HEPATOPROTECTIVE EFFECTS OF TURMERIC AND MILK THISTLE SEED FLOUR AGAINST ETHANOL LIVER DAMAGE IN WISTER RATS

Objective: This study was designed to chemical composition and hepatoprotective effects of a polyphenolic fraction of aerial parts of R. hypocrateriformis (PPFRH). It was shown to exhibit strong in vitro lipid peroxidation and scavenging activity against hydroxyl radical.Methods: The chemical composition of a polyphenolic fraction of R. hypocrateriformis was analyzed by High-performance liquid chromatography method. Hepatocellular injuries induced by paracetamol were assessed by liver damage in Wistar albino rat; the hepatoprotective effect was evaluated by biochemical parameters in rat serum, antioxidant hydroxyl radical scavenging activity and lipid peroxidation in liver tissue.Results: The polyphenolic fraction of aerial parts of R. hypocrateriformis for lipid peroxidation is significantly (p<0.05). In the hepatoprotective activity of liver enzymes and hepatic necrosis were significantly (p<0.001) closer to paracetamol. The correlation coefficient between the hydroxyl scavenging radical and total phenolic and flavonoid contents were found to be R² = 0.9045 and R² = 0.8876 suggesting the contribution of phenolic and flavonoid compounds of the polyphenolic fraction of aerial parts of R. hypocrateriformis by 90% and 88% to its radical scavenging activity.Conclusion: The polyphenolic fraction of aerial parts of R. hypocrateriformis possesses a significant protective effect against acute hepatotoxicity induced by paracetamol and which may be due to the phenolic and flavonoid components.

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Hepatoprotective Effects of an Anthocyanin Fraction from Purple-Fleshed Sweet Potato Against Acetaminophen-Induced Liver Damage in Mice

Journal of Medicinal Food ◽

10.1089/jmf.2007.0691 ◽

2009 ◽

Vol 12 (2) ◽

pp. 320-326 ◽

Cited By ~ 34

Author(s):

Jae Ho Choi ◽

Chul Yung Choi ◽

Kyung Jin Lee ◽

Yong Pil Hwang ◽

Young Chul Chung ◽

...

Keyword(s):

Sweet Potato ◽

Liver Damage ◽

Hepatoprotective Effects

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Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/161062 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 7

Author(s):

Hao-Jie Pu ◽

Yun-Feng Cao ◽

Rong-Rong He ◽

Zhi-Long Zhao ◽

Jin-Hui Song ◽

...

Keyword(s):

Free Radicals ◽

Liver Damage ◽

Restraint Stress ◽

Liver Cells ◽

Protective Effects ◽

Male Mice ◽

Stress Effects ◽

Restraint Tube ◽

Hepatoprotective Effects ◽

The Relationship

The present study was conducted to investigate the relationship between the anti-stress and hepato-protective effects of Schisandra Lignans Extract (SLE) on stress-induced liver damage. Seven weeks old male mice were fixed in a restraint tube for 18 h to induce liver damage. SLE was orally administered to animals for 5 days at dosages of 100 and 200 mg/kg/day before exposed to restraint stress. Oral administration of SLE significantly reduced restraint-induced liver damage in experimental animal. SLE was further found to significantly alleviate the provocation of corticosterone in stressed mice. SLE also significantly decreased oxidative damage and increased anti-oxidative capability of liver cells by preventing the over production and accumulation of free radicals. In conclusion, the protective effects of SLE on stress-induced liver damage were confirmed, and the correlation between hepatoprotective and anti-stress effects of schisandra lignans was possible related to its alleviation on the malignant effects of stressors for bio-homeostasis, such as balance of oxidation and reduction in cells.

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Duration-dependent hepatoprotective effects of propolis extract against carbon tetrachloride-induced acute liver damage in rats

Advances in Therapy ◽

10.1007/bf02877719 ◽

2007 ◽

Vol 24 (5) ◽

pp. 1136-1145 ◽

Cited By ~ 25

Author(s):

Monika Bhadauria ◽

Satendra Kumar Nirala ◽

Sangeeta Shukla

Keyword(s):

Carbon Tetrachloride ◽

Liver Damage ◽

Acute Liver Damage ◽

Propolis Extract ◽

Hepatoprotective Effects

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The Hepatoprotective Effects of Taiwan Folk Medicine Ham-Hong-Chho in Rats

The American Journal of Chinese Medicine ◽

10.1142/s0192415x96000293 ◽

1996 ◽

Vol 24 (03n04) ◽

pp. 231-240 ◽

Cited By ~ 20

Author(s):

Hwa-Woei Chih ◽

Chun-Ching Lin ◽

Kung-Sheng Tanga

Keyword(s):

Liver Damage ◽

Broad Spectrum ◽

Folk Medicine ◽

Protective Effects ◽

Histological Observation ◽

Bidens Pilosa ◽

Potential Effectiveness ◽

Liver Injuries ◽

Hepatoprotective Effects ◽

Hepatic Lesions

Bidens pilosa L. var minor (Blume) Sherff, B. pilosa L. and B. chilensis DC (compositae), commonly known as "Ham-hong-chho" in Taiwan, have been traditionally used for medicinal purposes. To clarify and compare the hepatoprotective effects of these three plants, we evaluated their potential effectiveness on CCl4- and acetaminophen-induced acute hepatic lesions in rats. The results indicated that the increase in SGOT and SGPT activities caused by CCl4 (3.0 mI/kg, s.c.) and acetaminophen administration (600 mg/kg, i.p.) could be significantly reduced by treating with the extracts of all the three kinds of "Ham-hong-chho" and the extract of B. chilensis exhibited the greatest hepatoprotective effects. These phenomena were also conflflDed by histological observation. Liver damage induced by CCl4 and acetaminophen was markedly improved in the extract of B. chilensis treated groups, while groups treated with the extracts of B. pilosa var minor and B. pilosa demonstrated only moderate protective effects. The pharmacological and pathological effects of these three crude groups were compared with Bupleurum chinense, which has been reported previously as a treatment criteria in the CCl4 model, and with silymarin as a standard reference medicine in the acetaminophen model. The results suggest that B. pilosa var minor, B. pilosa and B. chilensis can protect liver injuries from various hepatotoxins and have potential as broad spectrum antihepatic agents.

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