Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study Among Healthcare Workers in Turkey

2021 ◽  
Author(s):  
Abanoub Riad ◽  
Derya Sağıroğlu ◽  
Batuhan Üstün ◽  
Sameh Attia ◽  
Miloslav Klugar
2021 ◽  
Vol 10 (12) ◽  
pp. 2629
Author(s):  
Abanoub Riad ◽  
Derya Sağıroğlu ◽  
Batuhan Üstün ◽  
Andrea Pokorná ◽  
Jitka Klugarová ◽  
...  

Background: COVID-19 vaccine hesitancy is a serious threat to mass vaccination strategies that need to be accelerated currently in order to achieve a substantial level of community immunity. Independent (non-sponsored) studies have a great potential to enhance public confidence in vaccines and accelerate their uptake process. Methods: A nationwide cross-sectional study for the side effects (SE) of CoronaVac was carried out in February 2021 among Turkish healthcare workers who were recently vaccinated. The questionnaire inquired about local and systemic SEs that occurred in the short-term, within four weeks, following vaccination. Results: A total of 780 healthcare workers were included in this study; 62.5% of them experienced at least one SE. Injection site pain (41.5%) was the most common local SE, while fatigue (23.6%), headache (18.7%), muscle pain (11.2%) and joint pain (5.9%) were the common systemic SEs. Female healthcare workers (67.9%) were significantly more affected by local and systemic SEs than male colleagues (51.4%). Younger age, previous infection, and compromised health status (chronic illnesses and regular medicines uptake) can be associated with an increased risk of CoronaVac SEs; Conclusions: The independent research shows a higher prevalence of CoronaVac SEs than what is reported by phase I–III clinical trials. In general, the results of this study confirm the overall safety of CoronaVac and suggest potential risk factors for its SEs. Gender-based differences and SEs distribution among age groups are worth further investigation.


2021 ◽  
Vol Volume 12 ◽  
pp. 131-145
Author(s):  
Bewunetu Zewude ◽  
Tewodros Habtegiorgis ◽  
Ashenafi Hizkeal ◽  
Tamirat Dela ◽  
Getahun Siraw

Author(s):  
Kjell Torén ◽  
Linus Schiöler ◽  
Nancy P. Nenonen ◽  
Charles Hannoun ◽  
Anette Roth ◽  
...  

Abstract Background Norovirus outbreaks cause severe medico-socio-economic problems affecting healthcare workers and patients. The aim of the study was to investigate prevalence of norovirus infection and risk factors for infection in healthcare workers during nosocomial outbreaks. Methods A cross-sectional study of norovirus infections in healthcare workers was performed in seven outbreak wards in a large university hospital. Packs (swab for rectal sampling, and questionnaire) were posted to healthcare workers on notification of a ward outbreak. Rectal samples were examined with norovirus-specific real-time PCR. Replies from questionnaires were analysed using logistic regression models with norovirus genogroup (G)II positive findings as dependent variable. The results are expressed as odds ratios (OR) with 95% confidence intervals (CI). Sequencing and phylogenetic analyses (1040 nucleotides) were used to characterize norovirus strains from healthcare workers. Cluster analyses included norovirus GII.4 strains detected in ward patients during the ongoing outbreaks. Results Of 308 packs issued to healthcare workers, 129 (42%) were returned. norovirus GII was detected in 26 healthcare workers (20.2%). Work in cohort care (OR 4.8, 95% CI 1.4–16.3), work in wards for patients with dementia (OR 13.2, 95% CI 1.01–170.7), and having diarrhoea, loose stools or other gastrointestinal symptoms the last week (OR 7.7, 95% CI 2.5–27.2) were associated with increased norovirus prevalence in healthcare workers. Sequencing revealed norovirus GII.4 in healthcare workers samples, and strains detected in healthcare workers and ward patients during a given ward outbreak showed ≥ 99% similarity. Conclusion Norovirus positive findings in healthcare workers were strongly associated with symptomatic infection, close contact with sick patients, and dementia nursing.


Author(s):  
Aziz Ogutlu ◽  
Oguz Karabay ◽  
Unal Erkorkmaz ◽  
Ertugrul Guclu ◽  
Seher Sen ◽  
...  

Abstract Background This study aimed to investigate the specific risk factors for the transmission of novel coronavirus (SARS-CoV-2) among healthcare workers in different campuses of a university hospital and to reveal the risk factors for antibody positivity. Methods In this retrospective cross-sectional study, 2988 (82%) of 3620 healthcare workers in a university hospital participated. The coronavirus disease 2019 (COVID-19) antibody was investigated using serum from healthcare workers who underwent COVID-19 antibody testing. The antibody test results of the participants were evaluated based on their work campus, their profession and their workplace. The statistical significance level was p < 0.05 in all analyses. Results Of the participants in this study, 108 (3.6%) were antibody positive, and 2880 (96.4%) were negative. Antibody positivity rates were greater in nurses compared with other healthcare workers (p < 0.001). Regarding workplace, antibody positivity was greater in those working in intensive care compared to those working in other locations (p < 0.001). Conclusions Healthcare workers are at the highest risk of being infected with COVID-19. Those who have a higher risk of infection among healthcare workers and those working in high-risk areas should be vaccinated early and use personal protective equipment during the pandemic. Trial Registration: Retrospective permission was obtained from both the local ethics committee and the Turkish Ministry of Health for this study (IRB No:71522473/050.01.04/370, Date: 05.20.2020).


2021 ◽  
Author(s):  
Aziz Ogutlu ◽  
Oguz Karabay ◽  
Unal Erkorkmaz ◽  
Ertugrul Guclu ◽  
Seher Sen ◽  
...  

Abstract Background In this study, it is aimed to investigate the specific risk factors for the transmission of novel coronavirus (SARS-CoV-2) among healthcare workers in different campuses of a university hospital and to reveal the risk factors for antibody positivity. Methods In this cross-sectional study, 2988 (82%) of 3620 healthcare workers in a university hospital participated. The Coronavirus Disease (COVID-19) antibody was investigated by taking serum to the healthcare workers who accepted for the COVID-19 antibody test. The antibody test results of the participants were evaluated according to the campus they work, their profession and their workplace. Statistical significance level was accepted as p < 0.05 in all analyzes. Results Of the antibody test results of the participants in this study, 108 (3.6%) were positive and 2880 (96.4%) were negative. Antibody positivity were higher in nurses than in other healthcare workers (p < 0.001). When examined according to work places, antibody positivity was higher in those working in intensive care compared to those working in other places (p < 0.001). Conclusions Healthcare workers are at the highest risk of being infected with COVID-19. Those who have a higher risk of infection among healthcare workers and those working in high-risk areas should be vaccinated early and take care to work with personal protective equipment during the pandemic period. Trial Registration: Retrospective permission was obtained from both the local ethics committee and the Turkish Ministry of Health for this study. (IRB No:71522473/050.01.04/370, Date: 05.20.2020


2018 ◽  
Vol 2018 ◽  
pp. 1-9
Author(s):  
James Osei-Yeboah ◽  
Kenneth Kwame Kye-Amoah ◽  
William K. B. A. Owiredu ◽  
Sylvester Yao Lokpo ◽  
Joseph Esson ◽  
...  

Background. There is a dearth of information about the burden of cardiometabolic risk factors among the Ghanaian health workforce in the Western Region. This study sought to determine the prevalence of cardiometabolic risk factors among healthcare workers at the Sefwi-Wiawso Municipal Hospital in the Western Region of Ghana.Materials and Methods. A hospital-based cross-sectional study involving 112 employees of the Sefwi-Wiawso Municipal Hospital was conducted. The cardiometabolic risk variables assessed were obesity, hypertension, dyslipidaemia, and diabetes. Sociodemographic parameters were also captured. The prevalence of hypertension and obesity was determined using the JNC VII panel and WHO BMI criteria for obesity classifications. Blood lipids and glucose concentrations were evaluated using standard methods.Results. The prevalence of hypertension and prehypertension was 16.07% and 52.68%, respectively. About 38.39% of participants were overweight, and 12.50% were obese. Atherogenic dyslipidaemia was 26.79%, whereas prediabetes glycaemic levels and diabetes incidence were 5.41% and 4.50%, respectively. Fifty percent (50.00%) of participants presented at least one cardiometabolic risk factor. Aging and adiposity were associated with increasing cardiometabolic risk.Conclusion. Cardiometabolic risk factors are prevalent among healthcare providers in Sefwi-Wiawso. The cardiometabolic dysregulation observed among this cohort of healthcare professionals may be modulated by age and adiposity.


2019 ◽  
Author(s):  
seifadin Ahmed Shallo ◽  
Jibril Dori Boru

Abstract I. Abstract Objective: Breast cancer is the leading cause of death among reproductive age women worldwide. Regular breast self-examination is one of the most cost-effective methods for early detection of breast cancer. Therefore, this study intended to assess the magnitude of breast self-examination practice and associated factors among female healthcare workers in public health facility in Western Ethiopia. Institutional based cross-sectional study was conducted among 379 female healthcare workers. The study participants were recruited by lottery method. Data were collected from March to April 2019. Data were entered into Epi data version 3.1 and analyzed using SPSS version 25. Bivariate and multiple logistic regressions analysis were done to identify factors significantly associated with the dependent variables. With 95% CI, the level of significance was decided at p-value≤ 0.05 Results: The magnitude of regular breast self-examination practice was 32.6%. After adjusting for possible confounders; educational level, being aware of the risk factors of breast cancer, knowledge towards breast self-examination were independent predictors of regular breast self-examination practice. Regular awareness creation forum on breast self-examination technique, risk factors, and related matters should be facilitated so that all female health care workers will be reminded. Keywords: breast self-examination practice, female health workers,


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