scholarly journals Topical antibiotics for acute rhinosinusitis in children

2021 ◽  
pp. 67-70
Author(s):  
Denis A. Tulupov ◽  
Elena P. Karpova
Keyword(s):  
Viral Infection ◽  
Nasal Cavity ◽  
Mucous Membrane ◽  
Symptomatic Treatment ◽  
Respiratory Viral Infection ◽  
Acute Rhinosinusitis ◽  
Nasal Decongestants ◽  
Acute Respiratory Viral Infection ◽  
Acute Rhinitis ◽  
Combined Drugs

Rhinitis or nasopharyngitis are the most common manifestations of acute respiratory viral infection (ARVI) in children. Inflammation of the mucous membrane in the nasal cavity develops in more than 70% of ARVI cases, and rhinovirus infection is the most common etiological factor for these conditions. In this article, the authors present a short review of the existing data on the use of combined drugs based on N-acetylcysteine and tuamingheptan in the treatment of acute rhinological pathology in children. The authors present generalized data on the nature of the course of acute rhinitis, as the main manifestation of acute respiratory viral infection in children, and modern views on the tactics of treating this condition. The main theses on symptomatic treatment of nasal obstruction in acute rhinitis using nasal decongestants are presented. However, the use of nasal vasoconstrictor drugs as monotherapy to treat acute rhinitis may be less effective, as a buildup of thick discharge in the nasal cavity, which a patient is not always able to blow out from the nose (especially in childhood), prevents the drug injected into the nasal cavity from contacting the mucous membrane. The main pathogenetic grounds for the use of mucolytics in the treatment of acute rhinitis and acute rhinosinusitis are presented. The use of N-acetylcysteine-based drugs in otorhinolaryngological practice has been substantiated. N-acetylcysteine is a direct mucolytic agent. Its action is associated with the ability of its free sulfhydryl groups to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of a thick discharge. As conclusions, the authors talk about the prospect of using combined drugs based on N-acetylcysteine and tuamingheptan both in the symptomatic treatment of acute rhinitis and as an adjunct treatment for acute rhinosinusitis in children.

scholarly journals Highlights of prescribing herbal medicines in the complex therapy of acute rhinosinusitis

2020 ◽  
pp. 18-25
Author(s):  
S. V. Ryazantsev ◽  
A. A. Krivopalov ◽  
P. A. Shamkina ◽  
K. A. Lezhneva
Keyword(s):  
Viral Infection ◽  
Experimental Studies ◽  
Herbal Medicines ◽  
Influenza Viruses ◽  
Mucociliary Transport ◽  
Respiratory Viral Infection ◽  
Acute Rhinosinusitis ◽  
Complex Therapy ◽  
Syncytial Virus ◽  
Acute Respiratory Viral Infection

Today, acute rhinosinusitis is one of the most common infectious diseases in the world. Usually, acute rhinosinusitis develops against the background of acute respiratory viral infection caused by influenza viruses, parainfluenza, respiratory syncytial virus, adenoviruses, or rhinoviruses. At the same time, in 1–2% of cases, the course of acute respiratory viral infection is complicated by bacterial sinusitis. At the same time, in 1–2% of cases, the course of acute respiratory viral infection is complicated by bacterial sinusitis. Considering the stages of the process, it is extremely important to adequately prescribe therapy at the onset of acute respiratory viral infection before the development of symptoms of acute rhinosinusitis, since the prognosis largely depends on its effectiveness. Treatment of acute rhinosinusitis is aimed at relieving the symptoms of the disease, improving aeration of the nasal cavity and paranasal sinuses, restoring the functions of mucociliary transport, and in the case of bacterial agent attachment, at the eradication of the pathogen. Such problems are solved through complex therapy, including irrigation measures, decongestants, topical glucocorticosteroids, and antibiotics if indicated. To improve the function of mucociliary transport the standard therapy of acute rhinosinusitis is combined with herbal medicines, which have a mucoactive, secretomotor, secretolytic and anti-inflammatory effects. The article presents data on the pharmacokinetics and pharmacodynamics of the drug Sinupret, the results of experimental studies and clinical studies that prove the high effectiveness and safety of the drug in the complex treatment of acute rhinosinusitis. One of the important advantages of using the herbal drug Sinupret is an increase the effectiveness of antibiotic therapy, which allows for a faster recovery in bacterial sinusitis, and moreover in cases of acute post-viral sinusitis, Sinupret can be used as monotherapy.

Indicators of the kinin blood system in severe forms of acute respiratory viral infections in children

1982 ◽  
Vol 63 (2) ◽  
pp. 51-52
Author(s):  
V. A. Anokhin ◽  
A. D. Tsaregorodtsev
Keyword(s):  
Viral Infection ◽  
Viral Infections ◽  
Severe Form ◽  
Blood System ◽  
Control Group ◽  
Healthy Children ◽  
Respiratory Viral Infection ◽  
Respiratory Viral Infections ◽  
Acute Respiratory Viral Infection ◽  
Apparently Healthy

The aim of this work was to study the parameters of the components of the kinin blood system in children with severe forms of acute respiratory viral infections (ARVI) with neurotoxicosis syndrome. 55 children with ARVI (aged from 1 to 6 months - 14, from 6 months to 1 year - 18, from 1 to 3 years - 11, from 3 to 7 years - 12). 38 patients were admitted in the first three days of illness, 12 - on 4-5 days and 5 - at a later date. 30 children had a severe form of acute respiratory viral infection and 25 - moderate. Adenovirus infection was diagnosed in 14 patients, influenza - in 16, parainfluenza - in 7, MS-viral infection in 5, mixed viral infection - in 13. The control group consisted of 10 apparently healthy children.

Modern etiological and clinical features of acute respiratory viral infection in children. Are there any prerequisites for antiviral therapy? Literature review

Pharmateca ◽  
2020 ◽  
Vol 1_2020 ◽  
pp. 14-19 ◽  
Author(s):  
I.N. Zakharova Zakharova ◽  
I.M. Osmanov Osmanov ◽  
A.N. Goryainova Goryainova ◽  
N.V. Gavelya Gavelya ◽  
E.V. Ruchkina Ruchkina ◽  
...  
Keyword(s):  
Literature Review ◽  
Viral Infection ◽  
Antiviral Therapy ◽  
Clinical Features ◽  
Respiratory Viral Infection ◽  
Acute Respiratory Viral Infection

scholarly journals The practice of using a domestic antiviral drug in the etiotropic therapy of acute respiratory viral infection

2020 ◽  
Vol 92 (12) ◽  
pp. 160-164 ◽  
Author(s):  
D. A. Lioznov ◽  
I. I. Tokin ◽  
T. G. Zubkova ◽  
P. V. Sorokin
Keyword(s):  
Viral Infection ◽  
Antiviral Drug ◽  
Optimal Dose ◽  
Respiratory Viral Infection ◽  
Treatment Regimens ◽  
Pcr Method ◽  
Virus Antigens ◽  
Acute Respiratory Viral Infection

Aim.Evaluation of efficacy, safety, tolerability, and determination of the optimal dose of riamilovir in patients diagnosed with acute respiratory viral infection (ARVI). Materials and methods.The study included 270 patients with uncomplicated ARVI of mild and moderate severity (with a laboratory-confirmed PCR method for the presence of ARVI antigens, absence of influenza virus antigens). Patients were included in the study after signing an informed consent. Patients were randomized into 3 groups in a 1:1:1 ratio of 90 patients in each group. Completed the study in accordance with the Protocol: 267 patients. The study involved patients diagnosed with ARVI. Results.Confirmed the efficacy, safety and tolerability of the drug riamilovir. Adverse drug reactions associated, in the opinion of the doctor, with taking the drug and resulting in discontinuation of the drug, were not noted in this study. Conclusion.As a result of clinical study, the effectiveness of both ARVI treatment regimens with drug riamilovir has been shown. There were no differences in the effectiveness and safety of the proposed treatment regimens. Practical use of both treatment regimens is recommended. However, according to the authors, taking the drug 3 times a day is much more convenient for patients, improves the quality of life and adherence to therapy.

scholarly journals THE INFORMATIVE VALUE OF IMMUNOLOGICAL AND GENETIC TESTS IN THE DIAGNOSIS WEST NILE FEVER

2020 ◽  
Vol 76 (4) ◽  
pp. 42-45
Author(s):  
Т.V. Zamarina ◽  
◽  
N.P. Khrapova ◽  
I.A. Barkova ◽  
E.V. Pimenova ◽  
...  
Keyword(s):  
Viral Infection ◽  
Viral Rna ◽  
Unknown Etiology ◽  
West Nile Fever ◽  
West Nile ◽  
Respiratory Viral Infection ◽  
Blood Samples ◽  
Monitoring Centre ◽  
Laboratory Confirmation ◽  
Acute Respiratory Viral Infection

We used ELISA and PCR for laboratory verification of West Nile fever (MUC 4.2.3009-12). We analyzed serum and whole blood samples which had been sent to West Nile fever reference monitoring centre in 2018–2019. A total of 270 blood samples obtained from patients with presumed viral encephalitis of unknown etiology, acute respiratory viral infection, acute respiratory viral infection, meningitis, acute gastroenteritis were analyzed. Antibodies against WNV were detected in 193 (71,4 %) blood samples, while 146 samples were found to be capable of developing an immune response with viral RNA not being detected in them. Both WNV antibodies and viral RNA were detected in 47 (17,4 %) samples tested. WNV RNA was detected in only 14 (5,1 %) cases. Thus, laboratory confirmation of WNF was obtained in 76,6 % of cases (207 out of 270).

scholarly journals EPSTEIN-BARR VIRAL INFECTION IN CHILDREN

2019 ◽  
Vol 19 (1) ◽  
pp. 43-47
Author(s):  
N.I. Smoljar ◽  
N.L. Chukhray ◽  
S.V. Savchyn
Keyword(s):  
Viral Infection ◽  
Infectious Mononucleosis ◽  
Epstein Barr Virus ◽  
Adult Population ◽  
Epstein Barr Virus Infection ◽  
Respiratory Viral Infection ◽  
Number Of Children ◽  
Barr Virus ◽  
Epstein Barr ◽  
Acute Respiratory Viral Infection

Today there is a growing tendency in the prevalence of diseases caused by herpes viruses. At the same time there is an increase in the incidence of infectious mononucleosis, and the Epstein-Barr virus is one of its causative agents. The level of Epstein-Barr virus infection among the adult population of Ukraine has reached almost 100%, and more than 50% among the children. Epstein-Barr virus is a respiratory infection, and can be transmitted through saliva. According to statistic data, 85% of children are carriers of this virus, but it manifests itself only when immunity weakens. In many children, infectious mononucleosis occurs as an acute respiratory viral infection or quinine, and often paediatricians do not diagnose it. Usually children under the age of 10-14 are susceptible to the disease. In a large number of children, the course of infectious mononucleosis is quite similar to an acute respiratory viral infection or quinsy, and often paediatricians do not diagnose it. Usually children under the age of 10-14 are susceptible to the disease. The disease is characterized by feverish condition, sore throat, exanthema, enlargement of the lymph nodes, liver and spleen. All children with infectious mononucleosis manifest signs of tonsillopharyngitis that develops due to the growing activity of the opportunistic bacterial microflora, which densely colonizes the oropharyngeal mucosa in the immunocompromized condition caused by a herpes viral infection. At present, infectious mononucleosis plays a significant role in the overall infectious morbidity in children and is one of the leading causes of children hospitalization. Analysis of the case histories in patients aged 1-3, 4-6, 7-10, 11-15 and over 15 years through 2014-2018 has shown that infectious mononucleosis was predominantly diagnosed in male patients (222 cases) versus 150 cases of in female patients. The highest incidence of infectious mononucleosis has been registered among the residents of Lviv (287 cases) compared with the inhabitants of the Lviv region (85 cases). Regarding the age aspect, it has been found that the overwhelming majority of patients who have been diagnosed with an infectious mononucleosis are children under the age of 3 years.

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