scholarly journals EFFECT OF HEPATOPROTECTIVE ROLE EVALUATION OF Hibiscus rosa-sinensis LEAVES AND POMEGRANATE (Punica granatum) PEELS AQ UEOUS EXTRACTS ON MALE ALBINO RATS

2018 ◽  
Vol 45 (1) ◽  
pp. 349-362
Author(s):  
Mahmoud El-Sayed
Keyword(s):  
Punica Granatum ◽  
Albino Rats ◽  
Hibiscus Rosa Sinensis

scholarly journals ANTI IMPLANTATION AND PREGNANCY INTERRUPTION ACTIVITY OF JAPAKUSUMA (HIBISCUS ROSA SINENSIS) IN ALBINO RATS

2013 ◽  
Vol 4 (3) ◽  
pp. 387-389
Author(s):  
Kashinath Hadimur ◽  
R S Sarashetti ◽  
N D Lone ◽  
V G Kanthi ◽  
Neelamma Patil
Keyword(s):  
Albino Rats ◽  
Hibiscus Rosa Sinensis ◽  
Pregnancy Interruption

scholarly journals HIBISCUS ROSA SINENSIS LOADED SOLID LIPID NANOPARTICLES AND IN VIVO WOUND HEALING ACTIVITY IN WISTAR ALBINO RATS

2020 ◽  
pp. 78-83
Author(s):  
VIJAYANAND P. ◽  
JYOTHI V. ◽  
MOUNIKA A.
Keyword(s):  
Wound Healing ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Albino Rats ◽  
Herbal Extracts ◽  
Solid Lipid ◽  
Hibiscus Rosa Sinensis ◽  
Wistar Albino Rats ◽  
Wound Healing Activity

Objective: The objective of the present research was to investigate the wound-healing potency of solid lipid nano particles of Hibiscus rosa sinensis extract. Crude herbal extracts and rudimentary formulations containing herbal extracts are good for demonstrating the feasibility of the concept; however, such formulations suffer with poor oral bioavailability and variability within groups of subjects. Converting herbal extracts into novel drug delivery systems may prove effective in addressing some of these problems. Methods: In the present study an attempt was made to develop Hibiscus rosa sinensis extract loaded solid lipid nanoparticles (HSLNs) using lipids glycerol monostearate (GMS) or beeswax. The prepared HSLNs were characterised for their size, surface charge and morphology. The optimized HSLNs were incorporated into Carbopol gel and tested for wound healing activity in male Wistar albino rats using excision wound model. Results: HSLNs of ~175 nm in size carrying negative charge were obtained with the optimised procedure using beeswax. The shape of the HSLNs was nearly spherical. The HSLNs (10 mg/ml) treated wounds healed much faster compared to raw crude extract and healing was comparable to marketed preparation. Conclusion: It is concluded that converting crude herbal extracts into SLNs can be an effective way to enhance the effectiveness of herbal extracts and their in vivo activity.

scholarly journals Antidiabetic Action of Ethanolic Extracts of Punica granatum Linn. in Alloxan-induced Diabetic Albino Rats

1970 ◽  
Vol 2 (1) ◽  
pp. 14-21 ◽  
Author(s):  
Swamamoni Das ◽  
Gayatri Sama
Keyword(s):  
Blood Glucose ◽  
Liver Glycogen ◽  
Punica Granatum ◽  
Diabetic Rats ◽  
Seed Extract ◽  
Probable Mechanism ◽  
Albino Rats ◽  
Pharmaceutical Sciences ◽  
Ethanolic Extracts ◽  
Punica Granatum L

Antidiabetic action of ethanolic extracts of seed and rind of Punica granatum L. was evaluated on alloxan-induced diabetic albino rats. Both the extracts, each at a dose of 200mg/kg/d, were administered orally for two weeks to alloxan-induced diabetic rats. Blood glucose was estimated every week for two consecutive weeks. For evaluation of probable mechanism of action of the extracts, glycogen estimation was carried out in liver, heart and skeletal muscle and effect on adrenaline-induced hyperglycemia was observed. Both the extracts significantly (p<0.05) reduced the rise in blood glucose induced by alloxan, with the rind extract exhibiting significantly (p<0.05) better activity than seed extract. Both the extracts also produced significant (p<0.05) increase in liver glycogen and significantly (p<0.05) reduced adrenaline-induced hyperglycemia. These results support strong antidiabetic action in favor of P. granatum seed and rind extractsKey words: Punica granatum L.; Ethanolic extracts; Antidiabetic; Alloxan. DOI: 10.3329/sjps.v2i1.5810Stamford Journal of Pharmaceutical Sciences Vol.2(1) 2009: 14-21

scholarly journals Chemopreventive Efficacy of Punica granatum and Silybum marianum Extracts on Chemically-induced Hepatocellular Carcinoma in Rats

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Hend Maarof Tag ◽  
Ahlem Bargougui ◽  
Sara Gamal Alshayyal ◽  
Amany Kamal ◽  
Hekmat M. Tantawy ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepg2 Cells ◽  
Punica Granatum ◽  
In Vivo Model ◽  
Control Group ◽  
Albino Rats ◽  
Silybum Marianum ◽  
Chemically Induced

Punica granatum (POM) and Silybum marianum (MT) receiving attention as potential potent anti-oxidant and anti-mutant agents. In this context, the present study was designed to highlight their effects either in vitro as well as in vivo model of induced Hepatocellular carcinoma (HCC). Human hepatoma (HepG2 cells) were treated with MT and POM to explore their antitumor activity then in vivo were carried out on thirty-six male albino rats divided into six groups (n=6). Two weeks after induction of HCC, rats were co-treated with either MT or POM ethanolic extract (500 mg/kg, orally) daily for 8 weeks. The results displayed marked reduction in the viability of HepG2 cells with IC50 equal to 48.4 and 8.6 μg/mL of POM and MT treatment respectively. Considering, in vivo experiment HCC group displayed significant elevation liver function indices (p<0.05). It also elicited depletion of liver reduced glutathione (GSH), and increased content of liver malondialdehyde (MDA) compared to control group. HCC was proved after a significantly elevated alpha-fetoprotein (AFP) level (p<0.05). All of these measurements were diminished significantly after POM and MT treatments, except the GSH level that was increased significantly. Supplementation of pomegranate and milk thistle extracts had a protective effect against chemically induced HCC. 

Sign in / Sign up

Export Citation Format

Share Document