Evidence Synthesis Evaluating Body Weight Gain Among People Treating HIV with Antiretroviral Therapy - a Systematic Literature Review and Network Meta-Analysis

2021 ◽  
Author(s):  
Steve Kanters ◽  
Francoise Renaud ◽  
Ajay Rangaraj ◽  
Kenneth Zhang ◽  
Eve Limbrick-Oldfield ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Antiretroviral Therapy ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Body Weight Gain ◽  
Evidence Synthesis ◽  
Meta Analysis

scholarly journals Lurasidone compared to other atypical antipsychotic monotherapies for adolescent schizophrenia: a systematic literature review and network meta-analysis

2019 ◽  
Vol 29 (9) ◽  
pp. 1195-1205
Author(s):  
Celso Arango ◽  
Daisy Ng-Mak ◽  
Elaine Finn ◽  
Aidan Byrne ◽  
Antony Loebel
Keyword(s):  
Weight Gain ◽  
Literature Review ◽  
Atypical Antipsychotic ◽  
Systematic Literature Review ◽  
Atypical Antipsychotics ◽  
Meta Analysis ◽  
Similar Efficacy ◽  
Binary Outcomes ◽  
Schizophrenia Spectrum Disorders ◽  
Credible Intervals

AbstractThis network meta-analysis assessed the efficacy and tolerability of lurasidone versus other oral atypical antipsychotic monotherapies in adolescent schizophrenia. A systematic literature review identified 13 randomized controlled trials of antipsychotics in adolescents with schizophrenia-spectrum disorders. A Bayesian network meta-analysis compared lurasidone to aripiprazole, asenapine, clozapine, olanzapine, paliperidone extended-release (ER), quetiapine, risperidone, and ziprasidone. Outcomes included Positive and Negative Syndrome Scale (PANSS), Clinical Global Impressions-Severity (CGI-S), weight gain, all-cause discontinuation, extrapyramidal symptoms (EPS), and akathisia. Results were reported as median differences for continuous outcomes and odds ratios (ORs) for binary outcomes, along with 95% credible intervals (95% CrI). Lurasidone was significantly more efficacious than placebo on the PANSS (− 7.95, 95% CrI − 11.76 to − 4.16) and CGI-S (− 0.44, 95% CrI − 0.67 to − 0.22) scores. Lurasidone was associated with similar weight gain to placebo and statistically significantly less weight gain versus olanzapine (− 3.62 kg, 95% CrI − 4.84 kg to − 2.41 kg), quetiapine (− 2.13 kg, 95% CrI − 3.20 kg to − 1.08 kg), risperidone (− 1.16 kg, 95% CrI − 2.14 kg to − 0.17 kg), asenapine (− 0.98 kg, 95% CrI − 1.71 kg to − 0.24 kg), and paliperidone ER (− 0.85 kg, 95% CrI − 1.57 kg to − 0.14 kg). The odds of all-cause discontinuation were significantly lower for lurasidone than aripiprazole (OR = 0.28, 95% CrI 0.10–0.76) and paliperidone ER (OR = 0.25, 95% CrI 0.08–0.81) and comparable to other antipsychotics. Rates of EPS and akathisia were similar for lurasidone and other atypical antipsychotics. In this network meta-analysis of atypical antipsychotics in adolescent schizophrenia, lurasidone was associated with similar efficacy, less weight gain, and lower risk of all-cause discontinuation compared to other oral atypical antipsychotics.

scholarly journals Genes associated with body weight gain and feed intake identified by meta-analysis of the mesenteric fat from crossbred beef steers

PLoS ONE ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. e0227154
Author(s):  
Amanda K. Lindholm-Perry ◽  
Harvey C. Freetly ◽  
William T. Oliver ◽  
Lea A. Rempel ◽  
Brittney N. Keel
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Feed Intake ◽  
Body Weight Gain ◽  
Meta Analysis ◽  
Beef Steers ◽  
Mesenteric Fat

Body weight gain and risk of colorectal cancer: a systematic review and meta-analysis of observational studies

2015 ◽  
Vol 16 (7) ◽  
pp. 607-619 ◽  
Author(s):  
S. Schlesinger ◽  
W. Lieb ◽  
M. Koch ◽  
V. Fedirko ◽  
C. C. Dahm ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Body Weight ◽  
Weight Gain ◽  
Observational Studies ◽  
Body Weight Gain ◽  
Meta Analysis

scholarly journals Weight Gain Associated with COVID-19 Lockdown in Children and Adolescents: A Systematic Review and Meta-Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3668
Author(s):  
Tu-Hsuan Chang ◽  
Yu-Chin Chen ◽  
Wei-Yu Chen ◽  
Chun-Yu Chen ◽  
Wei-Yun Hsu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Body Weight ◽  
Weight Gain ◽  
Children And Adolescents ◽  
Body Weight Gain ◽  
Meta Analysis ◽  
School Age Children ◽  
Cochrane Library ◽  
The Cochrane Library ◽  
The Impact

Background: Lockdown is an effective nonpharmaceutical intervention to reduce coronavirus disease 2019 (COVID-19) transmission, but it restricts daily activity. We aimed to investigate the impact of lockdown on pediatric body weight and body mass index (BMI). Methods: The systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement. Four online databases (EMBASE, Medline, the Cochrane Library and CINAHL) were searched. Results: The pooled results showed that lockdown was associated with significant body weight gain (MD 2.67, 95% CI 2.12–3.23; p < 0.00001). The BMI of children with comorbidities or obesity did not change significantly. The BMI of general population was significantly higher during lockdown than before the pandemic (MD 0.94, 95% CI 0.32–1.56; p = 0.003). However, heterogeneity was high (I2 = 84%). Among changes in weight classification, increases in the rates of obesity (OR 1.23, 95% CI 1.10–1.37; p = 0.0002) and overweight (OR 1.17, 95% CI 1.06–1.29; p = 0.001) were reported. Conclusions: Our meta-analysis showed significant increases in body weight and BMI during lockdown among school-age children and adolescents. The prevalence of obesity and overweight also increased. The COVID-19 pandemic worsened the burden of childhood obesity.

scholarly journals Antipsychotics result in more weight gain in antipsychotic naive patients than in patients after antipsychotic switch and weight gain is irrespective of psychiatric diagnosis: A meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0244944
Author(s):  
Maarten Bak ◽  
Marjan Drukker ◽  
Shauna Cortenraad ◽  
Emma Vandenberk ◽  
Sinan Guloksuz
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Weight Change ◽  
Psychiatric Diagnosis ◽  
Body Weight Gain ◽  
Meta Analysis ◽  
Bodyweight Gain ◽  
Body Weight Change ◽  
Meta Analyses ◽  
The Impact

Introduction Antipsychotics are associated with bodyweight gain and metabolic disturbance. Previous meta-analyses were limited to mainly antipsychotic switch studies in patients with a diagnosis of schizophrenia or psychosis with short follow-up periods. The present meta-analysis aimed to analyse the impact of weight change in antipsychotic-naive and antipsychotics switch patients and whether body weight change depended on diagnosis. Method We performed a meta-analysis of clinical trials of antipsychotics that reported weight change, irrespective of psychiatric diagnosis. Outcome measure was body weight change. Studies were classified into antipsychotic-naive and antipsychotic-switch. Forest plots stratified by antipsychotic and the duration of antipsychotic use were generated and results were summarised in figures. Results In total, 404 articles were included for the quantitative synthesis. 58 articles were on antipsychotic naive patients. In the antipsychotic naive group, all antipsychotics resulted in body weight gain. In the antipsychotic switch group, most antipsychotics likewise resulted in bodyweight gain, with exception of amisulpride, aripiprazole and ziprasidone that showed no body weight gain or even some weight loss after switching antipsychotics. Diagnosis was not a discriminating factor of antipsychotic induced weight change. Conclusion Antipsychotic use resulted in substantial increase in body weight in antipsychotic-naive patients. In antipsychotic-switch patients the weight gain was mild and not present in amisulpride, aripiprazole and ziprasidone. In both groups, weight gain was irrespective of the psychiatric diagnosis.

scholarly journals Recommendation of Choline Inclusion in Lambs’ Diet

2021 ◽  
Author(s):  
José Alfredo Martínez Aispuro ◽  
María Teresa Sánchez-Torres Esqueda ◽  
José Luis Figueroa Velasco ◽  
José Luis Cordero Mora
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Literature Review ◽  
Detrimental Effect ◽  
Body Weight Gain ◽  
Choline Chloride ◽  
The Other ◽  
Productive Performance ◽  
Energy Metabolites ◽  
Positive Effects

Objective: To establish an inclusion recommendation for choline (herbal or synthetic) in fattening lambs’diet based on productive performance and blood metabolites.Design/Methodology/Approach: A literature review was carried out of herbal and synthetic choline supplementation in the diet of fattening lambs.Results: The addition of protected choline chloride (50% purity) in the lamb’s diet should be less than 2.5g/kg DM in order not to cause a detrimental effect on the productive performance. On the other hand, the inclusion of herbal choline in lambs’ diet should be greater than 6 g/kg DM to have positive effects on body gain and feed conversion.Study Limitations/Implications: It is necessary to establish the requirement for choline in fattening lambs because studies where choline is supplemented show that the contribution of conventional ingredients is insufficient.Findings/Conclusions: The inclusion of herbal (6 g/kg DM) and synthetic (2.5 g/kg DM) choline in lambs’ diet improves body weight gain and modifies energy metabolites

Quantitative relationship between body weight gain in adulthood and incident type 2 diabetes: a meta-analysis

2013 ◽  
Vol 15 (3) ◽  
pp. 202-214 ◽  
Author(s):  
S. Kodama ◽  
C. Horikawa ◽  
K. Fujihara ◽  
S. Yoshizawa ◽  
Y. Yachi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Meta Analysis ◽  
Quantitative Relationship ◽  
Incident Type ◽  
Incident Type 2 Diabetes
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