scholarly journals Aleukemic myeloid sarcoma of small intestine: masquerading as subacute intestinal obstruction: Review of literature

2020 ◽  
Vol 7 (7) ◽  
pp. C86-90
Author(s):  
Vidushi Joshi ◽  
Gaurav PS Gahlot ◽  
Ankur Ahuja ◽  
Tathagata Chatterjee ◽  
Sunita BS
Keyword(s):  
Intestinal Obstruction ◽  
English Literature ◽  
Right Hemicolectomy ◽  
Young Female ◽  
Myeloid Sarcoma ◽  
Lumbar Region ◽  
Non Hodgkin Lymphoma ◽  
Immature Myeloid Cells ◽  
Subacute Intestinal Obstruction

Background: Myeloid sarcoma (MS) is an extramedullary disease of immature myeloid cells with incidence of 1-2% among all acute myeloid leukemia (AML) cases. Less than twenty cases of aleukemic MS with initial presentation as intestinal mass have been described in the English literature. Case report: Here we report a case of 45 year old female with normal haematology workup who presented with acute abdominal pain and distension. On evaluation, she was found to have ileocolic intussusception of gangrenous bowel, so managed by limited right hemicolectomy and initially reported as Non Hodgkin lymphoma (NHL).During follow-up she was found to have a globular mass in right lumbar region that was diagnosed as myeloid sarcoma. On further followup, her TLC count was gradually increasing.  Conclusion: The index case highlights the unusual presentation of isolated intraabdominal MS which was clinical diagnosed as subacute intestinal obstruction in a young female with normal hematological profile.

scholarly journals Minimally Invasive Treatment of Sporadic Burkitt’s Lymphoma Causing Ileocaecal Invagination

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Paolo Panaccio ◽  
Michele Fiordaliso ◽  
Domenica Testa ◽  
Lorenzo Mazzola ◽  
Mariangela Battilana ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Intestinal Obstruction ◽  
Iliac Fossa ◽  
Abdominal Distension ◽  
Burkitt’S Lymphoma ◽  
Right Hemicolectomy ◽  
Burkitt's Lymphoma ◽  
Invasive Treatment ◽  
Diagnostic Dilemma ◽  
Non Hodgkin Lymphoma

Introduction. Primary NHL (non-Hodgkin lymphoma) of the colon represents only 0.2% to 1.2% of all colonic malignancies. Burkitt’s lymphoma (BL) is usually a disease reported in children and young people, most of them associated with EBV or HIV infection. We describe a rare case of intestinal obstruction due to sporadic Burkitt’s lymphoma causing ileocaecal invagination explaining our experienceMethods. A 31-year-old man presented with diffuse colic pain and weight loss. Clinical examination revealed an abdominal distension with pain in the right iliac fossa. Colonoscopy documented a caecal large lesion with ulcerated mucosa. Computed tomography (CT) have shown a 60 × 50 mm right colic parietal lesion with signs of ileocolic intussusception.Results. Laparoscopic right hemicolectomy was performed. Postoperative period was uneventful. CD20+ high-grade B-cell Burkitt’s lymphoma was confirmed by immunohistochemistry (CD20+, CD79+, and CD10+) and FISH test (t (8;14) (q24; q32). The patient was subsequently treated with adjuvant combination chemotherapy (Hyper-CVAD) and is alive and disease-free at 8 months follow-up.Discussion. Adult sporadic Burkitt’s lymphoma (BL) causing intestinal obstruction due to ileocaecal intussusception is an extremely rare occurrence and a diagnostic dilemma. Despite the surgical approach is selected based on patient’s conditions and surgeon’s expertise, minimally invasive method could be preferred.

scholarly journals Orbital myeloid sarcoma misdiagnosed for subperiostal hematoma: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Bahaa Razem ◽  
Mohamed Raiteb ◽  
Sanaa El Mrini ◽  
Faiçal Slimani
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Myeloid Leukemia ◽  
De Novo ◽  
Myeloid Sarcoma ◽  
Orbital Mass ◽  
Genetic Features ◽  
Immature Myeloid Cells ◽  
Acute Myeloid

Abstract Background Myeloid sarcoma is a solid tumor that consists of immature myeloid cells occurring at an extramedullary site. It can present before, concurrent with, or after the diagnosis of acute myeloid leukemia or other myeloproliferative diseases, and a proportion of patients never develop bone marrow infiltration. Only a few isolated cases of pediatric orbital myeloid sarcoma have been reported, and they are often associated with a high misdiagnosis rate. Case report We report a rare case of pediatric orbital myeloid sarcoma associated with blunt trauma in a 3-year-old Caucasian male patient, which was clinically and radiologically misdiagnosed for orbital subperiostal hematoma. The patient underwent a surgical intervention to drain the hematoma when an orbital mass was found. The microscopic, immunologic, and genetic features of the tumor and the myelogram were in favor of LAM2, and the patient was started with chemotherapy with a favorable evolution within 18 months follow-up. Conclusion Orbital myeloid sarcoma usually exhibits clinical and radiological features that can be easily misleading, especially if it happens de novo or as the first manifestation of acute myeloid leukemia. Only a few isolated cases have reported and proposed trauma as a trigger event of the onset of this type of tumor proliferation, but further investigations and evidence are needed to support this hypothesis.

scholarly journals Primary primitive neuroectodermal tumor of the adrenal gland: A unique tumor at an unusual site

2021 ◽  
Vol 8 (3) ◽  
pp. 429-432
Author(s):  
Rakhi V Jagdale ◽  
Jaydeep N Pol
Keyword(s):  
Primitive Neuroectodermal Tumor ◽  
English Literature ◽  
Young Female ◽  
Cell Tumor ◽  
Neuroectodermal Tumor ◽  
Unusual Site ◽  
Non Hodgkin Lymphoma ◽  
Blue Cell ◽  
Neuroectodermal Origin ◽  
Round Blue Cell Tumor

Ewing sarcoma/Primitive Neuroectodermal Tumor (ES/PNET) is a malignant small round blue cell tumor of neuroectodermal origin that affects bones and soft tissue in children and young adults. ES/PNET is very uncommon in parenchymal organs. We report a case of primary adrenal PNET in a young female having pregnancy induced persistent hypertension. She underwent right adrenalectomy for a large adrenal mass. On histopathology, it was typical malignant round cell tumor (MRCT). Immunohistochemistry confirmed the diagnosis of ES/PNET with expression of CD99, FLI-1 and NKX2.2. Until now, only 38 cases of primary adrenal ES/PNET have been reported in the English literature with just 5 cases from India. Adrenal ES/PNET can be mistaken with other MRCTs like Non-Hodgkin lymphoma and neuroblastoma. Since the biology, treatment and prognosis of these tumors is entirely different, we emphasize that pathologists must be aware of this possibility and try to differentiate them using ancillary techniques.

scholarly journals Extra skeletal Ewing's sarcoma: extra skeletal Ewing’s sarcoma of mesentery masquerading dysgerminoma ovary

2017 ◽  
Vol 4 (12) ◽  
pp. 4079
Author(s):  
Karthigesu Aimanan ◽  
Syazwan Arif Saprudin ◽  
Senthil Vassan Kanthasamy ◽  
Ramesh Tangarathnam ◽  
Chew Loon Guan
Keyword(s):  
Adjuvant Chemotherapy ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
English Literature ◽  
Right Hemicolectomy ◽  
Complete Resection ◽  
Ovarian Dysgerminoma ◽  
Extraosseous Ewing’S Sarcoma ◽  
Extraosseous Ewing Sarcoma

Extraosseous Ewing's sarcoma is a rare entity that involves the lower extremities, paravertebral regions of the spine, retroperitoneum, pelvis, and the chest wall. Involvement of mesentery as this case has been only reported five times in English literature. An eleven-year-old girl was planned for gynaecological surgery for suspected ovarian dysgerminoma. Intraoperatively she was referred to the surgical team since tumor arising from mesentery of the terminal ileum. Complete resection of the tumor with a right hemicolectomy was done. Histopathological assessment of the tumor revealed features of small blue round cell tumor which after an expert immunohistochemical staining reported as extraosseous Ewing sarcoma. She underwent a course of adjuvant chemotherapy and currently well during follow up. Due to the rarity of this tumor, a proper consensus on management has not been outlined. However, complete resection and adjuvant chemotherapy remain a standard therapy which showed an excellent post-operative outcome. 

scholarly journals A unique method for management of benign colonic masses: case report

2021 ◽  
Vol 9 (1) ◽  
pp. 217
Author(s):  
Anushtup De ◽  
Bhaskar Nandi ◽  
Jaspreet Singh Bajwa ◽  
Rajesh K. Singh ◽  
Deepika Parwan ◽  
...  
Keyword(s):  
Intestinal Obstruction ◽  
Young Female ◽  
Ascending Colon ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Enhanced Ct ◽  
Unique Method ◽  
Subacute Intestinal Obstruction ◽  
Laparoscopic Assisted ◽  
Specific Symptoms

Even though lipomas are most common non-epithelial tumors of the large intestine, they mostly present with non-specific symptoms. Intussusception is the most common morbidity related to such lesions and may present as intestinal obstruction. We present here a case of a young female who presented to gastroenterology department as a case of pain abdomen and nausea and a provisional diagnosis of subacute intestinal obstruction was kept. Contrast enhanced CT confirmed a diagnosis of intussusception due to an ascending colon mass? likely lipoma. The colonoscopy was done and biopsy was taken which was non-specific for malignancy. Patient, after taking due consent, was taken for surgery and laparoscopic assisted submucosal excision of lipoma was done and we will discuss the same. Endoscopic excision of lipomas has been reported but when failed, mostly segmental resection of the colon has been reported. To the best of our knowledge, this is the second reported case of laparoscopic assisted colotomy with submucosal excision of an intussuscepting colonic lipoma and first one in ascending colon.

scholarly journals Rare Case of Mediastinal Myeloid Sarcoma

2021 ◽  
Vol 6 (4) ◽  
pp. 533-537
Author(s):  
Kanta Devi ◽  
Salman Naseem Adil ◽  
Natasha Ali ◽  
Nasir Ali ◽  
Hammad Khan
Keyword(s):  
Myeloid Leukemia ◽  
Mediastinal Mass ◽  
Soft Tissues ◽  
Clinical Presentation ◽  
Bone Marrow Involvement ◽  
Young Female ◽  
Myeloid Sarcoma ◽  
Anterior Mediastinal Mass ◽  
Recommended Treatment ◽  
Immature Myeloid Cells

Myeloid sarcoma is a rare tumor mass with extra medullary growth pattern, composed of myeloblast or immature myeloid cells. Myeloid sarcoma (MS) is a distinct clinical presentation of acute myeloid leukemia (AML) where less than 1% of patients present with prominent extra medullary disease which most commonly involves the bone, skin, lymph node, soft tissues, gastrointestinal tract or testes. The recommended treatment regimen in isolated myeloid sarcoma or with bone marrow involvement is upfront systemic chemotherapy. We report a case of a young female with anterior mediastinal mass diagnosed as myeloid sarcoma which was refractory to chemotherapy.

CROHN´S DISEASE PRESENTING WITH SUBACUTE INTESTINAL OBSTRUCTION

2020 ◽  
Author(s):  
M Zaghloul ◽  
M Emara ◽  
H Albatee ◽  
I Amer ◽  
A Mahrous ◽  
...  
Keyword(s):  
Intestinal Obstruction ◽  
Subacute Intestinal Obstruction

Evaluation of R-CHOP and R-CVP in the treatment of elderly patient with non-Hodgkin lymphoma

MedPharmRes ◽  
2019 ◽  
Vol 3 (3) ◽  
pp. 1-6
Author(s):  
Truc Phan ◽  
Tram Huynh ◽  
Tuan Q. Tran ◽  
Dung Co ◽  
Khoi M. Tran
Keyword(s):  
Elderly Patients ◽  
Hodgkin Lymphoma ◽  
B Cell Lymphoma ◽  
Complete Response ◽  
The Elderly ◽  
Free Survival ◽  
Non Hodgkin Lymphoma ◽  
Common Sign ◽  
Related Mortality

Introduction: Little information is available on the outcomes of R-CHOP (rituximab with cyclophosphamide, doxorubicin, vincristine and prednisone) and R-CVP (rituximab with cyclophosphamide, vincristine and prednisone) in treatment of the elderly patients with non-Hodgkin lymphoma (NHL), especially in Vietnam. Material and methods: All patients were newly diagnosed with CD20-positive non-Hodgkin lymphoma (NHL) at Blood Transfusion and Hematology Hospital, Ho Chi Minh city (BTH) between 01/2013 and 01/2018 who were age 60 years or older at diagnosis. A retrospective analysis of these patients was perfomed. Results: Twenty-one Vietnamese patients (6 males and 15 females) were identified and the median age was 68.9 (range 60-80). Most of patients have comorbidities and intermediate-risk. The most common sign was lymphadenopathy (over 95%). The proportion of diffuse large B cell lymphoma (DLBCL) was highest (71%). The percentage of patients reaching complete response (CR) after six cycle of chemotherapy was 76.2%. The median follow-up was 26 months, event-free survival (EFS) was 60% and overall survival (OS) was 75%. Adverse effects of rituximab were unremarkable, treatment-related mortality accounted for less than 10%. There was no difference in drug toxicity between two regimens. Conclusions: R-CHOP, R-CVP yielded a good result and acceptable toxicity in treatment of elderly patients with non-Hodgkin lymphoma. In patients with known cardiac history, omission of anthracyclines is reasonable and R-CVP provides a competitive complete response rate.

Restaging of patients with lymphoma

2008 ◽  
Vol 47 (01) ◽  
pp. 37-42 ◽  
Author(s):  
T. Pfluger ◽  
V. Schneider ◽  
M. Hacker ◽  
N. Bröckel ◽  
D. Morhard ◽  
...  
Keyword(s):  
Low Dose ◽  
Non Hodgkin Lymphoma ◽  
Contrast Enhanced ◽  
Pet Ct ◽  
Significant Difference ◽  
18F Fdg ◽  
Sensitivity Specificity ◽  
Fdg Pet Ct

SummaryAim: Assessment of the clinical benefit of i.v. contrast enhanced diagnostic CT (CE-CT) compared to low dose CT with 20 mAs (LD-CT) without contrast medium in combined [18F]-FDG PET/CT examinations in restaging of patients with lymphoma. Patients, methods: 45 patients with non-Hodgkin lymphoma (n = 35) and Hodgkin's disease (n = 10) were included into this study. PET, LD-CT and CECT were analyzed separately as well as side-by-side. Lymphoma involvement was evaluated separately for seven regions. Indeterminate diagnoses were accepted whenever there was a discrepancy between PET and CT findings. Results for combined reading were calculated by rating indeterminate diagnoses according the suggestions of either CT or PET. Each patient had a clinical follow-up evaluation for >6 months. Results: Region-based evaluation suggested a sensitivity/specificity of 66/93% for LD-CT, 87%/91% for CE-CT, 95%/96% for PET, 94%/99% for PET/LD-CT and 96%/99% for PET/CE-CT. The data for PET/CT were obtained by rating indeterminate results according to the suggestions of PET, which turned out to be superior to CT. Lymphoma staging was changed in two patients using PET/ CE-CT as compared to PET/LD-CT. Conclusion: Overall, there was no significant difference between PET/LD-CT and PET/CE-CT. However, PET/CE-CT yielded a more precise lesion delineation than PET/LD-CT. This was due to the improved image quality of CE-CT and might lead to a more accurate investigation of lymphoma.

scholarly journals Appendiceal Neuroendocrine Tumours - Experience of One Service

2021 ◽  
Author(s):  
Vítor Devezas ◽  
Laura Elisabete Barbosa
Keyword(s):  
Retrospective Study ◽  
Acute Appendicitis ◽  
Neuroendocrine Tumours ◽  
Adult Population ◽  
Right Hemicolectomy ◽  
Good Prognosis ◽  
Alive Today

AbstractTumours of the appendix are rare and tend to be diagnosed incidentally, in cases of acute appendicitis. For some authors, appendiceal neuroendocrine tumours (ANETs) are the most frequent neoplasm of the appendix, observed in 0.3% to 0.9% of cases acute appendicitis. The present is a unicentric retrospective study conducted between January 2005 and March 2017. Out of a total of 3,007 surgeries for appendiceal pathologies performed in the adult population at the hospital where the present study was conducted, there were 70 (2.33%) malignant cases, 20 (28.6%) of which were ANETs. The patients had a median age of 44 years (range: 18 to 85 years), and were predominantly women (there were 1.9 times more women than men). In 16 cases (80%), a simple appendicectomy was performed (1 patient was submitted to a right hemicolectomy later). The cases of ANETs had a good prognosis in our series: 85% of the patients are either alive today or were alive after 5 years of follow-up. Despite the fact that ANETs are described as the most frequent tumor of the appendix, this was not confirmed in our series, in which they only represented 28.6% of the cases; adenocarcinoma was the most frequent tumor (65.7%) among our sample.

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