scholarly journals Assessment of Metformin Induced Vitamin-B12 Deficiency amongst Type-II Diabetic Patients Vis-À-Vis Evaluating the Quality of Life

2019 ◽  
Vol 6 (3) ◽  
Author(s):  
Sashidhar Reddy ◽  
Aditya Sai Rama Krishna K ◽  
Madaboina Suhas ◽  
T. Sneha Rao
Keyword(s):  
Quality Of Life ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Diabetic Patients ◽  
Type Ii ◽  
B12 Deficiency

scholarly journals Assessment of Vitamin B12 Deficiency Caused by Metformin in Type II Diabetic Patients

2021 ◽  
pp. 38-41
Author(s):  
R. Arun
Keyword(s):  
Quality Of Life ◽  
Peripheral Neuropathy ◽  
Vitamin B12 ◽  
Venous Blood ◽  
Vitamin B12 Deficiency ◽  
Diabetic Patients ◽  
Type Ii ◽  
Control Research ◽  
B12 Deficiency

Metformin use over time reduces vitamin B12 levels, according to several studies, and its clinical manifestation can be mistaken as diabetic peripheral neuropathy. In order to investigate vitamin-B12 deficiency in type II diabetic patients with long-term metformin treatment, a link between vitamin B12 and peripheral neuropathy, and to evaluate the quality of life in (T2DM) patients, the current study was done. At Sree Balaji Medical College and Hospital's outpatient and inpatient departments, a prospective observational case-control research was done. The study included 35 healthy volunteers (controls) and 35 Type 2 diabetes patients who had been on metformin for more than six months (cases). Patients' venous blood samples were collected in K2 EDTA vacutainers and centrifuged at 1500 rpm for 10 minutes, settled plasma was transferred into cryo-vials, and parameters such as Vitamin-B12, HbA1c, and CBP were estimated and this is used to conduct the statistical analysis. The prevalence of blood vitamin B12 deficiency and borderline deficiency in T2DM patients is 20.5 percent, while the mean HbA1C values in our study T2DM subjects are 9.07 percent, indicating either poor diabetes control or poor metformin drug compliance. Vitamin B12 insufficiency was found in 83 percent of T2DM patients who had been using metformin for 1 to 10 years. The reliability test was used to assess their quality of life, and the results revealed that the study participants' quality of life was poor.

scholarly journals The epidemiology and importance of vitamin B12 screening in diabetic patients

2021 ◽  
Author(s):  
Abrar A. A. Yamani ◽  
Jameel A. Awadain ◽  
Yousif A. A. Saleh ◽  
Mohammad S. Baothman ◽  
Feras H. Alhussainy ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Clinical Manifestations ◽  
Vitamin B12 Deficiency ◽  
Diabetic Patients ◽  
Type I ◽  
Type Ii ◽  
Impaired Metabolism ◽  
B12 Deficiency ◽  
Vitamin B12 Screening

Peripheral neuropathy is a commonly reported chronic adverse event among diabetes mellitus (DM) patients secondary to poor glycemic control. It might also result secondary to deficiency of vitamin B12, reportedly common among diabetic patients. Deficiency of vitamin B12 might result from prolonged metformin administration in patients with type II DM (T2DM). It might also result from reduced absorption and impaired metabolism-related events in type I DM (T1DM) patients. This occurs secondary to the presence of associated autoimmune disorders. Vitamin B12 deficiency is a commonly encountered condition among diabetic patients, both T1DM and T2DM, with variable etiologies. Our current study discussed the epidemiology and importance of screening of vitamin B12 in these patients. However, our findings show that screening is not commonly practiced in different settings. Therefore, awareness is low about the benefits and complications of this practice. Therefore, further research is encouraged to alleviate the quality of care in diabetic patients. Screening for vitamin B12 deficiency might intervene against any potential complications, including irreversible, painful, and potentially disabling nerve injury. Accordingly, it is recommended that screening should be initiated since the start of metformin administration and every year or when relevant clinical manifestations were reported.

scholarly journals Prevalence of Vitamin B12 deficiency in Type II diabetic patients using metformin.

2021 ◽  
Vol 28 (09) ◽  
pp. 1322-1325
Author(s):  
Tahir Ullah Khan ◽  
Rozina Arshad ◽  
Saleem Uz Zaman Adhami
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Cross Sectional Study ◽  
Protective Role ◽  
Diabetic Patients ◽  
Type Ii ◽  
Cross Sectional ◽  
B12 Deficiency ◽  
Diabetic Population

Objectives: To determine the prevalence of Vitamin B12 deficiency in type II diabetic patients using metformin. Study Design: Cross Sectional study. Setting: Endocrinology Unit Shalamar Hospital Lahore. Period: July to September 2017. Material & Methods: All of our patients were having previously diagnosed type II diabetes and using metformin for more than six months. Using strict exclusion criteria, vitamin B12 levels of patients were measured and analyzed. Results: It was evident from the present study that 27.33% of type II diabetic patients using metformin were having vitamin B12 levels less than 150pg/ml. Furthermore, our study showed that smokers are more liable to develop vitamin B12 deficiency than the nonsmokers. Also, use of multivitamins (containing vitamin B12) had a protective role against vitamin B12 deficiency. Conclusions: Long term use of metformin in type II diabetic patients is strongly associated with Vitamin B12 deficiency, therefore endocrinologists and physicians should take into consideration this significant adverse effect of metformin and screen for vitamin B12 deficiency in diabetic population before starting metformin therapy.

scholarly journals PREVALENCE AND RISK FACTORS OF VITAMIN B12 DEFICIENCY AMONG PATIENTS WITH TYPE II DIABETES ON METFORMIN: A STUDY FROM NORTHERN REGION OF UNITED ARAB EMIRATES

2018 ◽  
Vol 11 (8) ◽  
pp. 225 ◽  
Author(s):  
Moayad Shahwan ◽  
Nageeb Hassan ◽  
Adel Noshi
Keyword(s):  
Vitamin B12 ◽  
United Arab Emirates ◽  
Vitamin B12 Deficiency ◽  
Northern Region ◽  
Term Treatment ◽  
Diabetic Patients ◽  
Type Ii ◽  
Cross Sectional ◽  
Long Term Treatment ◽  
B12 Deficiency

Objectives: This study focused on the prevalence of Vitamin B12 deficiency in UAE patients with type 2 diabetes mellitus (T2DM) who were treated with or without metformin.Methods: A cross-sectional study was conducted on 213 patients having diabetes type II were randomly selected to be part of the study in Northern Regions of the UAE, from June 2014 to February 2015. The patients aged >45 years and who had taken metformin for at least 3 months were recruited with regular follow-up at the outpatient clinic. The patients were included in a survey after which they had their serum B12 levels measured. Serum B12 levels <150 pg/ml are defined as the B12 deficiency.Results: About 48% of diabetic patients had confirmed the B12 insufficiency through laboratory tests. The patients on metformin had statistically lower values of B12 (p=0.002). The majority of participants n (%) took metformin had neuropathy, hypertension, dyslipidemia, numbness or paresthesia, and depression, or mood changes 140 (70%), 183 (91.5%), 134 (67%), 136 (68%), 161 (80.5%), and 120 (60%), respectively.Conclusion: Our study shows that for the patients with T2DM, long-term treatment with metformin is associated with higher chances of developing Vitamin B12 deficiency. Clinicians should, therefore, recognize this significant element and should screen diabetics who are on metformin treatment for any B12 insufficiency, which may be hidden, especially patients coming with neurologic symptoms.

Anemia profile in Diabetic patients with preserved renal function

2021 ◽  
Vol 12 (2) ◽  
pp. 54-58
Author(s):  
Vinay Krishnamurthy ◽  
Akhila Rao Kerekoppa
Keyword(s):  
Renal Function ◽  
General Population ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Deficiency Anemia ◽  
Diabetic Patients ◽  
Severe Anemia ◽  
B12 Deficiency ◽  
Anemia Of Inflammation ◽  
Prevalence Of Anemia

Background: Diabetes is one of the largest global health emergencies of the 21st century. Prevalence of anemia in diabetic patients is two to three times higher than for patients with comparable renal impairment and iron stores in the general population. Aims and Objective: This study was done to analyse the prevalence of anemia and its profile in patients with preserved renal function. Materials and Methods: One-hundred diabetic patients with anemia with normal renal functions were selected. Complete blood count, peripheral blood smear, iron studies, vitamin B12 levels were assessed. Diabetic control was monitored by HbA1c. Patients were identified to have specific type of anemia, based on iron profile and vitamin B12 levels. Severity of anemia was also assessed. Appropriate statistical tests were applied to analyse the results. Results: Mean age of subjects in the study group was 53.4±13.6 years. The mean haemoglobin level was 9.41±2.18 g/dl. Out of the 100 cases, 43 patients had iron deficiency anemia, 40 patients had anemia of inflammation, and 8 patients had vitamin B12 deficiency, 8 patients had combined iron and vitamin B12 deficiency, and 1 patient had pancytopenia. Mean HbA1c was higher in iron deficient individuals with a significant p value and mean HbA1c was lower in Vitamin B12 deficient individuals. Among the cases, 16% had mild anemia, 61% had moderate anemia, and 23% had severe anemia. Severe anemia had a significantly lower HbA1c, which was statistically significant. Conclusion: According to our study, iron deficiency anemia was the commonest, followed by anemia of inflammation in diabetic patients with preserved renal function. Diabetes being a pro-inflammatory state had a higher incidence of anemia of inflammation compared to general population. We have to identify and acknowledge the higher prevalence of Anemia of Inflammation in diabetic patients in the absence of renal dysfunction.

Association Between Diabetic Nephropathy Grade and Quality of Life among Type II Diabetic Patients

2021 ◽  
Vol 23 (4) ◽  
pp. 268-294
Author(s):  
Amina Badawy Othman ◽  
Seham Abd Elalem ◽  
Dalia Elsherbini ◽  
Neima Riad
Keyword(s):  
Quality Of Life ◽  
Diabetic Nephropathy ◽  
Diabetic Patients ◽  
Type Ii

scholarly journals Prevalence of vitamin B12 deficiency in type 2 diabetic patients using metformin: a cross-sectional study

2016 ◽  
Vol 134 (6) ◽  
pp. 473-479 ◽  
Author(s):  
Charbel Pereira Damião ◽  
Amannda Oliveira Rodrigues ◽  
Maria Fernanda Miguens Castellar Pinheiro ◽  
Rubens Antunes da Cruz Filho ◽  
Gilberto Peres Cardoso ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
H2 Antagonists ◽  
H2 Antagonist ◽  
B12 Deficiency

ABSTRACT: CONTEXT AND OBJECTIVE: The prevalence of vitamin B12 deficiency varies from 5.8% to 30% among patients undergoing long-term treatment with metformin. Because of the paucity of data on Brazilian patients, this study aimed to determine the frequency of B12 deficiency and related factors among Brazilian patients with type 2 diabetes mellitus (T2DM) using metformin. DESIGN AND SETTING: Cross-sectional study at a public university hospital. METHODS: Patients with T2DM and a control group of non-diabetics were included. Serum B12 levels were measured and biochemical B12 deficiency was defined as serum levels < 180 pg/ml. Associations between B12 deficiency and age, duration of T2DM, duration of use and dosage of metformin, and use of proton pump inhibitors (PPIs) or histamine H2 antagonists were determined. RESULTS: 231 T2DM patients using metformin (T2DM-met) and 231 controls were included. No difference in the frequency of PPI or H2-antagonist use was seen between the groups. B12 deficiency was more frequent in the T2DM-met group (22.5% versus 7.4%) and this difference persisted after excluding PPI/H2-antagonist users (17.9% versus 5.6%). The factors that interfered with serum B12 levels were PPI/H2-antagonist use and duration of metformin use ≥ 10 years. Use of PPI/H2-antagonists was associated with B12 deficiency, with an odds ratio of 2.60 (95% confidence interval, 1.34-5.04). CONCLUSIONS: Among T2DM patients, treatment with metformin and concomitant use of PPI/H2-antagonists are associated with a higher chance of developing B12 deficiency than among non-diabetics.

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