The Pathophysiological Role of Diet in Non-Communicable Disease Etiology

2020 ◽  
Vol 8 (2) ◽  
pp. 266-274
Author(s):  
Nelson Sabila
2020 ◽  
Author(s):  
Carol Wang ◽  
John Attia ◽  
Stephen Lye ◽  
Wendy Oddy ◽  
Lawrence Beilin ◽  
...  

Abstract Background: It is well established that genetics, environment, and interplay between them play crucial roles in adult disease. We aimed to evaluate the role of genetics, early life nutrition, and interaction between them, on optimal adult health. Methods: As part of a large international consortium (n~154,000), we identified 60 SNPs associated with both birthweight and adult disease. Utilising the Raine Study, we developed a birthweight polygenic score (BW-PGS) based the 60 SNPs and examined relationships between BW-PGS and adulthood cardiovascular risk factors, specifically evaluating interactions with early life nutrition. Findings: Healthy nutrition was beneficial for all individuals; longer duration of any breastfeeding was associated with lower BMI and lower Systolic Blood Pressure in those with higher BW-PGS. Interpretation: Optimal breastfeeding offers the greatest benefit to reduce adult obesity and hypertension in those genetically predisposed to high birthweight. This provides an example of how precision medicine in early life can improve adult health.


Author(s):  
Mike Rayner ◽  
Kremlin Wickramasinghe ◽  
Julianne Williams ◽  
Karen McColl ◽  
Shanthi Mendis

This chapter is about the implementation of an non-communicable disease (NCD) prevention strategy, which is a specified set of activities designed to put interventions or policies into practice. After an overview of the various types of implementation and the emerging type of research which focuses on this, this chapter describes frameworks which can be useful in guiding the planning and organization of implementation. The chapter then describes the role of national health systems in responding to NCDs. It provides case studies which illustrate the implementation of NCD prevention interventions from around the world. The chapter includes an important discussion about tackling social inequalities in health and provides examples of entry points and some possible interventions to address CVD inequalities. The chapter also discusses disadvantaged groups as key stakeholders in developing global and national strategies to prevent and control NCDs.


2020 ◽  
Vol 123 (1) ◽  
pp. 373-386
Author(s):  
Jeff Bray ◽  
Heather Hartwell ◽  
Katherine Appleton ◽  
Sarah Price

PurposeDespite growing demand, little product information is available when eating out. Information that is provided is often not well understood leading to a lack of consumer control and acting as a barrier to healthy food choices. The AIDA model which highlights the key stages of effective marketing communication (awareness, interest, desire and action) is applied. Information provided through technological solutions is examined to provide clear guidance on future use.Design/methodology/approachExploratory qualitative methods through four focused group discussions allowed consumers views to be probed in-depth and key themes to emerge through thematic analysis.FindingsIn addition to the four key elements of the AIDA model, accessibility and relevance are found to be key constructs relevant to food information provision. Accessibility highlights the need for quick and clear data display, while relevance stresses how salient information is key to each consumer. Technological solutions may offer the most responsive, effective and trusted way to provide enhanced information.Practical implicationsWith increasing consumer demand for clear information, a competitive advantage can be gained through the provision of personalised enhanced dish information when eating out. Findings from this study highlight consumers’ desire for online (app or website-based) platforms.Social implicationsThe provision of enhanced food information when eating out has clear public health implications and may influence choice leading to a reduction in non-communicable disease.Originality/valueThis study evaluates consumers’ perceptions to the provision of enhanced food information out of home providing novel insights and guidance for both managerial and societal impact.


Author(s):  
Elia Biganzoli ◽  
Romano Demicheli

The paradigm of the Somatic Mutation Theory (SMT) is failing, and a new paradigm is underway but not yet established. What is being challenged is a conceptual approach that involves the entire human biology and the development of chronic diseases. The behavior of breast and other solid cancers is compatible with the concept that the primary tumor is able to control its microscopic metastases, in the same way that an organ (e.g., the liver) is able to control its physiological size. This finding suggested that cancer and its metastases may behave as an organoid. The new paradigm under construction considers the origin of tumors as a disturbance in the communication network between tissue cell populations and between cells and extracellular matrix, and supports a systemic approach to the study of both healthy and pathologic tissues. The commentary provides a rationale for the role of physical exercise in the control of tumor dormancy according to a human evolutionary perspective.


2020 ◽  
Vol 4 (1) ◽  
pp. 201-211
Author(s):  
Arief Andriyanto ◽  
Etty Rekawati ◽  
Dwi Cahya Rahmadiyah

Diabetes mellitus is classified as a non-communicable disease which has been estimated to have increased, so a risk factor control program recommended by the Ministry of Health is required according to the DM management pillar. Health cadre empowerment is also needed to actively support non-communicable diseases programs. The purpose of this community empowerment was to change the behaviour of people with type 2 diabetes in glucose control and improve the health cadres' skills in Posbindu PTM activities. The program was carried out in October 2018 until March 2019. The targets were: 86 type 2 diabetes patients, 24 cadres in Cisalak Pasar Kelurahan, 120 cadres in Cimanggis District, and 293 cadres in Depok City. The results showed that patients could control their glucose and health cadres experienced improved skills. The role of community nurses is continuously needed to provide appropriate interventions to the patients.


2021 ◽  
Author(s):  
Carol A Wang ◽  
John R Attia ◽  
Stephen J Lye ◽  
Wendy H Oddy ◽  
Lawrence Beilin ◽  
...  

Abstract Background: It is well established that genetics, environment, and interplay between them play a crucial role in adult disease. We aimed to evaluate the role of genetics, early life nutrition, and the interaction between them, on optimal adult health. Methods: As part of a large international consortium (n~154,000), we identified 60 SNPs associated with both birthweight and adult disease. Utilising the Raine Study, we developed a birthweight polygenic score (BW-PGS) based on the 60 SNPs and examined relationships between BW-PGS and adulthood cardiovascular risk factors, specifically evaluating interactions with early life nutrition. Findings: Healthy nutrition was beneficial for all individuals; longer duration of any breastfeeding was particularly associated with lower BMI and lower Systolic Blood Pressure in those with higher BW-PGS. Interpretation: Optimal breastfeeding offers the greatest benefit to reduce adult obesity and hypertension in those genetically predisposed to high birthweight. This provides an example of how precision medicine in early life can improve adult health.


Author(s):  
Mansi Gupta

Yoga aims to prevent disease, maintain health and to treat the diseases. Asanas & Pranayama help to keep the tridoshas under control and hence impart good health. Sthaulya is considered as one of the Ashtaninditiya. Sthaulya is the result of vikriti of medadhatu, vikriti of jatharagni and involvement of kapha and vata dosha . Sthaulya is one of the most prevalent non communicable disease in today’s era and Yoga & Pranayama play a major role in both preventing this condition and to treat it.


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