Screening of Oxidative Stress and Prostate Cancer Biomarkers among Rural and Urban Elderly People in Erbil Governorate-Kurdistan Region

: Prostate Cancer (PC) is one the most prominent cause of deaths in males worldwide especially in western countries. The exhaustive research into prostate cancer to date has demonstrated ELAC2, RNASEL, MSR1, NBS1, CHEK2, MYC, BCL-2, c-Kit, tumor suppressor genes, BRCA1, BRCA2, PACE4, GSTP1, PTEN,CDKN1B, NKX3.1, KLF6, FOXA1, Retinoblastoma, p53, androgen receptor, kallikreins, ETS, CYP17, SRD5A2, E-cadherin, KAI1/CD82, hepsin, AMACR, PIM1, MTA-1, EZH2, EPHB2, growth factors & its receptors, cannabinoid receptors, annexins, oxidative stress and inflammation are entailed changes underlying the initiation, development, and progression of PC. Furthermore, oncology would shift from a reactive to proactive discipline so exploring these targets open new area of research. Therefore, the present review is focused on molecular pathophysiology biomarkers for the progression of PC that would encourage the researchers and pharmaceutical industries to investigate potential therapeutic strategy to overcome demerits of currently available clinically therapies.

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Identification of prostate cancer biomarkers in urinary exosomes

Oncotarget ◽

10.18632/oncotarget.4851 ◽

2015 ◽

Vol 6 (30) ◽

pp. 30357-30376 ◽

Cited By ~ 94

Author(s):

Anders Øverbye ◽

Tore Skotland ◽

Christian J. Koehler ◽

Bernd Thiede ◽

Therese Seierstad ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Biomarkers ◽

Urinary Exosomes

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Discovery of prostate cancer biomarkers by microarray gene expression profiling

Expert Review of Molecular Diagnostics ◽

10.1586/erm.09.74 ◽

2010 ◽

Vol 10 (1) ◽

pp. 49-64 ◽

Cited By ~ 49

Author(s):

Karina Dalsgaard Sørensen ◽

Torben Falck Ørntoft

Keyword(s):

Gene Expression ◽

Prostate Cancer ◽

Gene Expression Profiling ◽

Expression Profiling ◽

Cancer Biomarkers ◽

Microarray Gene Expression ◽

Microarray Gene

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A Model for the Design and Construction of a Resource for the Validation of Prognostic Prostate Cancer Biomarkers

Advances in Anatomic Pathology ◽

10.1097/pap.0b013e31827b665b ◽

2013 ◽

Vol 20 (1) ◽

pp. 39-44 ◽

Cited By ~ 12

Author(s):

Sarah Hawley ◽

Ladan Fazli ◽

Jesse K. McKenney ◽

Jeff Simko ◽

Dean Troyer ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Biomarkers ◽

Design And Construction

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Fatores relacionados à autopercepção do estado de saúde em idosos residentes no meio rural do Brasil

Scientia Medica ◽

10.15448/1980-6108.2018.3.29698 ◽

2018 ◽

Vol 28 (3) ◽

pp. 29698 ◽

Cited By ~ 1

Author(s):

Eleia De Macedo ◽

Vivian Ulrich ◽

Antonio Miguel Gonçalves Bós ◽

Ângelo José Gonçalves Bós

Keyword(s):

Health Status ◽

Family Health ◽

Rural Elderly ◽

Urban Elderly ◽

Self Perception ◽

Rural And Urban ◽

Health Strategy ◽

The Family ◽

Family Health Strategy ◽

Perception Of Health

AIMS: To compare the self-perception of health status between rural and urban elderly and their possible associated factors.METHODS: The study consisted of a secondary analysis of data from the National Health Survey of 2013, conducted by the National Institute of Geography and Statistics, which included elderly who lived in rural and urban environments. The dependent variable was the self-perception of health status (evaluated as very good, good, fair, bad and very bad); and the independent variables were socio-demographic factors, clinical data, functionality of the elderly and household data. Relationships between the variables were tested by the chi-square test, and adjusted by self-perception of health status. The analysis were performed through the Epi InfoTM program version 7.2.1, accepting p<0.05 as significant.RESULTS: Rural elderly people were predominantly males, brown, married, illiterate and gainfully employed, despite having a low economic class. Among the rural elderly, self-perceived health status was more often regular or poor, the household was more often enrolled in the Family Health Strategy and most had no complementary health plan. Rural elderly also had better performance in the Basic Activities of Daily Living and worse performance in the Instrumental Activities of Daily Living, had less depressive symptoms and less multimorbidity. Rural elderly presented lower chances of self-perception of good or very good health, even adjusting for gender, race, marital status, occupation, socioeconomic class, coverage by the Family Health Strategy, depressive symptoms, multimorbidity, and performance in the Basic Activities of Daily Living.CONCLUSIONS: The rural elderly have worse self-perception of health status than the urban elderly, even controlling socio-demographic, economic, clinical and health access characteristics.

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