scholarly journals Temporal Clustering of Antiglomerular Basement Membrane Disease in COVID-19 Pandemic: A Case Series

2021 ◽  
Vol Volume 14 ◽  
pp. 393-398
Author(s):  
Rakesh Sebastian ◽  
Jegan Arunachalam ◽  
Manorajan Rajendran
Keyword(s):  
Basement Membrane ◽  
Case Series ◽  
Temporal Clustering

Anti-glomerular basement membrane disease: a case series from a single center in Western India

2021 ◽  
Vol 21 (1) ◽  
pp. 31
Author(s):  
Mital Parikh ◽  
Abhijit Konnur ◽  
Umapati Hegde ◽  
Sishir Gang ◽  
Hardik Patel ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Case Series ◽  
Western India ◽  
Single Center

scholarly journals Spatial and Temporal Clustering of Anti-Glomerular Basement Membrane Disease

2016 ◽  
Vol 11 (8) ◽  
pp. 1392-1399 ◽  
Author(s):  
Mark Canney ◽  
Paul V. O’Hara ◽  
Caitriona M. McEvoy ◽  
Samar Medani ◽  
Dervla M. Connaughton ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Temporal Clustering

scholarly journals Anti-glomerular basement membrane disease: Case series from a tertiary center in North India

2017 ◽  
Vol 27 (2) ◽  
pp. 108
Author(s):  
M Rathi ◽  
D Prabhakar ◽  
R Nada ◽  
RW Minz ◽  
V Kumar ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Case Series ◽  
North India ◽  
Disease Case ◽  
Tertiary Center

scholarly journals Anti-glomerular basement membrane disease case series in Trinidad and Tobago

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
E Mohammed ◽  
A Ramrattan ◽  
P Poon-King ◽  
A Bissessar ◽  
A Ramesar ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Trinidad And Tobago ◽  
Glomerular Basement Membrane ◽  
Case Series ◽  
Disease Case

scholarly journals Sampling trabecular meshwork using TrabEx+

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Vipul Ramjiani ◽  
Hardeep-Singh Mudhar ◽  
Thomas Julian ◽  
Graham Auger
Keyword(s):  
Basement Membrane ◽  
Cataract Surgery ◽  
Trabecular Meshwork ◽  
Open Angle Glaucoma ◽  
Periodic Acid ◽  
Case Series ◽  
Collagen Iv ◽  
Pigment Dispersion ◽  
Periodic Acid Schiff ◽  
Trabecular Meshwork Cells

Abstract Background To report sampling of the trabecular meshwork using the TrabEx+ (MicroSurgical Technology, Redmond, Washington, USA) device in ab interno trabeculectomy. Specifically, this series focusses upon preservation of the trabecular meshwork architecture for assessment of glaucomatous features using common histopathological techniques. Patients This series features six glaucomatous eyes undergoing TrabEx+ with or without cataract surgery. Three patients had primary open angle glaucoma and the remaining had pigment dispersion glaucoma, ocular hypertension or uveitic glaucoma. Four eyes had simultaneous cataract surgery. Methods Trabecular meshwork was excised using the TrabEx+ device and retrieved using vitreoretinal forceps. The samples were then processed into formalin-fixed paraffin-embedded 4 micron tissue segments and stained with haematoxylin and eosin, periodic acid–Schiff and elastin Van Gieson. Collagen IV was labelled using immunohistochemistry for the purpose of identifying the basement membrane of trabecular beams. Results Presence of trabecular meshwork was confirmed in five of the six samples taken. One of six samples consisted of blood only, but this was expected following early termination of the procedure due to patient restlessness. In the five positive cases trabecular beams with associated trabecular meshwork cells were identified on hematoxylin-eosin and periodic acid–Schiff staining. The beams retained their lamellar structure. The basement membrane underlying the trabecular cells was evident in three specimens, whilst two specimens were of insufficient size for collagen IV labelling. Conclusions This case series illustrates that TrabEx+ can be utilised to successfully retrieve trabecular meshwork samples with sufficient architectural perseveration of the tissue to enable histopathological and laboratory analysis.

scholarly journals Anti-Gbm Disease in Children: Outcomes and Association with Systemic Vasculitis

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Lung Biopsy ◽  
Systemic Vasculitis ◽  
Case Series ◽  
Autoimmune Disorder ◽  
Basement Membranes ◽  
Dual Positivity ◽  
Relapse Rates

Anti-Glomerular Basement Membrane (anti-GBM) disease is a rare autoimmune disorder affecting the glomerular and alveolar basement membranes. Diagnosis is based on the detection of anti-GBM autoantibodies, along with renal or lung biopsy. Some patients are both anti-GBM and ANCA positive, reflecting an association with systemic vasculitis that has been reported only in some adult cases. Dual positivity of anti-GBM and ANCA is associated with poorer prognosis and higher relapse rates therefore more aggressive and longer treatment is essential. In this case, series we report four cases of children diagnosed with anti-GBM disease that we also screened for signs of systemic vasculitis.

Endotoxin Alteration of the Mucopolysaccharide Blood Vessel Coating in Rats

1974 ◽  
Vol 32 ◽  
pp. 148-149
Author(s):  
D. E. Philpott ◽  
A. Takahashi
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Salivary Gland ◽  
Carotid Artery ◽  
Basement Membrane ◽  
Coronary Vessels ◽  
Ruthenium Red ◽  
E Coli ◽  
Old Rats ◽  
The Brain

Two month, eight month and two year old rats were treated with 10 or 20 mg/kg of E. Coli endotoxin I. P. The eight month old rats proved most resistant to the endotoxin. During fixation the aorta, carotid artery, basil arartery of the brain, coronary vessels of the heart, inner surfaces of the heart chambers, heart and skeletal muscle, lung, liver, kidney, spleen, brain, retina, trachae, intestine, salivary gland, adrenal gland and gingiva were treated with ruthenium red or alcian blue to preserve the mucopolysaccharide (MPS) coating. Five, 8 and 24 hrs of endotoxin treatment produced increasingly marked capillary damage, disappearance of the MPS coating, edema, destruction of endothelial cells and damage to the basement membrane in the liver, kidney and lung.

Physical Properties of Isolated Perfused Renal Tubular Basement Membranes

1971 ◽  
Vol 29 ◽  
pp. 390-391
Author(s):  
Jared Grantham ◽  
Larry Welling
Keyword(s):  
Basement Membrane ◽  
Basement Membranes ◽  
Transport Mechanisms ◽  
Permeability Characteristics ◽  
Peritubular Capillaries ◽  
Strategic Location ◽  
Tubular Lumen ◽  
Glomerular Filtrate ◽  
Urine Formation ◽  
Renal Tubular

In the course of urine formation in mammalian kidneys over 90% of the glomerular filtrate moves from the tubular lumen into the peritubular capillaries by both active and passive transport mechanisms. In all of the morphologically distinct segments of the renal tubule, e.g. proximal tubule, loop of Henle and distal nephron, the tubular absorbate passes through a basement membrane which rests against the basilar surface of the epithelial cells. The basement membrane is in a strategic location to affect the geometry of the tubules and to influence the movement of tubular absorbate into the renal interstitium. In the present studies we have determined directly some of the mechanical and permeability characteristics of tubular basement membranes.

Kalinin: A new epithelial basement membrane adhesion molecule

1991 ◽  
Vol 49 ◽  
pp. 178-179
Author(s):  
Douglas R. Keene ◽  
Gregory P. Lunstrum ◽  
Patricia Rousselle ◽  
Robert E. Burgeson
Keyword(s):  
Basement Membrane ◽  
Culture Media ◽  
Polyacrylamide Gel Electrophoresis ◽  
Human Keratinocytes ◽  
Positive Staining ◽  
Human Amnion ◽  
Epithelial Basement Membrane ◽  
Type Vii Collagen ◽  
Keratinocyte Cell ◽  
Epithelial Basement

A mouse monoclonal antibody produced from collagenase digests of human amnion was used by LM and TEM to study the distribution and ultrastructural features of an antigen present in epithelial tissues and in cultured human keratinocytes, and by immunoaffinity chromatography to partially purify the antigen from keratinocyte cell culture media.By immunofluorescence microscopy, the antigen displays a tissue distribution similar to type VII collagen; positive staining of the epithelial basement membrane is seen in skin, oral mucosa, trachea, esophagus, cornea, amnion and lung. Images from rotary shadowed preparations isolated by affinity chromatography demonstrate a population of rod-like molecules 107 nm in length, having pronounced globular domains at each end. Polyacrylamide gel electrophoresis suggests that the size of this molecule is approximately 440kDa, and that it is composed of three nonidentical chains disulfide bonded together.

Scanning Electron Microscopy of Human Jejunum in Whipple's Disease

1977 ◽  
Vol 35 ◽  
pp. 354-355
Author(s):  
John H. L. Watson ◽  
C. N. Sun
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Basement Membrane ◽  
Lamina Propria ◽  
Brush Border ◽  
Whipple’S Disease ◽  
Whipple's Disease ◽  
Biopsy Specimens ◽  
Brush Borders ◽  
Scanning Electron

That the etiology of Whipple's disease could be bacterial was first suggested from electron micrographs in 1960. Evidence for binary fission of the bacteria, their phagocytosis by histiocytes in the lamina propria, their occurrence between and within the cells of the epithelium and on the brush border of the lumen were reported later. Scanning electron microscopy has been applied by us in an attempt to confirm the earlier observations by the new technique and to describe the bacterium further. Both transmission and scanning electron microscopy have been used concurrently to study the same biopsy specimens, and transmission observations have been used to confirm those made by scanning.The locations of the brush borders, the columnar epithelial cells, the basement membrane and the lamina propria beneath it were each easily identified by scanning electron microscopy. The lamina propria was completely filled with the wiener-shaped bacteria, Fig. 1.

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