Sfgl2-Treg Positive Feedback Pathway Protects Against Atherosclerosis

2021 ◽  
Author(s):  
Tianhui An ◽  
You Ya ◽  
Mengyuan Guo ◽  
Cheng Fan ◽  
Shiyuan Huang ◽  
...  
Keyword(s):  
Positive Feedback ◽  
Feedback Pathway

A positive feedback pathway of estrogen biosynthesis in breast cancer cells is contained by resveratrol

Toxicology ◽  
2008 ◽  
Vol 248 (2-3) ◽  
pp. 130-135 ◽  
Author(s):  
Yun Wang ◽  
Lan Ye ◽  
Lai K. Leung
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Positive Feedback ◽  
Breast Cancer Cells ◽  
Estrogen Biosynthesis ◽  
Feedback Pathway

scholarly journals BMP4 Signaling Activates the Wnt-Lin28A-Blimp1-Wnt Positive Feedback Pathway to Promote Primordial Germ Cell Formation via Altering H3K4me2

2020 ◽  
Author(s):  
Qisheng Zuo ◽  
Yani Zhang ◽  
Guohong Chen ◽  
Bichun Li
Keyword(s):  
Wnt Signaling ◽  
Positive Feedback ◽  
Primordial Germ Cells ◽  
Primordial Germ Cell ◽  
Cell Formation ◽  
Feedback System ◽  
Developmental Characteristics ◽  
Technical Basis ◽  
Feedback Pathway

Abstract (Background) The unique developmental characteristics of bird primordial germ cells (PGC) have enabled genetic engineering–based breeding and restoration of endangered birds via transplantation in vitro. However, the limited number of PGC has limited their application. Thus, there is an urgent need to elucidate the mechanism of PGC formation in vitro to enhance its efficiency. (Results) Here, we confirmed that activation of BMP4 and Wnt signaling (Wnt5A/β-catenin/TCF7L2) is critical for PGC formation via RNA-seq (ESCs, PGC and SSCs) and in vitro induction models. Wnt signaling activated via BMP4 in turn activates transcription of Lin28A by inducing β-catenin to compete with LSD1 for binding to the transcription factor TCF7L2, causing LSD1 to dissociate from the Lin28A promoter and enhanced H3K4me2 methylation in this region. Lin28A promotes PGC formation by inhibiting gga-let7a-3p maturation to initiate Blimp1 expression. Interestingly, expression of Blimp1 helped sustain Wnt5A expression by preventing LSD1 binding to the Wnt5A promoter. We thus elucidated a positive feedback pathway involving Wnt-Lin28-Blimp1-Wnt, with BMP4 functioning as an activator that ensures PGC formation. (Conclusion) In summary, our study clarified the molecular mechanism by which BMP4 and Wnt signaling regulate PGC formation via a positive feedback system. Our data provide both a theoretical and technical basis for studies aimed at enhancing the generation of PGC in vitro.

scholarly journals HMGA1-TRIP13 Axis Promotes Stemness and Epithelial Mesenchymal Transition of Perihilar Cholangiocarcinoma in a Positive Feedback Loop Dependent on C-Myc

2021 ◽  
Author(s):  
Zhipeng Li ◽  
Jialiang Liu ◽  
Tianli Chen ◽  
Rongqi Sun ◽  
Zengli Liu ◽  
...  
Keyword(s):  
Positive Feedback ◽  
Epithelial Mesenchymal Transition ◽  
Prognostic Significance ◽  
Radical Resection ◽  
Perihilar Cholangiocarcinoma ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Dismal Prognosis ◽  
Feedback Pathway

Abstract Background: Cholangiocarcinoma is a highly malignant cancer with very dismal prognosis. Perihilar cholangiocarcinoma(pCCA) accounts for more than 50% of all cholangiocarcinoma and is well-characterized for its low rate of radical resection. Effects of radiotherapy and chemotherapy of pCCA are very limited. Methods: Here we screened potential biomarkers of pCCA with transcriptome sequencing and evaluated the prognostic significance of HMGA1 in a large cohort pCCA consisting of 106 patients. With bioinformatics and in vitro/vivo experiments, we showed that HMGA1 induced tumor cell stemness and epithelial-mesenchymal-transition(EMT), and thus facilitated proliferation, migration and invasion by promoting TRIP13 transcription. Moreover, TRIP13 was also an unfavorable prognostic biomarker of pCCA, and double high expression of HMGA1/TRIP13 could predict prognosis more sensitively. TRIP13 promoted pCCA progression by suppressing FBXW7 transcription and stabilizing c-Myc. c-Myc in turn induced the transcription and expression of both HMGA1 and TRIP13, indicating that HMGA-TRIP13 axis facilitated pCCA stemness and EMT in a positive feedback pathway. Conclusions: HMGA1 and TRIP13 were unfavorable prognostic biomarkers of pCCA. HMGA1 enhanced pCCA proliferation, migration, invasion, stemness and EMT, by inducing TRIP13 expression, suppressing FBXW7 expression and stabilizing c-Myc. Moreover, c-Myc can induce the transcription of HMGA1 and TRIP13, suggesting that HMGA-TRIP13 axis promoted EMT and stemness in a positive feedback pathway dependent on c-Myc.

scholarly journals Collagen-induced Platelet Shape Change Is Not Affected by Positive Feedback Pathway Inhibitors and cAMP-elevating Agents

2004 ◽  
Vol 280 (8) ◽  
pp. 6504-6510 ◽  
Author(s):  
Silvia Riondino ◽  
Lavinia V. Lotti ◽  
Lucia Cutini ◽  
Fabio M. Pulcinelli
Keyword(s):  
Positive Feedback ◽  
Shape Change ◽  
Feedback Pathway ◽  
Platelet Shape

scholarly journals HMGA1-TRIP13 axis promotes stemness and epithelial mesenchymal transition of perihilar cholangiocarcinoma in a positive feedback loop dependent on c-Myc

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Zhipeng Li ◽  
Jialiang Liu ◽  
Tianli Chen ◽  
Rongqi Sun ◽  
Zengli Liu ◽  
...  
Keyword(s):  
Positive Feedback ◽  
Epithelial Mesenchymal Transition ◽  
Prognostic Significance ◽  
Radical Resection ◽  
Perihilar Cholangiocarcinoma ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Dismal Prognosis ◽  
Feedback Pathway

Abstract Background Cholangiocarcinoma is a highly malignant cancer with very dismal prognosis. Perihilar cholangiocarcinoma(pCCA) accounts for more than 50% of all cholangiocarcinoma and is well-characterized for its low rate of radical resection. Effects of radiotherapy and chemotherapy of pCCA are very limited. Methods Here we screened potential biomarkers of pCCA with transcriptome sequencing and evaluated the prognostic significance of HMGA1 in a large cohort pCCA consisting of 106 patients. With bioinformatics and in vitro/vivo experiments, we showed that HMGA1 induced tumor cell stemness and epithelial-mesenchymal-transition (EMT), and thus facilitated proliferation, migration and invasion by promoting TRIP13 transcription. Moreover, TRIP13 was also an unfavorable prognostic biomarker of pCCA, and double high expression of HMGA1/TRIP13 could predict prognosis more sensitively. TRIP13 promoted pCCA progression by suppressing FBXW7 transcription and stabilizing c-Myc. c-Myc in turn induced the transcription and expression of both HMGA1 and TRIP13, indicating that HMGA-TRIP13 axis facilitated pCCA stemness and EMT in a positive feedback pathway. Conclusions HMGA1 and TRIP13 were unfavorable prognostic biomarkers of pCCA. HMGA1 enhanced pCCA proliferation, migration, invasion, stemness and EMT, by inducing TRIP13 expression, suppressing FBXW7 expression and stabilizing c-Myc. Moreover, c-Myc can induce the transcription of HMGA1 and TRIP13, suggesting that HMGA-TRIP13 axis promoted EMT and stemness in a positive feedback pathway dependent on c-Myc.

scholarly journals BMP4 activates the Wnt-Lin28A-Blimp1-Wnt pathway to promote primordial germ cells formation via altering H3K4me2

2020 ◽  
pp. jcs.249375
Author(s):  
Qisheng Zuo ◽  
Kai Jin ◽  
Man Wang ◽  
Yani Zhang ◽  
Guohong Chen ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Formation Mechanism ◽  
Germ Cells ◽  
Positive Feedback ◽  
Gene Editing ◽  
Wnt Pathway ◽  
Primordial Germ Cells ◽  
Bird Species ◽  
Developmental Characteristics ◽  
Feedback Pathway

The unique developmental characteristics of Chicken primordial germ cells (PGCs) enable it to be used in recovery of endangered bird species, gene editing and the generation of transgenic birds, but the limited number of PGCs greatly limits its application. Studies have shown that the formation of mammalian PGCs is induced by BMP4 signal, but the formation mechanism of chicken PGCs has not been determined. Here, we confirmed that Wnt signaling activated via BMP4 activates transcription of Lin28A by inducing β-catenin to compete with LSD1 for binding to TCF7L2, causing LSD1 to dissociate from the Lin28A promoter and enhanced H3K4me2 methylation in this region. Lin28A promotes PGCs formation by inhibiting gga-let7a-3p maturation to initiate Blimp1 expression. Interestingly, expression of Blimp1 helped sustain Wnt5A expression by preventing LSD1 binding to the Wnt5A promoter. We thus elucidated a positive feedback pathway involving Wnt-Lin28-Blimp1-Wnt, that ensures PGCs formation. In summary, our data provide a new insights in the development of PGCs in chickens.

cAMP Induces Syncytialization of Cytotrophoblastic Cells Via a CRH Positive Feedback Pathway.

2010 ◽  
pp. P3-360-P3-360
Author(s):  
YX Chen ◽  
M Allars ◽  
C Abou-Seif ◽  
RC Nicholson
Keyword(s):  
Positive Feedback ◽  
Feedback Pathway ◽  
Cytotrophoblastic Cells

scholarly journals ERO1L promotes IL6/sIL6R signaling and regulates MUC16 expression to promote CA125 secretion and the metastasis of lung cancer cells

2020 ◽  
Vol 11 (10) ◽  
Author(s):  
Yuanyuan lei ◽  
Ruochuan Zang ◽  
Zhiliang Lu ◽  
Guochao Zhang ◽  
Jianbing Huang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Signaling Pathway ◽  
Positive Feedback ◽  
Disulfide Bonds ◽  
Feedback Loop ◽  
Research Subject ◽  
Lung Cancer Cell ◽  
C Terminus ◽  
Feedback Pathway ◽  
Cell Supernatant

Abstract The abnormal secretion of CA125, a classic tumor marker, is usually related to a poor prognosis in various tumors. Thus, this study aimed to explore the potential mechanisms that promote CA125 secretion in lung cancer. By querying the database, the gene endoplasmic reticulum oxidoreductase 1L (ERO1L) was identified and chosen as the research subject. The antibody chips were used to screen the lung cancer cell supernatant and found that the most obvious secreted protein was CA125. ERO1L was found to promote the secretion of IL6R by affecting the formation of disulfide bonds. IL6R bound to IL6 and triggered the activation of the NF-κB signaling pathway. Then, NF-κB bound to the promoter of MUC16, resulting in overexpression of MUC16. The extracellular segment of MUC16 was cleaved to form CA125, while the C terminus of MUC16 promoted the EMT phenotype and the release of IL6, forming a positive feedback pathway. In conclusion, ERO1L might affect the secretion of CA125 through the IL6 signaling pathway and form a positive feedback loop to further promote the development of lung cancer. This might expand the application scope of CA125 in lung cancer.

Social anxiety disorder and memory for positive feedback.

2019 ◽  
Vol 128 (3) ◽  
pp. 228-233 ◽  
Author(s):  
Brianne L. Glazier ◽  
Lynn E. Alden
Keyword(s):  
Anxiety Disorder ◽  
Social Anxiety ◽  
Social Anxiety Disorder ◽  
Positive Feedback
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