scholarly journals Effects of mechanical loading on the degradability and mechanical properties of the nanocalcium-deficient hydroxyapatite–multi(amino acid) copolymer composite membrane tube for guided bone regeneration

2013 ◽  
pp. 2801 ◽  
Author(s):  
Hong Duan ◽  
Yang ◽  
Xiong ◽  
Yan Xiong ◽  
Cheng Ren ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Amino Acid ◽  
Bone Regeneration ◽  
Mechanical Loading ◽  
Composite Membrane ◽  
Guided Bone Regeneration ◽  
Acid Copolymer ◽  
Membrane Tube

Experimental study on repair of large segmental bone defects of goat femur by nano calcium-deficient hydroxyapatite-multi (amino acid) copolymer membrane tubes

2021 ◽  
pp. 088532822110002
Author(s):  
Yan Xiong ◽  
Hong Duan ◽  
Bin Zhang ◽  
Cheng Ren ◽  
Zeping Yu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Bone Defects ◽  
Torsional Stiffness ◽  
Control Group ◽  
Allogenic Bone ◽  
Acid Copolymer ◽  
Membrane Tube ◽  
Segmental Bone ◽  
Experimental Group ◽  
Segmental Bone Defects

Objective The purpose of this study was to observe feasibility of nano calcium-deficient hydroxyapatite-multi (amino acid) copolymer (n-CDHA-MAC) membrane tubes in repairing goat femurs’ large defects. Methods Twelve goats were divided into two groups, whose femurs were created 30 mm segmental bone defects and then implants were performed. In experimental group, the bone defect of right femur was reconstructed by n-CDHA-MAC membrane tube, while left side was reconstructed by allogenic bone tube in control group. Every three goats were sacrificed at 4, 8, 16, 24 weeks after operation respectively. General observation, X-ray analysis, histology, Scanning electron microscope (SEM) examination and protein level comparison of BMP-2 were conducted to evaluate the effects of repairing segmental bone defects. Results All goats recovered well from anesthesia and surgical interventions. The radiographic evaluations showed that periosteal reaction outside of the membrane tubes and allogenic bone tubes were observed 4 weeks after surgery. At 16 weeks, callus was continuously increased in experimental group, which was more obvious than control group. At 24 weeks, callus outside of the membrane tubes connected together. Histologic evaluation showed fibro-cartilage callus was evolved into bony callus in experimental group, which was more obvious than control group at 8 and 16 weeks. The protein expression level of BMP-2 increased at 4, 8 weeks and peaked at 16 weeks in experimental groups. There were statistical differences at 8 and 16 weeks ( P < 0.05). At each time point in 8, 16, 24 weeks after surgery, the bending stiffness, torsional stiffness and compressive strength of the two groups were similar, and there was no significant difference ( P > 0.05). Conclusions This novel surface degradation n-CDHA-MAC membrane tube has good ability to maintain enough membrane space, which can provide long-term and stable biomechanical support for large bone defects and integrate well with the surrounding bone.

scholarly journals Zn-Containing Membranes for Guided Bone Regeneration in Dentistry

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1797
Author(s):  
Manuel Toledano ◽  
Marta Vallecillo-Rivas ◽  
María T. Osorio ◽  
Esther Muñoz-Soto ◽  
Manuel Toledano-Osorio ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Bone Healing ◽  
Bone Repair ◽  
Complex Modulus ◽  
Bacterial Colonization ◽  
Guided Bone Regeneration ◽  
M2 Macrophage

Barrier membranes are employed in guided bone regeneration (GBR) to facilitate bone in-growth. A bioactive and biomimetic Zn-doped membrane with the ability to participate in bone healing and regeneration is necessary. The aim of the present study is to state the effect of doping the membranes for GBR with zinc compounds in the improvement of bone regeneration. A literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI, Embase, Scopus and Web of Science. A narrative exploratory review was undertaken, focusing on the antibacterial effects, physicochemical and biological properties of Zn-loaded membranes. Bioactivity, bone formation and cytotoxicity were analyzed. Microstructure and mechanical properties of these membranes were also determined. Zn-doped membranes have inhibited in vivo and in vitro bacterial colonization. Zn-alloy and Zn-doped membranes attained good biocompatibility and were found to be non-toxic to cells. The Zn-doped matrices showed feasible mechanical properties, such as flexibility, strength, complex modulus and tan delta. Zn incorporation in polymeric membranes provided the highest regenerative efficiency for bone healing in experimental animals, potentiating osteogenesis, angiogenesis, biological activity and a balanced remodeling. Zn-loaded membranes doped with SiO2 nanoparticles have performed as bioactive modulators provoking an M2 macrophage increase and are a potential biomaterial for promoting bone repair. Zn-doped membranes have promoted pro-healing phenotypes.

Antibacterial Properties of Guided Bone Regeneration Membrane for Periodontal Applications

2014 ◽  
Vol 606 ◽  
pp. 47-50
Author(s):  
Nur Najiha Saarani ◽  
K. Jamuna-Thevi ◽  
Ida Idayu Muhammad ◽  
Hendra Hermawan
Keyword(s):  
Staphylococcus Aureus ◽  
Bone Regeneration ◽  
Composite Membrane ◽  
Lauric Acid ◽  
Antibacterial Properties ◽  
Guided Bone Regeneration ◽  
Significant Inhibition ◽  
Thermally Induced ◽  
Zones Of Inhibition ◽  
Gbr Membrane

Guided Bone Regeneration (GBR) membrane is used as a barrier to prevent soft tissue ingrowth and to encourage bone regeneration through cellular exclusion. This study aims to assess antibacterial properties of recently developed three-layered poly(lactic-co-glycolic acid) (PLGA) /lauric acid (LA) composite membrane towards Staphylococcus aureus. One of the outmost layers of three-layered membrane was incorporated with 1-3 wt% of LA. The composite membrane was developed using thermally induced phase separation/solvent leaching technique. SEM results shows formation of PLGA matrix with smaller pores by the addition of 1 wt% LA compared with pure PLGA membrane. Samples of 1.7 cm diameter disk containing 1, 2 and 3 wt% of lauric acid were tested and pure membrane without lauric acid was used as a control. Results showed that the zones of inhibition were 2.3 cm and 2.5 cm for the 2 wt% and 3 wt% LA-containing membranes, respectively. However, 1 wt% LA-containing membrane observed to have no inhibition at all, indicating that increasing concentration of LA has significant inhibition against Staphylococcus aureus. The 3 wt% LA composition will be used in the mechanically optimized membranes for degradation studies in future works.

In Vitro and In Vivo Evaluation of a nHA/PA66 Composite Membrane for Guided Bone Regeneration

2011 ◽  
Vol 22 (1-3) ◽  
pp. 263-275 ◽  
Author(s):  
Jidong Li ◽  
Yi Man ◽  
Yi Zuo ◽  
Li Zhang ◽  
Cui Huang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Composite Membrane ◽  
Guided Bone Regeneration ◽  
In Vivo Evaluation

Development of a PCL-silica nanoparticles composite membrane for Guided Bone Regeneration

2018 ◽  
Vol 85 ◽  
pp. 154-161 ◽  
Author(s):  
Antonio G.B. Castro ◽  
Mani Diba ◽  
Monique Kersten ◽  
John A. Jansen ◽  
Jeroen J.J.P. van den Beucken ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Silica Nanoparticles ◽  
Composite Membrane ◽  
Guided Bone Regeneration

A mechanically robust and flexible PEGylated poly(glycerol sebacate)/β-TCP nanoparticle composite membrane for guided bone regeneration

2019 ◽  
Vol 7 (20) ◽  
pp. 3279-3290 ◽  
Author(s):  
Shuang Yu ◽  
Jun Shi ◽  
Yutong Liu ◽  
Jiawen Si ◽  
Yuan Yuan ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Composite Membrane ◽  
Guided Bone Regeneration

A PEGS/β-TCP composite membrane was fabricated by a simple prepolymer mixing-in situ crosslinking method for guided bone regeneration.

scholarly journals PRGF-Modified Collagen Membranes for Guided Bone Regeneration: Spectroscopic, Microscopic and Nano-Mechanical Investigations

2019 ◽  
Vol 9 (5) ◽  
pp. 1035 ◽  
Author(s):  
Cristian Ratiu ◽  
Marcel Brocks ◽  
Traian Costea ◽  
Liviu Moldovan ◽  
Simona Cavalu
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Enzymatic Degradation ◽  
Young Modulus ◽  
Guided Bone Regeneration ◽  
Fiber Density ◽  
New Approach ◽  
Before And After ◽  
Collagen Membranes ◽  
Membrane Type

The aim of our study was to evaluate the properties of different commercially available resorbable collagen membranes for guided bone regeneration, upon addition of plasma rich in growth factors (PRGF). The structural and morphological details, mechanical properties, and enzymatic degradation were investigated in a new approach, providing clinicians with new data in order to help them in a successful comparison and better selection of membranes with respect to their placement and working condition. Particular characteristics such as porosity, fiber density, and surface topography may influence the mechanical behavior and performances of the membranes, as revealed by SEM/AFM and nanoindentation measurements. The mechanical properties and enzymatic degradation of the membranes were analyzed in a comparative manner, before and after PRGF-modification. The changes in Young modulus values are correlated with the ultrastructural properties of each membrane type. The enzymatic (trypsin) degradation test also emphasized that PRGF-modified membranes exhibit a slower degradation compared to the native ones.

Polylactide/polycaprolactone asymmetric membranes for guided bone regeneration

e-Polymers ◽  
2016 ◽  
Vol 16 (5) ◽  
pp. 351-358 ◽  
Author(s):  
Patrycja Domalik-Pyzik ◽  
Anna Morawska-Chochół ◽  
Jan Chłopek ◽  
Izabella Rajzer ◽  
Agata Wrona ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Freeze Drying ◽  
Bone Cells ◽  
Water Environment ◽  
Guided Bone Regeneration ◽  
Tissue Growth ◽  
Drying Methods ◽  
Asymmetric Membranes ◽  
Resorbable Polymers

AbstractThe aim of this work was to develop bioresorbable, asymmetric membranes for guided bone regeneration (GBR). Two resorbable polymers – polylactide (PLA) and polycaprolactone (PCL) were used in fabrication process. Two different manufacturing methods were applied: electrospinning in the case of PLA and freeze-drying of PCL. Mechanical properties, stability in a water environment and biocompatibility of fabricated membranes were evaluated. Microstructure [scanning electron microscopy (SEM)] of the membranes was assessed in terms of level of porosity, as well as size and shape of the pores. Study showed that combination of electrospinning and freeze-drying methods allows biocompatible PLA/PCL bi-phasic materials of appropriate mechanical properties and diverse microstructure to be produced, that should on the one hand prevent soft tissue growth, and on the other hand be a suitable scaffold for the growth of bone cells.

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