Cost-Effectiveness of Risk-Stratified Endoscopic Screening for Esophageal Cancer in High-Risk Areas of China: A Modeling Study

2021 ◽  
Author(s):  
Ruyi Xia ◽  
He Li ◽  
Jufang Shi ◽  
Wenjun Liu ◽  
Maomao Cao ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cost Effectiveness ◽  
High Risk ◽  
Endoscopic Screening ◽  
Risk Areas ◽  
Modeling Study

Cost-effectiveness of risk-stratified endoscopic screening for esophageal cancer in high-risk areas of China: a modeling study

2021 ◽  
Author(s):  
Ruyi Xia ◽  
He Li ◽  
Jufang Shi ◽  
Wenjun Liu ◽  
Maomao Cao ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cost Effectiveness ◽  
High Risk ◽  
Endoscopic Screening ◽  
Risk Areas ◽  
Modeling Study

164 EFFECTIVENESS OF ONE-TIME ENDOSCOPIC SCREENING PROGRAM IN PREVENTION OF ESOPHAGEAL CANCER IN CHINA: A MULTI-CENTER POPULATION-BASED COHORT STUDY

2020 ◽  
Vol 33 (Supplement_1) ◽  
Author(s):  
R Chen ◽  
Y Liu ◽  
G Song ◽  
B Li ◽  
D Zhao ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cohort Study ◽  
High Risk ◽  
Cancer Incidence ◽  
Screening Program ◽  
Population Based ◽  
Control Group ◽  
Endoscopic Screening ◽  
Incidence And Mortality ◽  
Risk Areas

Abstract   Esophageal cancer is one of the most common cancers worldwide and half of all new cases occurred in China. Population-based endoscopic screening has been carried out in some high-risk areas in China since 2005, but previous evidence was based predominately on small-sample, single-center studies. We undertook a population-based, multi-center cohort study to estimate the effectiveness of endoscopic screening program in reducing the incidence and mortality of esophageal in high risks areas in China. Methods This study was conducted in six areas in China from 2005 to 2015. All permanent residents aged 40–69 yeas were identified as target subjects. We defined those who were invited and undertook endoscopic screening as the screened group, and those who refused screening as the non-screened group. The target subjects who were not invited to screening was assigned to the control group. The effectiveness of endoscopic screening and screening program were evaluated by comparing the reductions in the incidence and mortality from esophageal cancer in those screened or those invited to screening with reductions in the control group, respectively. Results Our cohort analysis included 637 500 people: 299 483 in the control group and 338 017 in the invited to screening group, 113 340 (33.53%) of whom were screened eventually. Compared with subjects in the control group, esophageal cancer incidence and mortality were reduced by 26% (relative risk(RR) 0.74, 95% confidence interval(CI), 0.69–0.79) and 60% (0.40, 0.36–0.45) respectively in those screened, and they were reduced by 15% (0.85, 0.82–0.89) and 33% (0.67, 0.63–0.71) respectively in those invited to screening. Conclusion Among individuals aged 40–69 years in high risk areas of esophageal cancer, one-time endoscopic screening program was associated with a significant decrease in esophageal cancer incidence and mortality.

scholarly journals Estimated Cost-effectiveness of Endoscopic Screening for Upper Gastrointestinal Tract Cancer in High-Risk Areas in China

2021 ◽  
Vol 4 (8) ◽  
pp. e2121403
Author(s):  
Ruyi Xia ◽  
Hongmei Zeng ◽  
Wenjun Liu ◽  
Li Xie ◽  
Mingwang Shen ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Gastrointestinal Tract ◽  
High Risk ◽  
Upper Gastrointestinal Tract ◽  
Endoscopic Screening ◽  
Tract Cancer ◽  
Gastrointestinal Tract Cancer ◽  
Risk Areas ◽  
Upper Gastrointestinal

Esophageal cancer in high-risk areas of China: research progress and challenges

2017 ◽  
Vol 27 (3) ◽  
pp. 215-221 ◽  
Author(s):  
Yingsong Lin ◽  
Yukari Totsuka ◽  
Baoen Shan ◽  
Chaochen Wang ◽  
Wenqiang Wei ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
High Risk ◽  
Research Progress ◽  
Risk Areas

scholarly journals Associations between cancer family history and esophageal cancer and precancerous lesions in high-risk areas of China

2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jiachen Zhou ◽  
Kexin Sun ◽  
Shaoming Wang ◽  
Ru Chen ◽  
Minjuan Li ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Family History ◽  
High Risk ◽  
Precancerous Lesions ◽  
Cancer Family ◽  
Cancer Family History ◽  
Risk Areas

The relationship between a cohort endoscopic screening of 15,000 subjects and the death of patients with esophageal and gastric cancers in high-risk areas

2009 ◽  
Vol 6 (4) ◽  
pp. 271-276
Author(s):  
Zhifeng Chen ◽  
Guohui Song ◽  
Jun Hou ◽  
Cuilan Guo ◽  
Guoliang Jin ◽  
...  
Keyword(s):  
High Risk ◽  
Endoscopic Screening ◽  
Gastric Cancers ◽  
Risk Areas ◽  
The Relationship

scholarly journals Modeling the Cost-effectiveness of Esophageal Cancer Screening in China

2020 ◽  
Author(s):  
Yuanyuan LI ◽  
Lingbin Du ◽  
Youqing Wang ◽  
Yuxuan Gu ◽  
Xuemei Zhen ◽  
...  
Keyword(s):  
Sensitivity Analysis ◽  
Esophageal Cancer ◽  
Cost Effectiveness ◽  
Cancer Screening ◽  
Cost Effective ◽  
Endoscopic Screening ◽  
Lugol’S Iodine ◽  
Iodine Staining ◽  
The Cost

Abstract Background : This study aimed to examine the cost-effectiveness of standard endoscopic screening with Lugol’s iodine staining for EC (esophageal cancer) screening in China. Methods : A Markov decision analysis model with eleven states was built. Individuals aged 40 to 69 years were classified into six age groups according to five-year intervals. Three different strategies were adopted for each cohort: (1) no screening; (2) endoscopic screening with Lugol’s iodine staining with annual follow-up for low-grade intraepithelial neoplasia; and (3) endoscopic screening with Lugol’s iodine staining without follow-up. Quality-adjusted life-years (QALYs) indicated the effectiveness . The incremental cost-effectiveness ratio (ICER) was used as the evaluating indicator. Sensitivity analysis was performed to assess the robustness of the model. Results : Screening with follow-up was the undominated strategy, which saved USD 10942.57 and USD 6611.73 for individuals aged 40-44 and 45-49 years, respectively, per QALY gained. For those aged 50-69 years, the nonscreening scenarios were undominated. Screening without follow-up were extended dominated strategies. Compared to screening strategies without follow-up, all the follow-up strategies were found to be cost effective, with the ICER increasing from 299.57 USD/QALY for individuals 40-44 years to 1617.72 USD/QALY for individuals 65-69 years. Probabilistic sensitivity analysis supported the results of the base case analysis. Conclusions : EC screening with follow-up targeting individuals aged 40-49 years was the most cost-effective strategy.

Common genetic variants of TP53 and BRCA2 in esophageal cancer patients and healthy individuals from low and high risk areas of northern China

2003 ◽  
Vol 27 (2) ◽  
pp. 132-138 ◽  
Author(s):  
Nan Hu ◽  
Wen-Jun Li ◽  
Hua Su ◽  
Chaoyu Wang ◽  
A.M Goldstein ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Genetic Variants ◽  
Northern China ◽  
Healthy Individuals ◽  
Common Genetic Variants ◽  
Risk Areas
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