The role of DSCAM in the regulation of synaptic plasticity: possible involvement in neuropsychiatric disorders

ABSTRACTWhile monoaminergic hypotheses of psychopathology remain popular, there has been growing interest in the role of neurotrophins in neuropsychiatric disorders. Basic laboratory work has documented the importance of neurotrophins in neuronal survival and synaptic plasticity, and a range of clinical studies has provided analogous evidence of their role in neuropathology. Work on gene variants in brain-derived neurotrophic factor, and associated changes in structural and function brain imaging, have further contributed to our understanding of this area. Much remains to be done to delineate fully the relevant mechanisms by which brain-derived neurotrophic factor and other neurotrophins contribute to psychopathology, and to develop targeted therapeutic interventions. Nevertheless, the neurotrophin hypothesis has already given impetus to a range of valuable research.

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P-782 - The role of RNA binding proteins and micrornas in the regulation of synaptic plasticity and neuropsychiatric disorders

European Psychiatry ◽

10.1016/s0924-9338(12)74949-0 ◽

2012 ◽

Vol 27 ◽

pp. 1

Author(s):

G. Serafini ◽

M. Pompili ◽

M. Innamorati ◽

Y. Dwivedi ◽

P. Girardi

Keyword(s):

Synaptic Plasticity ◽

Binding Proteins ◽

Rna Binding ◽

Rna Binding Proteins ◽

Neuropsychiatric Disorders

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Faculty Opinions recommendation of Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1019172.253673 ◽

2004 ◽

Author(s):

Michael Ehlers

Keyword(s):

Synaptic Plasticity ◽

Nmda Receptor ◽

Receptor Subtypes ◽

Hippocampal Synaptic Plasticity

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Gut Microbiota and Antipsychotics Induced Metabolic Alteration

Global Clinical and Translational Research ◽

10.36316/gcatr.01.0020 ◽

2019 ◽

pp. 131-143

Author(s):

Dong-Yu Kan ◽

Su-Juan Li ◽

Chen-Chen Liu ◽

Ren-Rong Wu

Keyword(s):

Gut Microbiota ◽

Body Weight Gain ◽

Neuropsychiatric Disorders ◽

Elevated Risk ◽

Metabolic Disturbance ◽

Metabolic Dysfunction ◽

Sequencing Technology ◽

Severe Mental Disorder ◽

Metabolic Alteration

Schizophrenia is a chronic and severe mental disorder with antipsychotics as primary medications, but the antipsychotic-induced metabolic side effects may contribute to the elevated risk of overall morbidity and mortality in patients with psych-iatric diseases. With the development in sequencing technology and bioinformatics, dysbiosis has been shown to contribute to body weight gain and metabolic dysfunction. However, the role of gut microbiota in the antipsychotic-induced metabolic alteration remains unknown. In this paper, we reviewed the recent studies of the gut microbiota with psychiatric disorders and antipsychotic-induced metabolic dysfunction. Patients with neuropsychiatric disorders may have a different composi-tion of gut microbiota compared with healthy controls. In addition, it seems that the use of antipsychotics is concurrently associated with both altered composition of gut microbiota and metabolic disturbance. Further study is needed to address the role of gut microbiota in the development of neuropsychiatric disorders and antipsychotic-induced metabolic disturbance, to develop novel therapeutics for both neuropsychiatric disorders and metabolic dysfunction.

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Role of Nicotinic and Muscarinic Receptors on Synaptic Plasticity and Neurological Diseases

Current Pharmaceutical Design ◽

10.2174/1381612822666160127112021 ◽

2016 ◽

Vol 22 (14) ◽

pp. 2004-2014 ◽

Cited By ~ 13

Author(s):

Marco Fuenzalida ◽

Miguel Ángel Pérez ◽

Hugo R. Arias

Keyword(s):

Synaptic Plasticity ◽

Muscarinic Receptors ◽

Neurological Diseases

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The Role of Neurohypophyseal Hormones Vasopressin and Oxytocin in Neuropsychiatric Disorders

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530318666180220104900 ◽

2018 ◽

Vol 18 (4) ◽

pp. 341-347 ◽

Cited By ~ 14

Author(s):

Michele Iovino ◽

Tullio Messana ◽

Giovanni De Pergola ◽

Emanuela Iovino ◽

Franca Dicuonzo ◽

...

Keyword(s):

Neuropsychiatric Disorders ◽

Neurohypophyseal Hormones

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Dysregulation of Astrocyte–Neuronal Communication in Alzheimer’s Disease

International Journal of Molecular Sciences ◽

10.3390/ijms22157887 ◽

2021 ◽

Vol 22 (15) ◽

pp. 7887

Author(s):

Carmen Nanclares ◽

Andres Mateo Baraibar ◽

Alfonso Araque ◽

Paulo Kofuji

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Synaptic Plasticity ◽

Neuronal Excitability ◽

Active Role ◽

Ionic Homeostasis ◽

Neuronal Communication ◽

Structural Support

Recent studies implicate astrocytes in Alzheimer’s disease (AD); however, their role in pathogenesis is poorly understood. Astrocytes have well-established functions in supportive functions such as extracellular ionic homeostasis, structural support, and neurovascular coupling. However, emerging research on astrocytic function in the healthy brain also indicates their role in regulating synaptic plasticity and neuronal excitability via the release of neuroactive substances named gliotransmitters. Here, we review how this “active” role of astrocytes at synapses could contribute to synaptic and neuronal network dysfunction and cognitive impairment in AD.

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Monitoring and Modulating Inflammation-Associated Alterations in Synaptic Plasticity: Role of Brain Stimulation and the Blood–Brain Interface

Biomolecules ◽

10.3390/biom11030359 ◽

2021 ◽

Vol 11 (3) ◽

pp. 359

Author(s):

Maximilian Lenz ◽

Amelie Eichler ◽

Andreas Vlachos

Keyword(s):

Synaptic Plasticity ◽

Brain Stimulation ◽

Vascular Function ◽

Neuropsychiatric Symptoms ◽

Systemic Infection ◽

Brain Functions ◽

Blood Brain ◽

Brain Interface ◽

The Central Nervous System

Inflammation of the central nervous system can be triggered by endogenous and exogenous stimuli such as local or systemic infection, trauma, and stroke. In addition to neurodegeneration and cell death, alterations in physiological brain functions are often associated with neuroinflammation. Robust experimental evidence has demonstrated that inflammatory cytokines affect the ability of neurons to express plasticity. It has been well-established that inflammation-associated alterations in synaptic plasticity contribute to the development of neuropsychiatric symptoms. Nevertheless, diagnostic approaches and interventional strategies to restore inflammatory deficits in synaptic plasticity are limited. Here, we review recent findings on inflammation-associated alterations in synaptic plasticity and the potential role of the blood–brain interface, i.e., the blood–brain barrier, in modulating synaptic plasticity. Based on recent findings indicating that brain stimulation promotes plasticity and modulates vascular function, we argue that clinically employed non-invasive brain stimulation techniques, such as transcranial magnetic stimulation, could be used for monitoring and modulating inflammation-induced alterations in synaptic plasticity.

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The role of elevated autophagy on the synaptic plasticity impairment caused by CdSe/ZnS quantum dots

Biomaterials ◽

10.1016/j.biomaterials.2013.09.048 ◽

2013 ◽

Vol 34 (38) ◽

pp. 10172-10181 ◽

Cited By ~ 41

Author(s):

Liang Chen ◽

Yanyan Miao ◽

Lin Chen ◽

Peipei Jin ◽

Yingying Zha ◽

...

Keyword(s):

Quantum Dots ◽

Synaptic Plasticity

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Imbalanced post- and extrasynaptic SHANK2A functions during development affect social behavior in SHANK2-mediated neuropsychiatric disorders

Molecular Psychiatry ◽

10.1038/s41380-021-01140-y ◽

2021 ◽

Author(s):

Ahmed Eltokhi ◽

Miguel A. Gonzalez-Lozano ◽

Lars-Lennart Oettl ◽

Andrey Rozov ◽

Claudia Pitzer ◽

...

Keyword(s):

Synaptic Plasticity ◽

Social Interaction ◽

Social Behavior ◽

Ampa Receptors ◽

Signal To Noise Ratio ◽

Signal Transmission ◽

Neuropsychiatric Disorders ◽

Autism Spectrum ◽

Strong Impact ◽

Odor Processing

AbstractMutations in SHANK genes play an undisputed role in neuropsychiatric disorders. Until now, research has focused on the postsynaptic function of SHANKs, and prominent postsynaptic alterations in glutamatergic signal transmission have been reported in Shank KO mouse models. Recent studies have also suggested a possible presynaptic function of SHANK proteins, but these remain poorly defined. In this study, we examined how SHANK2 can mediate electrophysiological, molecular, and behavioral effects by conditionally overexpressing either wild-type SHANK2A or the extrasynaptic SHANK2A(R462X) variant. SHANK2A overexpression affected pre- and postsynaptic targets and revealed a reversible, development-dependent autism spectrum disorder-like behavior. SHANK2A also mediated redistribution of Ca2+-permeable AMPA receptors between apical and basal hippocampal CA1 dendrites, leading to impaired synaptic plasticity in the basal dendrites. Moreover, SHANK2A overexpression reduced social interaction and increased the excitatory noise in the olfactory cortex during odor processing. In contrast, overexpression of the extrasynaptic SHANK2A(R462X) variant did not impair hippocampal synaptic plasticity, but still altered the expression of presynaptic/axonal signaling proteins. We also observed an attention-deficit/hyperactivity-like behavior and improved social interaction along with enhanced signal-to-noise ratio in cortical odor processing. Our results suggest that the disruption of pre- and postsynaptic SHANK2 functions caused by SHANK2 mutations has a strong impact on social behavior. These findings indicate that pre- and postsynaptic SHANK2 actions cooperate for normal neuronal function, and that an imbalance between these functions may lead to different neuropsychiatric disorders.

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