scholarly journals Design and protocol of the multimorbidity and mental health cohort study in frailty and aging (MiMiCS-FRAIL): unraveling the clinical and molecular associations between frailty, somatic disease burden and late life depression

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ivan Aprahamian ◽  
Ronei Luciano Mamoni ◽  
Nilva Karla Cervigne ◽  
Taize Machado Augusto ◽  
Carla Vasconcelos Romanini ◽  
...  
Keyword(s):  
Mental Health ◽  
Cohort Study ◽  
Hospital Admissions ◽  
Frailty Index ◽  
Late Life ◽  
Well Being ◽  
Adverse Outcomes ◽  
Pathophysiological Mechanism ◽  
Late Life Depression ◽  
Health Cohort Study

Abstract Background To explore the mutual relationship between multimorbidity, mental illness and frailty, we have set-up the Multimorbidity and Mental health Cohort Study in FRAILty and Aging (MiMiCS-FRAIL) cohort. At the population level, multimorbidity, frailty and late-life depression are associated with similar adverse outcomes (i.e. falls, disability, hospitalization, death), share the same risk factors, and partly overlap in their clinical presentation. Moreover, these three variables may share a common underlying pathophysiological mechanism like immune-metabolic dysregulation. The overall objectives of MiMiCS-FRAIL are 1) to explore (determinants of) the cross-sectional and longitudinal relationship between multimorbidity, depression, and frailty among non-demented geriatric outpatients; 2) to evaluate molecular levels of senoinflammation as a broad pathophysiological process underlying these conditions; and 3) to examine adverse outcomes of multimorbidity, frailty and depression and their interconnectedness. Methods MiMiCS-FRAIL is an ongoing observational cohort study of geriatric outpatients in Brazil, with an extensive baseline assessment and yearly follow-up assessments. Each assessment includes a comprehensive geriatric assessment to identify multimorbidity and geriatric syndromes, a structured psychiatric diagnostic interview and administration of the PHQ-9 to measure depression, and several frailty measures (FRAIL, Physical Phenotype criteria, 36-item Frailty Index). Fasten blood samples are collected at baseline to assess circulating inflammatory and anti-inflammatory cytokines, leukocytes' subpopulations, and to perform immune-metabolic-paired miRome analyses. The primary outcome is death and secondary outcomes are the number of falls, hospital admissions, functional ability, well-being, and dementia. Assuming a 5-year mortality rate between 25 and 40% and a hazard rate varying between 1.6 and 2.3 for the primary determinants require a sample size between 136 and 711 patients to detect a statistically significant effect with a power of 80% (beta = 0.2), an alpha of 5% (0.05), and an R2 between the predictor (death) and all covariates of 0.20. Local ethical board approved this study. Discussion Frailty might be hypothesized as a final common pathway by which many clinical conditions like depression and chronic diseases (multimorbidity) culminate in many adverse effects. The MiMiCS-FRAIL cohort will help us to understand the interrelationship between these variables, from a clinical perspective as well as their underlying molecular signature.

scholarly journals Military spouses with deployed partners are at greater risk of poor perinatal mental health: a scoping review

2019 ◽  
Vol 165 (5) ◽  
pp. 363-370 ◽  
Author(s):  
Lauren Rose Godier-McBard ◽  
L Ibbitson ◽  
C Hooks ◽  
M Fossey
Keyword(s):  
Mental Health ◽  
Social Support ◽  
Scoping Review ◽  
Healthcare Providers ◽  
Well Being ◽  
Perinatal Period ◽  
Poor Mental Health ◽  
Adverse Outcomes ◽  
Military Spouses ◽  
Perinatal Mental Health

BackgroundPoor mental health in the perinatal period is associated with a number of adverse outcomes for the individual and the wider family. The unique circumstances in which military spouses/partners live may leave them particularly vulnerable to developing perinatal mental health (PMH) problems.MethodsA scoping review was carried out to review the literature pertaining to PMH in military spouses/partners using the methodology outlined by Arksey and O’Malley (2005). Databases searched included EBSCO, Gale Cengage Academic OneFile, ProQuest and SAGE.ResultsThirteen papers fulfilled the inclusion criteria, all from the USA, which looked a PMH or well-being in military spouses. There was a strong focus on spousal deployment as a risk factor for depressive symptoms and psychological stress during the perinatal period. Other risk factors included a lack of social/emotional support and increased family-related stressors. Interventions for pregnant military spouses included those that help them develop internal coping strategies and external social support.ConclusionsUS literature suggests that military spouses are particularly at risk of PMH problems during deployment of their serving partner and highlights the protective nature of social support during this time. Further consideration needs to be made to apply the findings to UK military spouses/partners due to differences in the structure and nature of the UK and US military and healthcare models. Further UK research is needed, which would provide military and healthcare providers with an understanding of the needs of this population allowing effective planning and strategies to be commissioned and implemented.

scholarly journals Cohort profile: the Men and Parenting Pathways (MAPP) Study: a longitudinal Australian cohort study of men’s mental health and well-being at the normative age for first-time fatherhood

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e047909
Author(s):  
Jacqui A Macdonald ◽  
Lauren M Francis ◽  
Helen Skouteris ◽  
George J Youssef ◽  
Liam G Graeme ◽  
...  
Keyword(s):  
Mental Health ◽  
Cohort Study ◽  
Data Collection ◽  
Online Survey ◽  
Sleep Problems ◽  
Meta Analysis ◽  
Well Being ◽  
Work And Family ◽  
Depressive Symptom Severity ◽  
Health And Well Being

PurposeThe Men and Parenting Pathways (MAPP) Study is a prospective investigation of men’s mental health and well-being across the normative age for transitioning to fatherhood. This includes trajectories and outcomes for men who do and do not become fathers across five annual waves of the study.ParticipantsAustralian resident, English-speaking men aged 28–32 years at baseline were eligible. Recruitment was over a 2-year period (2015–2017) via social and traditional media and through engagement with study partners. Eight hundred and eighteen eligible men consented to participate. Of these, 664 men completed the first online survey of whom 608 consented to ongoing participation. Of the ongoing sample, 83% have participated in at least two of the first three annual online surveys.Findings to dateThree waves of data collection are complete. The first longitudinal analysis of MAPP data, published in 2020, identified five profiles that characterise men’s patterns of depressive symptom severity and presentations of anger. Profiles indicating pronounced anger and depressive symptoms were associated with fathers’ lack of perceived social support, and problems with coparenting and bonding with infants. In a second study, MAPP data were combined with three other Australian cohorts in a meta-analysis of associations between fathers’ self-reported sleep problems up to 3 years postpartum and symptoms of depression, anxiety and stress. Adjusted meta-analytic associations between paternal sleep and mental health risk ranged from 0.25 to 0.37.Future plansMAPP is an ongoing cohort study. Waves 4 and 5 data will be ready for analyses at the end of 2021. Future investigations will include crossed-lagged and trajectory analyses that assess inter-relatedness and changing social networks, mental health, work and family life. A nested study of COVID-19 pandemic-related mental health and coping will add two further waves of data collection in a subsample of MAPP participants.

An examination of the quality of late-life depression websites on the Internet (Preprint)

2022 ◽  
Author(s):  
Teaghan Pryor ◽  
Kristin Reynolds ◽  
Paige Kirby ◽  
Matthew Bernstein
Keyword(s):  
Mental Health ◽  
Older Adults ◽  
Health Literacy ◽  
Health Information ◽  
Mental Health Literacy ◽  
Late Life ◽  
The Internet ◽  
Late Life Depression ◽  
Mental Health Information

BACKGROUND The Internet can increase the accessibility of mental health information and improve the mental health literacy of older adults. The quality of mental health information on the Internet can be inaccurate or biased, leading to misinformation OBJECTIVE This study’s objectives were to evaluate the quality, usability, and readability of websites providing information concerning depression in later life. METHODS Websites were identified through a Google search, and evaluated by assessing quality (DISCERN), usability (Patient Education Materials Assessment Tool; PEMAT) and readability (Simple Measure of Gobbledygook; SMOG). RESULTS The overall quality of late-life depression websites (N = 19) was moderate, usability was low, and readability was poor. No significant relationship was found between quality and readability of websites. CONCLUSIONS Websites can be improved by enhancing information quality, usability, and readability related to late-life depression. The use of high-quality websites may improve mental health literacy and shared treatment decision-making for older adults.

Late-Life Depression and Mental Health Services in Primary Care

2002 ◽  
Vol 15 (3) ◽  
pp. 134-140 ◽  
Author(s):  
Deborah Banazak Wagenaar ◽  
Maureen A. Mickus ◽  
Kris A. Gaumer ◽  
Christopher C. Colenda
Keyword(s):  
Mental Health ◽  
Primary Care ◽  
Mental Health Services ◽  
Health Services ◽  
Late Life ◽  
Late Life Depression

scholarly journals THE EFFECT OF RETIREMENT TIMING ON HEALTH AND WELL-BEING OF HISPANICS COMPARED TO NON-HISPANIC WHITES LIVING IN THE U.S.

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S130-S130
Author(s):  
Antonia E Diaz-Valdes Iriarte
Keyword(s):  
Mental Health ◽  
Cultural Sensitivity ◽  
Late Life ◽  
Well Being ◽  
Subjective Health ◽  
Productive Aging ◽  
Retirement Age ◽  
Foreign Born ◽  
Retirement Timing ◽  
Health And Well Being

Abstract In the context of an aging society, where the proportion of older adults is rapidly increasing, ensuring healthier longer lives is key for individuals, families, policy makers and the population as a whole. In this context the productive aging framework has gained increased importance. There is evidence showing that engagement is related to late-life well-being and health (i.e., Hinterlong, 2006; Everard et al, 2000; Rozario et al, 2004; Matz-Costa et al, 2012). However, the productive aging framework lacks cultural sensitivity and evidence about the association between the effect of retirement on health and well-being in late-life is mixed. The current study seeks to contribute to this gap by exploring the consequences of the discrepancies between planned and actual retirement age on subjective health and well-being, comparing Hispanics and non-Hispanic Whites. A series of regression models were conducted to explore the effect of the discrepancy between planned and actual retirement age on retirement satisfaction, self-rated health and mental health (CESD). Results indicates that native born Hispanics presented more differences when compared to foreign born Hispanic than non-Hispanic Whites, which could indicate the effect of acculturation and its fading effect on cultural attitudes, such as familismo. Hispanic tend to have higher retirement satisfaction than non-Hispanics which is aligned with the happiness paradox found by Calvo and collagues (2017). Additionally, SES has a significant effect on health for non-Hispanic Whites but not among Hispanics. Finally, retirement timing predicted mental health among foreign born Hispanic but among native born Hispanics and non-Hispanic Whites.

scholarly journals Determinants for undetected dementia and late-life depression

2013 ◽  
Vol 203 (3) ◽  
pp. 203-208 ◽  
Author(s):  
Ruoling Chen ◽  
Zhi Hu ◽  
Ruo-Li Chen ◽  
Ying Ma ◽  
Dongmei Zhang ◽  
...  
Keyword(s):  
Mental Health ◽  
Older Adults ◽  
Low Income ◽  
Late Life ◽  
Female Gender ◽  
Service Development ◽  
Late Life Depression ◽  
History Of ◽  
High Risk Populations ◽  
Low Levels

BackgroundDeterminants for undetected dementia and late-life depression have been not well studied.AimsTo investigate risk factors for undetected dementia and depression in older communities.MethodUsing the method of the 10/66 algorithm, we interviewed a random sample of 7072 participants aged ⩽60 years in six provinces of China during 2007–2011. We documented doctor-diagnosed dementia and depression in the interview. Using the validated 10/66 algorithm we diagnosed dementia (n= 359) and depression (n= 328).ResultsWe found that 93.1% of dementia and 92.5% of depression was undetected. Both undetected dementia and depression were significantly associated with low levels of education and occupation, and living in a rural area. The risk of undetected dementia was also associated with ‘help available when needed‘, and inversely, with a family history of mental illness and having functional impairment. Undetected depression was significantly related to female gender, low income, having more children and inversely with having heart disease.ConclusionsOlder adults in China have high levels of undetected dementia and depression. General socioeconomic improvement, associated with mental health education, targeting high-risk populations are likely to increase detection of dementia and depression in older adults, providing a backdrop for culturally acceptable service development.

scholarly journals Could listening to music during pregnancy be protective against postnatal depression and poor wellbeing post birth? Longitudinal associations from a preliminary prospective cohort study

BMJ Open ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. e021251 ◽  
Author(s):  
Daisy Fancourt ◽  
Rosie Perkins
Keyword(s):  
Mental Health ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Postnatal Depression ◽  
Prospective Cohort ◽  
Depression Scale ◽  
Well Being ◽  
Secondary Outcome ◽  
Confounding Variables ◽  
Mental Well Being

ObjectivesThis study explored whether listening to music during pregnancy is longitudinally associated with lower symptoms of postnatal depression and higher well-being in mothers post birth.DesignProspective cohort study.ParticipantsWe analysed data from 395 new mothers aged over 18 who provided data in the third trimester of pregnancy and 3 and 6 months later (0–3 and 4–6 months post birth).Primary and secondary outcome measuresPostnatal depression was measured using the Edinburgh Postnatal Depression Scale, and well-being was measured using the Short Warwick-Edinburgh Mental Well-being Scale. Our exposure was listening to music and was categorised as ‘rarely; a couple of times a week; every day <1 hour; every day 1–2 hours; every day 3–5 hours; every day 5+hrs’. Multivariable linear regression analyses were carried out to explore the effects of listening to music during pregnancy on depression and well-being post birth, adjusted for baseline mental health and potential confounding variables.ResultsListening during pregnancy is associated with higher levels of well-being (β=0.40, SE=0.15, 95% CI 0.10 to 0.70) and reduced symptoms of postnatal depression (β=−0.39, SE=0.19, 95% CI −0.76 to −0.03) in the first 3 months post birth. However, effects disappear by 4–6 months post birth. These results appear to be particularly found among women with lower levels of well-being and high levels of depression at baseline.ConclusionsListening to music could be recommended as a way of supporting mental health and well-being in pregnant women, in particular those who demonstrate low well-being or symptoms of postnatal depression.

Sign in / Sign up

Export Citation Format

Share Document