Clinical-pharmacological aspects of the choice of phytocomponents for the regulation of the gastrointestinal function

The presentations of dyspepsia include a range of clinical symptoms, each of which has different mechanisms of development, and, therefore, requires different approaches to the correction. In this context, the combination preparations containing components of natural origin with polymodal action on the gastrointestinal tract deserve special attention. Combination of synergistic components: highly bioavailable curcumin and prebiotic fibers; artichoke leaf extract and chamomile flower extract provide simultaneous effects on three key digestive organs: stomach, pancreas and liver. Curcumin has an anti-inflammatory effect, helps to normalize acidity and restore microflora; epithelialization of ulcers; normalization of the gallbladder function; elimination of toxins. It inhibits the processes of primary tumour formation and prevents the development of metastatic processes in gastrointestinal cancer. Pharmaceutical technologies using cyclodextrin as an excipient increase curcumin’s water solubility, dispersibility and absorption, which has been confirmed in several comparative bioavailability studies in healthy volunteers. Chamomile flower extract has anti-inflammatory, antimicrobial, antispasmodic, antiulcer, wound healing and astringent effects. Chamomile is rich in slimy substances that envelop and protect the inflamed mucous membrane, including the stomach, from irritation with hydrochloric acid, bile components, food, and drugs. Mucous substances also have an anti-inflammatory effect and improve digestion. The artichoke facilitates the outflow of bile, affects the secretion of gastric glands, pancreas, increases the enzymatic activity of gastric juice, enhances intestinal motility during its atony, and has a hepatoprotective effect. As can be seen from the above, a combination of these synergistic components can be used in patients with chronic diseases, functional disorders as part of combination therapy, as well as for the prevention of gastrointestinal diseases in healthy people.

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Validation of a RP-HPLC-DAD Method for Chamomile (Matricaria recutita) Preparations and Assessment of the Marker, Apigenin-7-glucoside, Safety and Anti-Inflammatory Effect

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/828437 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 6

Author(s):

Felipe Galeti Miguel ◽

Amanda Henriques Cavalheiro ◽

Nathália Favaretto Spinola ◽

Diego Luis Ribeiro ◽

Gustavo Rafael Mazzaron Barcelos ◽

...

Keyword(s):

High Performance ◽

Biological Effects ◽

Reversed Phase ◽

Natural Sources ◽

Rp Hplc ◽

Anti Inflammatory ◽

Interday Precision ◽

Lps Treatment ◽

Chamomile Flower ◽

Inflammatory Effect

Chamomile is a medicinal plant, which presents several biological effects, especially the anti-inflammatory effect. One of the compounds related to this effect is apigenin, a flavonoid that is mostly found in its glycosylated form, apigenin-7-glucoside (APG), in natural sources. However, the affectivity and safety of this glycoside have not been well explored for topical application. In this context, the aim of this work was to develop and validate a reversed-phase high-performance liquid chromatography (RP-HPLC-DAD) method to quantify APG in chamomile preparations. Additionally, the safety and the anti-inflammatory potential of this flavonoid were verified. The RP-HPLC-DAD method was developed and validated with linearity at 24.0–36.0 μg/mL range (r=0.9994). Intra- and interday precision (RSD) were 0.27–2.66% and accuracy was 98.27–101.21%. The validated method was applied in the analysis of chamomile flower heads, glycolic extract, and Kamillen cream, supporting the method application in the quality control of chamomile preparations. Furthermore, the APG safety was assessed by MTT cytotoxicity assay and mutagenic protocols and the anti-inflammatory activity was confirmed by a diminished TNF-αproduction showed by mice macrophages treated with APG following LPS treatment.

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Investigating the Anti-Inflammatory Activity of Curcumin-Loaded Silica-Containing Redox Nanoparticles

Journal of Nanomaterials ◽

10.1155/2021/6655375 ◽

2021 ◽

Vol 2021 ◽

pp. 1-11

Author(s):

Khoa Minh Le ◽

Nhu-Thuy Trinh ◽

Vinh Dinh-Xuan Nguyen ◽

Tien-Dat Van Nguyen ◽

Thu-Ha Thi Nguyen ◽

...

Keyword(s):

Chronic Inflammation ◽

Self Assembly ◽

Water Solubility ◽

Nitroxide Radical ◽

Pharmacokinetic Profile ◽

Ros Scavenging ◽

Anti Inflammatory ◽

Inflammatory Effect

Chronic inflammation is considered as one of the challenging diseases, and overproduction of reactive oxygen species (ROS) is strongly related to the onset of chronic inflammation. Therefore, antioxidant and anti-inflammatory approaches are particularly becoming suitable treatment and prevention of inflammation. Curcumin (CUR), a main component of turmeric extract, is well known as an effective agent in both antioxidant and anti-inflammatory activities; however, there are still some limitations of its use including poor water solubility, low bioavailability, and oxidation by ROS. Nanotechnology has been used as a drug delivery system, which is a promising approach in overcoming the aforementioned drawbacks of CUR; hence, it improves the antioxidant and anti-inflammatory effects of conventional medications. In this research, silica-containing redox nanoparticles (siRNP) were designed with the size of several tens of nanometers, prepared by self-assembly of an amphiphilic block copolymer consisting of drug absorptive silica moiety and ROS-scavenging nitroxide radical moiety in the hydrophobic segment. CUR was simply encapsulated into siRNP through the dialysis method, creating CUR-loaded siRNP (CUR@siRNP), which significantly improved the water solubility of CUR. The efficient antioxidant activity and anti-inflammatory effect of CUR@siRNP in vitro were also improved via 2,2-diphenyl-1-picrylhydrazyl assay and lipopolysaccharide-induced macrophage cell line activation, respectively. Oral administration of CUR@siRNP showed improvement in pharmacokinetic profile in vivo including AUC and Cmax values as compared to free CUR. Furthermore, the anti-inflammatory effect of nanoformulation was investigated in the colitis mouse model induced by dextran sodium sulfate.

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Anti-inflammatory and barrier stabilising effects of myrrh, coffee charcoal and chamomile flower extract in a multicomponent-cell-model of the intestinal mucosa

10.1055/s-0039-3399958 ◽

2019 ◽

Author(s):

L Weber ◽

KH Goos ◽

J Arnhold ◽

C Vissiennon

Keyword(s):

Intestinal Mucosa ◽

Cell Model ◽

Flower Extract ◽

Anti Inflammatory ◽

Chamomile Flower

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Anti-Inflammatory Effect of Rosa rugosa Flower Extract in Lipopolysaccharide-Stimulated RAW264.7 Macrophages

Biomolecules & Therapeutics ◽

10.4062/biomolther.2015.090 ◽

2016 ◽

Vol 24 (2) ◽

pp. 184-190 ◽

Cited By ~ 18

Author(s):

Xirali Tursun ◽

Yongxin Zhao ◽

Zulfiya alat ◽

Xuelei Xin ◽

AdilaTursun ◽

...

Keyword(s):

Rosa Rugosa ◽

Flower Extract ◽

Raw264.7 Macrophages ◽

Anti Inflammatory ◽

Inflammatory Effect

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Anti-Inflammatory Effect of Erigeron annuus L. Flower Extract through Heme Oxygenase-1 Induction in RAW264.7 Macrophages

Journal of the Korean Society of Food Science and Nutrition ◽

10.3746/jkfn.2011.40.11.1507 ◽

2011 ◽

Vol 40 (11) ◽

pp. 1507-1511 ◽

Cited By ~ 6

Author(s):

Mi-Sun Sung ◽

Young-Hwa Kim ◽

Young-Min Choi ◽

Hyeon-Mi Ham ◽

Heon-Sang Jeong ◽

...

Keyword(s):

Heme Oxygenase ◽

Heme Oxygenase 1 ◽

Flower Extract ◽

Raw264.7 Macrophages ◽

Erigeron Annuus ◽

Anti Inflammatory ◽

Inflammatory Effect

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Anti-inflammatory and healing effect of leaf-flower mixture extract of Cytisus triflorus L

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v9i6.3625 ◽

2019 ◽

Vol 9 (6) ◽

pp. 1-6

Author(s):

Soraya Madoui ◽

Kamel Mokhnache ◽

Hanane Khither ◽

Sana Aouchria ◽

Noureddine Charef

Keyword(s):

Traditional Medicine ◽

Leaf Extract ◽

Inflammatory Diseases ◽

Complete Healing ◽

Flower Extract ◽

Healing Effect ◽

Anti Inflammatory ◽

Rat Paw ◽

Made In ◽

Inflammatory Effect

Objective: The present study aims to study the anti-inflammatory and healing effects of the crude leaf and flower mixture extract of Cytisus triflorus L., known in Algeria as Igoulli. Methodology and results: The method consists of studying the anti-inflammatory effect by measuring the diameter of edema of the paw of rats that received carrageenan. In addition, 2 cm diameter circular incision wounds were made in rats to evaluate the healing activity of the crude leaf and flower mixture extract of Cytisus triflorus L. at doses of 200 mg/kg and 400 mg/kg. The anti-inflammatory effect of C. triflorus showed that E.Br at the dose 400 mg has the higher activity, which induces a significant decrease in the thickness of the rat paw from the second hour, its effects being similar to those of Diclofenac. The percentages of inhibition of edema at 4 h and 6 h are 80.05 and 88.56% for E.Br and Diclofenac respectively. With respect to healing activity, the results show that after 18 days, complete healing was achieved with almost two concentrations of crude C. triflorus, tissue remodeling and reoccurrence of hair was observed at level of scars. Conclusion: The results of the study show that the leaf extract and flower extract of Cytisus triflorus L. has healing and anti-inflammatory properties that could justify the use of this plant in traditional medicine against inflammatory diseases. Keywords: Cytisus triflorus, anti-inflammatory, healing activity.

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Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000620 ◽

2019 ◽

pp. 1-9

Author(s):

Samira Salem ◽

Essaid Leghouchi ◽

Rachid Soulimani ◽

Jaouad Bouayed

Keyword(s):

Time Course ◽

Acute Inflammation ◽

Lichen Species ◽

Paw Edema ◽

Sod Activity ◽

Edema Formation ◽

Lobaria Pulmonaria ◽

Anti Inflammatory ◽

Endogenous Antioxidant ◽

Inflammatory Effect

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.

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