosis of BIRC5 or miR-497-5p expression in patients with HCC was assessed by TCGA RNA-seq dataset. hsa_circ_0026939 (circANKRD52) or BIRC5 was identified to bind with miR-497-5p by luciferase gene report, RIP and circRIP assays. MTT, colony formation, Transwell assays and a xenograft tumor model were used to estimate the role of miR-497-5p or circANKRD52 in HCC cells. As a result, we found that elevated expression of BIRC5 or decreased expression of miR-497-5p was linked to poor survival in HCC. Restored expression of miR-497-5p repressed cell proliferation, colony formation and invasiveness by targeting BIRC5, but its inhibitor showed the opposite results. Furthermore, circANKRD52 possessed a tumor-promoting effect by acting as a sponge of miR-497-5p and thereby upregulated BIRC5 in HCC cells. In conclusion, our findings demonstrated that circANKRD52 enhances the tumorigenesis of HCC by sponging miR-497-5p and upregulating BIRC5 expression.

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