scholarly journals Extramedullary hematopoiesis (EMH) and other pathological conditions in canine spleens

2016 ◽  
Vol 72 (12) ◽  
pp. 768-772
Author(s):  
Gintaras Zamokas ◽  
Aidas Grigonis ◽  
Lina Babickaitė ◽  
Vita Riškevičienė ◽  
Kristina Lasienė ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Rare Condition ◽  
Bone Marrow Examination ◽  
Extramedullary Hematopoiesis ◽  
White Pulp ◽  
Pathological Conditions ◽  
Spleen Enlargement ◽  
Red Pulp

The aim of the study was to evaluate pathological conditions in canine spleens. The spleens of 105 dogs were examined histopathologically. The age of dogs ranged from 2 months (n = 6) to 21 years (n = 99). There were 78 male and 27 female animals. Macroscopically, 93 spleens were enlarged. During histophatological examination, different pathological conditions were found (extramedullary hemopoiesis (EMH), lymphoma, inflammation, amyloidosis, diffuse and follicular white pulp hyperplasia, red pulp hyperplasia, hematomas). Although it is a rare condition, EHM was found in the spleens of 72 dogs (68.6 percent), and further investigations are needed together with bone marrow examination. We observed that splenomegaly, especially as a focal spleen enlargement, is common in dogs, but often missdiagnosed as malignant spleen tumor.

scholarly journals Extramedullary Hematopoiesis Presenting as Progressive Headache: A Case Report and Review of Literature

2021 ◽  
Author(s):  
Mohammad Reza Babaee ◽  
Iman Mohseni ◽  
Mohammad Ali Mohammadi-Vajari ◽  
Ghazale Tefagh ◽  
Nima Rakhshankhah ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Differential Diagnosis ◽  
Blood Cells ◽  
Medical Condition ◽  
Rare Condition ◽  
Extramedullary Hematopoiesis ◽  
Review Of Literature ◽  
Imaging Studies ◽  
Level Of Consciousness ◽  
Underlying Medical Condition

Extramedullary Hematopoiesis (EMH) is defined as the production of blood cells in organs other than bone marrow. Intracranial EMH is a rare condition. In this article, we presented a case of intracranial EMH presenting as progressive headache. Our patient was a 33-yearold man with thalassemia presenting with acute progressive flaccid quadriplegia, severe progressive headache, and decreased level of consciousness. His imaging studies showed evidence of intracranial and presacral EMH. Most asymptomatic intracranial EMH can present as a variety of symptoms, including progressive headache; therefore, the differential diagnosis should be kept in mind when evaluating a patient with a relevant underlying medical condition.

scholarly journals Radioautographic Study of Cellular Migration Using Parabiotic Rats

Blood ◽  
1972 ◽  
Vol 39 (2) ◽  
pp. 249-266 ◽  
Author(s):  
Ruth W. Tyler ◽  
N. B. Everett
Keyword(s):  
Bone Marrow ◽  
Plasma Cells ◽  
Cell Types ◽  
Cellular Migration ◽  
Thoracic Duct Lymph ◽  
White Pulp ◽  
Direct Transformation ◽  
Circulating Cells ◽  
Splenic Red Pulp ◽  
Red Pulp

Abstract Leukocyte exchange between the hemopoietic tissues of parabiotic rats was studied subsequent to giving multiple injections of 3H-thymidine to one member of each pair while arresting the cross-circulation. Cell types that migrated from one parabiont to the other were segmented granulocytes, small, medium and large lymphocytes, immunoblasts, monocytoid cells, macrophages or their immediate precursors, and plasma cells. Evidence for the transformation of circulating cells to other cell types was rarely seen. The long-lived small lymphocytes were equilibrated between parabionts, suggesting that this is a single pool of cells with respect to kinetic behavior and recirculation. There was no evidence for a trephocytic function of lymphocytes. A small number of bone marrow lymphocytes coursed directly to lymph nodes and spleen. Evidence is given for a limited recirculation of short-lived lymphocytes of thoracic duct lymph (TDL), as well as for long-lived cells. Only a few immunoblasts of TDL recirculated. The majority of cells that entered the white pulp of the spleen were long-lived small lymphocytes, while the majority of immigrant cells to the red pulp were monocytoid cells and granulocytes. Many small lymphocytes originated in splenic red pulp and entered the blood. No immigrant cells to the thymic cortex were noted, although some small lymphocytes and monocytoid cells entered the medullary areas. Immigrant cells to the bone marrow (less than 2% of the cells in marrow) included monocytoid cells, small lymphocytes, and plasma cells. Evidence for the direct transformation of a circulating cell into a committed blast, based on reduction in grain count, was noted only in bone marrow.

Fundamentals of Bone Marrow Examination

1994 ◽  
Vol 8 (4) ◽  
pp. 651-663 ◽  
Author(s):  
Bong H. Hyun ◽  
Alan J. Stevenson ◽  
Cheryl A. Hanau
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Examination

Pancytopenia: A Challenging Problem for Treating Physician

2018 ◽  
Vol 2 (01) ◽  
pp. 22-28
Author(s):  
Md. Rezaul Karim Chowdhury ◽  
Amina Begum ◽  
Md. Haroon Ur Rashid ◽  
Md. Kamrul Hasan
Keyword(s):  
Bone Marrow ◽  
Physical Examination ◽  
Blood Smear ◽  
Peripheral Blood Smear ◽  
Bone Marrow Examination ◽  
Challenging Problem ◽  
Trephine Biopsy ◽  
Life Threatening ◽  
Underlying Pathology ◽  
Careful History

Pancytopenia is an important clinico-haematological entity and striking feature of many serious and life-threatening illnesses. Many haematological and non-haematological diseases involve the bone marrow primarily or secondarily and cause pancytopenia. Decrease in haemopoietic cell production, ineffective haemopoiesis and peripheral sequestration or destruction of the cells are the main pathophysiology of pancytopenia. The cause of pancytopenia thus may be lying in the bone marrow or in the periphery or both. Careful history, physical examination, simple blood work, review of the peripheral blood smear, sometimes bone marrow examination and trephine biopsy are required for diagnosis. Treatment and prognosis depend on the severity of pancytopenia and underlying pathology.

Bone marrow necrosis and fat embolism syndrome: a near fatal complication in previously undiagnosed sickle beta + thalassaemia

2021 ◽  
Vol 14 (1) ◽  
pp. e238317
Author(s):  
Nibash Budhathoki ◽  
Sunita Timilsina ◽  
Bebu Ram ◽  
Douglas Marks
Keyword(s):  
Bone Marrow ◽  
Multiorgan Failure ◽  
Rare Condition ◽  
Altered Mental Status ◽  
Fat Embolism ◽  
Bone Marrow Necrosis ◽  
Embolism Syndrome ◽  
Hb S ◽  
High Index Of Suspicion ◽  
Specific Symptoms

Prevalence of haemoglobin sickle-β+ thalassaemia (Hb S/β+thal) is variable with geography ranging from 0.2% to 10% among sickle cell patients. Clinical presentation of Hb S/β+thal patients depends on HbA level, with milder disease often going undiagnosed. However, rarely these patients can present with a fulminant vaso-occlusive crisis (VOC). Given VOC can present with non-specific symptoms, the diagnosis and treatment is often delayed. Here, we present a patient who initially developed altered mental status, pancytopenia and multiorgan failure due a critical VOC resulting in bone marrow necrosis and fat embolism. Subsequent workup confirmed that our patient had Sickle-β+ thalassaemia, which had gone undiagnosed, despite subclinical evidence of haemolysis on routine lab work for years. Following diagnosis and initiation of RBC exchange, he improved significantly and was discharged home. High index of suspicion and bone marrow biopsy is vital for early diagnosis and management of this rare condition.

Granulocytopenia Associated With Thymoma in a Domestic Shorthaired Cat

2008 ◽  
Vol 44 (4) ◽  
pp. 210-217 ◽  
Author(s):  
Janean L. Fidel ◽  
Indira S. Pargass ◽  
Michael J. Dark ◽  
Shannon P. Holmes
Keyword(s):  
Bone Marrow ◽  
Radiation Therapy ◽  
Immune Suppression ◽  
Bone Marrow Examination ◽  
Coarse Fraction ◽  
External Beam ◽  
Mass Treatment ◽  
Left Shift ◽  
Immune Mediated ◽  
Blood Neutrophils

A 5-year-old, spayed female cat was referred because of a mass in the cranial mediastinum noted on thoracic radiographs. A thymoma was diagnosed following ultrasound and biopsy of the mass. Treatment was initiated with coarse-fraction radiation therapy using external-beam therapy (four fractions of 5 Gy). The mass responded, but granulocytopenia developed. Bone marrow examination showed a myeloid to erythroid ratio of approximately 1:1, with a left shift within the myeloid line. These findings, as well as the lack of toxic changes within the peripheral blood neutrophils, suggested immune-mediated destruction of peripheral granulocytes. Immune suppression with prednisone and cyclosporine was instituted. After 7 weeks, the neutrophil count returned to normal. The tumor was removed, and cyclosporine was reduced and eventually discontinued 3 weeks postsurgery.

AB1377 Clinical interest of bone marrow examination in rheumatology practice: An observationnal study of 257 patients

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 716.12-716
Author(s):  
P. Ornetti ◽  
A. Loctin ◽  
C. Fortunet ◽  
J.-F. Maillefert ◽  
C. Tavernier
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Examination ◽  
Clinical Interest ◽  
Rheumatology Practice

BONE MARROW PROFILE IN HEMATOLOGICAL DISORDERS IN YEMENI PATIENS

2021 ◽  
pp. 61-65
Author(s):  
Saeed Thabet Nasher ◽  
Fayed Alyousufy ◽  
Khaled Alkubati ◽  
Sadam Al Halimy ◽  
Ramia Al Athwary
Keyword(s):  
Bone Marrow ◽  
Visceral Leishmaniasis ◽  
Lymphoblastic Leukemia ◽  
Bone Marrow Examination ◽  
Myeloproliferative Disorder ◽  
Lymphocytic Leukemia ◽  
Published Data ◽  
Hematological Disorders ◽  
Hematological Diseases ◽  
Age Related

There is paucity of information about the prevalence of hematological disorders in Yemen and neighboring countries .This is the rst project to evaluate the relative spectrum of hematological diseases in Taiz and Ibb governorate Yemen ,by method of bone marrow examination which is considered an important valuable diagnostic tool, for evaluation and nal diagnosis of various hematological and non-hematological disorders especially when CBC and peripheral blood lm study and other investigation failed to give a diagnosis . OBJECTIVES: The aim of this study was to evaluate the spectrum of haematological diseases diagnosed by bone marrow examination in Taiz and IBB governorates Yemen between September 2016 and October 2020 .Patients and method : A total of 1108 patients aged between (1 -100 )years old were evaluated by bone marrow examination at referral hematological center in IBB city Yemen . Relevant investigations were performed when needed. After exclusion of 98 patients with normal bone marrow ndings ,a total of 1010 patients had hematological disorders , and their data were analyzed. There were 527 (52.2 %) males and 483(47.8 %) females . A total of 655(64.9%) patients had benign hematological diseases and 355 (35.1% ) patients had malignant hematological diseases . RESULTS :A total of 138 patients had Iron deciency anemia ,107 had immune thrombocytopenic purpura (ITP) , 92 had hypersplenism,84 had Acute lymphoblastic leukemia ,79 had Acute myeloid leukaemia, 71 had megaloblastic anemia 58 had myeloproliferative disorder , 53 had Chronic myeloid leukemia , 45 had hemolytic anemia ,45had visceral leishmaniasis. 44 had malaria, 38 had chronic lymphocytic leukemia 38 had anemia of chronic disease ,25 had aplastic anemia ,25 had myelodysplastic syndromes, ,21 had anemia of infection ,19 had congenital syndroms,7had multiple myeloma ,6 had mixed deciency anemia and 5 had metastatic deposits , 4 had myeloid leukomoid reaction ,4 had lymphoma inltration and 2 had hairy cell leukemia . Sex- and age-related distribution of the various disorders was also presented. CONCLUSION: The anemias of all types were the most frequently encountered diagnosis followed by acute and chronic leukemias , ITP , Hypersplenism , ,myeloproliferative disorder , visceral leishmaniasis , malaria, myelodysplastic syndrome and congenital syndromes respectively. The other haematological disorders were less common. These ndings are comparable with published data in previous studies done in Yemen and other developing countries

scholarly journals Myeloproliferative Neoplasm with Prominent Eosinophilia

2014 ◽  
Vol 31 (3) ◽  
pp. 162-167
Author(s):  
S Giti ◽  
MN Bhuiyan ◽  
MR Hossain ◽  
MS Islam ◽  
F Ahmed ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Intensive Care ◽  
Haematological Malignancy ◽  
Past History ◽  
Myeloproliferative Neoplasm ◽  
Oral Prednisolone ◽  
Bone Marrow Examination ◽  
Atrial Thrombus ◽  
Care Facilities ◽  
History Of

The patient, a young soldier aged 36 years having past history of malaria, was admitted in CMH Dhaka on 17 August 2011 as a transferred case from CMH Saidpur and died on 22 August 2011. The deceased was admitted in CMH Saidpur on 05 August 2011 with high fever for 05 days along with generalized joint and muscle pain. In spite of all available treatment the patient was deteriorating and he was then transferred to CMH Dhaka. At that time the patient was febrile, dehydrated and toxic with lymphadenopathy, extremely tender joints and muscles. The patient rapidly developed acute kidney failure and gradually developed features of DIC. His bone marrow examination revealed dyserythropoiesis with predominantly eosinophilic granulopoiesis, suggestive of myeloproliferative neoplasm with prominent eosinophilia. The patient was treated with injectable antibiotics, antimalarial and oral prednisolone with all intensive care facilities. Ultimately all attempts were proved unsuccessful and he died on 22 August 2011 at 1700 hrs. On autopsy the deceased had intra atrial thrombus and possibly that was the immediate cause of death. A haematological malignancy, myeloproliferative neoplasm with prominent eosinophilia, can very well produce such a fatal condition. DOI: http://dx.doi.org/10.3329/jbcps.v31i3.20985 J Bangladesh Coll Phys Surg 2013; 31: 162-167

scholarly journals THE UTILITY OF BLOOD AND BONE MARROW FILMS AND TREPHINE BIOPSY SECTIONS IN THE DIAGNOSIS OF PARASITIC INFECTIONS

2015 ◽  
Vol 7 ◽  
pp. e2015039 ◽  
Author(s):  
Clare Miller ◽  
Barbara Bain
Keyword(s):  
Bone Marrow ◽  
Iron Deficiency Anaemia ◽  
Parasitic Infection ◽  
Clinical History ◽  
Bone Marrow Examination ◽  
Accurate Diagnosis ◽  
Parasitic Infections ◽  
Trephine Biopsy ◽  
Deficiency Anaemia ◽  
Blood Examination

The laboratory haematologist has a role in the diagnosis of parasitic infections. Peripheral blood examination is critical in the diagnosis of malaria, babesiosis, filariasis and trypanosomiasis. Bone marrow examination is important in the diagnosis of leishmaniasis and occasionally leads to the diagnosis of other parasitic infections. The detection of eosinophilia or iron deficiency anaemia can alert the laboratory haematologist or physician to the possibility of parasitic infection. In addition to morphological skills, an adequate clinical history is important for speedy and accurate diagnosis, particularly in non-endemic areas.

Sign in / Sign up

Export Citation Format

Share Document