scholarly journals Good Practices of Comirnaty® Vaccine Injection Using Uncrimped Materials

2021 ◽  
Author(s):  
Laetitia Le ◽  
Justine Touchard ◽  
Aymeric Chastel ◽  
Judith Pineau ◽  
Nicolas Martelli ◽  
...  
Keyword(s):  
Drug Information ◽  
Dead Volume ◽  
Liquid Volume ◽  
Good Reproducibility ◽  
Good Practices ◽  
Reference Dose ◽  
Air Bubble ◽  
Vaccine Injection

Abstract Background In 2020, the first mRNA COVID vaccine was approved by the with six doses from single vial. In the context of material shortages, the aim of the study was to compare different protocols to extract doses using uncrimped materials with good trueness and reproducibility. Methods To optimize the extraction of the sixth dose from a single vial with uncrimped materials, alternative protocols of preparation were tested, derived from the drug information. Results The repeatability of injected volume was acceptable for all protocols (CV<5.3%). To prepare six 0.3mL doses using uncrimped materials, protocols with an air bubble were evaluated to offset the high dead volume inherent to uncrimped materials. Regarding the limited doses observed using long intramuscular needle (92.8% of the reference dose), the air bubble protocol with a liquid volume adjustment at 0.27mL was finally validated to respect the administration of full doses. Conclusion Results highlighted the necessity to adapt the drug information protocol for the preparation and administration of Cominarty®, due to the use of high dead volume materials. Despite the good reproducibility and accuracy of the air bubble protocols, some precautions have therefore to be taken to maintain the integrity of the vaccine suspension for efficient administration.

scholarly journals Air-Bubble Induced Mixing: A Fluidic Mixer Chip

Micromachines ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 195 ◽  
Author(s):  
Xiaoyu Jia ◽  
Bingchen Che ◽  
Guangyin Jing ◽  
Ce Zhang
Keyword(s):  
Bulk Solution ◽  
Liquid Volume ◽  
Mixing Efficiency ◽  
Flow Profile ◽  
Air Bubbles ◽  
Complex Flow ◽  
Air Bubble ◽  
Potential Applications ◽  
Unique Approach ◽  
Medical Analysis

In this study, we report the design and fabrication of a novel fluidic mixer. As proof-of-concept, the laminar flow in the main channel is firstly filled with small air-bubbles, which act as active stirrers inducing chaotic convective turbulent flow, and thus enhance the solutes mixing even at a low input flow rate. To further increase mixing efficiency, a design of neck constriction is included, which changes the relative positions of the inclusion bubbles significantly. The redistribution of liquid volume among bubbles then causes complex flow profile, which further enhances mixing. This work demonstrates a unique approach of utilizing air bubbles to facilitate mixing in bulk solution, which can find the potential applications in microfluidics, fast medical analysis, and biochemical synthesis.

A Simple Dichromatic Stain for Plastic Embedded Tissues

1970 ◽  
Vol 28 ◽  
pp. 296-297 ◽  
Author(s):  
G. R. Mackay ◽  
M. L. Mead
Keyword(s):  
Electron Microscopy ◽  
Toluidine Blue ◽  
Biological Material ◽  
Good Reproducibility ◽  
Routine Work ◽  
Staining Techniques

Color contrasting of 1 to 2 micron sections of plastic embedded biological material is an important adjunct to electron microscopy. The procedures in general use today are simple and rapid giving monochromatic results, e.g., toluidine blue. Although many di- and polychromatic histologic staining techniques have been modified to obtain a counterstaining effect with plasticembedded tissue, the methods are usually undesirable for routine work because they are time consuming, complicated and often defy good reproducibility.

Professional Good Practices Scale--Nursing Homes

2018 ◽  
Author(s):  
Gema Pérez-Rojo ◽  
C. Noriega ◽  
C. Velasco ◽  
J. López
Keyword(s):  
Nursing Homes ◽  
Good Practices

EDPS of Clinical Case Record and Scientific Document in the Industry Post-Marketing Surveillance of Drugs

1983 ◽  
Vol 22 (03) ◽  
pp. 135-148 ◽  
Author(s):  
T. Kitaguchi ◽  
T. Nojiri ◽  
S. Suzuki ◽  
T. Fukita ◽  
T. Kawana
Keyword(s):  
Data Base ◽  
Clinical Case ◽  
Drug Information ◽  
Case Record ◽  
Post Marketing Surveillance ◽  
Japanese Character ◽  
Record Data ◽  
Post Marketing ◽  
On Line ◽  
Line Drug

In order to meet the multifarious needs for drug information and to cope with the post-marketing surveillance of drugs adequately, an on-line drug information network, which is composed of two data bases, clinical case record data base and literature data base, has been developed. Primary considerations in designing these systems were input of clean data, accurate input, insuring that no ADRs are overlooked, accumulation of the latest data, saving manpower required for processing, and processing large quantities of data. This system is also designed to input and to output in Japanese character.

National Survey of Drug Information Centers practice: Leadership and Practice management at Ministry of Health Hospital in Saudi Arabia

2018 ◽  
Vol 4 (3) ◽  
pp. 497-503
Author(s):  
Yousef Ahmed Alomi ◽  
Saeed Jamaan Alghamdi ◽  
Radi Abdullah Alattyh
Keyword(s):  
Saudi Arabia ◽  
National Survey ◽  
Drug Information ◽  
Information Services ◽  
Practice Management ◽  
Full Time ◽  
Drug Information Services ◽  
Ministry Of Health ◽  
Patient Counselling ◽  
Health Hospital

Objective: To explore the National Survey of Drug Information Centers practice in Saudi Arabia: Leadership and Practice management at Ministry of Health hospital. Method: It is a cross-sectional four months national survey of Drug Information Services at Ministry of Health hospital. It contained ten domains with 181 questions designed by the authors. It was derived from Internal Pharmaceutical Federation, American Society of Health-System Pharmacists best practice guidelines. This survey was distributed to forty hospital pharmacies that run drug information services. In this study, domain of Drug Monitoring and Patient Counselling System explored and analyzed. It consisted of eight questions about the written policy and procedure and application methods for Leadership and Practice management in the drug information centers. All analysis was done through survey monkey system. Results: The survey distributed to 45 of hospitals, the response rate, was 40 (88.88%) hospitals. The highest score of the DIC had policy and procedures with a clear mission, vision, and values were Evidence of valid Saudi Council of Health Specialties license to practice in Saudi Arabia did not exist in 3 (7.5%) hospitals while 30 (75%) of hospitals 100% applied the elements. The highest score of the Drug information centers had a space, adequate furniture, hours of operation were determined and announced as well as there was a qualified and licensed staffing. All Drug Information Centers staff had valid licenses from Saudi Commission for Health Specialties to practice in Saudi Arabia, did not exist in 6 (15%) hospitals while 30 (75%) of hospitals 100% applied the elements. The highest score of the Drug Information Centers Supervisor, reports workload statistics to the appropriate and leadership number of Full Time Employee staff and actual workload published was the answering question depends on the priority of the question did not exist in 6 (15%) hospitals while only 22 (55%) of hospitals 100% applied the elements. The highest score of the Drug Information Centers showed evidence of Quality Improvement, and the process for Drug Information Centers Networking. The reporting any questionable drug quality to Pharmacy director, did not exist in 4 (10 %) hospitals while only 25 (62.5%) of hospitals 100% applied the elements. Conclusion: There were an acceptable implementation leadership and practice management in drug information centers practice. The drug information centers workload analysis and quality management should improve. Drug information centers network indication required an implementation to improve the services at Ministry of Health hospital in Kingdom of Saudi Arabia.

ASSESSMENT OF ANATOMICAL & FUNCTIONAL SUCCESS IN EXTERNAL DACRYOCYSTORHINOSTOMY BY AIR BUBBLE TEST

2019 ◽  
Vol 3 (9) ◽  
Author(s):  
Dr. Vikas Tantuway
Keyword(s):  
Case Series ◽  
Invasive Procedure ◽  
Nasolacrimal Duct ◽  
Good Tool ◽  
Predictive Values ◽  
Reliability Indices ◽  
Air Bubble ◽  
Bubble Test ◽  
External Dacryocystorhinostomy ◽  
Anatomical Success

Aim: To assess reliability indices of Air Bubble Test (ABT) for anatomical and functional success in external Dacryocystorhinostomy (DCR). Methods: Prospective case series of nasolacrimal duct obstruction underwent DCR. Functional success defined as Munk score 0 & 1 & anatomical success as free irrigation at followup.ABT performed by putting antibiotic drops into eye& asking patient to exhale while keeping nose & mouth closed. Formation of bubbles at punctum considered as positive test. Specificity, sensitivity, positive & negative predictive values calculated. Results: There were 103 DCR in 97 patients(23 male,74 female)with mean age 45.56 yr. Anatomical and functional success was 99.02% & 98.05%, respectively.ABT showed sensitivity 96.07%, specificity 100% for anatomical success after DCR. Sensitivity and specificity were 97.02% & 100% for functional success. Conclusion: As non-invasive procedure ABT is a good tool to assess success of DCR, though lacrimal syringing remains the gold standard. Keywords: Anatomical, Dacryocystorhinostomy & Air Bubble Test.

Design of an External Combustion Engine and its Application in a Free Piston Compressor

2007 ◽  
Vol 3 ◽  
Author(s):  
Jonathan Hogan Webb
Keyword(s):  
Combustion Engine ◽  
Piston Compressor ◽  
Dead Volume ◽  
Transfer Energy ◽  
Free Piston ◽  
Combustion Gases ◽  
Intermediate Chamber ◽  
Fuel Mixtures ◽  
External Combustion ◽  
External Combustion Engine

The design of a free piston compressor and an analysis on integrating an external combustion engine into the compressor design are presented in this article. A free piston compressor is a device which converts chemical energy to work on a volume of air through the kinetic energy of an inertia driven piston, which is not rigidly attached to a ground. An external combustion engine serves as in intermediate chamber which transfers combustion gases to a device to perform some work. The following discusses the design and experiments on an external combustion engine, with a focus on eliminating an injection holding force on a free piston compressor’s elastomeric membranes. The efficiency of the external combustion engine to transfer energy without significant losses due to heat, dead volume, air/fuel mixtures, and actuated valve speed are also presented.

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