Hepatoprotective effects of Cassia tora on CCl4 induced liver damage in albino rats

Carbon tetrachloride (CCl4) is a toxic chemical that causes liver injury. CCl4 triggers endoplasmic reticulum (ER) stress and unfolded protein response (UPR). UPR triggers autophagy to deal with the damage. The aim of this study was to investigate the effect of baicalein, derived from Scutellaria baicalensis, on CCl4-induced liver damage concerning ER stress and autophagy. Two groups of Wistar albino rats (n = 7/groups) were treated with 0.2 ml/kg CCl4 for 10 days with and without baicalein. Histological and transmission electron microscopy (TEM) analysis, autophagy, and ER stress markers measurements were carried out to evaluate the effect of baicalein. Histological examinations showed that baicalein reduced liver damage. TEM analysis indicated that baicalein inhibited ER stress and triggered autophagy. CCl4-induced elevation of C/EBP homologous protein (CHOP), glucose-regulating protein 78 (GRP78), activating transcription factor 4 (ATF4), activating transcription factor 6 (ATF6), inositol requiring enzyme 1 (IRE1), pancreatic ER kinase (PERK), and active/spliced form of X-box-binding protein 1 (XBP1s) ER stress markers were decreased by baicalein. Baicalein also increased the autophagy-related 5 (ATG5), Beclin1, and Microtubule-associated protein 1A/1B-light chain 3-phosphatidylethanolamine-conjugated form (LC3-II) autophagy marker levels. In conclusion, baicalein reduced the CCl4-induced liver damage by inhibiting ER stress and the trigger of autophagy.

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Evaluation of anti-hepatotoxic potential of Cassia javanica (L.) methanol extract against paracetamol-induced liver damage in Wistar albino rats

Proceedings of the Mizoram Science Congress 2018 (MSC 2018) - Perspective and Trends in the Development of Science Education and Research ◽

10.2991/msc-18.2018.40 ◽

2018 ◽

Author(s):

Esther Lalhmingliani ◽

Zodinpuii ◽

R.K. Lalremtluangi ◽

Lalramdinthara Chenkual ◽

Lalthansangi

Keyword(s):

Liver Damage ◽

Methanol Extract ◽

Albino Rats ◽

Wistar Albino Rats

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Antioxidants as recipes for efavirenz-induced liver damage: A study in albino rats

Journal of Contemporary Medical Sciences ◽

10.22317/jcms.03201809 ◽

2018 ◽

Vol 4 (1) ◽

Keyword(s):

Liver Damage ◽

Albino Rats

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Hepatoprotective effects of dieckol-rich phlorotannins from Ecklonia cava, a brown seaweed, against ethanol induced liver damage in BALB/c mice

Food and Chemical Toxicology ◽

10.1016/j.fct.2012.03.078 ◽

2012 ◽

Vol 50 (6) ◽

pp. 1986-1991 ◽

Cited By ~ 31

Author(s):

Min-Cheol Kang ◽

Ginnae Ahn ◽

Xiudong Yang ◽

Kil-Nam Kim ◽

Sung-Myung Kang ◽

...

Keyword(s):

Liver Damage ◽

Brown Seaweed ◽

Ecklonia Cava ◽

Hepatoprotective Effects

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Role of Ginger as Anti-inflammatory and Anti-apoptotic in Protection of Liver Damage Induced by Metalaxyl Fungicide in Male Albino Rats

Journal of Clinical & Experimental Pathology ◽

10.4172/2161-0681.1000346 ◽

2018 ◽

Vol 08 (03) ◽

Author(s):

Marwa Fouad Hassa ◽

Samy Hussein ◽

Yakout El Senosi ◽

Mogda Kamal Mansour ◽

Aziza Amin

Keyword(s):

Liver Damage ◽

Albino Rats ◽

Anti Inflammatory

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PROTECTIVE ROLE AND ANTIOXIDANT ACTIVITY OF AQUEOUS EXTRACT OF ROSMARINUS OFFICINALIS AGAINST TRICHLOROACETATE-INDUCED TOXICITY IN LIVER OF MALE RATS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i6.25353 ◽

2018 ◽

Vol 11 (6) ◽

pp. 420

Author(s):

Medhat Mostafa Abozid ◽

Hoda Ea Farid

Keyword(s):

Aqueous Extract ◽

Liver Damage ◽

Protective Role ◽

Rosmarinus Officinalis ◽

Male Rats ◽

Control Group ◽

Albino Rats ◽

Gamma Glutamyl Transferase ◽

Group I ◽

Glutamyl Transferase

Objective: The current study was designed to estimate the potential protective role of the aqueous extract of rosemary (AER) (Rosmarinus officinalis) against trichloroacetic acid (TCA)-created hepatotoxicity in male albino rats.Methods: Forty male albino rats were separated into four groups of ten: Group I served as control; Group II was given AER (200 mg/kg/day) by gavage; Group III received TCA at the dose 50 mg/kg/day, and Group V was treated with AER (200 mg/kg/day) and received TCA (50 mg/kg/day). The experiment was carried out for 2 months.Results: The toxicity of TCA for rats was revealed by an elevation in liver marker enzymes activities (gamma-glutamyl transferase [GGT], alkaline phosphatase [ALP], aspartate transaminase [AST], alanine aminotransferase [ALT]) and conjugated bilirubin (CB) level, and a decrease in albumin and total protein (TP) levels. The TCA administration also caused a significant increase in the activities of catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD), and also malondialdehyde (MDA) level in liver tissues. These biochemical effects were accompanied by histological indicators of liver damage. Treatment with ARE recovered the liver damage instigated by TCA, as showed by perfection of liver enzyme markers (GGT, ALT, AST, ALP), CB, TP and albumin; as well as antioxidant parameters (CAT, SOD, GPx) and lipid peroxidation (MDA) and amelioration of histopathology changes in the liver tissues.Conclusion: It could be concluded that AER supplementation for 2 months in TCA-induced toxicity in rats benefited hepatic antioxidant status and improved liver injury and damage in male albino rats exposed to TCA.

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