MicroRNAs as Novel Biomarkers for P2Y12 – Inhibitors Resistance Prediction

Colorectal cancer (CRC) is the leading cause of cancer death worldwide and its incidence is increasing. In most patients with CRC, the PI3K/AKT signaling axis is over-activated. Regulatory oncogenic or tumor suppressor microRNAs (miRNAs) for PI3K/AKT signaling regulate cell proliferation, migration, invasion, angiogenesis, as well as resistance to chemo-/radio-therapy in colorectal cancer tumor tissues. Thus, regulatory miRNAs of PI3K/AKT/mTOR signaling represent novel biomarkers for new patient diagnosis and obtaining clinically invaluable information from post-treatment CRC patients for improving therapeutic strategies. This review summarizes the current knowledge of miRNAs’ regulatory roles of PI3K/AKT signaling in CRC pathogenesis.

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Evidence-Based Choice of P2Y12 Inhibitors in End Stage Renal Disease Patients: A Mini-Review

Current Drug Metabolism ◽

10.2174/138920021602150713114437 ◽

2015 ◽

Vol 16 (2) ◽

pp. 97-104 ◽

Cited By ~ 3

Author(s):

Yassine Bouatou ◽

Caroline Samer ◽

Pierre Fontana ◽

Youssef Daali ◽

Jules Desmeules

Keyword(s):

Renal Disease ◽

End Stage Renal Disease ◽

Evidence Based ◽

P2y12 Inhibitors ◽

Stage Renal Disease ◽

End Stage

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MicroRNAs as Potential Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma

Current Drug Targets ◽

10.2174/1389450120666190307095720 ◽

2019 ◽

Vol 20 (11) ◽

pp. 1129-1140 ◽

Cited By ~ 8

Author(s):

Seyed Mostafa Parizadeh ◽

Reza Jafarzadeh-Esfehani ◽

Maryam Ghandehari ◽

Fatemeh Goldani ◽

Seyed Mohammad Reza Parizadeh ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Early Diagnosis ◽

Biological Activities ◽

Radical Resection ◽

High Rate ◽

Average Survival ◽

Specific Tumor ◽

Serum Alpha Fetoprotein ◽

Novel Biomarkers ◽

Patients Experience

Hepatocellular carcinoma (HCC) is a common cancer, and the second most common cause of cancer-associated death globally. One of the major reasons for this high rate of mortality is a failure to make an early diagnosis. The average survival in untreated HCC patients is estimated to be approximately three months. The 5-year overall survival rate after radical resection is about 15-40% and within two years, more than two third of patients experience a relapse. To date, the most common biomarker which has been used for the diagnosis of HCC is serum alpha-fetoprotein (AFP). However, there is a lack of sensitive and specific tumor biomarkers for the early diagnosis of HCC. MicroRNAs are a class of short endogenous RNA with crucial role in many biological activities and cellular pathways and can be found in various tissues and body fluids. The aim of this review was to summarize the results of recent studies investigating miRNAs as novel biomarkers for the early diagnosis and prognostic risk stratification of patients with this type of liver cancer.

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Exosome: An Emerging Source of Biomarkers for Human Diseases

Current Molecular Medicine ◽

10.2174/1566524019666190429144310 ◽

2019 ◽

Vol 19 (6) ◽

pp. 387-394 ◽

Cited By ~ 4

Author(s):

Li Xu ◽

Long-Fei Wu ◽

Fei-Yan Deng

Keyword(s):

Breast Milk ◽

Intercellular Communication ◽

Translational Medicine ◽

Disease Diagnosis ◽

Human Diseases ◽

Isolation And Identification ◽

Biomarker Identification ◽

Biological Features ◽

Diagnosis And Prognosis ◽

Novel Biomarkers

Exosomes are 30-120nm long endocytic membrane-derived vesicles, which are secreted by various types of cells and stably present in body fluids, such as plasma, urine, saliva and breast milk. Exosomes participate in intercellular communication. Recently accumulative studies have suggested that exosomes may serve as novel biomarkers for disease diagnosis and prognosis. Herein, we reviewed the biological features of exosomes, technologies for exosome isolation and identification, as well as progress in exosomal biomarker identification, highlighting the relevance of exosome to human diseases and significance and great potential in translational medicine.

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