IN VITRO PROPAGATION AND IN VIVO PRODUCTION OF Zingiber officinale,ROSC.PLANTS

2007 ◽  
Vol 12 (2) ◽  
pp. 437-452
Author(s):  
Azza Arafa
Keyword(s):  
In Vitro Propagation ◽  
Zingiber Officinale

Anti-giardial therapeutic potential of dichloromethane extracts of Zingiber officinale and Curcuma longa in vitro and in vivo

2016 ◽  
Vol 115 (7) ◽  
pp. 2637-2645 ◽  
Author(s):  
Ahmad K. Dyab ◽  
Doaa A. Yones ◽  
Zedan Z. Ibraheim ◽  
Tasneem M. Hassan
Keyword(s):  
Therapeutic Potential ◽  
Curcuma Longa ◽  
Zingiber Officinale

In-vitro and in vivo studies of traditionally prepared Zingiber officinale juice for Antimitotic and Lethality activity

2021 ◽  
pp. 4652-4656
Author(s):  
Nadar Sowmya ◽  
Chouhan Raghavendra Singh ◽  
Kosha Patel ◽  
Harshil Patel ◽  
Tanvi Dodiya ◽  
...  
Keyword(s):  
Zingiber Officinale ◽  
In Vivo Studies ◽  
Root Tip ◽  
Inhibition Assay ◽  
Lc50 Value ◽  
Antimitotic Activity ◽  
Ic50 Value ◽  
Traditionally Prepared

According to the literature survey most of the studies done on Adarak (Zingiber officinale rhizome) were performed on alcoholic extracts or isolated entities of ginger but no profound work has been done on the traditionally prepared or commonly consumed way of ginger. So, in this current study, fresh ginger rhizomes were traditionally pounded to make Adarak juice. The different concentration (0.05%, 0.5%, 1%, 2.5%, 5%, 10%) were taken as sample to perform onion root tip inhibition assay and brine shrimp lethality bioassay. It showed antimitotic inhibition in the range of 0.05-10% concentration with an IC50 value of 0.37 % on number of rootlets was 0.08 % on length of rootlets. The traditionally prepared Adarak juice showed cytotoxicity in the range of 0.05-2.5% concentration with LC50 value of 1.59%. The traditionally prepared Adarak juice possesses cytotoxic and antimitotic activity.

scholarly journals WS-5 Extract of Curcuma longa, Chaenomeles sinensis, and Zingiber officinale Contains Anti-AChE Compounds and Improves β-Amyloid-Induced Memory Impairment in Mice

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Ju Eun Kim ◽  
Abinash Chandra Shrestha ◽  
Hyo Shin Kim ◽  
Ha Neul Ham ◽  
Jun Hyeong Kim ◽  
...  
Keyword(s):  
Memory Impairment ◽  
Antioxidant Activities ◽  
Curcuma Longa ◽  
Senile Plaques ◽  
Total Antioxidant Status ◽  
Ethanol Extract ◽  
Zingiber Officinale ◽  
Chaenomeles Sinensis

Alzheimer's disease (AD) is linked to an extensive neuron loss via accumulation of amyloid-beta (Aβ) as senile plaques associated with reactive astrocytes and microglial activation in the brain. The objective of this study was to assess the therapeutic effect of WS-5 ethanol extract in vitro and in vivo against Aβ-induced AD in mice and to identify the extract’s active constituents. In the present study, WS-5 exerted a significant inhibitory effect on acetylcholinesterase (AChE). Analysis by transmission electron microscopy (TEM) revealed that WS-5 prevented Aβ oligomerization via inhibition of Aβ1-42 aggregation. Evaluation of antioxidant activities using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) demonstrated that WS-5 possessed a high antioxidant activity, which was confirmed by measuring the total antioxidant status (TAS). Furthermore, the anti-inflammatory properties of WS-5 were examined using lipopolysaccharide-stimulated BV-2 microglial cells. WS-5 significantly inhibited the lipopolysaccharide–induced production of nitric oxide and two proinflammatory cytokines, TNF-α and IL-6. The memory impairment in mice with Aβ-induced AD was studied using the Morris water maze and passive avoidance test. Immunohistochemistry was performed to monitor pathological changes in the hippocampus and cortex region of the mouse brain. The animal study showed that WS-5 (250 mg/kg) treatment improved learning and suppressed memory impairment as well as reduced Aβ plaque accumulation in Aβ-induced AD. HPLC analysis identified the extract’s active compounds that exert anti-AChE activity. In summary, our findings suggest that WS-5 could be applied as a natural product therapy with a focus on neuroinflammation-related neurodegenerative disorders.

scholarly journals Evaluation of Anti-Colitis Effect of KM1608 and Biodistribution of Dehydrocostus Lactone in Mice Using Bioimaging Analysis

Plants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 1175
Author(s):  
Sullim Lee ◽  
Sang-Back Kim ◽  
Jaemin Lee ◽  
Jimin Park ◽  
Sungyoul Choi ◽  
...  
Keyword(s):  
Zingiber Officinale ◽  
Complex Nature ◽  
Marker Compound ◽  
Tnf Α ◽  
Optical Fluorescence ◽  
Inflammatory Bowel ◽  
Dehydrocostus Lactone ◽  
Natural Medicines

Inflammatory bowel disease (IBD) is a chronic relapsing disorder modulated by numerous factors. Recent failures of drugs targeting single factors suggest that multitargeting drugs could be useful for the treatment of IBD. Natural medicines may be an alternative option for the treatment of IBD, owing to the complex nature of the disease. However, most natural medicines have poor in vitro and in vivo translational potential because of inadequate pharmacokinetic study. KM1608, a mixture of the medicinal plants Aucklandia lappa, Terminalia chebula, and Zingiber officinale, was examined for its anti-colitis effects and biodistribution using bioimaging. Dehydrocostus lactone, as a marker compound, was analyzed to assess the biodistribution of KM1608. KM1608 significantly attenuated the disease activity of dextran sodium sulfate-induced colitis in mice and suppressed inflammatory mediators such as myeloperoxidase, proinflammatory cytokines (TNF-α and IL-6), and the Th2-type cytokine IL-4 in the colon. Optical fluorescence imaging revealed that KM1608 was distributed in the intestinal area as a target organ. Collectively, our findings suggest that KM1608 is a potential therapeutic formulation for IBD.

scholarly journals Biological Properties of 6-Gingerol: A Brief Review

2014 ◽  
Vol 9 (7) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Shaopeng Wang ◽  
Caihua Zhang ◽  
Guang Yang ◽  
Yanzong Yang
Keyword(s):  
Fruits And Vegetables ◽  
Biological Activities ◽  
Zingiber Officinale ◽  
Biological Properties ◽  
Anticancer Activities ◽  
Inhibition Of Angiogenesis ◽  
Underlying Mechanisms ◽  
Pharmacologically Active

Numerous studies have revealed that regular consumption of certain fruits and vegetables can reduce the risk of many diseases. The rhizome of Zingiber officinale (ginger) is consumed worldwide as a spice and herbal medicine. It contains pungent phenolic substances collectively known as gingerols. 6-Gingerol is the major pharmacologically-active component of ginger. It is known to exhibit a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation. 6-Gingerol has been found to possess anticancer activities via its effect on a variety of biological pathways involved in apoptosis, cell cycle regulation, cytotoxic activity, and inhibition of angiogenesis. Thus, due to its efficacy and regulation of multiple targets, as well as its safety for human use, 6-gingerol has received considerable interest as a potential therapeutic agent for the prevention and/or treatment of various diseases. Taken together, this review summarizes the various in vitro and in vivo pharmacological aspects of 6-gingerol and the underlying mechanisms.

The hidden mechanism beyond ginger ( Zingiber officinale Rosc.) potent in vivo and in vitro anti-inflammatory activity

2018 ◽  
Vol 214 ◽  
pp. 113-123 ◽  
Author(s):  
Shahira M. Ezzat ◽  
Marwa I. Ezzat ◽  
Mona M. Okba ◽  
Esther T. Menze ◽  
Ashraf B. Abdel-Naim
Keyword(s):  
Zingiber Officinale ◽  
Inflammatory Activity ◽  
Anti Inflammatory

scholarly journals ECONOMICAL STUDY OF IN VIVO AND IN VITRO PROPAGATION OF RUSSELIA EQUISETIFORMIS

2018 ◽  
Vol 5 (1) ◽  
pp. 67-87
Author(s):  
M. Meshaal ◽  
K. Emam ◽  
F. Ghareb ◽  
E. Khella
Keyword(s):  
In Vitro Propagation

scholarly journals Effectiveness of Daphne L. (Thymelaeaceae) in vitro propagation, rooting of microshoots and acclimatization of plants

2012 ◽  
Vol 65 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Ewa Hanus-Fajerska ◽  
Alina Wiszniewska ◽  
Przemysław Czaicki
Keyword(s):  
Plant Material ◽  
In Vitro Propagation ◽  
Shoot Formation ◽  
Mineral Salts ◽  
Shrub Species ◽  
Multiplication Coefficient ◽  
Shoot Propagation ◽  
Propagation Media

In this study, an attempt was made to investigate <i>in vitro</i> morphogenetic competence of three shrub species from the <i>Thymelaeaceae</i> family. The studied plant material originated from Russia, Greece and China, and the effectiveness of <i>in vitro</i> shoot formation and rhizogenesis of <i>Daphne caucasica</i>, <i>D. jasminea</i>, and <i>D. tangutica</i> was verified. The multiplication coefficient was compared for different propagation media. Medium composed of WPM mineral salts, MS microelements and a set of vitamins, supplemented with 1.0 mg dm<sup>-3</sup> 2iP, 0.1 mg dm<sup>-3</sup> NAA, and 0.65 g dm<sup>-3</sup> calcium gluconate, was appropriate for micropropagation of the tested genotypes. Shoot propagation in medium containing B<sub>5</sub> vitamins and microelements was not as effective as on WPM/MS medium. The rooting phase, especially in <i>D. tangutica</i>, needs further optimization in order to reduce the costs associated with acclimatization of microplantlets obtained to <i>in vivo</i> conditions. After stabilization, the plants were successfully cultivated under greenhouse conditions.

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