scholarly journals Preliminary Study on the Relationship of BRAF Mutations with the Outcome of the First 131I Radiotherapy and Malignant Biological Characteristics in Papillary Thyroid Carcinoma

2021 ◽  
Vol Volume 14 ◽  
pp. 8981-8989
Author(s):  
Linjue Shangguan ◽  
Peipei Zhang ◽  
Shengwei Fang ◽  
Kaili Xiang ◽  
Yawen Geng ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Biological Characteristics ◽  
Papillary Thyroid ◽  
Braf Mutations ◽  
Preliminary Study ◽  
Relationship Of ◽  
The Relationship

scholarly journals Preliminary Study on The Relationship of BRAF Mutations to The Outcome of The First 131I Radiotherapy and Malignant Biological Characteristics in Papillary Thyroid Carcinoma

2021 ◽  
Author(s):  
Linjue Shangguan ◽  
Peipei Zhang ◽  
Shengwei Fang ◽  
Kaili Xiang ◽  
Yawen Geng ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Tumor Tissue ◽  
Biological Characteristics ◽  
Single Mutation ◽  
Papillary Thyroid ◽  
Mutation Site ◽  
Tumor Tissues ◽  
Relationship Of ◽  
The Relationship

Abstract Objective To investigate the relationship of BRAF mutation to the outcome of the first postoperative 131I treatment and malignant biological characteristics in papillary thyroid carcinoma (PTC) and the clinical value of circulating tumor DNA (ctDNA). Methods Thirty-three patients with PTC underwent the first 131I treatment after total thyroidectomy were enrolled in this study. BRAF mutation based on postoperative tumor tissue and ctDNA in peripheral blood before 131I treatment were detected. According to the status of BRAF mutation, all patients were divided into 2 groups for the categories of tumor tissues and ctDNA respectively: i) BRAF mutated, ii) BRAF wild-type. The Fisher's exact test was performed to analyze the relationship of BRAF mutation in either tumor tissue or ctDNA to the outcome of the first 131I treatment and malignant characteristics of PTC. Results BRAF mutation was detected in 25 patients based on tumor tissue (25/33,75.8%), and all the patients had single mutation site. In ctDNA, BRAF mutation was detected in 5 patients (5/33, 15.2%), and all the patients had single mutation site. BRAF mutation showed no relationship with the outcome of the first 131I treatment and the malignant biological characteristics in both tumor tissues and ctDNA(P>0.05). Conclusion The value of BRAF mutation alone might be limited in predicting therapeutic outcome of the first 131I treatment in PTC. No certain relevance was found between BRAF mutation and malignant biological features in PTC.

scholarly journals Association between Thyroiditis and Multifocality in Papillary Thyroid Carcinoma

2020 ◽  
Author(s):  
Rogério Aparecido Dedivitis ◽  
Leandro Luongo de Matos ◽  
Felipe Guilherme Silva Souza ◽  
Jose Luis Bogado Ortiz
Keyword(s):  
Retrospective Study ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Direct Relationship ◽  
Statistical Significance ◽  
Hashimoto Thyroiditis ◽  
Papillary Thyroid ◽  
Multifocal Lesions ◽  
The Relationship

Abstract Introduction Hashimoto thyroiditis (HT) shares many characteristics with papillary thyroid carcinoma (PTC), and some studies show that, when associated, PTC is diagnosed mostly with smaller lesions and multifocal pattern. Objective To evaluate the relationship between HT and PTC. Methods A retrospective study of 155 patients who underwent total thyroidectomy from 2009 to 2015. Demographical, clinical and ultrasonographical data, as well as anatomopathological findings were evaluated. Results There were signs of thyroidits in 35 patients, and 114 patients had a unifocal disease. There was no statistical significance between the variables studied and thyroiditis. However, when compared with the occurrence of unifocal or multifocal lesions, there was statistical significance regarding age (p = 0.038) and mass (p = 0.031). There was no direct relationship between thyroiditis and multifocality (p = 0.325) nor between thyroiditis and cervical extension of the disease (p = 0.300 e p = 0.434). Conclusion There was no relationship between thyroiditis and multifocality in cases of PTC.

scholarly journals BRAF mutations in papillary thyroid carcinoma and emerging targeted therapies (Review)

2012 ◽  
Vol 6 (4) ◽  
pp. 687-694 ◽  
Author(s):  
GIULIA COSTANZA LEONARDI ◽  
SAVERIO CANDIDO ◽  
MAURIZIO CARBONE ◽  
FABIO RAITI ◽  
VALERIA COLAIANNI ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Targeted Therapies ◽  
Papillary Thyroid ◽  
Braf Mutations

Coexistence of TERT Promoter and BRAF Mutations in Papillary Thyroid Carcinoma: Added Value in Patient Prognosis?

2015 ◽  
Vol 33 (6) ◽  
pp. 667-668 ◽  
Author(s):  
Miguel Melo ◽  
Adriana Gaspar da Rocha ◽  
João Vinagre ◽  
Manuel Sobrinho-Simões ◽  
Paula Soares
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Added Value ◽  
Papillary Thyroid ◽  
Braf Mutations ◽  
Tert Promoter ◽  
Patient Prognosis

scholarly journals Overexpression of PAX8-AS1 Inhibits Malignant Phenotypes of Papillary Thyroid Carcinoma Cells via miR-96-5p/PKN2 Axis

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Ping Zhou ◽  
Tongdao Xu ◽  
Hao Hu ◽  
Fei Hua
Keyword(s):  
Cell Proliferation ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Luciferase Reporter ◽  
Human Thyroid ◽  
Thyroid Cell ◽  
Papillary Thyroid ◽  
Western Blot Assay ◽  
Proliferation And Apoptosis ◽  
Relationship Of

Background. Thyroid carcinoma (THCA) is the most frequent endocrine malignancy. Papillary thyroid carcinoma (PTC) is the major subtype of THCA, accounting for over 80% of all THCA cases. LncRNA PAX8-AS1, a tumor suppressor associated with various human cancers, has been reported to be relevant to the regulation of all sorts of cellular processes. The purpose of this study was to verify the role of PAX8-AS1 in PTC. Methods. Three human PTC cell lines (K1, TPC-1, and IHH4) and one normal human thyroid cell line, Nthy-ori3-1, were used in our study. The expression of genes was detected by qRT-PCR. The bioinformatic analysis and luciferase reporter assay were used to confirm the binding relationship of PAX8-AS1 to miR-96-5p, and the targeting relationship of miR-96-5p to PKN2 was also predicted. Cell proliferation and apoptosis capacities were assessed by MTT and flow cytometry, respectively. EdU assay was used to detect cell proliferation. Western blot assay was employed to examine protein expression. Results. The expression of PAX8-AS1 was decreased in PTC tissues and cells. PAX8-AS1 overexpression inhibited the proliferation of PTC cells and promoted cell apoptosis. In addition, PAX8-AS1 bonds with miR-96-5p, whose downregulation elevated the expression of PKN2 in PTC cells. Importantly, according to the rescue experiments, PKN2 silencing partially reversed the inhibitory effects of PAX8-AS1 expression on PTC cell proliferation and apoptosis. Conclusions. We found that the PAX8-AS1/miR-96-5p/PKN2 axis was closely related to the progression of PTC, which could be a potential target for treating PTC patients.

The relationship between multiple intrathyroidal involvement in papillary thyroid carcinoma and chronic non-specific thyroiditis

1998 ◽  
Vol 122 (1-2) ◽  
pp. 177-180 ◽  
Author(s):  
Kazuhiko Asanuma ◽  
Akira Sugenoya ◽  
Yoshio Kasuga ◽  
Nobuo Itoh ◽  
Shinya Kobayashi ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
The Relationship

Case of aggressive metastatic follicular variant papillary thyroid carcinoma with BRAF K601E and BCORL1 mutations

2020 ◽  
Vol 13 (6) ◽  
pp. e234208
Author(s):  
Doaa Attia ◽  
Alexander Lurie ◽  
Qihui Zhai ◽  
Robert Smallridge
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Left Lobe ◽  
Papillary Thyroid ◽  
Braf Mutations ◽  
Follicular Variant ◽  
Positron Emission ◽  
Small Defect ◽  
Tumour Biopsy ◽  
The Right

BCL6 corepressor like-1 (BCORL1) mutation has rarely been described in thyroid cancer or in association with BRAF mutations in any malignancy. However, we report a 49-year-old woman who had aggressive follicular variant papillary thyroid carcinoma (FV-PTC) with both the BRAF K601E and BCORL1 mutations. The patient underwent a total thyroidectomy for a 3.6 cm right thyroid nodule and a smaller lesion in the left lobe in 2007; both were FV-PTCs with no lymphovascular invasion or metastases. In 2015, a positron emission tomography–CT scan showed a small defect in the left posterior lateral fifth rib with mild increased hypermetabolic activity with standardised uptake value of 3.9 and another lesion in the right hip at the junction of the femoral neck and trochanter. Tumour biopsy and genetic analysis revealed an uncommon BRAF K601E and a rare BCORL1 mutation. While rare, we report a case of aggressive FV-PTC with both the BRAF K601E and BCORL1 mutations.

scholarly journals Warthin-Like Papillary Thyroid Carcinoma Associated with Lymphadenopathy and Hashimoto’s Thyroiditis

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Karla Judith González-Colunga ◽  
Abelardo Loya-Solis ◽  
Luis Ángel Ceceñas-Falcón ◽  
Oralia Barboza-Quintana ◽  
René Rodríguez-Gutiérrez
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Hashimoto’S Thyroiditis ◽  
Needle Aspiration ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Function Tests ◽  
Papillary Thyroid ◽  
Braf Mutations ◽  
Eosinophilic Cytoplasm ◽  
Biopsy Report

Defining the histologic variant of thyroid carcinoma is an important clinical implication as their progression, recurrence, aggressiveness, and prognosis differ. Warthin-like variant is one of the rarest histologic variants of papillary thyroid cancer. A 36-year-old female sought consult for assessment of a painless right neck tumor. High-resolution neck ultrasound revealed a right hypoechoic, 1.71 × 1.05 cm thyroid nodule. Ultrasound-guided fine-needle aspiration biopsy report was a Bethesda grade III. Thyroid function tests showed Hashimoto’s thyroiditis. The patient underwent right hemithyroidectomy. Microscopically, the tumor was composed of papillae lined by cells with eosinophilic cytoplasm, nuclear chromatin clearing, grooves, and pseudoinclusions and a characteristic lymphoplasmacytic infiltrate of the papillae cores. Extension into the perithyroidal soft tissue and 3 ipsilateral lymph nodes was found to be positive for cancer. Warthin-like variant is an uncommon and relatively unknown variant of papillary thyroid carcinoma that has been usually associated with an excellent prognosis. Interestingly, BRAF mutations have been reported to be present in up to 75% of the patients. It is frequently associated with Hashimoto’s thyroiditis and presents unique morphological features that make it recognizable on histologic examination. The cytological diagnosis is difficult to assess due to the overlap in its findings with the classical variant and Hashimoto’s thyroiditis.

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