scholarly journals α-lipoic acid suppresses neuronal excitability and attenuates colonic hypersensitivity to colorectal distention in diabetic rats

2017 ◽  
Vol Volume 10 ◽  
pp. 1645-1655 ◽  
Author(s):  
Yan Sun ◽  
Pan-Pan Yang ◽  
Zhen-Yuan Song ◽  
Yu Feng ◽  
Duan-Min Hu ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Neuronal Excitability ◽  
Diabetic Rats ◽  
Alpha Lipoic Acid ◽  
Colorectal Distention

scholarly journals Alpha-lipoic Acid suppresses P2X receptor activities and visceral hypersensitivity to colorectal distention in diabetic rats

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Ji Hu ◽  
Xin Qin ◽  
Zhen-Yuan Song ◽  
Pan-Pan Yang ◽  
Yu Feng ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Diabetic Rats ◽  
Visceral Hypersensitivity ◽  
P2x Receptor ◽  
Alpha Lipoic Acid ◽  
Colorectal Distention

Long-Term Alpha-Lipoic Acid (ALA) Antioxidant Therapy Reduces Damage in the Cardiovascular System of Streptozotocin-Induced Diabetic Rats

2021 ◽  
pp. 1-15
Author(s):  
Cristiane Simões Coelho Britto Ramos ◽  
Vivian Alves Pereira da Silva ◽  
Lanna Beatriz Neves Silva Corrêa ◽  
Renato de Souza Abboud ◽  
Gilson Teles Boaventura ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Lipoic Acid ◽  
Diabetic Rats ◽  
Antioxidant Therapy ◽  
Alpha Lipoic Acid

scholarly journals Effect of alpha-lipoic acid on antioxidant gene expression and kidney injury in alloxan-induced diabetic rats

2018 ◽  
Vol 8 (1) ◽  
pp. 6-6 ◽  
Author(s):  
Parisa Jamor ◽  
Hassan Ahmadvand ◽  
Hesam Ashoory ◽  
Esmaeel Babaeenezhad
Keyword(s):  
Gene Expression ◽  
Lipoic Acid ◽  
Kidney Injury ◽  
Diabetic Rats ◽  
Pcr Analysis ◽  
Control Group ◽  
Diabetic Patients ◽  
Alpha Lipoic Acid ◽  
The Impact ◽  
Gpx Activity

Background: Myeloperoxidase (MPO) is involved in the initiation, progression, and complications of atherosclerosis in diabetic patients. Objectives: In the current study, the impact of alpha-lipoic acid (LA), a natural antioxidant and a cofactor in the enzyme complexes on MPO, catalase (CAT) and glutathione peroxidase (GPx) activity, glutathione (GSH) and malondialdehyde (MDA) level, histopathology of kidney and expression of antioxidant enzymes, superoxide dismutase (SOD), GPx and CAT which are involved in the detoxification of reactive oxygen species (ROS), was evaluated in alloxan-induced diabetic rats. Materials and Methods: In this study, 30 male Rattus norvegicus rats randomly divided into three groups; control (C), non-treated diabetic (NTD), and LA-treated diabetics (LATD) was induced by alloxan monohydrate (100mg/kg; subcutaneous [SC]). Then treatment was performed with alphaLA (100 mg/kg intraperitoneal (i.p) daily to 6 weeks). Blood sample of animals collected to measure levels of MPO, CAT and GPx activity GSH and MDA. Kidney paraffin sections were prepared to estimate histological studies and to measure quantitative gene expression SOD, GPX and CAT in kidney. Results: Induction of diabetes led to a significant increase in MPO and MDA, reduced GSH level and GPx and CAT activities (P < 0.05). However, treatment with alpha-LA led to a significant elevation in GPx, CAT and GSH levels with a reduction in MPO activities and MDA levels (P < 0.05). Furthermore, the real-time reverse transcriptase-polymerase chain reaction (RT-PCR) analysis results showed increased expressions of GPx, CAT and SOD enzyme in the treatment group compared with the diabetic control group. Histopathological lesions such as increased glomerular volume and lymphocyte infiltration were attenuated in the alpha-LA treated group. Conclusions: Our findings indicated that alpha-LA supplementation is effective in preventing complications induced by oxidative stress and atherosclerosis in diabetic rats.

The Effect of Alpha-Lipoic Acid on the Protection of Epidermal Nerve Fibers and Microcapillaries in the Streptozotocin-Induced Diabetic Rats

2007 ◽  
Vol 31 (6) ◽  
pp. 488
Author(s):  
Ming Han Piao ◽  
Heung Yong Jin ◽  
Sun Kyung Song ◽  
Seun Mi Kang ◽  
So Young Kim ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Diabetic Rats ◽  
Nerve Fibers ◽  
Alpha Lipoic Acid

Effect Of alpha-Lipoic Acid On Lipid Peroxidation And Anti-Oxidant Enzyme Activities In Diabetic Rats

2002 ◽  
Vol 29 (4) ◽  
pp. 281-284 ◽  
Author(s):  
Yildiz Dincer ◽  
Aysegul Telci ◽  
Refik Kayali ◽  
Ilker A Yilmaz ◽  
Ufuk Cakatay ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Lipoic Acid ◽  
Enzyme Activities ◽  
Diabetic Rats ◽  
Alpha Lipoic Acid ◽  
Anti Oxidant

scholarly journals Alleviative Effect of Alpha-Lipoic Acid on Cognitive Impairment in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Rats

2021 ◽  
Vol 13 ◽  
Author(s):  
Chih-Yuan Ko ◽  
Jian-Hua Xu ◽  
Yangming Martin Lo ◽  
Rong-Syuan Tu ◽  
James Swi-Bea Wu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Synaptic Plasticity ◽  
Protein Kinase ◽  
Lipoic Acid ◽  
High Fat Diet ◽  
Diabetic Rats ◽  
Alpha Lipoic Acid ◽  
High Fat ◽  
Protein Expressions

Background: The intricate relationship between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD) suggests that insulin is involved in modulating AD-related proteins. Alpha-lipoic acid (ALA) can improve insulin resistance (IR) in diabetic rats. However, the role of ALA in alleviating the cognitive decline of T2DM is not yet clear. This study examined the ameliorative effect of ALA on cognitive impairment, cerebral IR, and synaptic plasticity abnormalities in high-fat diet (HFD) plus streptozotocin (STZ) induced diabetic rats.Methods: The HFD/STZ-induced T2DM male Wistar rats were orally administered with ALA (50, 100, or 200 mg/kg BW) once a day for 13 weeks. Abilities of cognition were measured with a passive avoidance test and Morris water maze. Specimens of blood and brain were collected for biochemical analysis after the rats were sacrificed. Western blotting was used to determine protein expressions in the hippocampus and cortex in the insulin signaling pathways, long-term potentiation (LTP), and synaptic plasticity-related protein expressions.Results: Alpha-lipoic acid improved hyperinsulinemia and the higher levels of free fatty acids of the T2DM rats. Behavioral experiments showed that the administration of ALA improved cognitive impairment in HFD/STZ-induced T2DM rats. ALA ameliorated insulin-related pathway proteins [phosphoinositide 3-kinase (PI3K), phospho-protein kinase B (pAkt)/Akt, and insulin-degrading enzyme (IDE)] and the LTP pathway, as well as synaptic plasticity proteins (calmodulin-dependent protein kinase II, cyclic AMP response element-binding protein, and postsynaptic density protein-95) of the cerebral cortex or hippocampus in HFD/STZ-induced T2DM rats.Conclusion: Our findings suggested that ALA may ameliorate cognition impairment via alleviating cerebral IR improvement and cerebral synaptic plasticity in diabetic rats.

scholarly journals Efek Pemberian Asam Alfa Lipoat pada Histopatologi Aorta Torakalis Tikus Diabetes Melitus Tipe 2

2021 ◽  
Vol 14 (1) ◽  
pp. 33
Author(s):  
Rijalun Arridho ◽  
Ismawati Ismawati ◽  
Enikarmila Asni ◽  
Ilhami Romus
Keyword(s):  
Thoracic Aorta ◽  
Lipoic Acid ◽  
Diabetic Rats ◽  
Male Rat ◽  
Diabetic Rat ◽  
Measured Parameter ◽  
Alpha Lipoic Acid ◽  
Significant Difference ◽  
Type 2 Diabetic

Atherosclerosis is arterial wall’s disease initiated by lipid retention, oxidation, and modification, provoking chronic inflmmation ultimately causing stenosis and thrombosis. This study investigated the effect of alpha lipoic acid (ALA) on thoracic aorta type 2 diabetic rat. Fifteen adult male rat of Rattus novergicus Wistar strain were separated into three groups (n=5), there were labelled as control, type 2 diabetes (DM), and DM + ALA. Type 2 diabetic rats were induced by streptozotocin (50 mg/kg bodyweight) and nicotinamide (110 mg/kg bodyweight) and categorized as diabetic rat if blood glucose level >250 mg/dl. Alpha lipoic acid was administered via intraperitoneal (60 mg/kg/day) and conducted for 3 weeks. The measured parameter was atherosclerosis lesion score. Results showed that there was no significant difference in atherosclerosis lesion scores between all groups designed (p=0,071). It can be concluded that ALA did not have a significant effect on atherosclerosis lesion of thoracic aorta type 2 diabetic rat.

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