scholarly journals D-α-tocopherol polyethylene glycol 1000 succinate-modified liposomes with an siRNA corona confer enhanced cellular uptake and targeted delivery of doxorubicin via tumor priming

2019 ◽  
Vol Volume 14 ◽  
pp. 1255-1268 ◽  
Author(s):  
Xi Tan ◽  
Yan Fang ◽  
Yuanyuan Ren ◽  
Yinghuan Li ◽  
Peicheng Wu ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Cellular Uptake ◽  
Targeted Delivery ◽  
Alpha Tocopherol ◽  
Polyethylene Glycol 1000 ◽  
Tumor Priming

Co-encapsulation of gemcitabine and tocotrienols in nanovesicles enhanced efficacy in pancreatic cancer

Nanomedicine ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. 373-389
Author(s):  
Geetha Maniam ◽  
Chun-Wai Mai ◽  
Mohd Zulkefeli ◽  
Ju-Yen Fu
Keyword(s):  
Pancreatic Cancer ◽  
Polyethylene Glycol ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Proof Of Concept ◽  
Pancreatic Cancer Cells ◽  
Polyethylene Glycol 1000 ◽  
Span 60 ◽  
Dual Drug

Aim: To synthesize niosomes co-encapsulating gemcitabine (GEM) and tocotrienols, and physicochemically characterize and evaluate the antipancreatic effects of the nanoformulation on Panc 10.05, SW 1990, AsPC-1 and BxPC-3 cells. Materials & methods: Niosomes-entrapping GEM and tocotrienols composed of Span 60, cholesterol and D-α-tocopheryl polyethylene glycol 1000 succinate were produced by Handjani-Vila and film hydration methods. Results: The film hydration produced vesicles measuring 161.9 ± 0.5 nm, approximately 50% smaller in size than Handjani-Vila method, with maximum entrapment efficiencies of 20.07 ± 0.22% for GEM and 34.52 ± 0.10% for tocotrienols. In Panc 10.05 cells, GEM’s antiproliferative effect was enhanced 2.78-fold in combination with tocotrienols. Niosomes produced a significant ninefold enhancement in cytotoxicity of the combination, supported by significantly higher cellular uptake of GEM in the cells. Conclusion: This study is a proof of concept on the synthesis of dual-drug niosomes and their efficacy on pancreatic cancer cells in vitro.

d-α-Tocopheryl polyethylene glycol 1000 succinate conjugated folic acid nanomicelles: towards enhanced bioavailability, stability, safety, prolonged drug release and synergized anticancer effect of plumbagin

RSC Advances ◽  
2016 ◽  
Vol 6 (81) ◽  
pp. 78106-78121 ◽  
Author(s):  
Atmaram Pawar ◽  
Rabiya Patel ◽  
S. Arulmozhi ◽  
C. Bothiraja
Keyword(s):  
Folic Acid ◽  
Polyethylene Glycol ◽  
Drug Release ◽  
Targeted Delivery ◽  
Anticancer Effect ◽  
Polyethylene Glycol 1000 ◽  
Prolonged Drug Release

Plumbagin (PLB) loadedd-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) with folic acid (FOL) conjugated nanomicelles achieved controlled and targeted delivery with synergized anticancer potency and reduced PLB toxicity.

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