EFFICACY OF OVERDOSING OF VITAMIN D3 SUPPLEMENTATION ON GROWTH PERFORMANCE AND SOME BLOOD CONSTITUENTS OF JAPANESE QUAIL

Meta-analyses of randomized controlled trials (RCTs) have demonstrated a protective effect of vitamin D3 (cholecalciferol) supplementation against cancer mortality. In the VITAL study, a RCT including 25,871 men ≥ 50 years and women ≥ 55 years, protective effects of vitamin D3 supplementation (2000 IU/day over a median of 5.3 years) with respect to incidence of any cancer and of advanced cancer (metastatic cancer or cancer death) were seen for normal-weight participants but not for overweight or obese participants. We aimed to explore potential reasons for this apparent variation of vitamin D effects by body mass index. We conducted complementary analyses of published data from the VITAL study on the association of body weight with cancer outcomes, stratified by vitamin D3 supplementation. Significantly increased risks of any cancer and of advanced cancer were seen among normal-weight participants compared to obese participants in the control group (relative risk (RR), 1.27; 95% confidence interval (CI), 1.07–1.52, and RR, 1.44; 95% CI, 1.04–1.97, respectively). No such patterns were seen in the intervention group. Among those with incident cancer, vitamin D3 supplementation was associated with a significantly reduced risk of advanced cancer (RR, 0.86; 95% CI, 0.74–0.99). The observed patterns point to pre-diagnostic weight loss of cancer patients and preventive effects of vitamin D3 supplementation from cancer progression as plausible explanations for the body mass index (BMI)—intervention interactions. Further research, including RCTs more comprehensively exploring the potential of adjuvant vitamin D therapy for cancer patients, should be pursued with priority.

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Vitamin D Receptor (VDR) Allelic Variants Correlating with Response to Vitamin D3 Supplementation in Breast Cancer Survivors

Nutrition and Cancer ◽

10.1080/01635581.2020.1869790 ◽

2021 ◽

pp. 1-14

Author(s):

Elham Kazemian ◽

Sayed Hossein Davoodi ◽

Mohammad Esmaeil Akbari ◽

Nariman Moradi ◽

Safoora Gharibzadeh ◽

...

Keyword(s):

Breast Cancer ◽

Vitamin D ◽

Cancer Survivors ◽

Vitamin D Receptor ◽

Vitamin D3 ◽

Breast Cancer Survivors ◽

Allelic Variants ◽

Vitamin D3 Supplementation

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The Effect of Dietary L-Carnitine Supplementation on Growth Performance, Carcass Traits, and Composition of Edible Meat in Japanese Quail (Coturnix coturnix japonica)

The Journal of Applied Poultry Research ◽

10.1093/japr/14.4.709 ◽

2005 ◽

Vol 14 (4) ◽

pp. 709-715 ◽

Cited By ~ 11

Author(s):

S. Sarica ◽

M. Corduk ◽

K. Kilinc

Keyword(s):

Growth Performance ◽

Japanese Quail ◽

Carcass Traits ◽

Coturnix Japonica ◽

Carnitine Supplementation ◽

Coturnix Coturnix Japonica ◽

Coturnix Coturnix

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Impact of different litter materials on behaviour, growth performance, feet health and plumage score of Japanese quail (Coturnix japonica)

10.1399/eps.2017.172 ◽

2017 ◽

Author(s):

Hesham H. Mohammed* ◽

Enas N. Said ◽

Shereen EL. Abdel-Hamid

Keyword(s):

Growth Performance ◽

Japanese Quail ◽

Coturnix Japonica

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Impact of dietary supplementation with a synbiotic, organic acids or their combination on growth performance, carcass traits, economic efficiency, jejunum histomorphometry and some blood indices of broiler chickens

Animal Production Science ◽

10.1071/an18156 ◽

2019 ◽

Vol 59 (7) ◽

pp. 1318 ◽

Cited By ~ 2

Author(s):

Ayman S. Salah ◽

Mahmoud S. El-Tarabany ◽

Mohamed A. Ali

Keyword(s):

Organic Acids ◽

Growth Performance ◽

Carcass Traits ◽

Dietary Supplementation ◽

Control Group ◽

Cost Ratio ◽

Feed Conversion ◽

Fat Percentage ◽

Blood Indices ◽

Blood Constituents

The objective was to explore the possible impacts of dietary supplementation with a synbiotic, organic acids or their combination on the growing efficiency, carcass traits and some blood constituents in broilers. In total, 160 1-day-old male broilers (Ross 308) were randomly assigned into four equal groups (40 birds with 8 replicates). The control group received the basal diet with no supplements, while diets of the treated groups were supplemented with organic acids (OA; 1 g/kg), a synbiotic (S; 1 g/kg) and an equal mix of OA and the synbiotic (OS; 2 g/kg). The dietary supplementation with OA decreased the feed intake (P = 0.011) and bodyweight gain (P = 0.011) when compared with other experimental groups. However, the dietary supplementation with the synbiotic plus OA resulted in a considerable improvement in the overall feed conversion rate when compared with the control and OA-supplemented groups (P = 0.001). Groups fed the diets supplemented with the synbiotic or the synbiotic plus OA showed significantly higher net profits and the profit to cost ratio than did the CON and OA-supplemented groups (P = 0.010 and 0.005 respectively). Birds in the S and OS groups had a significantly higher jejunum villus height (P = 0.001), and carcass (P = 0.012) and breast meat (P = 0.001) yields than did those in the control and OA groups. However, the synbiotic-supplemented group produced significantly lower abdominal fat percentage (P = 0.021). The dietary supplementation with the synbiotic or the synbiotic plus OA decreased the lymphocyte counts (P = 0.003) and the serum reduced glutathione concentration (P = 0.001), but significantly decreased the heterophil to lymphocyte ratio (P = 0.001), and the serum cholesterol (P = 0.014) and oxidised glutathione (P = 0.002) concentrations compared with the control and OA-supplemented groups. The present findings showed that dietary supplementation with a synbiotic or a synbiotic plus OA can improve the growth performance, carcass traits, serum antioxidant activity and blood-related indices in broilers.

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