Tularemia Seroprevalence in Humans in the Region of the Hittite-Arzawa War (Inner Aegean Region), Where the First Biological Weapon Was Used 3300 Years Ago

2021 ◽  
Author(s):  
İSMAİL DAVARCI ◽  
Canan ERYILDIZ ◽  
Duygu PERÇİN-RENDERS ◽  
Ufuk BERBEROĞLU ◽  
Şaban GÜRCAN

Author(s):  
David Kaniewski ◽  
Elise Van Campo

The collapse of Bronze Age civilizations in the Aegean, southwest Asia, and the eastern Mediterranean 3200 years ago remains a persistent riddle in Eastern Mediterranean archaeology, as both archaeologists and historians believe the event was violent, sudden, and culturally disruptive. In the first phase of this period, many cities between Pylos and Gaza were destroyed violently and often left unoccupied thereafter. The palace economy of the Aegean Region and Anatolia that characterized the Late Bronze Age was replaced by the isolated village cultures of the Dark Ages. Earthquakes, attacks of the Sea Peoples, and socio-political unrest are among the most frequently suggested causes for this phenomenon. However, while climate change has long been considered a potential prime factor in this crisis, only recent studies have pinpointed the megadrought behind the collapse. An abrupt climate shift seems to have caused, or hastened, the fall of the Late Bronze Age world by sparking political and economic turmoil, migrations, and famines. The entirety of the megadrought’s effects terminated the Late Bronze Age in the eastern Mediterranean.



Author(s):  
Nicholas Evans ◽  
Thomas Inglesby

This chapter introduces ethical issues that arise in the context of biosecurity: policies and actions intended to prevent the development or emergence, or mitigate the consequences, of serious biological threats. These threats could include deliberate biological weapon attacks (bioterrorism), pandemics, emerging infectious diseases, or major laboratory accidents. The basic values that underpin these public health concerns are first introduced. Ethical issues that arise before, during, and following a biosecurity crisis are then examined, including issues of resource allocation, dual-use research, and the possibility of quarantine. Their resolution requires trade-offs among different ethical values, including utility, fairness, and liberty.





2021 ◽  
pp. 1-8
Author(s):  
Laurent Tatu ◽  
Jean-Paul Feugeas

Botulinum toxin is nowadays approved as an effective medication for various neurological disorders. The extreme toxicity of this toxin-inducing botulism, a severe lethal muscle-paralyzing illness, has been well known since the seminal works of the end of the 19th century. Because of this toxicity, botulinum toxin was one of the first agents to be considered for use as a biological weapon. The Second World War was a crucial period for the first attempts to weaponize this toxin even if many unknown factors about botulinum toxin still existed at the outbreak of the war. Using documents from the British National Archives and other published sources, we discuss the main points of the attempts to weaponize this toxin in German and Allied armies. During WW2, Allied intelligence services regularly reported a major German threat related to the potential use of botulinum toxin as a biological weapon, especially during the preparation of <i>Operation Overlord</i>, the Allied invasion to liberate Europe. All these reports would ultimately prove to be inaccurate: botulinum toxin was not part of the German military arsenal even if some German scientists tried to use the results of the French pre-war military research. Misinformation spread by intelligence services stimulated military research at Porton Down facilities in England and at Camp Detrick in the USA. These studies led to a succession of failures and myths about the weaponization of botulinum toxin. Nevertheless, major progress (purification, toxoid) arose from the military research, providing useful data for the first steps of the therapeutic use of botulinum toxin in the post-war years.



2020 ◽  
Vol 12 (24) ◽  
pp. 10420
Author(s):  
Ioannis Chatziioannou ◽  
Efthimios Bakogiannis ◽  
Charalampos Kyriakidis ◽  
Luis Alvarez-Icaza

One of the biggest challenges of our time is climate change. Every day, at different places of the world, the planet sends alarming messages about the enormous transformations it is experiencing due to human-based activities. The latter are responsible for changing weather patterns that threaten food production, energy production and energy consumption, the desertification of land, the displacement of people and animals because of food and water shortages due to the reductions in rainfall, natural disasters and rising sea levels. The effects of climate change affect us all, and if drastic measures are not considered in a timely manner, it will be more difficult and costly to adapt to the aforementioned effects in the future. Considering this context, the aim of this work is to implement a prospective study/structural analysis to the identified sectors of a regional plan of adaptation to climate change so as to promote the resilience of the region against the negative phenomena generated by the climate crisis. This was achieved in two steps: first, we identified the relationships between the strategic sectors of the plan and organized them in order of importance. Second, we assessed the effectiveness of several public policies oriented towards a city’s resilience according to their impact upon the strategic sectors of the plan and the co-benefits generated by their implementation for society. The results highlight that the most essential sectors for the mitigation of climate change are flood risk management, built environment, forest ecosystem management, human health, tourism and rise in sea level. As a consequence, the most important measures for the resilience of the North Aegean Region against climate change are the ones related to the preparation of strategic master plans for flood protection projects.





2017 ◽  
Vol 24 (2) ◽  
pp. 239-249 ◽  
Author(s):  
Ülker Güner Bacanli
Keyword(s):  


2000 ◽  
Vol 95 ◽  
pp. 207-217 ◽  
Author(s):  
Helen Mangou ◽  
Panayiotis V. Ioannou

Seven bun type, one slab type, and 44 oxhide type Late Bronze Age ingots found in the Aegean region, Crete and Mainland Greece have been analysed for their chemical content (twelve elements) by atomic absorption spectroscopy. The results show that the ingots contain variable amounts of oxygen as copper(I) oxide. The oxhide ingots are made of purer copper, the bun type are of relatively pure copper and bronze, while the slab type is bronze. The oxhide ingots from Crete may have a different origin from those found in the Aegean and in Mainland Greece because they have a different chemical composition. The metallographic examination of twenty ingots, three of bun and seventeen of oxhide type, revealed that they have been cast in open moulds, followed by slow cooling. Microanalyses of inclusions in fifteen ingots revealed the presence of copper(I) sulphide, copper(I) oxide, copper-iron and copper-iron-sulphur and their origin is discussed. Hardness measurements on fourteen ingots of various types revealed that they are somewhat harder for a cast object than control alloys and likely explanations are given.



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