scholarly journals Comparative Study of Methanolic Extract of Banana, Ranitidine and Omeprazole on Total Acid Secretion and Gastric Ulcer Healing Effect in Albino Rats

2020 ◽  
Vol 7 (2) ◽  
Author(s):  
Manish Kumar Prasad ◽  
Sukanta Sen ◽  
Nadeem Arshad ◽  
Matiur Rahman ◽  
C B Choudhary
Keyword(s):  
Gastric Ulcer ◽  
Comparative Study ◽  
Acid Secretion ◽  
Ulcer Healing ◽  
Methanolic Extract ◽  
Albino Rats ◽  
Total Acid ◽  
Gastric Ulcer Healing ◽  
Healing Effect

scholarly journals ANTIOXIDANT AND GASTRIC ULCER HEALING EFFECT OF ORTHOSIPHONSTAMINEUS (BENTH.) LEAVES EXTRACT IN ASPIRIN-INDUCED RATS

2017 ◽  
Vol 10 (2) ◽  
pp. 397 ◽  
Author(s):  
Ari - Yuniarto
Keyword(s):  
Gastric Ulcer ◽  
Ulcer Healing ◽  
Control Group ◽  
Histopathological Analysis ◽  
Antiulcer Activity ◽  
Gastric Ulcer Healing ◽  
Orthosiphon Stamineus ◽  
Mucosal Integrity ◽  
Healing Effect ◽  
Dpph Method

Objective: In the gastrointestinal system, gastric ulcer is one of the common serious problems in human life and gives contribution against morbidity and mortality incidence. The pathophysiology of gastric ulcer is an imbalance between aggressive factor and mucosal integrity factor. Increase of aggressive factors and decrease of mucosal integrity factors have potential against developed of gastric ulcer disease. The objective of the research was to evaluate antioxidant and gastric ulcer healing effect of Orthosiphon stamineus (Benth.) leaves extract in aspirin-induced rats.Methods: In vivo antiulcer activity of Orthosiphon leaves extract was evaluated through several parameters involves gastric acidity, number of ulcers, diameters of ulcers, ulcer index (UI), and healing ratio. Dose level of Orthosiphon leaves extract which used in this study such as 250 and500 mg/kg, respectively. Antioxidant activity of Orthosiphon leaves extract was evaluated by 1,1-diphenyl-2-picrylhydrazyl hydrate (DPPH) method. Histopathological of the stomach was performed using hematoxylin-eosin stained.Results: The results of the study showed that groups which given Orthosiphon leaves extract have significantly different for gastric ulcer healing compared to the control group and were supported by histopathological analysis. The Orthosiphon leaves extract also showed maximum scavengingactivity at a concentration of 100 µg/ml (58.86% inhibition) and minimum at 50 μg/ml (29.60% inhibition) with inhibitory concentration 50% (IC  )50 84.54 µg/ml when compared to ascorbic acid as the standard with IC5.08 µg/ml by DPPH method.Conclusion: It can be concluded that from the experimental study of O. stamineus (Benth.) leaves extract has potential antiulcer activity in aspirin- induced rats model and antioxidant effect using DPPH method. Stomach tissues regeneration in gastric ulcer model might be affected by the improvement of antioxidant status.Keywords: Orthosiphon stamineus (Benth.), Extract, Ulcer, Aspirin, 1,1-diphenyl-2-picrylhydrazyl hydrate.

Angiogenesis, cell proliferation and apoptosis in gastric ulcer healing. Effect of a selective cox-2 inhibitor

2004 ◽  
Vol 505 (1-3) ◽  
pp. 187-194 ◽  
Author(s):  
Susana Sánchez-Fidalgo ◽  
Inés Martín-Lacave ◽  
Matilde Illanes ◽  
Virginia Motilva
Keyword(s):  
Cell Proliferation ◽  
Gastric Ulcer ◽  
Ulcer Healing ◽  
Gastric Ulcer Healing ◽  
Healing Effect ◽  
Proliferation And Apoptosis ◽  
Cox 2

Effects of artemisinin, with or without lumefantrine and amodiaquine on gastric ulcer healing in rat

2018 ◽  
Vol 29 (5) ◽  
pp. 515-524 ◽  
Author(s):  
Kazeem O. Ajeigbe ◽  
Benjamin O. Emikpe ◽  
Samuel Babafemi Olaleye
Keyword(s):  
Gastric Ulcer ◽  
Ulcer Healing ◽  
Neutrophil Infiltration ◽  
Mucosal Injury ◽  
Total Leukocyte Count ◽  
Control Group ◽  
Albino Rats ◽  
Gastric Ulcer Healing ◽  
Neutrophil Lymphocyte Ratio ◽  
Reactive Protein

Abstract Background Antimalarial drugs have been shown to predispose the stomach to ulceration in rats. However, their role in the modulation of gastric ulcer healing is not known. The aim of the present study is to investigate the effect of artemisinin-based combination therapies on ulcer healing. Methods Gastric kissing ulcers were induced in 40 male albino rats (150–180 g) using 0.2 mL 50% acetic acid. One day after the ulcer induction, experimental rats were divided into four groups and treated once daily orally for 3 days as follows: (1) normal saline, (2) artemether-lumefantrine (2/12 mg/kg), (3) artesunate-amodiaquine (4/10 mg/kg), and (4) artesunate (2 mg/kg) only. A fifth group of 10 rats served as overall control with no ulcer induced and no treatment given. Ulcer healing was determined on days 4 and 7 post induction using ulcer score and planimetry. Results Artesunate decreased ulcer severity by 12.5% and 52.0% on days 4 and 7, respectively. Significant increases in severity were observed in rats treated with artemether-lumefantrine (25.0% and 40.0%) and artesunate-amodiaquine (50.0% and 95.0%). Lipid peroxidation was decreased by artesunate by day 7 (27%; p<0.05) but increased in artemether-lumefantrine and artesunate-amodiaquine administered rats (63.6% and 55%; p<0.05). The activity of superoxide dismutase was reduced by artesunate-amodiaquine on day 7 (22%; p<0.05) but no effect in the artemether-lumefantrine treatment. Neutrophil infiltration, total leukocyte count, neutrophil-lymphocyte ratio, and C-reactive protein values were significantly increased in the artemether-lumefantrine and artesunate-amodiaquine treated groups when compared with the untreated ulcer control group (p<0.05). These variables were all reduced by artesunate (p<0.05). Conclusions This study revealed that although artesunate may be beneficial in gastric ulcer healing, its combination with either lumefantrine or amodiaquine may delay healing of gastric mucosal injury.

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