scholarly journals THERAPY OF PATIENTS WITH ANXIETY DISORDERS AND METABOLIC SYNDROME X

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Olena V. Kaushanska ◽  
Olena V. Zaliavska ◽  
Olha M. Nika
Keyword(s):  
Metabolic Syndrome ◽  
Anxiety Disorders ◽  
Outpatient Service ◽  
Complete Recovery ◽  
Main Group ◽  
Adult Patients ◽  
Metabolic Syndrome X ◽  
Syndrome X ◽  
Control Group ◽  
And Control

Objective of the research: to investigate the efficacy and safety of Afobazole in the treatment of adult patients with anxiety disorders and metabolic syndrome X. The study included 60 adult patients (18–65 years) (36 men, 24 women), whose clinical picture revealed mild and moderate forms of neurotic disorders observed in the therapeutic hospital and outpatient service. The main group (30 people) and control group (30 people) were formed on the basis of representativeness by gender and age (χ2emp <χ2krit, p ≤ 0.01). The sample consisted of patients who signed a written informed consent to participate in the study. The average age of the patients in the control group was 44.81 ± 2.17, in the main group ­– 45.13 ± 2.34 (p < 0.01); the average age of onset of mental disorders in the main group was 33.2 ± 3.1 years; in the control group it was 34.1 ± 3.4 years (p < 0.05); the average duration of psychopathological symptoms in the main group was 5.6 ± 0.6 months, in the control group – 5.8 ± 0.3 months (p < 0.05). The duration of treatment equaled 1 month of active therapy (later, the patients were transferred to maintenance therapy outside this study). Afobazole containing 0.01 g of active substance per tablet was used for treatment. The drug was prescribed 3 times a day (morning, afternoon and evening); the dose of the drug was increased: 1–1–2 (number of tablets per administration). There were changes in psychometric scaling, i.e. a significant decrease in state (by 57.2 and 42.9%; p ≤ 0.001) and trait (by 23.8 and 23.3%; p ≤ 0, 01) anxiety on the Spielberger–Khanin scale in the main and control groups at the end of treatment. In all groups of patients, we noted complete recovery (38.4%) or a significant improvement (37.9%); for most patients with mild manifestations, complete recovery was observed in 92% of cases. Among patients with moderate manifestations, a good response was recorded in 75% of cases; for the rest, moderate and minimal effects were observed, respectively. The changes in the severity as compared with baseline values were significantly positive (p < 0.05) already after 7 days of Afobazole therapy; similar changes were noted in the indicators of the overall effectiveness of therapy. No positive changes after Afobazole therapy were observed in 3.3% of cases, deterioration was registered in 3.3% of cases, while in the control group these values were 6.6% and 3.3%, respectively. The changes in somatic indicators also had positive trends in the control and main groups – SBP reduced by 11.0% and 18.0%, respectively (p ≤ 0.05); DBP – by 4.4% and 14.9% (p ≤ 0.05). The therapeutic effect of Afobazole is the reduction of viscero-vegetative manifestations of anxiety disorders, including relief of breathing, normalization of blood pressure and heart rate, reduction of muscle tension and pain, sweating and dizziness.

Thromboembolic complications prevention in the obstetric practice

2017 ◽  
pp. 19-24
Author(s):  
O.V. Grishchenko ◽  
◽  
V.V. Bobrytska ◽  
Keyword(s):  
Pulmonary Embolism ◽  
Comparison Group ◽  
Main Group ◽  
Control Group ◽  
Efficacy And Safety ◽  
Thromboembolic Complications ◽  
Moderate Risk ◽  
Obstetric Practice ◽  
Thrombotic Complications ◽  
And Control

The objective: To evaluate the clinical efficacy and safety of Enoxaparin-Pharmex for the prevention of thrombotic complications (pulmonary embolism) in the postoperative period in patients with moderate risk of these complications. Patients and methods. The study included 50 women after a caesarean section had an average degree of risk of pulmonary embolism. Patients were divided into the main group (n=25) and control group (n=25) in accordance with the treatment: patients of the main group received postoperative Еnoxaparin- Pharmex, group comparisons enoxaparin sodium (brand foreign manufacturer’s). Patients in both groups received the drug at a dose of 20 mg for 5 days, 1 time per day subcutaneously. Results. The research data analysis showed identity results of hemostasiogram of patients in the main group and the comparison group, no side effects after treatment in both groups. Conclusion. The clinical studies suggest the drug Enoxaparin-Pharmex is effective, safe LMWH, which can be used to prevent troboembolic complications, including post-operative treatment in obstetric practice. Spectrum of Enoxaparin-Pharmex can be extended to the prevention and treatment of thromboembolic conditions of varying severity with appropriate doses of the drug. Key words: Enoxaparin-Pharmex, prevention of pulmonary embolism.

Cut off value of plasma 25-hydroxyvitamin D concentration for predicting metabolic syndrome

2019 ◽  
pp. 68-73
Author(s):  
Trong Nghia Nguyen ◽  
Thi Nhan Nguyen ◽  
Thi Dua Dao
Keyword(s):  
Metabolic Syndrome ◽  
Medical Center ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
The Metabolic Syndrome ◽  
25 Hydroxyvitamin D ◽  
Key Words Metabolic Syndrome ◽  
And Control

Background: The metabolic syndrome is a constellation of cardiometabolic risk factors that tend to cluster together in affected individuals more often than predicted by chance. The presence of the metabolic syndrome substantially increases the risk of developing type 2 diabetes and cardiovascular disease, and is associated with a range of adverse clinical outcomes, many of which are closely associated with aging. Current estimates suggest that approximately 20 - 25% of the world’s population is affected by the metabolic syndrome. The prevalence of the metabolic syndrome rises with age and more than 45% of people aged over 60 years have the metabolic syndrome. Recent studies show that low vitamin D status is very common in the world and this is a risk factor of metabolic syndrome. Objective: (1) Plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome. (2) Cut off value of plasma 25-hydroxyvitamin D concentration for predicting metabolic syndrome. Material and method: A cross-sectional study with control group on 318 adult subjects for health examinations at International Medical Center at Hue Central Hospital, including 139 subjects with metabolic syndrome and control group of 179 healthy subjects. Metabolic syndrome was defined according to the IDF, NHLBI, AHA, WHF, IAS, IASO (2009). Plasma hydroxyvitamin D concentration was measured using chemiluminescent microparticle immunoassay. Reciever operating characteristic (ROC) curve were generated to assess sensitivity and specificity for different cut off value of 25-hydroxyvitamin D concentration for predicting metabolic syndrome. Results: Plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome was 26.4 ng/ml, incidence of plasma 25-hydroxyvitamin D deficiency (59.7%) was significantly higher than in control group (23.5%) (p < 0.001). The optimal cut off point for 25-OH-D concentration for predictor of metabolic syndrome as 26.4 ng/ml (AUC=0.657, sensitivity=53.4%, specificity=71.6%). Conclusion: In 139 subjects with metabolic syndrome, the plasma 25-hydroxyvitamin D concentration was 26.4 ng/ml and the incidence of 25-hydroxyvitamin D deficiency in the metabolic syndrome group was 59.7%. The optimal cut off point for plasma 25-hydroxyvitamin D concentration for predictor of metabolic syndrome as 26.4 ng/ml. Key words: Metabolic syndrome, 25-hydroxyvitamin D

The analysis of surface saccharide profiles through fluorescein-labelled lectins in a rat pancreatic tissue with established metabolic syndrome model

2018 ◽  
Vol 44 (1) ◽  
pp. 98-104
Author(s):  
Yosun Mater ◽  
Sule Beyhan-Ozdas
Keyword(s):  
Metabolic Syndrome ◽  
Metabolic Diseases ◽  
Pancreatic Tissue ◽  
Control Group ◽  
High Fructose Diet ◽  
Tissue Sections ◽  
Membrane Surfaces ◽  
High Fructose ◽  
A Cell ◽  
And Control

Abstract“Glycans”, which are generally referred as oligosaccharides and polysaccharides, are structures that are present on all cellular surfaces with proteins and lipids being attached to their basic chain structures. Many studies in the field of glycobiology have identified the various and complicated biological roles of these glycans which make them perfect molecules to use in labelling and selecting body cells specifically. This study aims at analyzing the modifications in saccharide units of glycans on a cell membrane surfaces of the pancreatic tissue of rats to which normal and metabolic syndrome (MetS) are established. To this end, a MetS model was created through a high fructose diet in Spraque Dawley breed of rats and the pancreatic tissue sections of the group with MetS and control group animals were evaluated comparatively. The targeted saccharide units were examined with Fluorescent Microscope by using two different Fluorescein (FITC) labelled lectins, namely Maackia amurensis-1 lectin [FITC-(MAL-I)] and the Wheat Germ Agglutinin (FITC-WGA). It was observed that FITC-MAL-1-labelled Galβ4GlcNAc units did not change much due to high- fructose diet. On the other hand, more GlcNAc, Neu5Ac and β-GlcNAc units which are labelled with FITC-WGA lectin increase in numbers in pancreatic sections of high fructose diet, compared to control group. Thus, a rapid and specific labelling method, which can identify surface saccharide sequences specifically, was developed. The method can be used in early diagnosis and/or treatment for metabolic diseases.

scholarly journals ANALYSIS OF THE DYNAMICS OF FUNCTIONAL OCCLUSION INDICATORS IN THE CONSTRUCTION OF OCCLUSION SURFACES OF ORTHOPEDIC STRUCTURES

2020 ◽  
Vol 73 (12) ◽  
pp. 2651-2656
Author(s):  
Svitlana P. Yarova ◽  
Sergii O. Turchenenko ◽  
Iryna M. Tkachenko ◽  
Yuriy Yu. Yarov
Keyword(s):  
Functional Condition ◽  
Masticatory Muscles ◽  
Main Group ◽  
Suggested Method ◽  
Control Group ◽  
Orthopedic Treatment ◽  
Functional Parameters ◽  
Occlusal Surfaces ◽  
Left And Right ◽  
And Control

The aim: Is to evaluate the effectiveness of the proposed method of constructing occlusal surfaces of orthopedic structures by monitoring the dynamics of functional indicators of occlusion and the functional condition of the masticatory muscles. Materials and methods: The object of the study was made up by 64 patients with included defects of the dentition of the 3rd class according to Kennedy. Patients were divided into two equal groups – the main group (patients were treated by using the suggested method of construction of occlusal surfaces of orthopedic structures) and control (dentition defects were replaced according to the traditional protocol). Results: The results of evaluating the effectiveness of the proposed method showed that the index of symmetry of the anterior bundles of the temporal muscles dropped by 18.5%, the index of symmetry of the masticatory muscles reduced by 22%, the torque of the mandible reduced by 32%, the index of stabilizing occlusal – by 27%, relative efforts of balance disturbance for more than 10 % regarding the left and right reduced by a factor of 4.4, the rate of opening time was 1.5 times higher than before, the rate of time of opening of the jaws – 1.8 times. Conclusions: The use of the suggested method of orthopedic treatment with temporary structures leads to probable changes in the studied functional parameters in comparison with the control group (p <0,05).

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