Evaluation of Nuclepore Membrane Filteration Technique for Diagnosis of Schistosoma haematobium Infection

Acute appendicitis is the most common acute surgical infection during pregnancy. Although usually pyogenic in origin, parasitic infections account for a small percentage of cases. Despite the relatively high prevalence of acute appendicitis in our environment, it is not commonly associated with schistosomiasis. We report here the association of pregnancy and appendicitis caused by Schistosoma haematobium. Schistosomiasis is very common complication of pregnancy in hyperendemic areas. Schistosome egg masses can lodge throughout the body and cause acute inflammation of the appendix, liver and spleen. Congestion of pelvic vessels during pregnancy facilitates passage of eggs into the villi and intervillous spaces, causing an inflammatory reaction. Tourism and immigration make this disease a potential challenge for practitioners everywhere.

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Faculty Opinions recommendation of A novel mouse model of Schistosoma haematobium egg-induced immunopathology.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14266040.15779072 ◽

2012 ◽

Author(s):

Paul J Brindley ◽

Gabriel Rinaldi

Keyword(s):

Mouse Model ◽

Schistosoma Haematobium

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Schistosoma Haematobium

SSRN Electronic Journal ◽

10.2139/ssrn.3695850 ◽

2020 ◽

Author(s):

Martin Nelwan

Keyword(s):

Schistosoma Haematobium

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Mastomys natalensis (Smith, 1834) as a natural host for Schistosoma haematobium (Bilharz, 1852) Weinland, 1858 x Schistosoma bovis Sonsino, 1876 introgressive hybrids

Parasitology Research ◽

10.1007/s00436-021-07099-7 ◽

2021 ◽

Author(s):

Boris A.E.S. Savassi ◽

Gauthier Dobigny ◽

Jonas R. Etougbétché ◽

Thalasse T. Avocegan ◽

François T. Quinsou ◽

...

Keyword(s):

Definitive Host ◽

Schistosoma Haematobium ◽

Rattus Rattus ◽

Introgressive Hybridization ◽

Mastomys Natalensis ◽

New Host ◽

Time Period ◽

Schistosoma Bovis ◽

Bulinus Globosus ◽

Internal Transcribed Spacer Rdna

AbstractCercarial emission of schistosomes is a determinant in the transmission to the definitive host and constitutes a good marker to identify which definitive host is responsible for transmission, mainly in introgressive hybridization situations. Our goal was to test the hypothesis that micro-mammals play a role in Schistosoma haematobium, S. bovis, and/or S. haematobium x S. bovis transmission. Small mammal sampling was conducted in seven semi-lacustrine villages of southern Benin. Among the 62 animals trapped, 50 individuals were investigated for Schistosoma adults and eggs: 37 Rattus rattus, 3 Rattus norvegicus, 9 Mastomys natalensis, and 1 Crocidura olivieri. Schistosoma adults were found in four R. rattus and two M. natalensis, with a local prevalence reaching 80% and 50%, respectively. Two cercarial chronotypes were found from Bulinus globosus experimentally infected with miracidia extracted from naturally infected M. natalensis: a late diurnal and nocturnal chronotype, and an early diurnal, late diurnal, and nocturnal chronotype. The cytochrome C oxidase subunit I mtDNA gene of the collected schistosomes (adults, miracidia, and cercariae) belonged to the S. bovis clade. Eleven internal transcribed spacer rDNA profiles were found; four belonged to S. bovis and seven to S. haematobium x S. bovis. These molecular results together with the observed multi-peak chronotypes add M. natalensis as a new host implicated in S. haematobium x S. bovis transmission. We discuss the origin of the new chronotypes which have become more complex with the appearance of several peaks in a 24-h day. We also discuss how the new populations of offspring may optimize intra-host ecological niche, host spectrum, and transmission time period.

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Confounding influences of malnutrition and Plasmodium falciparum and Schistosoma haematobium infections on haematological parameters in school children in Muyuka, Cameroon

BMC Infectious Diseases ◽

10.1186/s12879-021-06201-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Irene Ule Ngole Sumbele ◽

Ofon Vitalis Otia ◽

Lorraine Francis ◽

Orelien Sylvain Mtopi Bopda ◽

Calvin Bisong Ebai ◽

...

Keyword(s):

Plasmodium Falciparum ◽

Blood Cell ◽

Cell Count ◽

Schistosoma Haematobium ◽

Haemoglobin Concentration ◽

Haematological Parameters ◽

Blood Cell Count ◽

Malaria Parasites ◽

Mean Cell Volume ◽

Distribution Width

Abstract Background School-aged children (SAC) are a high-risk demographic group for infectious diseases and malnutrition. The objective of this study was to assess the burden and the effect of Plasmodium falciparum and Schistosoma haematobium infections on the haematological indices in SAC and the confounding influence of malnutrition on the outcomes. Methods This cross-sectional study was conducted in SAC 4–14 years old living in Ikata, Bafia and Mile 14-Likoko in Muyuka, Cameroon. Anthropometric measures of malnutrition were obtained and blood samples collected were used for detection of malaria parasites by Giemsa-stained blood films using light microscopy and complete blood count analysis using an automated haematology analyser. Urine samples collected were used to detect micro haematuria with the aid of reagent strips and the eggs of S. haematobium by urine filtration technique. Multiple linear regression model was used to examine influence of independent variables on haematological parameters. Results Out of the 606 SAC examined, the prevalence of single infections with Plasmodium or S. haematobium and co-infection with both parasites was 16.2, 16.3 and 8.3%, respectively. Overall, malaria parasite (MP), urogenital schistosomiasis, malnutrition, anaemia, haematuria, microcytosis and thrombocytopenia was prevalent in 24.4, 24.6, 25.9, 74.4, 12.2, 45.4 and 11.1% of SAC, respectively. A significant linear decline (P = 0.023) in prevalence of P. falciparum infection with the severity of stunting was observed. Factors that significantly influenced haematological parameters included haemoglobin: age, stunting and MP; haematocrit: age and MP; white blood cell count: age; red blood cell count; age and MP; lymphocyte counts: stunting; mean cell volume: age; mean cell haemoglobin: age and stunting; mean cell haemoglobin concentration: sex, stunting and red cell distribution width-coefficient of variation: sex, age and stunting. Conclusions Malnutrition, Plasmodium and S. haematobium infections are common while anaemia is a severe public health problem in Muyuka, Cameroon. The interaction between haematological parameters with malaria parasites as well as linear growth index was negative and other interactions indicate systemic inflammation. While findings provide contextual intervention targets to ensure the judicious use of the limited resources, there is need for regular monitoring and proper treatment to improve the health of the underserved population.

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Urogenital Schistosomiasis—History, Pathogenesis, and Bladder Cancer

Journal of Clinical Medicine ◽

10.3390/jcm10020205 ◽

2021 ◽

Vol 10 (2) ◽

pp. 205

Author(s):

Lúcio Lara Santos ◽

Júlio Santos ◽

Maria João Gouveia ◽

Carina Bernardo ◽

Carlos Lopes ◽

...

Keyword(s):

Schistosoma Haematobium ◽

Historical Perspective ◽

Hiv Transmission ◽

Parasite Infection ◽

Urogenital Schistosomiasis ◽

Host Parasite Interactions ◽

Immunodeficiency Virus ◽

Recent Outbreak ◽

Host Parasite ◽

Female Genital

Schistosomiasis is the most important helminthiasis worldwide in terms of morbidity and mortality. Most of the infections occurs in Africa, which about two thirds are caused by Schistosoma haematobium. The infection with S. haematobium is considered carcinogenic leading to squamous cell carcinoma (SCC) and urothelial carcinoma of the urinary bladder. Additionally, it is responsible for female genital schistosomiasis leading to infertility and higher risk of human immunodeficiency virus (HIV) transmission. Remarkably, a recent outbreak in Corsica (France) drew attention to its potential re-mergence in Southern Europe. Thus far, little is known related to host-parasite interactions that trigger carcinogenesis. However, recent studies have opened new avenues to understand mechanisms on how the parasite infection can lead cancer and other associated pathologies. Here, we present a historical perspective of schistosomiasis, and review the infection-associated pathologies and studies on host–parasite interactions that unveil tentative mechanisms underlying schistosomiasis-associated carcinogenesis.

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SCHISTOSOMA HÆMATOBIUM INFECTION SUCCESSFULLY TREATED WITH LUCANTHONE

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1972.tb47475.x ◽

1972 ◽

Vol 2 (10) ◽

pp. 570-571

Keyword(s):

Schistosoma Haematobium

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The sites of (1-14C) glucose assimilation in Schistosoma haematobium

Comparative Biochemistry and Physiology ◽

10.1016/0010-406x(67)90349-0 ◽

1967 ◽

Vol 23 (3) ◽

pp. 893-898 ◽

Cited By ~ 43

Author(s):

P.J Fripp

Keyword(s):

Schistosoma Haematobium ◽

Glucose Assimilation

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The cercarial output from three Nigerian bulinids infected with two strains of Schistosoma haematobium

Journal of Helminthology ◽

10.1017/s0022149x00011378 ◽

1988 ◽

Vol 62 (2) ◽

pp. 133-140 ◽

Cited By ~ 4

Author(s):

S. E. Fryer ◽

A. J. Probert

Keyword(s):

Schistosoma Haematobium ◽

Daily Production ◽

Bulinus Truncatus ◽

Low Levels ◽

Host Parasite ◽

Second Period ◽

Initial Peak

ABSTRACTThe daily cercarial output of two Nigerian strains of Schistosoma haematobium in sympatric Bulinus truncatus, B. globosus and B. senegalensis was measured at weekly intervals from the start of emission to the snails' death. In all cases cercariae were released throughout the life of the host, with no cases of “self cure”. Patterns of output through the course of infections in B. truncatus and B. senegalensis were similar to those reported for S. haematobium by other workers, with daily production of cercariae rising to a peak within a few weeks of the onset of shedding, then declining until the host's death. In the longer lived B. globosus production was significantly higher, but declined to very low levels after the initial peak; in some individuals cercarial output remained very low, while others showed a second period of high cercarial emission. The relative compatibility of each host-parasite combination is discussed.

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