scholarly journals Efficiency of screening for tuberculosis infection in children and adolescents in Moscow in 2019 based on the new procedure for using the intradermal test with tuberculosis recombinant allergen (ESAT-6/CFP-10)

2021 ◽  
Vol 99 (1) ◽  
pp. 15-25
Author(s):  
L. V. Slogotskaya ◽  
E. M. Bogorodskaya ◽  
L. F. Shamuratova ◽  
T. A. Sevostyanova
Keyword(s):  
Children And Adolescents ◽  
Tuberculosis Infection ◽  
Intradermal Test ◽  
Recombinant Allergen

POSSIBILITIES OF A LABORATORY TEST BASED ON THE DETERMINATION OF THE T-CELL RESPONSE TO STIMULATION WITH SPECIFIC CFP10 AND ESAT6 ANTIGENS IN THE DETECTION OF TUBERCULOSIS INFECTION IN CHILDREN AND ADOLESCENTS

2021 ◽  
Vol 100 (4) ◽  
pp. 128-132
Author(s):  
R.H. Fatykhova ◽  
◽  
L.А. Bаryshnikovа ◽  
D.A. Kudlay ◽  
A.P. Alekseev ◽  
...  
Keyword(s):  
Laboratory Test ◽  
Children And Adolescents ◽  
Retrospective Cohort ◽  
T Cell Response ◽  
Tuberculosis Infection ◽  
Mantoux Test ◽  
History Of ◽  
Positive Results ◽  
Reverse Development

Objective of the study: to explore the possibilities of T-SPOT.TB testing to detect tuberculosis infection (TI) in children and adolescents. Materials and methods of research: the design – a multicenter retrospective cohort noncomparative uncontrolled study. The results of examination of children aged 1 to 17 years using the T-SPOT.TB test (n=1565): 774 boys (49,5%), 791 girls (50,5%). The median age of children is 8 [5; 13] years. Results: the rate of positive T-SPOT.TB tests was 7,2% (n=113). Further examination and in-depth examination of children with positive results (n=28), in every 4th case, a history of contact with a tuberculosis (TB) patient was established, every 4th child had previously been under treatment with phthisiatrician. The coincidence of positive results of the T-SPOT.TB test with the Mantoux test – in 87%, with the test with a recombinant tuberculosis allergen – in 100% of cases. Local TB in the phase of reverse development was detected in one child (4%), active TB – in 2 (7%). Conclusion: the T-SPOT.TB test is an alternative method for screening children for TI.

scholarly journals SCREENING FOR TUBERCULOSIS INFECTION IN CHILDREN AND ADOLESCENTS IN RUSSIA – PAST, PRESENT, FUTURE

2019 ◽  
Vol 97 (9) ◽  
pp. 59-67 ◽  
Author(s):  
V. А. АKSENOVА ◽  
◽  
L. А. BАRYSHNIKOVА ◽  
N. I. KLEVNO ◽  
D. А. KUDLАY ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Tuberculosis Infection

scholarly journals A comparison of intradermal test with recombinant tuberculosis allergen (diaskintest) with other immunologic tests in the diagnosis of tuberculosis infection

2018 ◽  
Vol 7 (1) ◽  
pp. 32 ◽  
Author(s):  
Anna Starshinova ◽  
Viacheslav Zhuravlev ◽  
Irina Dovgaluk ◽  
Alexandr Panteleev ◽  
Vera Manina ◽  
...  
Keyword(s):  
Tuberculosis Infection ◽  
Intradermal Test ◽  
Immunologic Tests

scholarly journals Latent tuberculosis infection in children and adolescents in Russia

2020 ◽  
Vol 92 ◽  
pp. S26-S30 ◽  
Author(s):  
Valentina Alexandrovna Aksenova ◽  
Irina Anatolievna Vasilyeva ◽  
Tereza Chermenovna Kasaeva ◽  
Anastasia Gennadievna Samoilova ◽  
Natalia Yurievna Pshenichnaya ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection

scholarly journals Gene expression in peripheral blood cells for differentiation of active and latent tuberculosis infection in children and adolescents

2020 ◽  
Vol 97 (12) ◽  
pp. 28-32
Author(s):  
A. A. Elov ◽  
M. A. Vladimirskiy ◽  
S. V. Smerdin ◽  
O. I. Elufimova
Keyword(s):  
Children And Adolescents ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Messenger Rna ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Active Tuberculosis ◽  
Tuberculosis Infection ◽  
Patient Treatment ◽  
Modified Method

The objective: to analyze the expression of certain genes in the blood cells of children and adolescence to differentiate the active and latent phases of tuberculosis infection.Subjects and methods. Peripheral blood samples collected in 36 pediatric patients with latent tuberculosis infection and 24 patients aged 1 to 16 years undergoing in-patient treatment for pulmonary tuberculosis were tested. A modified method for isolating messenger RNA and reverse transcriptional polymerase chain reaction was used to identify the transcription of six genes selected for analysis.Results. In a comparative study of the expression values of six promising genes in blood cells in the study of two groups of children and adolescents with latent and active tuberculosis infection, it was found that the most differentiating feature for determining active tuberculosis infection was a significantly higher level of expression of PDCD1 gene encoding PD1 lymphocyte receptor. At the same time, the sensitivity to detect the active infection was found to be 95.8%, specificity – 94.4%, the accuracy of the positive prognosis of active tuberculosis infection was 93.3%.

scholarly journals Factors Associated with Tuberculosis among Children and Adolescents in Kelantan: A Cross-Sectional Study

2018 ◽  
Vol 24 (1) ◽  
pp. 1-14
Author(s):  
Hafizuddin Awang ◽  
Nik Rosmawati Nik Husain ◽  
Hasniza Abdullah
Keyword(s):  
Children And Adolescents ◽  
Female Gender ◽  
Cross Sectional Study ◽  
Tuberculosis Infection ◽  
Source Population ◽  
Sectional Study ◽  
Clinical Factors ◽  
Tuberculosis Screening ◽  
Cross Sectional ◽  
Immunodeficiency Virus

Objectives: This study aimed to estimate the proportion of tuberculosis patients among children and adolescents, to describe the socio-demography and clinical factors for tuberculosis infection among children and adolescents in Kelantan from 2012 until 2015. Methods: This study was a retrospective cross-sectional study between tuberculosis and non-tuberculosis cases among children and adolescents using Tuberculosis Information System as a source population. All notified cases that fulfilled the inclusion and exclusion criteria were included in the study. Descriptive statistics, simple and multiple logistic regressions were used for data analysis. Results: Out of 5412 tuberculosis cases, 8.4% were children and adolescents group with mean age of 15. Among 322 children and adolescents with tuberculosis, majority of them were Malay (91.2%), 7.5% illiterate and 79.6% resided in non-urban area. By clinical factors, 2.8% were Human Immunodeficiency Virus (HIV) positive and 14.6% were cigarettes smokers. Older age, cigarettes smoking, female gender, Malay ethnicity, good education level and non-urban residence were the significant associated factors for tuberculosis infection among children and adolescents with AOR 1.41 (95%CI: 1.29,1.54; p<0.001), 3.35 (95% CI: 1.86, 6.01; p<0.001), 1.88 (95% CI: 1.33, 2.65; p<0.001), 0.17 (95%CI: 0.07,0.44; p<0.001), 0.20 (95%CI: 0.12,0.33; p<0.001) and 1.92 (95% CI: 1.33, 2.79; p=0.001) respectively. Conclusion: The study provides important criteria of children and adolescents to be prioritized for tuberculosis screening, early diagnosis and prompt treatment, and might as well mitigate the dynamic transmission of tuberculosis in the community.

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