Comparative Validation of Three DNA Methylation Algorithms of Ageing and a Frailty Index in Relation to Mortality: Results From the ESTHER Cohort Study

2021 ◽  
Author(s):  
Xiangwei Li ◽  
Yan Zhang ◽  
Xīn Gào ◽  
Bernd Holleczek ◽  
Ben Schöttker ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cohort Study ◽  
Frailty Index ◽  
Comparative Validation

scholarly journals Comparative validation of three DNA methylation algorithms of ageing and a frailty index in relation to mortality: results from the ESTHER cohort study

EBioMedicine ◽  
2021 ◽  
Vol 74 ◽  
pp. 103686
Author(s):  
Xiangwei Li ◽  
Yan Zhang ◽  
Xīn Gào ◽  
Bernd Holleczek ◽  
Ben Schöttker ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cohort Study ◽  
Frailty Index ◽  
Comparative Validation

scholarly journals Children’s Greenness Exposure and IQ-Associated DNA Methylation: A Prospective Cohort Study

2021 ◽  
Vol 18 (14) ◽  
pp. 7429
Author(s):  
Kyung-Shin Lee ◽  
Yoon-Jung Choi ◽  
Jin-Woo Cho ◽  
Sung-Ji Moon ◽  
Youn-Hee Lim ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cohort Study ◽  
Literature Review ◽  
Cognitive Ability ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Association Studies ◽  
The Body ◽  
Genome Wide Association Studies ◽  
Regulatory Pathways

Epigenetics is known to be involved in regulatory pathways through which greenness exposure influences child development and health. We aimed to investigate the associations between residential surrounding greenness and DNA methylation changes in children, and further assessed the association between DNA methylation and children’s intelligence quotient (IQ) in a prospective cohort study. We identified cytosine-guanine dinucleotide sites (CpGs) associated with cognitive abilities from epigenome- and genome-wide association studies through a systematic literature review for candidate gene analysis. We estimated the residential surrounding greenness at age 2 using a geographic information system. DNA methylation was analyzed from whole blood using the HumanMethylationEPIC array in 59 children at age 2. We analyzed the association between greenness exposure and DNA methylation at age 2 at the selected CpGs using multivariable linear regression. We further investigated the relationship between DNA methylation and children’s IQ. We identified 8743 CpGs associated with cognitive ability based on the literature review. Among these CpGs, we found that 25 CpGs were significantly associated with greenness exposure at age 2, including cg26269038 (Bonferroni-corrected p ≤ 0.05) located in the body of SLC6A3, which encodes a dopamine transporter. DNA methylation at cg26269038 at age 2 was significantly associated with children’s performance IQ at age 6. Exposure to surrounding greenness was associated with cognitive ability-related DNA methylation changes, which was also associated with children’s IQ. Further studies are warranted to clarify the epigenetic pathways linking greenness exposure and neurocognitive function.

Use of the frailty index in evaluating the prognosis of older people in Beijing: A cohort study with an 8-year follow-up

2016 ◽  
Vol 64 ◽  
pp. 172-177 ◽  
Author(s):  
Lina Ma ◽  
Li Zhang ◽  
Zhe Tang ◽  
Fei Sun ◽  
Lijun Diao ◽  
...  
Keyword(s):  
Cohort Study ◽  
Older People ◽  
Frailty Index

scholarly journals Frailty Index and functional level upon admission predict hospital outcomes: an interRAI-based cohort study of older patients in post-acute care hospitals

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hanna Kerminen ◽  
Heini Huhtala ◽  
Pirkko Jäntti ◽  
Jaakko Valvanne ◽  
Esa Jämsen
Keyword(s):  
Cohort Study ◽  
Acute Care ◽  
Older Patients ◽  
Frailty Index ◽  
Acute Care Hospitals ◽  
Functional Level ◽  
Hospital Outcomes ◽  
Post Acute Care

scholarly journals The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards: a large cohort study

BMC Medicine ◽  
2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Xia Li ◽  
Alexander Ploner ◽  
Ida K. Karlsson ◽  
Xingrong Liu ◽  
Patrik K. E. Magnusson ◽  
...  
Keyword(s):  
Cohort Study ◽  
Frailty Index ◽  
Large Cohort ◽  
Specific Mortality ◽  
Large Cohort Study ◽  
Familial Effects

scholarly journals Design and protocol of the multimorbidity and mental health cohort study in frailty and aging (MiMiCS-FRAIL): unraveling the clinical and molecular associations between frailty, somatic disease burden and late life depression

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ivan Aprahamian ◽  
Ronei Luciano Mamoni ◽  
Nilva Karla Cervigne ◽  
Taize Machado Augusto ◽  
Carla Vasconcelos Romanini ◽  
...  
Keyword(s):  
Mental Health ◽  
Cohort Study ◽  
Hospital Admissions ◽  
Frailty Index ◽  
Late Life ◽  
Well Being ◽  
Adverse Outcomes ◽  
Pathophysiological Mechanism ◽  
Late Life Depression ◽  
Health Cohort Study

Abstract Background To explore the mutual relationship between multimorbidity, mental illness and frailty, we have set-up the Multimorbidity and Mental health Cohort Study in FRAILty and Aging (MiMiCS-FRAIL) cohort. At the population level, multimorbidity, frailty and late-life depression are associated with similar adverse outcomes (i.e. falls, disability, hospitalization, death), share the same risk factors, and partly overlap in their clinical presentation. Moreover, these three variables may share a common underlying pathophysiological mechanism like immune-metabolic dysregulation. The overall objectives of MiMiCS-FRAIL are 1) to explore (determinants of) the cross-sectional and longitudinal relationship between multimorbidity, depression, and frailty among non-demented geriatric outpatients; 2) to evaluate molecular levels of senoinflammation as a broad pathophysiological process underlying these conditions; and 3) to examine adverse outcomes of multimorbidity, frailty and depression and their interconnectedness. Methods MiMiCS-FRAIL is an ongoing observational cohort study of geriatric outpatients in Brazil, with an extensive baseline assessment and yearly follow-up assessments. Each assessment includes a comprehensive geriatric assessment to identify multimorbidity and geriatric syndromes, a structured psychiatric diagnostic interview and administration of the PHQ-9 to measure depression, and several frailty measures (FRAIL, Physical Phenotype criteria, 36-item Frailty Index). Fasten blood samples are collected at baseline to assess circulating inflammatory and anti-inflammatory cytokines, leukocytes' subpopulations, and to perform immune-metabolic-paired miRome analyses. The primary outcome is death and secondary outcomes are the number of falls, hospital admissions, functional ability, well-being, and dementia. Assuming a 5-year mortality rate between 25 and 40% and a hazard rate varying between 1.6 and 2.3 for the primary determinants require a sample size between 136 and 711 patients to detect a statistically significant effect with a power of 80% (beta = 0.2), an alpha of 5% (0.05), and an R2 between the predictor (death) and all covariates of 0.20. Local ethical board approved this study. Discussion Frailty might be hypothesized as a final common pathway by which many clinical conditions like depression and chronic diseases (multimorbidity) culminate in many adverse effects. The MiMiCS-FRAIL cohort will help us to understand the interrelationship between these variables, from a clinical perspective as well as their underlying molecular signature.

scholarly journals Regulating role of fetal thyroid hormones on placental mitochondrial DNA methylation: epidemiological evidence from the ENVIRONAGE birth cohort study

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Bram G. Janssen ◽  
Hyang-Min Byun ◽  
Harry A. Roels ◽  
Wilfried Gyselaers ◽  
Joris Penders ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Mitochondrial Dna ◽  
Cohort Study ◽  
Thyroid Hormones ◽  
Birth Cohort ◽  
Birth Cohort Study ◽  
Epidemiological Evidence ◽  
Fetal Thyroid
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