scholarly journals Differences In High-Intensity Signal Volume Between Arterial Spin Labeling And Contrast-Enhanced T1-Weighted Imaging May Be Useful For Differentiating Glioblastoma From Brain Metastasis

2017 ◽  
Vol 64 (1.2) ◽  
pp. 58-63 ◽  
Author(s):  
Mungunbagana Ganbold, MD ◽  
Masafumi Harada, MD, PhD ◽  
Delgerdalai Khashbat, MD, PhD ◽  
Takashi Abe, MD, PhD ◽  
Teruyoshi Kageji, MD, PhD ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
High Intensity ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Contrast Enhanced ◽  
High Intensity Signal

Abstract T P174: Intra-Arterial Signal on Arterial Spin Labeling Perfusion MRI Can Identify Stagnant Flow in Patients with Acute Middle Cerebral Artery Occlusion

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Junichiro Satomi ◽  
Yoshiteru Tada ◽  
Takashi Abe ◽  
Kazuyuki Kuwayama ◽  
Shu Sogabe ◽  
...  
Keyword(s):  
High Intensity ◽  
Arterial Spin Labeling ◽  
Arterial Occlusion ◽  
Spin Labeling ◽  
Vessel Occlusion ◽  
Mca Occlusion ◽  
Asymptomatic Patients ◽  
Major Vessel ◽  
High Intensity Signal ◽  
Stagnant Flow

Introduction: T2*-weighted imaging (T2*WI) can detect acute endovascular clots by the susceptibility vessel sign (SVS). Stagnant flow in front of middle cerebral artery (MCA) occlusion sites may contribute to intra-arterial high-intensity signal on arterial spin labeling (ASL) magnetic resonance imaging (MRI), making it another potential marker of MCA occlusion. We compared intra-arterial high-intensity signal and SVS in patients with symptomatic and asymptomatic MCA occlusion and patients without major vessel occlusion. Methods: We identified transient ischemic attack or ischemic stroke patients by (a) 3-T MRI, diffusion-weighted imaging, ASL, T2*WI, and magnetic resonance angiography (MRA) performed within 24 h after stroke onset and (b) the presence of MCA occlusion (n=34 patients) or the absence of major vessel occlusion (n=24 patients). We included asymptomatic patients with MCA occlusion (n=6). The presence or absence of intra-arterial high-intensity signal and SVS was recorded as was its coincidence with the presence of MCA occlusion on MRA. Results: In patients with acute ischemic stroke the sensitivity of intra-arterial high-intensity signal was significantly higher than of the SVS (88% vs 50%; p<0.05). The accuracy of intra-arterial high-intensity signal was also higher than of the SVS (93% vs 71%; p<0.05). Neither the intra-arterial high-intensity signal nor the SVS was observed in patients without major vessel occlusion. The presence or absence of intra-arterial high-intensity signal was highly consistent with the presence or absence of MCA occlusion on MRA (κ=0.74). Positivity for the intra-arterial high signal was higher in symptomatic than asymptomatic patients with MCA occlusion (88% vs 17%; p<0.05), suggesting that acute rather than chronic arterial occlusion contributes to the visibility of the intra-arterial high-intensity signal. Conclusions: The intra-arterial high-intensity signal on ASL could identify stagnant flow in front of occlusion sites due to acute arterial occlusion.

scholarly journals Clinical Significance of Discrepancy between Arterial Spin Labeling Images and Contrast-enhanced Images in the Diagnosis of Brain Tumors

2015 ◽  
Vol 14 (4) ◽  
pp. 313-319 ◽  
Author(s):  
Takashi ABE ◽  
Yoshifumi MIZOBUCHI ◽  
Wataru SAKO ◽  
Saho IRAHARA ◽  
Yoichi OTOMI ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Clinical Significance ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Contrast Enhanced

scholarly journals Medullary hemangioblastoma in a child with von Hippel-Lindau disease: vascular tumor perfusion depicted by arterial spin labeling and dynamic contrast-enhanced imaging

2015 ◽  
Vol 16 (1) ◽  
pp. 50-53 ◽  
Author(s):  
Hyun Woo Goo ◽  
Young-Shin Ra
Keyword(s):  
Arterial Spin Labeling ◽  
Vascular Tumor ◽  
Spin Labeling ◽  
Diagnostic Value ◽  
Tumor Perfusion ◽  
Von Hippel Lindau ◽  
Dynamic Contrast Enhanced Imaging ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Von Hippel Lindau Disease

Medullary hemangioblastoma is very rare in children. Based on small nodular enhancement with peritumoral edema and without dilated feeding arteries on conventional MRI, hemangioblastoma, pilocytic astrocytoma, oligodendroglioma, and ganglioglioma were included in the differential diagnosis of the medullary tumor. In this case report, the authors emphasize the diagnostic value of arterial spin labeling and dynamic contrast-enhanced MRI in demonstrating vascular tumor perfusion of hemangioblastoma in a 12-year-old boy who was later found to have von Hippel-Lindau disease.

Non-contrast enhanced 4D intracranial MR angiography based on pseudo-continuous arterial spin labeling with the keyhole and view-sharing technique

2018 ◽  
Vol 80 (2) ◽  
pp. 719-725 ◽  
Author(s):  
Makoto Obara ◽  
Osamu Togao ◽  
Gabriele M. Beck ◽  
Shuhei Shibukawa ◽  
Tomoyuki Okuaki ◽  
...  
Keyword(s):  
Arterial Spin Labeling ◽  
Mr Angiography ◽  
Spin Labeling ◽  
View Sharing ◽  
Contrast Enhanced ◽  
Continuous Arterial Spin Labeling

scholarly journals 3D GRASE Pulsed Arterial Spin Labeling at Multiple Inflow Times in Patients with Long Arterial Transit Times: Comparison with Dynamic Susceptibility-Weighted Contrast-Enhanced MRI at 3 Tesla

2015 ◽  
Vol 35 (3) ◽  
pp. 392-401 ◽  
Author(s):  
Steve Z Martin ◽  
Vince I Madai ◽  
Federico C von Samson-Himmelstjerna ◽  
Matthias A Mutke ◽  
Miriam Bauer ◽  
...  
Keyword(s):  
Cerebral Artery ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
3 Tesla ◽  
Acquisition Time ◽  
Dynamic Susceptibility ◽  
Flow Measurements ◽  
Transit Times ◽  
Contrast Enhanced ◽  
Transit Delay

Pulsed arterial spin labeling (PASL) at multiple inflow times (multi-TIs) is advantageous for the measurement of brain perfusion in patients with long arterial transit times (ATTs) as in steno-occlusive disease, because bolus-arrival-time can be measured and blood flow measurements can be corrected accordingly. Owing to its increased signal-to-noise ratio, a combination with a three-dimensional gradient and spin echo (GRASE) readout allows acquiring a sufficient number of multi-TIs within a clinically feasible acquisition time of 5 minutes. We compared this technique with the clinical standard dynamic susceptibility-weighted contrast-enhanced imaging—magnetic resonance imaging in patients with unilateral stenosis >70% of the internal carotid or middle cerebral artery (MCA) at 3 Tesla. We performed qualitative (assessment by three expert raters) and quantitative (region of interest (ROI)/volume of interest (VOI) based) comparisons. In 43 patients, multi-TI PASL-GRASE showed perfusion alterations with moderate accuracy in the qualitative analysis. Quantitatively, moderate correlation coefficients were found for the MCA territory (ROI based: r=0.52, VOI based: r=0.48). In the anterior cerebral artery (ACA) territory, a readout related right-sided susceptibility artifact impaired correlation (ROI based: r=0.29, VOI based: r=0.34). Arterial transit delay artifacts were found only in 12% of patients. In conclusion, multi-TI PASL-GRASE can correct for arterial transit delay in patients with long ATTs. These results are promising for the transfer of ASL to the clinical practice.

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