The Association of Plasma Trimethylamine N-Oxide with Coronary Atherosclerotic Burden in Patients with Type 2 Diabetes Among a Chinese North Population

Background: Coronary atherosclerotic burden is excessive in diabetic patients. The aim of present study was to assess the relationship between diabetes mellitus and plaque characteristics in patients with coronary artery disease.Methods: The coronary angiograms of 223 patients with significant obstructive lesions during April 2011 to May 2013 in College of Medical Sciences and Teaching Hospital were analyzed. The coronary lesions of patients with and without type 2 diabetes were compared. Results: 81 diabetic and 142 non-diabetic patients had significant coronary artery disease. Diabetic patients had more multivessel (64.2% versus 55.6%, p<0.05), and small vessel disease (74.1% versus 54.9%, p<0.05) than nondiabetic patients. Moreover, complex Type C lesion was significantly higher in the diabetic patients as compared to the nondiabetic patients (55.5% versus 29.6%, p<0.01). Conclusions: Complex coronary lesions were significantly more common in diabetic patients than in nondiabetic patients. Nepalese Heart Journal | Volume 10 | No.1 | November 2013| Pages 20-22 DOI: http://dx.doi.org/10.3126/njh.v10i1.9742

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The impact of site and extent of clinically evident cardiovascular disease and atherosclerotic burden on new cardiovascular events in patients with Type 2 diabetes. The SMART study

Diabetic Medicine ◽

10.1111/j.1464-5491.2007.02323.x ◽

2007 ◽

Vol 24 (12) ◽

pp. 1352-1360 ◽

Cited By ~ 17

Author(s):

P. M. Gorter ◽

F. L. J. Visseren ◽

A. Algra ◽

Y. van der Graaf ◽

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Cardiovascular Events ◽

Atherosclerotic Burden ◽

Smart Study ◽

The Impact

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Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross-sectional study

Journal of Internal Medicine ◽

10.1111/joim.12359 ◽

2015 ◽

Vol 278 (3) ◽

pp. 291-302 ◽

Cited By ~ 21

Author(s):

A. C. Shore ◽

H. M. Colhoun ◽

A. Natali ◽

C. Palombo ◽

G. Östling ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Atherosclerotic Burden

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Activin A and cardiovascular disease in type 2 diabetes mellitus

Diabetes and Vascular Disease Research ◽

10.1177/1479164111431171 ◽

2012 ◽

Vol 9 (3) ◽

pp. 234-237 ◽

Cited By ~ 22

Author(s):

Thor Ueland ◽

Pål Aukrust ◽

Svend Aakhus ◽

Camilla Smith ◽

Knut Endresen ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Activin A ◽

Atherosclerotic Burden ◽

Silent Coronary Artery Disease ◽

Extent Score ◽

Artery Disease

Background: Silent coronary artery disease is a frequent complication of type 2 diabetes (T2DM). Based on its multiple roles in inflammation, atherogenesis and glucose homeostasis, we hypothesised that activin A could be related to coronary atherosclerosis in T2DM. Methods: Activin A and follistatin were measured in 102 patients with T2DM and 20 age- and sex-matched healthy controls. Coronary angiography was performed in a sub-population of patients and associations with activin A were examined using multiple linear regression. Results: Serum activin A and the activin A/follistatin ratio were increased in patients with T2DM and coronary artery disease (CAD) compared with healthy volunteers and the elevated activin A was associated with the severity of coronary atherosclerotic burden as determined by the proportion of ≥2 vessel disease ( p = 0.035) after multivariable-adjusted trend analysis. No significant association between presence of CAD or extent score and activin A was observed. Conclusion: In patients with T2DM, increased activin A may reflect chronic underlying pathophysiological processes involved in development of cardiovascular disease.

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