scholarly journals SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) IN PAGE FAMILY MEMBER 4 (PAGE4) GENE IN MEN WITH BENIGN PROSTATE HYPERPLASIA FROM IRAQ.

2017 ◽  
Vol 5 (5) ◽  
pp. 562-567
Author(s):  
LindaFAbdul Sattar ◽  
◽  
HayderIAl Ameery ◽  
AbdulwahidBAl Shaibani ◽  
◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Family Member ◽  
Benign Prostate Hyperplasia ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Prostate Hyperplasia ◽  
Benign Prostate

scholarly journals Involvement of Fibroblast Growth Factor Receptor Genes in Benign Prostate Hyperplasia in a Korean Population

2013 ◽  
Vol 35 ◽  
pp. 869-875 ◽  
Author(s):  
Hae Jeong Park ◽  
Su Kang Kim ◽  
Jong Woo Kim ◽  
Sang Hyub Lee ◽  
Koo Han Yoo ◽  
...  
Keyword(s):  
Prostate Volume ◽  
Direct Sequencing ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Prostate Hyperplasia ◽  
Clinical Phenotypes ◽  
Prostate Growth ◽  
Benign Prostate

Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been implicated in prostate growth and are overexpressed in benign prostatic hyperplasia (BPH). In this study, we investigated whether single nucleotide polymorphisms (SNPs) of theFGFRgenes (FGFR1andFGFR2) were associated with BPH and its clinical phenotypes in a population of Korean men. We genotyped four SNPs in the exons ofFGFR1andFGFR2(rs13317 inFGFR1; rs755793, rs1047100, and rs3135831 inFGFR2) using direct sequencing in 218 BPH patients and 213 control subjects. No SNPs ofFGFR1orFGFR2genes were associated with BPH. However, analysis according to clinical phenotypes showed that rs1047100 ofFGFR2was associated with prostate volume in BPH in the dominant model (GA/AA versus GG,P= 0.010). In addition, a significant association was observed between rs13317 ofFGFR1and international prostate symptom score (IPSS) in the additive (TC versus CC versus TT,P= 0.0022) and dominant models (TC/CC versus TT,P= 0.005). Allele frequency analysis also showed significant association between rs13317 and IPSS (P= 0.005). These results suggested thatFGFRgenes could be related to progression of BPH.

scholarly journals Relevance of Interleukins 6 and 8 Single Nucleotide Polymorphisms in Prostate Cancer: A Multicenter Study

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Amany A. Ghazy ◽  
Mohammed Jayed Alenzi
Keyword(s):  
Prostate Cancer ◽  
High Frequency ◽  
Matched Control ◽  
Control Group ◽  
Nucleotide Polymorphisms ◽  
Significant Relation ◽  
Single Nucleotide ◽  
Prostate Hyperplasia ◽  
Statistical Correlations ◽  
Benign Prostate

The diverse roles of cytokines as IL-6 and IL-8 have been studied in terms of their SNPs in many diseases but their role in prostate cancer (PCa) is still uncertain. Aim. To determine the relevance of IL-6 rs1800795 SNP and/or IL-8 rs2227306 SNP with prostate cancer’s risk. Subjects and Methods. 40 PCa patients, 40 benign prostate hyperplasia (BPH) patients, and 40-age-matched-control group were enrolled in the study. Genotyping of IL-6 rs1800795 (G/C) SNP and IL-8 rs2227306 (C/T) SNP was determined using real-time PCR. Results. High frequency of IL-6 rs1800795GG and IL-8 rs2227306CC genotypes was noticed among PCa patients with associated OR 10.091 and 8.143, respectively. Comparisons based on allele frequencies revealed that IL-6G and IL-8C alleles are more frequent among PCa patients than other groups. Presence of IL-6 rs1800795G and IL-8 rs2227306C alleles in the same patient increase PCa risk by 16.7 times. Statistical correlations between PSA ratio and both of IL-6 and IL-8 SNP did not show any significant relation among PCa patients. Conclusion. IL-6 rs1800795G and IL-8 rs2227306C alleles could be considered risk factors for PCa development, particularly if presented together. However, no relation was found between both cytokines SNP and severity of prostate cancer.

Development of a simple method for the determination of single nucleotide polymorphisms

2010 ◽  
Vol 34 (8) ◽  
pp. S75-S75
Author(s):  
Weifeng Zhu ◽  
Zhuoqi Liu ◽  
Daya Luo ◽  
Xinyao Wu ◽  
Fusheng Wan
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Simple Method ◽  
Single Nucleotide

Sex Differences in Childhood Associations between DNA Markers and General Cognitive Ability

2007 ◽  
Vol 28 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Rosalind Arden ◽  
Nicole Harlaar ◽  
Robert Plomin
Keyword(s):  
Sex Differences ◽  
Single Nucleotide Polymorphisms ◽  
Cognitive Ability ◽  
Dna Markers ◽  
Community Sample ◽  
Nucleotide Polymorphisms ◽  
General Cognitive Ability ◽  
Single Nucleotide ◽  
The Difference

Abstract. An association between intelligence at age 7 and a set of five single-nucleotide polymorphisms (SNPs) has been identified and replicated. We used this composite SNP set to investigate whether the associations differ between boys and girls for general cognitive ability at ages 2, 3, 4, 7, 9, and 10 years. In a longitudinal community sample of British twins aged 2-10 (n > 4,000 individuals), we found that the SNP set is more strongly associated with intelligence in males than in females at ages 7, 9, and 10 and the difference is significant at 10. If this finding replicates in other studies, these results will constitute the first evidence of the same autosomal genes acting differently on intelligence in the two sexes.

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