Indicators of the kinin blood system in severe forms of acute respiratory viral infections in children

1982 ◽  
Vol 63 (2) ◽  
pp. 51-52
Author(s):  
V. A. Anokhin ◽  
A. D. Tsaregorodtsev
Keyword(s):  
Viral Infection ◽  
Viral Infections ◽  
Severe Form ◽  
Blood System ◽  
Control Group ◽  
Healthy Children ◽  
Respiratory Viral Infection ◽  
Respiratory Viral Infections ◽  
Acute Respiratory Viral Infection ◽  
Apparently Healthy

The aim of this work was to study the parameters of the components of the kinin blood system in children with severe forms of acute respiratory viral infections (ARVI) with neurotoxicosis syndrome. 55 children with ARVI (aged from 1 to 6 months - 14, from 6 months to 1 year - 18, from 1 to 3 years - 11, from 3 to 7 years - 12). 38 patients were admitted in the first three days of illness, 12 - on 4-5 days and 5 - at a later date. 30 children had a severe form of acute respiratory viral infection and 25 - moderate. Adenovirus infection was diagnosed in 14 patients, influenza - in 16, parainfluenza - in 7, MS-viral infection in 5, mixed viral infection - in 13. The control group consisted of 10 apparently healthy children.

scholarly journals Investigation of the drug «Cycloferon» influence on the morbidity of acute respiratory viral infections and flu and condition of local immunity in children of different age groups

2006 ◽  
Vol 5 (2) ◽  
pp. 119-126
Author(s):  
Ye. I. Kondratieva ◽  
L. A. Matveeva ◽  
Ye. Yu. Tyuteva ◽  
N. A. Ryzhakova ◽  
A. A. Terentieva ◽  
...  
Keyword(s):  
Viral Infection ◽  
Viral Infections ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Local Immunity ◽  
Respiratory Viral Infection ◽  
Upper Respiratory ◽  
Respiratory Viral Infections ◽  
Acute Respiratory Viral Infection

The aim of the research was the investigation of prophylactic using the drug «Cycloferon». Influence of Cycloferon on acute respiratory viral infection and flu and on their clinical manifestations as well as on local immunity condition was assessed. We examined 124 children aged from 4 to 18 years. It was revealed that duration of acute respiratory viral infections as well as flu decreased and local immunity of the upper respiratory ways increased considerably in children taking Cycloferon. The abovementioned changes were observed both just after the treatment and in the follow-up period.

scholarly journals STATE OF IMMUNITY IN PRESCHOOLERS WITH ACUTE RESPIRATORY VIRAL INFECTIONS ASSOCIATED WITH ADENOID VEGETATIONS

2021 ◽  
Vol 65 (2) ◽  
Author(s):  
Evgeniia Dmitrova ◽  
◽  
Oleksandr Smiyan ◽  
Viktoria Holubnycha ◽  
Kateryna Smiian ◽  
...  
Keyword(s):  
Viral Infections ◽  
Respiratory Infections ◽  
Age Groups ◽  
Statistical Processing ◽  
Control Group ◽  
Healthy Children ◽  
Acute Period ◽  
Study Results ◽  
Respiratory Viral Infections ◽  
Acute Respiratory Viral Infection

Introduction. Acute respiratory infections are the most common infectious diseases worldwide among children of different age groups. Materials and methods. 59 children between the ages of 3 and 7 participated in the study. The first group included 22 patients with an acute respiratory viral infection, the second one consisted of 23 patients with acute respiratory viral infections associated with adenoid vegetation, and 14 apparently healthy children were included in the control group. Immunology research was conducted during the acute period of the disease. Statistical processing of received data was done with the standard statistical software EZR 1.41. Results. After the research, most of the patients with acute respiratory viral infections were identified an actual increase in CD3+, CD4+, CD8+, CD22+- cells and IgA, IgM in the blood serum. Simultaneously, in patients with acute respiratory viral infections associated with adenoid vegetation during the acute period, the increase in total lymphocytes was identified due to CD4+, CD8+, CD22+ cells and IgG. A comparative analysis of the study results of both groups of patients showed that children from the second group had a significantly higher level of CD3+- cells, while the CD22+- lymphocytes, IgA, IgM and IgG were significantly lower from the similar indicators of the first group. Conclusions. The acute period of the disease in children with acute respiratory viral infections, associated with adenoid vegetation, had an imbalance in both the cell and the immune system's humoral component

scholarly journals ALTERED INTERFERON DEFENSE IN CHILDREN WITH DYNAMI-CALLY CHANGED INFECTIOUS MONONUCLEOSIS

2019 ◽  
Author(s):  
E. Kukushkina ◽  
S. Koteleva ◽  
M. Blyakher ◽  
I. Fedorova ◽  
Z. Ramazanova ◽  
...  
Keyword(s):  
Viral Infection ◽  
Infectious Mononucleosis ◽  
Blood Cells ◽  
Control Group ◽  
Healthy Children ◽  
Respiratory Viral Infection ◽  
Old Patients ◽  
Interferon Status ◽  
Interferon System ◽  
Acute Respiratory Viral Infection

The state of the interferon system in 38 children with acute infectious mononucleosis (IM) caused by the Epstein-Barr virus was analyzed. Interferon status was examined in accordance with F.I. Ershov method based on assessing related biological activity by measuring interferon level in the blood serum or produced by blood cells. The aim of the study was to gain scientifically justified data for use of interferon preparations or interferonogens in IM combination therapy. For this, interferon status in children with acute IM was compared with that one not only in control group (30 healthy children, aged 3-6 and 20 children, aged 7-14 years, examined earlier to create an intra-laboratory interferon normal range), but also in children with lacunar angina or acute respiratory viral infection, hospitalized in the same department of the clinic and comparable with the main group in severity of the condition. In addition, we assessed changes in IFN-status in IM patients receiving no interferon preparations, one month after the disease onset.The study showed that patients with moderate acute IM were featured with decreased potential of blood leukocytes to virus-induced IFNα and mitogen-induced IFNγ production observed with almost similar or some lower rate as in the control group of children hospitalized with angina or acute respiratory viral infection.Peripheral blood cells from moderate acute IM patients in the 3-6-year age group were found to produce virtually unaltered interferon level, whereas almost sole IFN-alpha production was affected in 7-14-year-old patients. Moreover, in 7-14-year old patients the level 1 and level 2 of IFNα deficiency was observed in 38% and 6% of cases, respectively. It is likely it was just this patient group requiring administration of any IFNα replacement therapy.As few as 12 children were re-examined after discharge from the clinic. Initially, prevalence and severity level of impaired interferon production in this subgroup did not differ from that one for total patient sample, whereas 1 month later a host potential to produce both IFNα and IFNγ even without therapy acting on interferon system was noted to be moderately augmented.

scholarly journals Macrolide Therapy in Respiratory Viral Infections

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Jin-Young Min ◽  
Yong Ju Jang
Keyword(s):  
Influenza Virus ◽  
Viral Infection ◽  
Viral Infections ◽  
Wide Spectrum ◽  
Influenza Virus Infection ◽  
Respiratory Viral Infection ◽  
Rsv Infection ◽  
Respiratory Viral Infections ◽  
Syncytial Virus ◽  
Viral Titers

Background. Macrolides have received considerable attention for their anti-inflammatory and immunomodulatory actions beyond the antibacterial effect. These two properties may ensure some efficacy in a wide spectrum of respiratory viral infections. We aimed to summarize the properties of macrolides and their efficacy in a range of respiratory viral infection.Methods. A search of electronic journal articles through PubMed was performed using combinations of the following keywords including macrolides and respiratory viral infection.Results. Bothin vitroandin vivostudies have provided evidence of their efficacy in respiratory viral infections including rhinovirus (RV), respiratory syncytial virus (RSV), and influenza virus. Much data showed that macrolides reduced viral titers of RV ICAM-1, which is the receptor for RV, and RV infection-induced cytokines including IL-1β, IL-6, IL-8, and TNF-α. Macrolides also reduced the release of proinflammatory cytokines which were induced by RSV infection, viral titers, RNA of RSV replication, and the susceptibility to RSV infection partly through the reduced expression of activated RhoA which is an RSV receptor. Similar effects of macrolides on the influenza virus infection and augmentation of the IL-12 by macrolides which is essential in reducing virus yield were revealed.Conclusion. This paper provides an overview on the properties of macrolides and their efficacy in various respiratory diseases.

scholarly journals Small Animal Models of Respiratory Viral Infection Related to Asthma

Viruses ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 682 ◽  
Author(s):  
Mingyuan Han ◽  
Charu Rajput ◽  
Tomoko Ishikawa ◽  
Caitlin Jarman ◽  
Julie Lee ◽  
...  
Keyword(s):  
Animal Models ◽  
Viral Infection ◽  
Viral Infections ◽  
Small Animal ◽  
Respiratory Viral Infection ◽  
Asthma Exacerbations ◽  
Small Animal Models ◽  
Respiratory Viral Infections ◽  
Syncytial Virus ◽  
Underlying Mechanisms

Respiratory viral infections are strongly associated with asthma exacerbations. Rhinovirus is most frequently-detected pathogen; followed by respiratory syncytial virus; metapneumovirus; parainfluenza virus; enterovirus and coronavirus. In addition; viral infection; in combination with genetics; allergen exposure; microbiome and other pathogens; may play a role in asthma development. In particular; asthma development has been linked to wheezing-associated respiratory viral infections in early life. To understand underlying mechanisms of viral-induced airways disease; investigators have studied respiratory viral infections in small animals. This report reviews animal models of human respiratory viral infection employing mice; rats; guinea pigs; hamsters and ferrets. Investigators have modeled asthma exacerbations by infecting mice with allergic airways disease. Asthma development has been modeled by administration of virus to immature animals. Small animal models of respiratory viral infection will identify cell and molecular targets for the treatment of asthma.

scholarly journals Antiviral therapy of acute respiratory viral infection and influenza in children in a hospital

2018 ◽  
Vol 10 (4) ◽  
pp. 82-88 ◽  
Author(s):  
E. V. Sharipova ◽  
I. V. Babachenko ◽  
A. S. Levina ◽  
S. G. Grigoriev
Keyword(s):  
Viral Infection ◽  
Influenza A ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Influenza B ◽  
General Group ◽  
Respiratory Viral Infection ◽  
The Third ◽  
Number Of Patients ◽  
Acute Respiratory Viral Infection

Objective: to study the efficacy and safety of antiviraltherapy for influenza and acute respiratory viral infection with Kagocel in children in a hospital. Materials and methods: in the observational study included 80 children aged 3 to 11 years, hospitalized with symptoms of influenza and acute respiratory viral infection. The etiological confirmation of the diagnosis was carried out by the PCR method based onthe study of nasal swabs.The drug Kagocel was administered according to the instructions for use during the first 24 hours of hospitalization.The analysis of the virus release after the course of therapy with Kagocel (at 5–6 days from the beginning of treatment) was carried out only in patients with verified influenza and acute respiratory viral infection. Results: the dominant influence of viruses in the development of acute respiratory infections in children aged 3 to 11 years in the period of rising morbidity in St. Petersburg from September 2015 to May 2016. At the same time, 25% of the total number of patients were sick with influenza A and/or B. There was a significant decrease in fever to the third day (p <0,001) and normalization of body temperature from the fourth day after the beginning of therapy with Kagocel in the general group and in patients with confirmed influenza diagnosis. The intoxication syndrome, most pronounced with the flu, was mostly stopped by the fourth day(р<0,001). Catarrhalsyndrome, prevalent in the general group of acute respiratory viral infection, had longer periods of clinical manifestation and against the background of the therapy completely eliminated to the third or seventh day of therapy.Negative PCR results after the course of Kagocel therapy were established in 57,1% of the total group of patients. Among all detected viruses, the most typical is the absence of repeated isolation of influenza B and A viruses, PC virus (86% and 53,8%, 71,4%, respectively), the elimination of rhinoviruses was less frequent (33,3%). Conclusion: according to the results of the study, the effectiveness of therapy with the inclusion of the drug Kagocel in relieving fever by 3–4 days of treatment, as well as intoxication syndrome by 5–6 days in patients with acute respiratory viral infections, including patients with influenza, has been established. Negative results of PCR at the time of completion of therapy occurred mainly in patients with influenza A and B, PC infection. No adverse events were noted.

scholarly journals Combined therapy of acute respiratory viral infections, including coronavirus infection, using a specialized mattress in the background

2020 ◽  
Vol 8 (11) ◽  
pp. 3804
Author(s):  
Edvard V. Kryzhanovskii ◽  
Alexander B. Yavorsky
Keyword(s):  
Respiratory Tract ◽  
Viral Infection ◽  
Respiratory Infection ◽  
Viral Infections ◽  
Nasal Congestion ◽  
Combined Therapy ◽  
Double Blind ◽  
Respiratory Viral Infection ◽  
Acute Respiratory Viral Infection ◽  
Tract Infections

Background: Acute respiratory viruses are associated with lower respiratory tract diseases, providing an essential load on the public health system worldwide. Acute respiratory tract infections can be caused by many different viruses, and no approved vaccines or medicines exist for most of them. New approaches to respiratory infection treatment complement the molecular methods by focusing on improving the quality of daily life stages. One of the most important stages is sleep, which is associated with the overall organism restoration and, therefore, is critical to the recovery efficacy. We consider a specialized mattress with a bioactive vicuna cover as a facility improving the sleep quality and estimate its influence on the respiratory infection dynamics for patients under treatment by conventional medication.Methods: Data from 24 patients with the acute respiratory viral infection were collected in the 5 day period, during which they were treated with conventional medication and were sleeping either on the specialized mattresses or on regular mattresses. The patients were split into four groups depending on the mattress type and information that they had about that type, under the double-blind experiment setup. The data comprised the dynamics of several symptoms of the disease, including fever, headache, cough, mucosal hyperemia, and others.Results: Patients with the acute respiratory viral infection demonstrated faster recovery under conditions of sleeping on the specialized mattresses, as compared to the patients who were sleeping on regular mattresses. This difference in the recovery rate was observed for all considered symptoms of the disease, with the largest difference exhibited by nasal congestion (33% difference in the rate between the specialized and regular mattress groups), cough (25%), and rheum (25%). The control for the placebo effect did not reveal its essential influence for most symptoms.Conclusions: The specialized mattresses with the bioactive vicuna cover can effectively be used by patients with the acute respiratory viral infection in addition to conventional tools and medicine. Sleeping on these mattresses alleviate the dynamical state of patients with the disease and facilitates in relieving patients of the symptoms.

scholarly journals Respiratory viral infections by Non-influenza viruses are associated with more adverse clinical outcome in patients with underlying liver disease: a single centre laboratory based study.

2020 ◽  
Author(s):  
Ekta Gupta ◽  
Abhishek Padhi ◽  
Kavita Agarwal ◽  
Krithiga Ramachandran ◽  
Reshu Aggarwal ◽  
...  
Keyword(s):  
Liver Disease ◽  
Clinical Outcome ◽  
Viral Infection ◽  
Critically Ill ◽  
Viral Infections ◽  
Influenza Viruses ◽  
Respiratory Viral Infection ◽  
Respiratory Viral Infections ◽  
Tract Infections ◽  
Clinical Records

Background Respiratory viral infections are an important cause of acute respiratory tract infections. They are caused by both Influenza and non influenza viruses. Respiratory viral infections are known to be associated with severe clinical outcome especially in the critically ill. A constant surveillance is needed for early etiological identification which can help in timely and appropriate management and will further help in prevention of indiscriminate use of antibiotics in patients with viral etiology. Methods In this retrospective study, clinical records of all adult liver disease patients with clinically confirmed ARI, whose request for respiratory viral testing were received in the virology laboratory during September 2016 - March 2019 were reviewed. Respiratory viruses were identified by real time PCR on FilmArray 2.0 instrument (BioFire Diagnostics, Utah, USA) using Respiratory panel as per the manufacturer's instructions. Results Of the 603 patients of liver disease with clinically confirmed influenza like illness, over all incidence of respiratory viral infection was 24.3% (n= 147). Infections by non-influenza viruses (87, 59.1%) were more than influenza group of viruses. Mortality was higher in non influenza group (43, 49.4%) as compared to influenza (24, 40%) [p=0.015] being maximum in Rhinovirus, 22 (32.8%). Two peaks were observed in both influenza and non influenza groups, first in the months of January and February and the other one in August and October. Conclusion With the emergence of SARS- CoV-2 it has now become imperative for a constant surveillance of the non influenza viruses for early etiological identification of the respiratory viral infection for proper and timely management in the critically ill.

scholarly journals Clinical-epidemiological peculiarities of acute respiratory infections in children from 3 to 12 years and evaluation of effectiveness of antivirus therapy

2019 ◽  
Vol 11 (3) ◽  
pp. 38-45
Author(s):  
S. A. Khmilevskaya ◽  
N. I. Zryachkin ◽  
V. E. Mikhailova
Keyword(s):  
Viral Infections ◽  
Respiratory Infections ◽  
Molecular Genetic ◽  
Respiratory Viruses ◽  
Acute Respiratory Infections ◽  
Age Group ◽  
Leading Role ◽  
Respiratory Viral Infections ◽  
Acute Respiratory Viral Infection ◽  
Tract Infections

The aim: to study the etiological structure of acute respiratory infections in children aged 3 to 12 hospitalized in the early stages of the disease in the department of respiratory infections of the children’s hospital, and to reveal the features of their clinical course and the timing of DNA / RNA elimination of respiratory viruses from nasal secretions, depending on the method of therapy. Materials and methods: 100 children with acute respiratory infections aged 3 to 12 years were monitored. The nasal secrets on the DNA / RNA of respiratory viruses were studied by PCR. Depending on the method of therapy, patients were divided into 2 groups: patients of group 1 (comparison) received basic treatment (without the use of antiviral drugs), in patients of the 2nd group (main), along with basal therapy, the drug was used umifenovir in a 5-day course at the ageappropriate dosage. Results: In the etiologic structure of ARVI in children from 3 to 12 years, the leading place was taken by rhinovirus, influenza and metapneumovirus infections (isolated – 18%, 19% and 20% respectively, in the form of a mixed infection – 11%). The main syndromic diagnosis at the height of the disease was rhinopharyngitis. Complications were observed in 42% of cases, as often as possible with flu – 53% of cases. Features of metapneumovirus infection in children of this age group were: predominance of non-severe forms of the disease in the form of acute fever with symptoms of rhinopharyngitis, as well as a small incidence of lower respiratory tract infections. The use of the drug umiphenovir in children with acute respiratory viral infections of various etiologies contributed to significantly faster elimination of viral DNA / RNA from the nasal secretion, which was accompanied by a ecrease in the duration of the main clinical and hematological symptoms of the disease, a decrease in the incidence of complications, and reduced the duration of stay in hospital. Conclusion: application of modern molecular genetic methods of diagnostics made it possible to identify the leading role of influenza, metapneumovirus and rhinovirus infections in the etiology of acute respiratory viral infection in patients aged 3 to 12 years, and to determine a number of clinical features characteristic of this age group. The results of the study testify to the effectiveness of umiphenovir in the treatment of children with acute respiratory viral infections of various etiologies and allow us to recommend this drug as an effective and safe etiotropic agent.

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