Cervical Cancer Knowledge and Screening among Young Female Adults in the Kintampo Municipal Hospital, Bono East Ghana.

Purpose: This study sought to determine the cervical cancer knowledge and screening among young female adults in Kintampo North Municipality. Methodology: A cross-sectional study was employed using a quantitative approach. Data was collected from 341 participants using a consecutive sampling with structured questionnaire and analysed using SPSS version 23. Descriptive statistics was used to analyse continuous variables like age and expressed as means and standard deviations, whilst categorical variables were summarized into frequencies and percentages. Pearson’s Chi-square test was used to determine the associations between the independent and dependent variables. Findings: More than half (58%) of the respondents had knowledge of cervical cancer. The two major sources of cervical cancer knowledge to respondents were the health workers (45.6%) and radio/television/internet (45.1%). Most (70.5%) had no idea about the causes of cervical cancer. Again, more than half (55.5%) of the respondents had no idea on the signs and symptoms of cervical cancer while less than half (48.4%) also had no idea about prevention of cervical cancer. Almost all (94.6%) the respondents had never been screened. Recommendations: Cervical cancer knowledge and screening is low among young female adults attending the Kintampo North Municipal Hospital. As such, there is the need to put strategies in place to increase cervical cancer knowledge and screening in the Kintampo North and its environs.

Effective Treatment Strategies for the Removal of Antibiotic-Resistant Bacteria, Antibiotic-Resistance Genes, and Antibiotic Residues in the Effluent From Wastewater Treatment Plants Receiving Municipal, Hospital, and Domestic Wastewater: Protocol for a Systematic Review

Background The widespread and unrestricted use of antibiotics has led to the emergence and spread of antibiotic-resistant bacteria (ARB), antibiotic-resistance genes (ARGs), and antibiotic residues in the environment. Conventional wastewater treatment plants (WWTPs) are not designed for effective and adequate removal of ARB, ARGs, and antibiotic residues, and therefore, they play an important role in the dissemination of antimicrobial resistance (AMR) in the natural environment. Objective We will conduct a systematic review to determine the most effective treatment strategies for the removal of ARB, ARGs, and antibiotic residues from the treated effluent disposed into the environment from WWTPs that receive municipal, hospital, and domestic discharge. Methods We will search the MEDLINE, EMBASE, Web of Science, World Health Organization Global Index Medicus, and ProQuest Environmental Science Collection databases for full-text peer-reviewed journal articles published between January 2001 and December 2020. We will select only articles published in the English language. We will include studies that measured (1) the presence, concentration, and removal rate of ARB/ARGs going from WWTP influent to effluent, (2) the presence, concentration, and types of antibiotics in the effluent, and (3) the possible selection of ARB in the effluent after undergoing treatment processes in WWTPs. At least two independent reviewers will extract data and perform risk of bias assessment. An acceptable or narrative synthesis method will be followed to synthesize the data and present descriptive characteristics of the included studies in a tabular form. The study has been approved by the Ethics Review Board at the International Centre for Diarrhoeal Disease Research, Bangladesh (protocol number: PR-20113). Results This protocol outlines our proposed methodology for conducting a systematic review. Our results will provide an update to the existing literature by searching additional databases. Conclusions Findings from our systematic review will inform the planning of proper treatment methods that can effectively reduce the levels of ARB, ARGs, and residual antibiotics in effluent, thus lowering the risk of the environmental spread of AMR and its further transmission to humans and animals. International Registered Report Identifier (IRRID) PRR1-10.2196/33365

Evaluation of the Direct Costs of Managing Adverse Drug Events in all Ages and of Avoidable Adverse Drug Events in Older Adults in Japan

In Japan, medical costs are increasing annually, and the increase in national medical costs, particularly in the direct cost of managing adverse drug events, is high. An in-depth understanding of these costs is important for their reduction. This study aimed to calculate the direct cost of managing adverse drug events in all ages, including older adults, and that of avoidable adverse drug events in older adults. We conducted a retrospective survey on patients aged 1 year or older who visited Gifu Municipal Hospital in Japan. We investigated and calculated the direct cost of managing adverse drug events and that of avoidable adverse drug events based on the Beers Criteria Japanese version (BCJ) and “Guidelines for medical treatment and its safety in the elderly 2015” (GMTSE-2015) in inpatients and outpatients. Among 6,504 patients, 11.1% visited the hospital or were hospitalized due to adverse drug events. The direct costs per patient with adverse drug events were 21,281 and 22,590 yen (166 and 176 euros as on September 13, 2021) for outpatients, and 853,175 and 874,582 yen (6,648 and 6,815 euros) for inpatients of all ages and older adults, respectively. The direct costs of avoidable adverse drug events per patient using drugs listed in the BCJ and GMTSE-2015 for older adults were 3,212 and 3,341 yen (25 and 26 euros) for outpatients, and 55,548 and 80,246 yen (433 and 625 euros) for inpatients, respectively. In sum, considering both inpatients and outpatients in the whole country, the direct costs of managing adverse drug events were 804.53 billion and 597.19 billion yen (6,269 million and 4,653 million euros) per year for all ages and older ages, respectively. The direct cost of avoidable adverse drug events in older adults was 83.43–258.44 billion yen (650–2,013 million euros) per year. We found that, in Japan, high medical costs are often caused by managing adverse drug events, and that the costs of avoidable adverse drug events in older adults based on the BCJ and GMTSE-2015 account for a substantial proportion of the medical cost. Therefore, by using the BCJ and GMTSE-2015, avoiding adverse drug events and reducing medical costs may be possible.

A study of haemoglobin percentage among pregnant woman at first visit in antenatal clinic in South Dumdum Municipal hospital, Kolkata

Background: Low maternal haemoglobin concentrations during pregnancy have been reported to increase risk of small for gestational age (SGA) birth, which is a predictor of stillbirth. The objective was to find out a study of Hb% among pregnant woman.Methods: All consenting of 200 pregnant woman attending antenatal clinic in the department of obstetrics and gynaecology at South Dumdum municipal hospital, Dumdum, Nager Bazar, Kolkata were included in the study.Results: Out of 200 pregnant woman, 75 woman were anaemic and there average Hb% was 10.10 and 125 mothers were non-anaemic and their average Hb% was 11.61. 39 mothers whose parity p0+0 and avg. Hb%-11.305 out of them 10 mothers are anaemic. In contrast 73 mothers whose parity P0+1 and average Hb% was 23.860, out of them 30 mothers were anaemic. In contrast 5 mothers whose parity P0+2 and average Hb% was 10.76, out of them 0 mother was anaemic. In contrast 22 mothers whose parity P1+0 and average Hb% was 10.31, out of them 13 mothers were anaemic. In contrast 56 mothers whose parity P1+1 and average Hb% was 11.31, out of them 19 mothers were anaemic. In contrast one mother whose parity P1+2 and average Hb% was 0.2 and she was anaemic. In contrast one mother whose parity P2+0 and Hb% was 10 and she was anaemic. In contrast two mothers whose parity were P2+1 and Hb% was 9.55 and out of them one mother was anaemic. In contrast one mother whose parity is p3+1 and Hb% was 12.Conclusions: Out of 200 pregnant woman 75 were anaemic and 125 woman were non-anaemic.

Application of the immune-correcting therapy in complex treatment of surgical forms of erysipelas

Objective. To investigate the efficacy of immunomodulating and immunostimulating therapy in complex treatment of patients, suffering surgical forms of erysipelas.Materials and methods. Retrospectively and prospectively there were analyzed 284 patients’ hospital charts, who were treated stationary in Centre of Purulent-Septic Surgery of Zaporizhzhya Municipal Hospital №3 in 2016 - 2021 yrs. Results. In patients, suffering erythematous form of erysipelas, disorders in cellular and humoral chains of immunity were not revealed. The immune disorders formula in bullous form was following: CD3 + 1, CD4 + 1, CD8-1, CD16-2, CD22-1, what witnessed about misbalance of the immune system Degree I, of possibly compensatory character; in a phlegmonous one - CD3 + 1, CD4-1, CD8-1, CD16-2, CD22-1, witnessing actuality of the immune disorders of Degree І, while in the necrotic one - CD3-2, CD4-2, CD8-1, CD16-2, CD22-1, trusting presence of the immune disorders of Degree ІІI. Conclusion. Administration of erbisol-extra and laferon for destructive forms of erysipelas is pathogenetically substantiated and may be applied in complex treatment of the disease.

Introduction of 3D Printing in a German Municipal Hospital—Practice Guide for CMF Surgery

Study Design: This study aimed to introduce 3D printing in a municipal hospital to improve the treatment of craniomaxillofacial patients and optimize costs and operating time. Thus we describe the implementation of low-cost in-house 3D printing to facilitate orbital- and mandible reconstruction in CMF surgery. Moreover, we address legal requirements, safety at work, fire- and data protection. Finally, we want to share our experiences using 3D printing and point out its advantages in providing better patient care. Methods: We outline the setup of in-house 3D printing and focus on obeying German health care regulations. We based our approach on a fused deposition modeling 3D printer and free software. As proof of concept, we treated 4 cases of severe orbital trauma and 1 case of mandibular reconstruction. We printed a 3D patient-specific model for each case and adapted a titanium mesh implant, respectively, a titanium reconstruction plate before performing the surgery. Results: Our approach reduced costs, duration of anesthesia, operating time, recovery time, and postoperative swelling and increased the revenue. Functional outcome in orbital reconstruction like eye movement and double vision, was improved compared to the conventional technique. No severe complications like loss-of-vision or surgical revision occurred. Likewise, mandibular reconstruction showed no plate loosening or plate fracture. Conclusion: The implementation of cost-efficient 3D printing resulted in successful patient treatment with excellent outcomes. Our practice guide offers a 3D printing workflow and could be adapted to fit the needs of other specialties like neurosurgery, orthopedic surgery as well.