scholarly journals The relevance of topical drugs endaural use in otosurgical practice

2021 ◽  
pp. 212-216
Author(s):  
S. V. Morozova ◽  
K. V. Eremeeva ◽  
W. H.A. Suaifan ◽  
E. M. Pawlushina
Keyword(s):  
Povidone Iodine ◽  
Healing Process ◽  
Degree Of Contamination ◽  
Skin Microbiota ◽  
Ear Surgery ◽  
Skin Preparation ◽  
Antiseptic Treatment ◽  
Microbiological Examination ◽  
Before And After ◽  
A Prospective Study

Introduction. Preoperative, in particular, antiseptic, preparation of the external auditory canal (EAC) is an important issue for the otosurgeon to take in mind, especially with endaural approach.The aim of the study is to assess the skin microbiota of the EAC and the effectiveness of antiseptic treatment before endaural intervention.Materials and methods. A prospective study including 19 patients who underwent ear surgery by endaural approach: 10 stapedoplasty; 9 tympanoplasty. Ear swabs culture were taken from all the patients preoperatively and after removing the tamponade. Of the 10 patients with otosclerosis, 5 underwent skin preparation with 10% povidone iodine and a swab culture.Results. According to the microbiological examination results, Staphulacoccus Auricularis prevailed in the first smear - 52.6%. In 5 patients with otosclerosis, in comparison to the 1st swab: one case with absence of microorganisms growth, in the other 4 -decrease in the degree of contamination by half. In the 3rd swab, there was no growth in these patients and in the rest, who didn't undergo antiseptic preparation. Patients, without antiseptic preparation of the ear canal, after tympanoplasty (9 patients) in the second smear, had an increase of contamination (from 105 to 106 CFU/ml).Conclusions. Analysis of the microbiome before and after the operation revealed the growth of predominantly (94.7%) opportunistic microorganisms. Preoperative antiseptic preparation reduces the degree of contamination of the skin, which, in our opinion, prevents complications and improves the healing process.

Clinical Assessment of Gustatory Function before and after Middle Ear Surgery: A Prospective Study with a Two-Year Follow-up Period

2008 ◽  
Vol 117 (10) ◽  
pp. 769-773 ◽  
Author(s):  
Christian A. Mueller ◽  
Saher Khatib ◽  
Asami Naka ◽  
Andreas F. P. Temmel ◽  
Thomas Hummel
Keyword(s):  
Middle Ear ◽  
Anterior Part ◽  
Middle Ear Surgery ◽  
Chorda Tympani Nerve ◽  
Self Assessment ◽  
Ear Surgery ◽  
Visual Analog Scales ◽  
Gustatory Function ◽  
Before And After ◽  
A Prospective Study

Objectives: Middle ear surgery can affect gustatory function because of the course of the chorda tympani nerve (CTN) close to the tympanic membrane. The aim of the study was to evaluate the sense of taste before and after middle ear surgery with a test suitable for clinical routine. Moreover, subjective complaints were assessed over a relatively long period of time. Methods: Forty-seven patients (26 female, 21 male; mean age, 42 years) were investigated before and 4 days after surgery on both sides of the anterior part of the tongue. Self-assessment of taste function was performed by visual analog scales. Results: The mean (±SD) taste scores significantly decreased on the side ipsilateral to the operated ear in patients with major manipulation of the CTN (12.0 ± 4.5 before surgery and 6.9 ± 4.5 after surgery; p < 0.001), whereas no significant changes were measured in patients with minor manipulation of the CTN (12.5 ± 3.1 before surgery and 11.2 ± 3.9 after surgery; p = 0.14). Self-assessed ratings of taste function significantly decreased after surgery in all patients (p < 0.001). Reassessment of subjective taste function after 2 years indicated no persisting complaints. Conclusions: Depending on the amount of manipulation of the CTN, taste function is decreased after surgery. However, long-lasting changes of gustatory function seem to be rare.

Quality of Life Before and After Endovascular and Open Repair of Asymptomatic AAAs: A Prospective Study

2000 ◽  
Vol 7 (5) ◽  
pp. 372-379 ◽  
Author(s):  
Martin Malina ◽  
Marie Nilsson ◽  
Jan Brunkwall ◽  
Krasnodar Ivancev ◽  
Timothy Resch ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prospective Study ◽  
Open Repair ◽  
Before And After ◽  
A Prospective Study

scholarly journals Treatment of HIV-associated facial lipoatrophy: impact on infection progression assessed by viral load and CD4 count

2013 ◽  
Vol 88 (4) ◽  
pp. 570-577 ◽  
Author(s):  
Flávia Machado Gonçalves Soares ◽  
Izelda Maria Carvalho Costa
Keyword(s):  
Viral Load ◽  
Disease Progression ◽  
Statistical Significance ◽  
Undetectable Viral Load ◽  
Fat Distribution ◽  
Cd4 Count ◽  
Before And After ◽  
Facial Lipoatrophy ◽  
A Prospective Study ◽  
The Impact

BACKGROUND: HIV/AIDS-Associated Lipodystrophy Syndrome includes changes in body fat distribution, with or without metabolic changes. The loss of fat from the face, called facial lipoatrophy, is one of the most stigmatizing signs of the syndrome.OBJECTIVES:To evaluate the effect of FL treatment using polymethylmethacrylate (PMMA) implants on disease progression, assessed by viral load and CD4 cell count.METHODS: This was a prospective study of 44 patients treated from July 2009 to December 2010. Male and female patients, aged over 18 years, with clinically detectable FL and who had never been treated were included in the study. PMMA implantation was done to fill atrophic areas. Laboratory tests were conducted to measure viral load and CD4 count before and after treatment.RESULTS: Of the 44 patients, 72.72% were male and 27.27% female, mean age of 44.38 years. Before treatment, 82% of patients had undetectable viral load, which increased to 88.6% after treatment, but without statistical significance (p = 0.67). CD4 count before treatment ranged from 209 to 1293, averaging 493.97. After treatment, the average increased to 548.61. The increase in CD4 count after treatment was statistically significant with p = 0.02.CONCLUSION: The treatment of FL with PMMA implants showed a statistically significant increase in CD4 count after treatment, revealing the impact of FL treatment on disease progression. Viral load before and after treatment did not vary significantly.

scholarly journals A prospective study to establish the minimal clinically important difference of the Mini-BESTest in individuals with stroke

2021 ◽  
pp. 026921552110251
Author(s):  
Marla K Beauchamp ◽  
Rudy Niebuhr ◽  
Patricia Roche ◽  
Renata Kirkwood ◽  
Kathryn M Sibley
Keyword(s):  
Stroke Rehabilitation ◽  
Minimal Clinically Important Difference ◽  
Clinical Importance ◽  
Minimal Detectable Change ◽  
Global Rating ◽  
Detectable Change ◽  
Clinically Important Difference ◽  
Before And After ◽  
Small Change ◽  
A Prospective Study

Objective: To determine the minimal clinically important difference of the Mini-BESTest in individuals’ post-stroke. Design: Prospective cohort study. Setting: Outpatient stroke rehabilitation. Subjects: Fifty outpatients with stroke with a mean (SD) age of 60.8 (9.4). Intervention: Outpatients with stroke were assessed with the Mini-BESTest before and after a course of conventional rehabilitation. Rehabilitation sessions occurred one to two times/week for one hour and treatment duration was 1.3–42 weeks (mean (SD) = 17.4(10.6)). Main measures: We used a combination of anchor- and distribution-based approaches including a global rating of change in balance scale completed by physiotherapists and patients, the minimal detectable change with 95% confidence, and the optimal cut-point from receiver operating characteristic curves. Results: The average (SD) Mini-BESTest score at admission was 18.2 (6.5) and 22.4 (5.2) at discharge (effect size: 0.7) ( P = 0.001). Mean change scores on the Mini-BESTest for patient and physiotherapist ratings of small change were 4.2 and 4.3 points, and 4.7 and 5.3 points for substantial change, respectively. The minimal detectable change with 95% confidence for the Mini-BESTest was 3.2 points. The minimally clinical importance difference was determined to be 4 points for detecting small changes and 5 points for detecting substantial changes. Conclusions: A change of 4–5 points on the Mini-BEST is required to be perceptible to clinicians and patients, and beyond measurement error. These values can be used to interpret changes in balance in stroke rehabilitation research and practice.

scholarly journals Investigate the improvement of facial skin texture with the VISIA system after total thyroidectomy

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Spencer C. H. Kuo ◽  
Faye Huang ◽  
Shun-Yu Chi ◽  
Hui-Ping Lin ◽  
Peng-Chen Chien ◽  
...  
Keyword(s):  
Total Thyroidectomy ◽  
Surgical Removal ◽  
Facial Skin ◽  
Skin Texture ◽  
Sphericity Test ◽  
Preoperative Stage ◽  
Before And After ◽  
A Prospective Study ◽  
Skin Quality ◽  
Tsh Levels

Abstract Background During clinical practice we have noticed that some patients with hyperthyroidism have finer skin with less wrinkles, pores, and spots after thyroidectomy, and the improvement can be observed within a few weeks after the operation. However, there is no evidence or study in the literature to proof this finding. Aim and objective This study was designed to evaluate and quantify the skin characters of patients with hyperthyroidism before and after thyroidectomy. Material and methods This is a prospective study to include patients with hyperthyroidism who received total thyroidectomy between March 1st, 2018 and February 28th, 2019. The patients received blood test for T4 and TSH analysis and VISIA measurements for skin texture quantification, at the preoperative stage, three, and six months postoperatively. A total of 8 patients were included. Repeated measurement was used to determine the lab data and VISIA measurement changes before and after the operation. Mauchly’s sphericity test was performed to determine whether the violation of sphericity occurs, and the Greenhouse–Geisser correction was used when the violation of sphericity occurs. Results All the patients were female and generally healthy without systemic medical disease except the hyperthyroidism. The T4 and TSH levels were not significantly different before and after the thyroidectomy. In terms of the skin character measurements, the wrinkles, texture, pores, UV spots, and brown spots were not improved after thyroidectomy. A trend of improvement in spots, red area, and porphyrin was noted, although not statistically significant. Conclusions Surgical removal of the thyroid gland in patients with hyperthyroidism does not improve the skin quality and texture in examinations via the VISIA system.

Olfactory Training Using Heavy and Light Weight Molecule Odors

Perception ◽  
2016 ◽  
Vol 46 (3-4) ◽  
pp. 343-351 ◽  
Author(s):  
Sophia C. Poletti ◽  
Elisabeth Michel ◽  
Thomas Hummel
Keyword(s):  
Molecular Weight ◽  
Olfactory Dysfunction ◽  
Light Weight ◽  
Short Term ◽  
Olfactory Loss ◽  
Short Term Exposure ◽  
Before And After ◽  
Phenyl Ethyl Alcohol ◽  
A Prospective Study ◽  
Olfactory Training

Background Repeated short-term exposure to odors is known to improve olfaction in patients with acquired olfactory dysfunction. The aim was to find out whether differences in molecular weight of odors used for olfactory training influences olfaction. We hypothesized a greater improvement following training with light weight molecule (LWM) odors. Methods A prospective study was performed in patients with posttraumatic (PTOL) and postviral olfactory loss (PVOL). Olfactory training was performed over a period of 5 months. One group ( n = 48) used four odors containing heavy weight molecules (HWM; >150 g/mol) and another ( n = 48) containing LWM (<150 g/mol). Olfaction was tested before and after the training using the Sniffin’ Sticks test. Results Olfactory training was associated with olfactory improvement, with the improvement in PVOL patients being three times greater than that seen in the PTOL group. Compared with LWM training, HWM training was associated with a significantly greater improvement in Phenyl Ethyl Alcohol (PEA) threshold scores in PVOL patients; however, no such improvement could be shown for other subtests or in PTOL patients. Conclusion Overall, training was associated with olfactory improvement. With the exception of threshold scores in PVOL, there were no significant differences between LWM and HWM groups.

Effect of topically applied povidone-iodine on transient evoked otoacoustic emissions in guinea pigs

2003 ◽  
Vol 117 (9) ◽  
pp. 700-703 ◽  
Author(s):  
Recep Yagiz ◽  
Abdullah Tas ◽  
Cem Uzun ◽  
Mustafa Kemal Adali ◽  
Muhsin Koten ◽  
...  
Keyword(s):  
Middle Ear ◽  
Guinea Pigs ◽  
Otoacoustic Emissions ◽  
Povidone Iodine ◽  
Positive Control ◽  
Middle Ear Surgery ◽  
Iodine Solution ◽  
Before And After ◽  
Transiently Evoked Otoacoustic Emissions ◽  
Povidone Iodine Solution

The possible cochlear toxicity of topically applied povidone-iodine solution was investigated in guinea pigs by measuring transiently evoked otoacoustic emissions (TEOAEs). Seven adult pigmented guinea pigs (14 ears) with a normal acoustic pinna reflex were used. After the baseline TEOAE measurements, 0.1mL of povidone-iodine solution was applied transtympanically into the middle ear in the study group. Saline solution and gentamicin were used as negative and positive control, respectively. TEOAE measurements were repeated on the 10th day, and four weeks after the first application. Tympanometric measurements were also carried out for both ears of all animals at the end of the study. Responses in all ears, which had povidone-iodine applied to them, disappeared in a way similar to those recorded in gentamicin-treated ears. Tympanometric measurements at the end of the study showed ’type A’ tympanograms in all ears of all animals. The present study showed that povidone-iodine could have a cochleotoxic effect in guinea pigs. A study in humans with TEOAE before and after middle-ear surgery, where povidone-iodine can reach into the middle-ear cavity, may be useful for evaluating this result for clinical practice.

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